A dual-path composite colorimetric sensor based on alkaline phosphatase induction and application thereof

By utilizing a dual-pathway composite colorimetric sensor induced by alkaline phosphatase, and leveraging silver deposition growth on the surface of gold nanoparticles and NO-specific recognition of dye molecule Rd, the problem of single colorimetric development in existing colorimetric sensors is solved, enabling early visual detection of bone metastases in prostate cancer, and improving detection accuracy and device portability.

CN117169201BActive Publication Date: 2026-07-14HANGZHOU NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HANGZHOU NORMAL UNIVERSITY
Filing Date
2023-08-21
Publication Date
2026-07-14

AI Technical Summary

Technical Problem

Existing colorimetric sensors have limited colorimetric capabilities, resulting in low accuracy in visual analysis. This makes it difficult to achieve convenient and low-cost early daily monitoring of bone metastases in prostate cancer, especially in resource-scarce environments where portable and inexpensive testing equipment is lacking.

Method used

We developed a dual-pathway composite colorimetric sensor based on alkaline phosphatase induction. Through silver deposition growth on the surface of gold nanoparticles and NO-specific recognition of dye molecule Rd, we generated a variety of color changes, achieving a simple and efficient colorimetric reaction.

Benefits of technology

It improves human visual recognition and detection sensitivity, enabling early visual detection of bone metastases in prostate cancer, reducing detection costs, and is suitable for portable devices, as well as for on-site environmental monitoring and food inspection.

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Abstract

The application discloses a double-path composite color developing sensor based on alkaline phosphatase induction and application thereof. + is reduced into Ag 0 and is deposited and grown into a silver shell layer on the surface of the gold nanoparticles, changes the size of the appearance, and is accompanied by local surface plasmon resonance peak displacement and color change; meanwhile, ascorbic acid reacts with s-nitroso glutathione to produce NO, and reacts with a NO specific recognition molecule, accompanied by color change from white to pink. The above two paths are combined to develop color, enhance the recognition degree of the human eye, and the color change is bright, simple and efficient, rapid in color development, high in sensitivity, and can realize early monitoring of prostate cancer bone metastasis, and has wide application prospect in daily monitoring of cancer diseases.
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