一种制备顺式2,6-二甲基吗啡啉的方法
By using a palladium-on-carbon catalyst to hydrogenate compound 4 under mild conditions, the problems of high cost, harsh conditions, and low selectivity in the preparation of cis-2,6-dimethylmorpholine in the prior art have been solved, and high-purity and environmentally friendly industrial production has been achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- 河南金鹏化工有限公司
- Filing Date
- 2022-06-01
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for preparing cis-2,6-dimethylmorpholine suffer from high costs, harsh reaction conditions, low selectivity, and poor environmental friendliness, making it difficult to meet the demands for high purity and large-scale production.
cis-2,6-dimethylmorpholine was prepared by hydrogenation reduction of compound 4 under mild conditions using a palladium-on-carbon catalyst. The synthesis route involved the preparation of compounds 1, 2, 3, and 4. Finally, the hydrogenation debenzylation and reduction reactions were carried out in methanol solvent using palladium-on-carbon as a catalyst. The reaction conditions were mild, and the catalyst could be reused.
The method achieves highly selective preparation of cis-2,6-dimethylmorpholine with a purity of over 98.5%, reducing production costs and wastewater discharge, and meeting the requirements for large-scale industrial production.
Smart Images
Figure CN117186024B_ABST