Breast simulation model for interventional procedure training and method of making the same

Abstract

The application discloses a breast simulation model for interventional operation training and a preparation method thereof. The breast simulation model for interventional operation training comprises a simulation epidermis layer, an inner filling surrounding tissue and a simulation mass; the simulation mass is coated in the inner filling surrounding tissue; the inner filling surrounding tissue is prepared from water and a mixed material with a mass ratio of 1200-2000:1, the mixed material is composed of collagen hydrolysate, a plasticizing agent, a surfactant and a thickening agent; and the simulation mass is a collagen hydrate solid body prepared from water and collagen powder. The breast simulation model has background development under ultrasound, can display a structure similar to human body under ultrasound, has real intervention feedback, is easy to be sucked under vacuum negative pressure, can be cut into strips when being sucked by vacuum after being cut off from the simulation mass and the inner filling surrounding tissue, does not block the channel, and can be smoothly rotary cut or puncture sampled.

Description

Technical Field

[0001] This invention relates to the field of medical simulation training model technology, and in particular to a breast simulation model for interventional surgery training and its preparation method. Background Technology

[0002] Currently, there are no simulation devices or models based on artificial materials technology for training in breast interventional surgery that can be applied to ultrasound-guided rotary cutting or puncture sampling, especially under vacuum aspiration conditions. The simulation device or model must have realistic interventional feedback and be able to completely remove the sample to avoid channel blockage.

[0003] Currently, most breast simulation models are made of silicone or latex. These materials produce no background ultrasound under ultrasound imaging, unlike actual human tissue, resulting in inaccurate ultrasound images. Furthermore, the cutting or puncture devices generate debris after sampling from latex or silicone materials. This debris can easily clog the channels, thus making them unsuitable for training in cutting or puncture procedures. Summary of the Invention

[0004] To overcome the shortcomings of existing technologies, it is necessary to provide a breast simulation model for interventional surgery training. This model has background imaging under ultrasound, can display structures similar to those of the human body under ultrasound, has realistic interventional feedback, and is easily aspirated under vacuum negative pressure. After the simulated mass and the surrounding tissue are cut off, they can be cut into strips when vacuumed without blocking the channel, and can be smoothly rotated or punctured for sampling.

[0005] The present invention includes the following technical solutions.

[0006] A breast simulation model for interventional surgery training includes a simulated epidermis, an inner filling surrounding tissue, and a simulated mass; the simulated mass is enclosed within the inner filling surrounding tissue.

[0007] The inner filling surrounding tissue is prepared from water and a mixed material in a mass ratio of 1200 to 2000:1, wherein the mixed material consists of collagen hydrolysate, plasticizer, surfactant and thickener;

[0008] The simulated mass is a collagen hydrate gel made from water and collagen powder.

[0009] In some embodiments, the mass ratio of the collagen hydrolysate, plasticizer, surfactant, and thickener is 100:0.2-2:5-40:5-30.

[0010] In some embodiments, the mass ratio of the collagen hydrolysate, plasticizer, surfactant, and thickener is 100:0.5-1.5:15-25:10-20.

[0011] In some embodiments, the mass ratio of the collagen hydrolysate, plasticizer, surfactant, and thickener is 100:0.8-1.2:18-22:13-17.

[0012] In some embodiments, the ratio of water to the mixed material is 1500 to 1700:1.

[0013] In some embodiments, the collagen hydrolysate consists of alanine and isoelectronic gelatin.

[0014] In some embodiments, the collagen hydrolysate consists of an extract of alanine and animal protein, AJIEP, in a mass ratio of 1:45 to 55.

[0015] In some embodiments, the plasticizer is dioctyl phthalate (DOP) and / or dioctyl sebate.

[0016] In some embodiments, the surfactant is Pluronic PE10500 and / or lauroyl glutamic acid.

[0017] In some embodiments, the thickener is carboxymethyl cellulose (CMC) and / or carboxypropyl methyl cellulose.

[0018] In some embodiments, the thickener is a flocculent thickening particle of 1800-2200 mesh.

[0019] In some embodiments, the mixture consists of collagen hydrolysate, dioctyl phthalate, Pluronic PE10500, and carboxymethyl cellulose. The collagen hydrolysate consists of alanine and an animal protein extract, AJIEP, in a mass ratio of 1:48–52. The mass ratio of the collagen hydrolysate, dioctyl phthalate, Pluronic PE10500, and carboxymethyl cellulose is 100:0.9–1.1:19–21:14–16.

