Blood glucose measurement method, device, and medium

Abstract

The application provides a tympanic membrane temperature measuring device, a blood glucose measuring method, a system and equipment. First, a target tympanic membrane temperature is acquired, then a target oral cavity temperature is estimated through a pre-established temperature correspondence between the tympanic membrane and the oral cavity, then a temperature correspondence between a blood glucose increment and an oral cavity temperature increment is established through a pre-calibrated invasive blood glucose value and an oral cavity calibration temperature, and then a target blood glucose increment can be calculated, finally, a target blood glucose value is calculated according to the target blood glucose increment and the pre-calibrated invasive blood glucose value, thereby improving the body feeling degree of the blood glucose measuring process, and reducing the influence of other factors on the blood glucose measurement.

Description

Technical Field

[0001] This application relates to the field of blood glucose monitoring, and more particularly to a blood glucose measurement method, device and medium. Background Technology

[0002] In recent years, with the continuous development of science and technology, blood glucose monitoring technology has gradually evolved from invasive blood glucose monitoring technology to non-invasive blood glucose monitoring technology to meet people's needs for blood glucose monitoring in daily life.

[0003] Currently, most non-invasive blood glucose monitoring technologies measure blood glucose levels by measuring the temperature of the finger skin or the oral cavity. However, measuring blood glucose levels by measuring the temperature of the finger skin is often easily affected by the external temperature environment, leading to inaccurate measurements. On the other hand, measuring blood glucose levels by measuring the temperature of the oral cavity is cumbersome, requiring frequent opening of the mouth to measure the oral temperature, making the monitoring process less comfortable. Summary of the Invention

[0004] The main objective of this application is to provide a blood glucose measurement method, device, and medium that can improve the user experience of the blood glucose measurement process while reducing the influence of other factors on blood glucose measurement.

[0005] To achieve the above objectives, a first aspect of this application provides a blood glucose measurement method, comprising the following steps:

[0006] Obtain the target tympanic membrane temperature and the target ambient temperature;

[0007] Based on the relationship between ambient temperature and the temperature difference between the tympanic membrane and the oral cavity, the target ambient temperature is converted to obtain the temperature difference between the tympanic membrane and the oral cavity at the target ambient temperature.

[0008] Based on the temperature difference, the target tympanic membrane temperature is converted to obtain the target oral cavity temperature;

[0009] Based on the relationship between oral temperature and blood glucose, the target oral temperature is converted to a corresponding blood glucose value to obtain the target blood glucose value.

[0010] Furthermore, in some embodiments, based on the relationship between ambient temperature and the temperature difference between the tympanic membrane and the corresponding oral cavity, a relationship conversion is performed on the target ambient temperature to obtain the temperature difference between the tympanic membrane and the oral cavity at the target ambient temperature. This also includes the following steps:

[0011] Obtain multiple environmental calibration temperatures, and their corresponding tympanic membrane calibration temperature and oral cavity calibration temperature;

[0012] Based on the environmental calibration temperature, the difference between the tympanic membrane calibration temperature and the oral cavity calibration temperature at each environmental calibration temperature is calculated to obtain the temperature difference between the tympanic membrane and the oral cavity at multiple environmental calibration temperatures.

[0013] Based on multiple environmental calibration temperatures and their corresponding temperature differences, the relationship between the target temperature difference between the tympanic membrane and the oral cavity under different environmental temperatures is determined.

[0014] Based on the target temperature difference relationship, the target ambient temperature is converted to obtain the temperature difference between the tympanic membrane and the oral cavity at the target ambient temperature.

