一种多功能柔性管神经电极及其制备方法

By combining flexible circuit board technology and microfabrication, a multifunctional flexible tube neural electrode was fabricated, which solved the problems of high spatiotemporal resolution and low cost in the long-term implantation of neural probes, and realized efficient neural modulation and intracranial function detection.

CN117179775BActive Publication Date: 2026-07-17HANGZHOU UNIV OF ELECTRONIC SCI & TECH WENZHOU RES INST CO LTD +1

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HANGZHOU UNIV OF ELECTRONIC SCI & TECH WENZHOU RES INST CO LTD
Filing Date
2023-04-28
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing neural probes are difficult to record and stimulate neural signals with high spatiotemporal resolution during long-term implantation, and their preparation costs are high. Traditional microfabrication processes are unreliable and expensive.

Method used

By combining flexible circuit board technology and microfabrication technology, a multifunctional flexible tube neural electrode is fabricated. The FPC neural electrode is spirally wound on a substrate microtube and combined with optical fiber, injection pump and pressure sensor to achieve high spatiotemporal resolution neural modulation and intracranial drug delivery and pressure detection functions.

Benefits of technology

It achieves high spatiotemporal resolution recording and stimulation of neural signals, reduces preparation costs, minimizes tissue damage and mechanical mismatch, and has the capability for intracranial drug delivery and pressure detection.

✦ Generated by Eureka AI based on patent content.

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Abstract

本发明公开了一种多功能柔性管神经电极及其制备方法。目前,商用的SEEG电极虽然能够实现一些神经系统疾病的诊断和治疗,但其还存在植入损伤大、成本高、通道数少和分辨率差的问题。本发明提出一种在柔性聚酰亚胺(PI)微管上缠绕柔性线路板(FPC)来制备和集成多功能柔性管电极的方法。通过在柔性微管上缠绕多金属层FPC神经电极,可实现高分辨率的深脑记录和刺激。此外,该柔性管电极具有的微流体通道可以实现微流体给药和颅内压力测量,通过插入光纤还可以辅组电极植入并实现光刺激。这种将商用FPC与PI微管相结合来制备多功能神经电极的技术可以提高现有商用SEEG电极的空间分辨率并大幅降低成本。
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