[0020] In some embodiments, the mass ratio of water to collagen powder in the collagen hydrate gel is 150–250:1.

[0021] In some embodiments, the mass ratio of water to collagen powder in the collagen hydrate gel is 180–220:1.

[0022] In some embodiments, the mass ratio of water to collagen powder in the collagen hydrate gel is 195–205:1.

[0023] In some embodiments, the raw materials for preparing the internal filling surrounding tissue also include an ultrasonic imaging agent.

[0024] In some embodiments, the simulated skin layer is made of latex.

[0025] In some embodiments, the breast simulation model for interventional surgery training also includes a fixing base plate. Fixing the model to the fixing base plate facilitates operation by personnel conducting interventional surgery training.

[0026] The present invention also provides a method for preparing the above-mentioned breast simulation model for interventional surgery training, including the following technical solutions.

[0027] A method for preparing the above-mentioned breast simulation model for interventional surgery training includes the following steps:

[0028] (1) The 0-degree latex was coated onto the heating preparation module to form a film, thus preparing a simulated skin layer.

[0029] (2) The collagen hydrolysate, plasticizer, surfactant and thickener are thoroughly mixed to obtain a mixed material. The mixed material and water are then thoroughly mixed. An ultrasonic contrast agent may or may not be added as needed. The mixture is thoroughly mixed and allowed to stand to defoam.

[0030] (3) Add the mixed material obtained in step (2) to the heating preparation module of step (1) in layers, and add the collagen hydrate solid to the required layers to act as a simulated tumor, and heat;

[0031] (4) Let stand to defoam, cool, and solidify to obtain the product.

[0032] In some embodiments, the heating in step (3) is heating to a temperature of 40°C to 80°C for 3 to 8 minutes.

[0033] In some embodiments, the heating in step (3) is heating to a temperature of 65°C to 75°C for 5 to 6 minutes.

[0034] In some embodiments, the cooling in step (4) is cooling to 15°C to 25°C.

[0035] In some embodiments, the method for preparing the breast simulation model for interventional surgery training further includes the following steps: placing a fixed base plate on the model after solidification in step (4), applying pressure for 3 to 8 minutes, heating to 55°C to 65°C, maintaining for 20 to 30 minutes, cooling to room temperature, and removing the model to obtain the breast simulation model for interventional surgery training.

[0036] The principles and beneficial effects of this invention are as follows:

[0037] Ultrasound has good penetrability in aqueous materials, and its propagation speed and loss vary in materials of different densities, resulting in different displayed images. This invention utilizes this principle and, through extensive experimental research, discovered that by using collagen hydrolysate, plasticizer, surfactant, thickener, and water as raw materials to prepare an internal filling and surrounding tissue, and using collagen hydrate gel made from water and collagen powder as a simulated mass, aqueous materials of different densities can be created. The resulting breast simulation model can achieve the effect of clearly displaying mass images under ultrasound. Furthermore, the mass in this breast simulation model has low toughness after rotary cutting, achieving the effect of not blocking the needle after rotary cutting or puncture.

[0038] Therefore, the advantages of the breast simulation model of the present invention are as follows: it exhibits background contrast under ultrasound, and the feedback from interventional puncture and rotary cutting closely approximates that of real human tissue; furthermore, it is easily aspirated under vacuum negative pressure, and after the simulated mass and surrounding tissue are cut, they can be cut into strips during vacuum aspiration without blocking the channel, allowing for smooth rotary cutting or puncture sampling, and can be used for training in rotary cutting or puncture surgery. Furthermore, after puncture and rotary cutting, the breast simulation model of the present invention can be gently squeezed to reduce the contrast of the needle tract, facilitating reuse.

[0039] Furthermore, adding an ultrasound contrast agent to the raw materials used to prepare the tissue filling can enhance the clarity of ultrasound images.

[0040] Furthermore, by further optimizing the specific types and ratios of collagen hydrolysate, plasticizer, surfactant, and thickener, as well as the ratio of water to collagen powder in the collagen hydrate coagulated solid, the clarity of ultrasound images can be further enhanced. This will make the simulated mass in the obtained breast simulation model appear very close to the clinical image under ultrasound, and will make excision or puncture sampling easier. Attached Figure Description

[0041] Figure 1 This is a schematic diagram of the structure of a breast simulation model used for interventional surgery training.