[0015] Furthermore, in some embodiments, determining the target temperature difference relationship between the tympanic membrane and the oral cavity under different ambient temperatures based on multiple environmental calibration temperatures and their corresponding temperature differences further includes the following steps:

[0016] The universal temperature difference relationship between the tympanic membrane and the oral cavity is obtained as the first temperature difference relationship;

[0017] Based on multiple environmental calibration temperatures and corresponding temperature differences, the temperature difference relationship between the tympanic membrane and the oral cavity under different environmental temperatures is determined as the second temperature difference relationship;

[0018] Under the same ambient temperature, the difference between the first temperature difference relationship and the second temperature difference relationship is compared with a preset threshold to obtain the target temperature difference relationship.

[0019] Furthermore, in some embodiments, under the same ambient temperature, the difference between the first temperature difference relationship and the second temperature difference relationship is compared with a preset threshold to obtain the target temperature difference relationship, which further includes the following steps:

[0020] If the absolute value of the relationship difference is less than the preset threshold, then the second temperature difference relationship is taken as the target temperature difference relationship;

[0021] Alternatively, if the absolute value of the relationship difference is greater than or equal to a preset threshold, the relationship curve of the first temperature difference relationship is shifted up or down in the corresponding direction according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is taken as the target temperature difference relationship.

[0022] Furthermore, in some embodiments, if the absolute value of the relationship difference is greater than or equal to a preset threshold, the relationship curve of the first temperature difference relationship is shifted vertically in the corresponding direction according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is used as the target temperature difference relationship. The method further includes the following steps:

[0023] When the relationship difference is positive, the relationship curve of the first temperature difference relationship is shifted downward according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is taken as the target temperature difference relationship.

[0024] Alternatively, when the relationship difference is negative, the relationship curve of the first temperature difference relationship is shifted upwards according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is taken as the target temperature difference relationship.

[0025] Furthermore, in some embodiments, obtaining the universal temperature difference relationship between the tympanic membrane and the oral cavity as the first temperature difference relationship further includes the following steps:

[0026] Obtain multiple environmental universal temperatures, and the corresponding tympanic membrane universal temperature and oral cavity universal temperature under these multiple environmental universal temperatures;

[0027] Based on the ambient temperature, the difference between the ambient temperature of the tympanic membrane and the ambient temperature of the oral cavity under each ambient temperature is calculated to obtain the first ambient temperature difference between the tympanic membrane and the oral cavity under multiple ambient temperatures.

[0028] The first universal temperature difference under different environmental universal temperatures is reduced in dimensionality to obtain the second universal temperature difference under different environmental universal temperatures.

[0029] Based on multiple universal environmental temperatures and their corresponding second universal temperature differences, the universal temperature difference relationship between the tympanic membrane and the oral cavity under different universal environmental temperatures is determined and used as the first temperature difference relationship.

[0030] Furthermore, in some embodiments, the target oral temperature is converted to a corresponding blood glucose value based on the relationship between oral temperature and blood glucose to obtain the target blood glucose value, and the method further includes the following steps:

[0031] Acquire calibrated blood glucose and oral calibrated temperature prior to oral temperature measurement. The calibrated blood glucose was calibrated invasively.

[0032] The target oral temperature increment is obtained based on the target oral temperature and the oral calibration temperature;

[0033] Based on the relationship between oral temperature increment and blood glucose increment, the target oral temperature increment is converted to obtain the target blood glucose increment.

[0034] The target blood glucose value is obtained based on the calibrated blood glucose value and the target blood glucose increment.

[0035] Furthermore, in some embodiments, the target oral temperature increment is converted based on the relationship between the oral temperature increment and the blood glucose increment to obtain the target blood glucose increment, and the method further includes the following steps:

[0036] Obtain multiple oral calibrated temperatures and multiple calibrated blood glucose values;

[0037] Based on multiple oral calibration temperatures, the differences between oral calibration temperatures at adjacent times are calculated sequentially to obtain multiple oral calibration temperature increments;

[0038] Based on multiple calibrated blood glucose values, the differences between calibrated blood glucose values ​​at adjacent time points are calculated sequentially to obtain multiple calibrated blood glucose value increments;

[0039] The relationship between oral temperature increment and blood glucose increment was determined based on multiple oral temperature increments and corresponding blood glucose increments.

