Tympanic cavity administration device

Abstract

The embodiment of the present application discloses a tympanic cavity administration device, which comprises a catheter for piercing the eardrum, an administration assembly comprising a ventilation tube and an administration part fixed at the end of the ventilation tube, and the administration assembly can be switched between a storage state and an open state; when the administration assembly is in the storage state, the administration assembly is stored in the catheter, and the administration part is located on one side close to the distal end in the catheter; when the administration assembly is in the open state, the administration part is pushed out of the catheter, and the administration part is configured to be capable of abutting against the inner wall of the tympanic cavity.

Description

Technical Field

[0001] This invention relates to the field of medical devices, and more specifically, to a tympanic cavity drug delivery device. Background Technology

[0002] Current methods for administering medication to the middle ear involve puncturing the tympanic membrane with a hollow tube and then inserting the medication through a needle via a ventilation tube, or suctioning out pus from the middle ear using a needle. The specific procedure involves inserting a very thin needle through the hollow tube into the middle ear, positioned in front of and below the tympanic membrane, and slowly injecting the medication into the middle ear cavity, allowing it to flow into the inner ear and take effect.

[0003] However, when using a needle to administer medication, the drug cannot reach the affected area directly. Summary of the Invention

[0004] One object of the present invention is to provide a new technical solution for a tympanic cavity drug delivery device.

[0005] In one embodiment of the present invention, a tympanic cavity drug delivery device is provided, comprising a catheter for puncturing the tympanic membrane; a drug delivery assembly comprising a ventilation tube and a drug delivery portion, the drug delivery portion being fixed to the end of the ventilation tube; the drug delivery assembly being switchable between a retracted state and an open state; when the drug delivery assembly is in the retracted state, the drug delivery assembly is retracted within the catheter, and the drug delivery portion is located on the distal side of the catheter; when the drug delivery assembly is in the open state, the drug delivery portion is pushed out of the catheter, and the drug delivery portion is configured to abut against the inner wall of the tympanic cavity.

[0006] Optionally, the drug delivery unit includes a support arm, one end of which is connected to the ventilation tube, and the other end of which is provided with a drug-carrying plate;

[0007] When the drug delivery assembly is in the open state, the outer wall of the drug-carrying plate can abut against the inner wall of the tympanic cavity.

[0008] Optionally, when the drug delivery assembly is in the open state, the angle between the drug delivery plate and the support arm is 140° to 90°.

[0009] Optionally, the system includes multiple drug-carrying plates arranged around the ventilation duct, with the multiple drug-carrying plates forming a ring.

[0010] Optionally, the support arm is connected to the end face of the drug-carrying plate near the ventilation duct.

[0011] Optionally, it also includes an ejection device having a rod and an ejection plate;

[0012] When the drug delivery assembly is in the retracted state, the ejector plate abuts against the end face of the ventilation tube near the proximal end of the ventilation tube, and the ejector plate is located between the rod and the ventilation tube.

[0013] Optionally, the distal end of the conduit has a constricted structure, and the inner diameter of the opening at the distal end of the conduit is consistent with the inner diameter of the ventilation pipe.

[0014] Optionally, the drug-loaded plate is made of a biodegradable material.

[0015] Optionally, the ventilation duct is integrally formed with the support arm.

[0016] Optionally, a needle-punching portion is provided at the distal end of the catheter, the needle-punching portion being disposed around the opening of the distal end of the catheter.

[0017] By placing the medication applicator against the inner wall of the tympanic cavity, the medication is applied directly to the affected area on the inner wall of the patient's tympanic cavity, effectively avoiding the drawback of existing techniques where the medication cannot directly reach the affected area.

[0018] Other features and advantages of this specification will become clear from the following detailed description of exemplary embodiments with reference to the accompanying drawings. Attached Figure Description

[0019] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments of this specification and, together with their description, serve to explain the principles of this specification.

[0020] Figure 1 This is one of the structural schematic diagrams of the tympanic cavity drug delivery device in a stored state according to an embodiment of the present invention;

[0021] Figure 2 This is the second schematic diagram of the tympanic cavity drug delivery device in the storage state in an embodiment of the present invention;

[0022] Figure 3 This is a schematic diagram of the drug delivery component of the tympanic cavity drug delivery device in an embodiment of the present invention in an open state.