[0042] Figure 2 This is a structural breakdown diagram of a breast simulation model used for interventional surgery training. Detailed Implementation

[0043] The technical solution of the present invention will be further illustrated below through specific embodiments. Those skilled in the art should understand that the embodiments are merely illustrative of the present invention and should not be construed as limiting the invention.

[0044] Unless otherwise defined, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to limit the invention.

[0045] The terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion. For example, a process, method, apparatus, product, or device that includes a series of steps is not limited to the steps or modules listed, but may optionally include steps not listed, or may optionally include other steps inherent to such process, method, product, or device.

[0046] In this invention, "multiple" refers to two or more. "And / or" describes the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A alone, A and B simultaneously, or B alone. The character " / " generally indicates that the preceding and following related objects have an "or" relationship.

[0047] The following are specific examples.

[0048] Example 1

[0049] The method for preparing a breast simulation model for interventional surgery training provided in this embodiment includes the following steps:

[0050] (1) The 0-degree latex (0 degrees refers to hardness) is applied to the heating preparation module by brushing to form a film, thus obtaining a simulated skin layer.

[0051] (2) The collagen hydrolysate (composed of alanine and isoelectronic gelatin (an extract of animal protein AJIEP) in a mass ratio of 1:50), the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose are thoroughly mixed to obtain a mixed material. The mixed material is then thoroughly mixed with water, and an ultrasonic imaging agent is added. The mixture is then allowed to stand to defoam. The mass ratio of the collagen hydrolysate, the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose is 100:1:20:15. The mass ratio of the mixed material to water is 1:1600.

[0052] (3) Add the mixed material obtained in step (2) to the heat preparation module of step (1) in layers, and add collagen hydrate solid (made by mixing water and collagen powder in a mass ratio of 200:1) to the required layers to act as a simulated mass, heat to 70°C and maintain for 6 minutes.

[0053] (4) Let stand to defoam, cool to 20°C, and solidify to obtain the product.

[0054] (5) Place a fixed base plate on the solidified model in step (4), apply pressure for 5 minutes, heat to about 60°C, maintain for 25 minutes, cool to room temperature, and remove the model to obtain the breast simulation model used for interventional surgery training.

[0055] The model obtained in this embodiment is fixed on a fixed base plate, which facilitates operation by personnel undergoing interventional surgery training. Furthermore, the obtained breast simulation model includes three structures: a simulated epidermis, an inner filling surrounding tissue, and a simulated mass. The simulated mass is enclosed within the inner filling surrounding tissue, and its structure is as follows: Figure 1 As shown, the exploded view of its heating preparation module and the resulting model is as follows: Figure 2 As shown.

[0056] Researchers used a rotary cutting device to cut the mass in the obtained breast tissue simulation model, observing the integrity of the cut mass and the feel of the cutting. The results showed that the breast tissue simulation model prepared in this embodiment did not block the needle tract under vacuum suction conditions, allowing for strip cutting and successful rotary cutting sampling; the mass could be completely cut. Simultaneously, background contrast was visible under ultrasound, the ultrasound image was clear, and the feedback from the rotary cutting needle insertion closely resembled the real situation of human tissue. Furthermore, after puncture and rotary cutting, slight compression of the model could reduce needle tract contrast, facilitating reuse.

[0057] Example 2

[0058] The method for preparing a breast simulation model for interventional surgery training provided in this embodiment includes the following steps:

[0059] (1) The 0-degree latex was brushed onto the heating preparation module to form a film, thus obtaining a simulated skin layer.

[0060] (2) The collagen hydrolysate (composed of alanine and animal protein extract AJIEP in a mass ratio of 1:50), the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500 and the thickener carboxymethyl cellulose are thoroughly mixed to obtain a mixed material. The mixed material is then thoroughly mixed with water, an ultrasonic developer is added, and the mixture is thoroughly mixed and allowed to stand to defoam. The mass ratio of the collagen hydrolysate, the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500 and the thickener carboxymethyl cellulose is 100:1:20:15; the mass ratio of the mixed material and water is 1:2000.

[0061] (3) Add the mixed material obtained in step (2) to the heat preparation module of step (1) in layers, and add collagen hydrate solid (made by mixing water and collagen powder in a mass ratio of 200:1) to the required layers to act as a simulated mass, heat to 70°C and maintain for 6 minutes.

