一种稠环氢化异喹啉化合物及其制备方法和应用
The synthesis of fused-ring hydrogenated isoquinoline compounds was simplified by using a tandem ring isomerization reaction catalyzed by a gold catalyst and methanesulfonic acid, solving the problem of complex synthesis methods in the prior art and providing novel compounds with anti-hepatocellular carcinoma activity for use in pharmaceutical compositions.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
- Filing Date
- 2023-07-31
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for synthesizing fused-ring hydrogenated isoquinoline compounds are complex and lengthy, making rapid and large-scale preparation difficult. Furthermore, there are few reports on their use in synthesizing 1,6-diyne substrates, which limits their application in drug development.
A tandem ring isomerization reaction catalyzed by gold catalyst and methanesulfonic acid was used to generate tetracyclic fused-ring cage-like compounds containing a hydrogenated isoquinoline skeleton from 1,6-diyne compounds at room temperature. Alcohols or ethers containing the isoquinoline skeleton were then generated in one step using different nucleophiles.
This study enables the simplified preparation of fused-ring hydrogenated isoquinoline compounds with excellent anti-hepatocellular carcinoma activity, providing novel compounds for use in pharmaceutical compositions, simplifying the synthesis process and improving preparation efficiency.
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Figure CN117186007B_ABST