[0023] Explanation of reference numerals in the attached figures:

[0024] 100. Catheter; 110. Acupuncture site; 120. Distal; 130. Proximal;

[0025] 200. Drug delivery assembly; 210. Ventilation duct; 211. Support arm; 222. Drug delivery plate;

[0026] 310. Rod section; 320. Top plate. Detailed Implementation

[0027] Embodiments of the present invention will now be described in detail. Examples of these embodiments are illustrated in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0028] The terms "first" and "second" in the specification and claims of this invention may explicitly or implicitly include one or more of those features. In the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0029] In the description of this invention, it should be understood that the terms "center," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," and "circumferential" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0030] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0031] According to one embodiment of the present invention, such as Figures 1-3 As shown, a tympanic cavity drug delivery device is provided, comprising a catheter 100 for puncturing the tympanic membrane; a drug delivery assembly 200 including a ventilation tube 210 and a drug delivery portion fixed to the end of the ventilation tube 210; the drug delivery assembly 200 is switchable between a retracted state and an open state; when the drug delivery assembly 200 is in the retracted state, it is retracted within the catheter 100, and the drug delivery portion is located within the catheter 100 on the side near the distal end 120; when the drug delivery assembly 200 is in the open state, the drug delivery portion is pushed out of the catheter 100, and the drug delivery portion is configured to abut against a predetermined position on the inner wall of the tympanic cavity.

[0032] like Figure 1 , Figure 2 and Figure 3 As shown, the catheter 100 is used to accommodate the drug delivery component 200, providing a passage for the drug delivery component 200 to enter the tympanic cavity. The distal end 120 of the catheter 100 is the section away from the operator, and the proximal end 130 of the catheter 100 is the end closer to the operator. In actual operation, the distal end 120 of the catheter 100 punctures the tympanic membrane and extends into the tympanic cavity, while the proximal end 130 of the catheter 100 remains on the outer side of the tympanic membrane away from the tympanic cavity. The ventilation tube 210 is a hollow tubular structure, which allows for ventilation of the tympanic cavity to maintain a dry and cool environment. The drug delivery portion carries the medication. The medication can be applied to the outer surface of the drug delivery portion by smearing. The drug delivery portion is elastic and can be housed within the catheter 100. After being extended by the catheter 100, the drug delivery portion can open to abut against the inner wall of the tympanic cavity. In this way, the drug delivery portion can abut against the inner wall of the tympanic cavity, thereby directly delivering the medication to the affected area on the inner wall of the patient's tympanic cavity. This method effectively avoids the drawback of existing technologies where medication cannot directly act on the patient's affected area when applied to the tympanic cavity.

[0033] For example, the drug delivery unit includes a support arm 211, one end of which is connected to the ventilation tube 210, and the other end of which is provided with a drug-carrying plate 222; when the drug delivery assembly 200 is in the open state, the outer wall of the drug-carrying plate 222 can abut against a predetermined position of the middle ear wall.

[0034] For example, one end of the support arm 211 is fixed to the distal end 120 of the ventilation duct 210, and the support arm 211 and the ventilation duct 210 can be an integral structure. The support arm 211 and the ventilation duct 210 are made of elastic materials, such as medical rubber or silicone, or shape memory alloy. During storage, the proximal end 130 of the ventilation duct 210 can be inserted into the conduit 100 through the distal end 120, and the proximal end 130 of the conduit 100 pulls the ventilation duct 210 into the conduit 100. The ventilation duct 210 drives the support arm 211 into the conduit 100. When the support arm 211 stops against the outer wall of the distal end 120 of the conduit 100, the ventilation duct 210 is pulled further, and the support arm 211 is compressed under the stopping action of the distal end 120 of the conduit 100, so that it is stored in the conduit 100. In the ejected state, the ventilation tube 210 can be driven by the proximal end 130 of the conduit 100 to move toward the distal end 120 of the conduit 100 to push the support arm 211 out of the conduit 100.

[0035] For example, the drug-carrying plate 222 is a plate-like structure that carries the drug. When retracted, the drug-carrying plate 222 can change its angle with the support arm 211 under the stop at the distal end 120 of the catheter 100 so that it can be retracted into the catheter 100. When extended, the drug-carrying plate 222 opens in the tympanic cavity after leaving the catheter 100 and contacts the inner wall of the tympanic cavity to deliver the drug to the inner wall of the tympanic cavity.

[0036] This increases the contact area between the drug-carrying part and the inner wall of the tympanic cavity, and allows the drug-carrying plate 222 to directly apply the drug to the inner wall of the tympanic cavity.

[0037] For example, in order to allow the drug-carrying plate 222 to make closer contact with the inner wall of the drum, the angle between the drug-carrying plate 222 and the support arm 211 in the open state is between 140° and 90°. Within this range, the drug-carrying plate 222 can make better contact with the inner wall of the drum.