[0062] (4) Let stand to defoam, cool to 20°C, and solidify to obtain the product.

[0063] (5) Place a fixed base plate on the solidified model in step (4), apply pressure for 5 minutes, heat to about 60°C, maintain for 25 minutes, cool to room temperature, and remove the model to obtain the breast simulation model used for interventional surgery training.

[0064] Example 3

[0065] The method for preparing a breast simulation model for interventional surgery training provided in this embodiment includes the following steps:

[0066] (1) The 0-degree latex was brushed onto the heating preparation module to form a film, thus obtaining a simulated skin layer.

[0067] (2) The collagen hydrolysate (composed of alanine and animal protein extract AJIEP in a mass ratio of 1:50), the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose are thoroughly mixed to obtain a mixed material. The mixed material is then thoroughly mixed with water, an ultrasonic imaging agent is added, and the mixture is thoroughly mixed and allowed to stand to defoam. The mass ratio of the collagen hydrolysate, the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose is 100:1:20:15; the mass ratio of the mixed material to water is 1:1200.

[0068] (3) Add the mixed material obtained in step (2) to the heat preparation module of step (1) in layers, and add collagen hydrate solid (made by mixing water and collagen powder in a mass ratio of 200:1) to the required layers to act as a simulated mass, heat to 70°C and maintain for 6 minutes.

[0069] (4) Let stand to defoam, cool to 20°C, and solidify to obtain the product.

[0070] (5) Place a fixed base plate on the solidified model in step (4), apply pressure for 5 minutes, heat to about 60°C, maintain for 25 minutes, cool to room temperature, and remove the model to obtain the breast simulation model used for interventional surgery training.

[0071] Example 4

[0072] The method for preparing a breast simulation model for interventional surgery training provided in this embodiment includes the following steps:

[0073] (1) The 0-degree latex was brushed onto the heating preparation module to form a film, thus obtaining a simulated skin layer.

[0074] (2) The collagen hydrolysate (composed of alanine and animal protein extract AJIEP in a mass ratio of 1:50), the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose are thoroughly mixed to obtain a mixed material. The mixed material is then thoroughly mixed with water, an ultrasonic developer is added, and the mixture is thoroughly mixed and allowed to stand to defoam. The mass ratio of the collagen hydrolysate, the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose is 100:0.5:25:10; the mass ratio of the mixed material to water is 1:1600.

[0075] (3) Add the mixed material obtained in step (2) to the heat preparation module of step (1) in layers, and add collagen hydrate solid (made by mixing water and collagen powder in a mass ratio of 200:1) to the required layers to act as a simulated mass, heat to 70°C and maintain for 6 minutes.

[0076] (4) Let stand to defoam, cool to 20°C, and solidify to obtain the product.

[0077] (5) Place a fixed base plate on the solidified model in step (4), apply pressure for 5 minutes, heat to about 60°C, maintain for 25 minutes, cool to room temperature, and remove the model to obtain the breast simulation model used for interventional surgery training.

[0078] Example 5

[0079] The method for preparing a breast simulation model for interventional surgery training provided in this embodiment includes the following steps:

[0080] (1) The 0-degree latex was brushed onto the heating preparation module to form a film, thus obtaining a simulated skin layer.

[0081] (2) The collagen hydrolysate (composed of alanine and animal protein extract AJIEP in a mass ratio of 1:50), the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose are thoroughly mixed to obtain a mixed material. The mixed material is then thoroughly mixed with water, an ultrasonic imaging agent is added, and the mixture is thoroughly mixed and allowed to stand to defoam. The mass ratio of the collagen hydrolysate, the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose is 100:1.5:15:20; the mass ratio of the mixed material to water is 1:1600.

[0082] (3) Add the mixed material obtained in step (2) to the heat preparation module of step (1) in layers, and add collagen hydrate solid (made by mixing water and collagen powder in a mass ratio of 200:1) to the required layers to act as a simulated mass, heat to 70°C and maintain for 6 minutes.

[0083] (4) Let stand to defoam, cool to 20°C, and solidify to obtain the product.

[0084] (5) Place a fixed base plate on the solidified model in step (4), apply pressure for 5 minutes, heat to about 60°C, maintain for 25 minutes, cool to room temperature, and remove the model to obtain the breast simulation model used for interventional surgery training.