[0038] Optionally, such as Figure 3 As shown, the angle between the support arm 211 and the drug-carrying plate 222 is 120°. In this way, in the open state, the set angle between the support arm 211 and the drug-carrying plate 222 is between 120° and 90°. When the drug-carrying plate 222 enters the tympanic cavity and is opened, it adheres to the inner wall of the tympanic cavity due to the obstruction of the inner wall of the tympanic cavity.

[0039] In one example, such as Figure 3 As shown, it may include multiple drug-carrying plates 222, which are arranged around the ventilation pipe 210 and together form a ring.

[0040] For example, multiple drug-carrying plates 222 can be connected end-to-end in the open state to form a continuous ring. This increases the contact area between the drug delivery site and the inner wall of the tympanic cavity. When there are multiple drug-carrying plates 222, the number of support arms 211 matches the number of drug-carrying plates 222, with each support arm 211 corresponding to a drug-carrying plate 222. When the drug-carrying plates 222 are a continuous ring, there are at least two support arms 211 to provide radial support for the annular drug-carrying plates 222.

[0041] For example, multiple drug-loaded plates 222 can be spaced apart to form an intermittent ring. This makes it easier to house the drug-loaded plates 222 within the catheter 100.

[0042] For example, the support arm 211 is connected to the end face of the drug-carrying plate 222 near the ventilation tube 210. The drug-carrying plate 222 has two opposing end faces, with a side wall between them. In the open state, the outer side wall of the drug-carrying plate 222 abuts against the inner wall of the tympanic cavity. The upper end face of the drug-carrying plate 222 is closer to the ventilation tube 210 along the extension direction of the side wall, while the lower end face is farther away from the ventilation tube 210. The support arm 211 is connected to the upper end face of the drug-carrying plate 222. This makes it easier for the drug-carrying plate 222 to be pulled into the ventilation tube 210 by the support arm 211 during storage.

[0043] In one example, such as Figure 1 As shown, the tympanic cavity drug delivery device also includes an ejector device having a rod 310 and an ejector plate 320. When the drug delivery assembly 200 is in the retracted state, the ejector plate 320 abuts against the end face of the ventilation tube 210 near its proximal end 130, and the ejector plate 320 is located between the rod 310 and the ventilation tube 210. After the drug delivery assembly 200 is pulled into the catheter 100, the ejector device extends into the catheter 100 through the opening of the proximal end 130. The ejector plate 320 can move relative to the inner wall of the catheter 100 under the action of the rod, and the side edge of the ejector plate 320 is in clearance fit with the inner wall of the catheter 100. In actual use, the tympanic membrane is first cut open using the distal end 120 of the catheter 100. After the distal end 120 of the catheter 100 is inserted into the tympanic cavity through the tympanic membrane, the proximal end 130 of the catheter 100 drives the rod portion 310, thereby driving the ejector plate 320 to push the ventilation tube 210 toward the distal end 120 of the catheter 100. When the drug delivery part extends out from the distal end 120 of the catheter 100, the connecting arm and the drug-carrying plate open respectively to attach the drug-carrying plate to the inner wall of the tympanic cavity.

[0044] For example, such as Figure 3 As shown, there can be multiple connecting arms, which are symmetrically arranged. This creates a repulsive force between the symmetrical connecting arms after the drug-carrying plate 222 is attached to the inner wall of the tympanic cavity, thus supporting the ventilation tube 210 within the tympanic cavity. This prevents the ventilation tube 210 from swaying within the tympanic cavity and further increases the adhesion between the drug-carrying plate 222 and the inner wall of the tympanic cavity.

[0045] In one example, the drug-loaded plate 222 is a biodegradable material. For example, it can be a synthetic medical polymer, such as polyglycolic acid (PGA) or polylactic acid (PLA). The drug can be mixed with the biodegradable material to form the drug-loaded plate 222. During contact with the tympanic cavity wall, the drug-loaded plate 222 decomposes spontaneously, thereby continuously delivering the drug to the affected area.

[0046] In one example, such as Figure 2 As shown, the distal end 120 of the conduit 100 has a constricted structure, and the inner diameter of the opening of the distal end 120 of the conduit 100 is the same as the inner diameter of the ventilation pipe 210.

[0047] like Figure 2 As shown, the inner diameter of the distal end 120 of the conduit 100 gradually increases towards the proximal end 130 of the conduit 100. The inner diameter of the opening of the distal end 120 of the conduit 100 is consistent with the inner diameter of the ventilation pipe 210, so that the ventilation pipe 210 can be entered into the conduit 100 through the opening of the distal end 120 of the conduit 100 and exited from the conduit 100 through the opening of the distal end 120 of the conduit 100.

[0048] In actual use, if the catheter 100 and the ventilation tube 210 are left in the tympanic cavity together, it will cause contamination of the tympanic cavity. To prevent external bacteria from entering the tympanic cavity through the gap between the catheter 100 and the ventilation tube 210 and causing tympanic cavity contamination, the catheter 100 can be pulled out after the medication delivery device enters the tympanic cavity, leaving the ventilation tube 210 in place on the tympanic membrane. Specifically, after the medication delivery device opens and abuts against the inner wall of the tympanic cavity at a predetermined position, pressure is applied to the rod 310 of the ejection device to hold the ventilation tube 210, and then a pulling force is applied to the proximal end 130 of the catheter 100 to pull the catheter 100 out of the tympanic cavity.

[0049] By setting the distal end 120 of the catheter 100 to a constricted structure, the trauma area of ​​the tympanic membrane can be effectively reduced. After the catheter 100 is pulled out of the tympanic cavity and separated from the tympanic membrane, the tympanic membrane can wrap around the outer wall of the ventilation tube 210. This also prevents dirt and grime from accumulating in the space between the catheter 100 and the ventilation tube 210, and also prevents dust from entering the tympanic cavity.

[0050] Optionally, such as Figure 2 As shown, a needle-like portion 110 is provided at the distal end 120 of the conduit 100, surrounding the opening of the distal end 120 of the conduit 100. The size and cross-sectional shape of the needle-like portion 110 match the cross-sectional shape of the ventilation tube 210. The needle-like portion 110 allows the opening of the tympanic membrane to be exactly the same as the inner diameter of the ventilation tube 210, thereby enabling the tympanic membrane to form a tighter wrap around the ventilation tube 210 after the conduit 100 is withdrawn. This not only provides stable support for the adhesion of the drug-eluting plate 222 to the inner wall of the tympanic cavity, but also further reduces the wound surface of the tympanic membrane.

[0051] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0052] Although embodiments of the invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A tympanic cavity drug delivery device, characterized in that, include: The catheter is used to puncture the tympanic membrane; A drug delivery assembly, comprising a ventilation tube and a drug delivery part, wherein the drug delivery part is fixed to the end of the ventilation tube; The drug delivery component can switch between a retracted state and an open state; When the drug delivery component is in the retracted state, the drug delivery component is retracted into the catheter, and the drug delivery portion is located on the side of the catheter closer to the distal end. When the drug delivery assembly is in the open state, the drug delivery portion is pushed out of the catheter, and the drug delivery portion is configured to abut against the inner wall of the tympanic cavity; The drug delivery unit includes multiple elastic support arms. One end of each support arm is connected to the ventilation pipe, and the other end of each support arm is provided with a drug-carrying plate, which is a plate-shaped structure for carrying drugs. When the drug delivery assembly is in the open state, the outer wall of the drug-carrying plate can abut against the inner wall of the tympanic cavity; The drug delivery unit also includes multiple drug-carrying plates, which are arranged around the ventilation tube and together form a ring. The number of support arms matches the number of drug-carrying plates.

2. The tympanic cavity drug delivery device according to claim 1, characterized in that, When the drug delivery assembly is in the open state, the angle between the drug delivery plate and the support arm is 140° to 90°.

3. The tympanic cavity drug delivery device according to claim 1, characterized in that, The support arm is connected to the end face of the drug-carrying plate near the ventilation duct.

4. The tympanic cavity drug delivery device according to claim 1, characterized in that, It also includes an ejector device having a rod and an ejector plate; When the drug delivery assembly is in the retracted state, the ejector plate abuts against the end face of the ventilation tube near the proximal end of the ventilation tube, and the ejector plate is located between the rod and the ventilation tube.

5. The tympanic cavity drug delivery device according to claim 1, characterized in that, The distal end of the conduit has a constricted structure, and the inner diameter of the opening at the distal end of the conduit is the same as the inner diameter of the ventilation pipe.

6. The tympanic cavity drug delivery device according to claim 1, characterized in that, The drug-loaded plate is made of a biodegradable material.

7. The tympanic cavity drug delivery device according to claim 1, characterized in that, The ventilation duct is integrally formed with the support arm.

8. The tympanic cavity drug delivery device according to claim 1, characterized in that, A needle-punching section is provided at the distal end of the catheter, and the needle-punching section is arranged around the opening of the distal end of the catheter.

Images