[0085] Example 6

[0086] The method for preparing a breast simulation model for interventional surgery training provided in this embodiment includes the following steps:

[0087] (1) The 0-degree latex was brushed onto the heating preparation module to form a film, thus obtaining a simulated skin layer.

[0088] (2) The collagen hydrolysate (composed of alanine and animal protein extract AJIEP in a mass ratio of 1:50), the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose are thoroughly mixed to obtain a mixed material. The mixed material is then thoroughly mixed with water, an ultrasonic imaging agent is added, and the mixture is thoroughly mixed and allowed to stand to defoam. The mass ratio of the collagen hydrolysate, the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose is 100:1:20:15; the mass ratio of the mixed material to water is 1:1600.

[0089] (3) Add the mixed material obtained in step (2) to the thermal preparation module of step (1) in layers, and add collagen hydrate solid (made by mixing water and collagen powder in a mass ratio of 180:1) to the required layers to act as a simulated mass, heat to 70°C and maintain for 6 minutes.

[0090] (4) Let stand to defoam, cool to 20°C, and solidify to obtain the product.

[0091] (5) Place a fixed base plate on the solidified model in step (4), apply pressure for 5 minutes, heat to about 60°C, maintain for 25 minutes, cool to room temperature, and remove the model to obtain the breast simulation model used for interventional surgery training.

[0092] Example 7

[0093] The method for preparing a breast simulation model for interventional surgery training provided in this embodiment includes the following steps:

[0094] (1) The 0-degree latex was brushed onto the heating preparation module to form a film, thus obtaining a simulated skin layer.

[0095] (2) The collagen hydrolysate (composed of alanine and animal protein extract AJIEP in a mass ratio of 1:50), the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose are thoroughly mixed to obtain a mixed material. The mixed material is then thoroughly mixed with water, an ultrasonic imaging agent is added, and the mixture is thoroughly mixed and allowed to stand to defoam. The mass ratio of the collagen hydrolysate, the plasticizer dioctyl phthalate, the surfactant Pluronic PE10500, and the thickener carboxymethyl cellulose is 100:1:20:15; the mass ratio of the mixed material to water is 1:1600.

[0096] (3) Add the mixed material obtained in step (2) to the thermal preparation module of step (1) in layers, and add collagen hydrate solid (made by mixing water and collagen powder in a mass ratio of 220:1) to the required layers to act as a simulated mass, heat to 70°C and maintain for 6 minutes.

[0097] (4) Let stand to defoam, cool to 20°C, and solidify to obtain the product.

[0098] (5) Place a fixed base plate on the solidified model in step (4), apply pressure for 5 minutes, heat to about 60°C, maintain for 25 minutes, cool to room temperature, and remove the model to obtain the breast simulation model used for interventional surgery training.

[0099] Through more than 20 rotary cutting tests, the researchers found that the breast simulation models prepared in Examples 1-6 could all achieve the effect of not blocking the needle tract under vacuum suction conditions. At the same time, they could ensure that the feedback of the rotary cutting needle insertion was close to the real situation, the mass could be completely cut, and the ultrasound image was clear. Among them, Example 1 had the best effect.

[0100] Comparative Example 1

[0101] The method for preparing the breast simulation model for interventional surgery training provided in this comparative example includes the following steps:

[0102] (1) The 0-degree latex was brushed onto the heating preparation module to form a film, thus obtaining a simulated skin layer.

[0103] (2) Add the 0-degree latex material in layers to the heat preparation module of step (1), and add collagen hydrate solid (made by mixing water and collagen powder in a mass ratio of 200:1) to the required layers to act as a simulated mass, heat to 70°C and maintain for 6 minutes.

[0104] (3) Let stand to defoam, cool to 20°C, and solidify to obtain the product.

[0105] (4) Place a fixed base plate on the solidified model in step (3), apply pressure for 5 minutes, heat to about 60°C, maintain for 25 minutes, cool to room temperature, and remove the model to obtain the breast simulation model used for interventional surgery training.

[0106] Researchers used a rotary cutting device to cut the lump in the breast simulation model obtained in this comparative example, observed the integrity of the cut lump, and the feel of the cut. The experimental results showed that: under vacuum suction conditions, the breast simulation model prepared in this comparative example could not be used because the aspirated material would block the needle channel during the rotary cutting process.

[0107] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0108] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. A breast simulation model for interventional surgery training, characterized in that, It includes a simulated epidermis, an inner filling surrounding tissue, and a simulated mass; the simulated mass is enclosed within the inner filling surrounding tissue; The inner filling surrounding tissue is prepared from water and a mixed material in a mass ratio of 1200~2000:1, wherein the mixed material consists of collagen hydrolysate, plasticizer, surfactant and thickener; The simulated mass is a collagen hydrate gel made of water and collagen powder; The mass ratio of the collagen hydrolysate, plasticizer, surfactant, and thickener is 100:0.2~2:5~40:5~30; The mass ratio of water to collagen powder in the collagen hydrate solid is 150~250:1; The collagen hydrolysate consists of alanine and isoelectronic gelatin.

2. The breast simulation model for interventional surgery training according to claim 1, characterized in that, The mass ratio of the collagen hydrolysate, plasticizer, surfactant, and thickener is 100:0.5~1.5:15~25:10~20.

3. The breast simulation model for interventional surgery training according to claim 2, characterized in that, The mass ratio of the collagen hydrolysate, plasticizer, surfactant, and thickener is 100:0.8~1.2:18~22:13~17.

4. The breast simulation model for interventional surgery training according to claim 1, characterized in that, The mass ratio of water to the mixed material is 1500~1700:

1.

5. The breast simulation model for interventional surgery training according to claim 1, characterized in that... The collagen hydrolysate is composed of AJIEP, an extract of alanine and animal protein in a mass ratio of 1:45~55.

6. The breast simulation model for interventional surgery training according to any one of claims 1-5, characterized in that, The plasticizer is dioctyl phthalate and / or dioctyl sebate; and / or... The surfactant is Pluronic PE10500 and / or lauroyl glutamic acid; and / or, The thickener is carboxymethyl cellulose and / or carboxypropyl methyl cellulose; and / or, The thickener is a flocculent thickening particle with a mesh size of 1800-2200.

7. The breast simulation model for interventional surgery training according to any one of claims 1-5, characterized in that, The mixture consists of collagen hydrolysate, dioctyl phthalate, Pluronic PE10500, and carboxymethyl cellulose. The collagen hydrolysate is composed of alanine and AJIEP, an extract of animal protein, in a mass ratio of 1:48~52. The mass ratio of the collagen hydrolysate, dioctyl phthalate, Pluronic PE10500, and carboxymethyl cellulose is 100:0.9~1.1:19~21:14~16.

8. The breast simulation model for interventional surgery training according to any one of claims 1-5, characterized in that, The mass ratio of water to collagen powder in the collagen hydrate solid is 180~220:

1.

9. The breast simulation model for interventional surgery training according to claim 8, characterized in that, The mass ratio of water to collagen powder in the collagen hydrate solid is 195~205:

1.

10. The breast simulation model for interventional surgery training according to any one of claims 1-5, characterized in that, The raw materials used to prepare the tissue containing the filling material also include an ultrasonic contrast agent; and / or, The simulated epidermis is made of latex; and / or, The breast simulation model used for interventional surgery training also includes a fixed base plate.

11. A method for preparing a breast simulation model for interventional surgery training as described in any one of claims 1-10, characterized in that, Includes the following steps: (1) The 0-degree latex was coated onto the heating preparation module by brushing to form a film, thus preparing a simulated skin layer; (2) The collagen hydrolysate, plasticizer, surfactant and thickener are thoroughly mixed to obtain a mixed material. The mixed material and water are then thoroughly mixed. An ultrasonic contrast agent may or may not be added as needed. The mixture is thoroughly mixed and allowed to stand to defoam. (3) Add the mixed material obtained in step (2) to the heating preparation module of step (1) in layers, and add the collagen hydrate solids to the required layers to act as simulated tumors, and heat; (4) Let stand to defoam, cool, and solidify to obtain the product.

12. The method for preparing a breast simulation model for interventional surgery training according to claim 11, characterized in that, The heating mentioned in step (3) refers to heating to a temperature of 40℃~80℃ for 3 minutes~8 minutes; and / or, The cooling mentioned in step (4) refers to cooling to 15°C~25°C; and / or, The method for preparing the breast simulation model for interventional surgery training further includes the following steps: placing a fixed base plate on the model after solidification in step (4), applying pressure for 3 to 8 minutes, heating to 55°C to 65°C, maintaining for 20 to 30 minutes, cooling to room temperature, and removing the model to obtain the breast simulation model for interventional surgery training.

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