[0040] Based on the relationship between oral temperature increment and blood glucose increment, the target oral temperature increment is converted to obtain the target blood glucose increment.

[0041] To achieve the above objectives, a second aspect of this application provides an electronic device, which includes a memory and a processor. The memory stores a computer program, and the processor executes the computer program to implement the method described in the first aspect of the embodiment.

[0042] To achieve the above objectives, a third aspect of the present application provides a storage medium, which is a computer-readable storage medium storing a computer program that, when executed by a processor, implements the method described in the first aspect of the present application.

[0043] The embodiments of this application have the following beneficial effects: First, the target tympanic membrane temperature is obtained. Then, the target oral temperature is estimated by establishing a temperature correspondence between the tympanic membrane and the oral cavity. Next, a temperature correspondence between the blood glucose increment and the oral temperature increment is established by establishing a temperature correspondence between the invasive blood glucose value and the oral temperature calibration value. The target blood glucose increment can then be calculated. Finally, the target blood glucose value is calculated based on the target blood glucose increment and the invasive blood glucose value, thereby improving the sensory experience of the blood glucose measurement process and reducing the influence of other factors on blood glucose measurement. Attached Figure Description

[0044] Figure 1 This is a flowchart of a blood glucose measurement method provided in some embodiments of this application;

[0045] Figure 2 This is a flowchart of a blood glucose measurement method provided in some other embodiments of this application;

[0046] Figure 3 This is a flowchart of a blood glucose measurement method provided in some other embodiments of this application;

[0047] Figure 4This is a flowchart of a blood glucose measurement method provided in some other embodiments of this application;

[0048] Figure 5 This is a flowchart of a blood glucose measurement method provided in some other embodiments of this application;

[0049] Figure 6 This is a flowchart of a blood glucose measurement method provided in some other embodiments of this application;

[0050] Figure 7 This is a graph showing the universal relationship between the ambient temperature and the difference between the tympanic membrane temperature and the oral cavity temperature of multiple volunteers provided in some embodiments of this application;

[0051] Figure 8 This is a graph comparing the equations of the relationship curves between the ambient temperature and the difference between the tympanic membrane temperature and the oral cavity temperature of volunteer B provided in some embodiments of this application and the universal relationship curve.

[0052] Figure 9 This is a graph comparing the equations of the relationship curves between the ambient temperature and the difference between the tympanic membrane temperature and the oral cavity temperature of volunteer C provided in some embodiments of this application and the universal relationship curve.

[0053] Figure 10 This is a flowchart of a blood glucose measurement method provided in some other embodiments of this application;

[0054] Figure 11 This is a flowchart of a blood glucose measurement method provided in some other embodiments of this application;

[0055] Figure 12 This is a dynamic curve of tympanic membrane temperature of volunteer D over 24 hours, provided in some embodiments of this application;

[0056] Figure 13 This is a schematic diagram of the hardware structure of an electronic device provided in some embodiments of this application. Detailed Implementation

[0057] To make the objectives, technical solutions, and advantages of this application clearer, the following detailed description is provided in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this application.

[0058] In the description of this application, it should be understood that the orientation descriptions, such as up, down, front, back, left, right, etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.

[0059] It should also be noted that in the description of this application, "several" means one or more, "multiple" means two or more, "greater than," "less than," and "exceeding" are understood to exclude the stated number, while "above," "below," and "within" are understood to include the stated number. If the terms "first" and "second" are used, they are only for distinguishing technical features and should not be construed as indicating or implying relative importance, or implicitly indicating the number of indicated technical features, or implicitly indicating the order of the indicated technical features.

[0060] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing embodiments of this application only and is not intended to limit this application.

[0061] In the description of this application, the terms "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0062] First, let's analyze some of the terms used in this application:

[0063] Non-invasive blood glucose testing technology: Non-invasive blood glucose testing technology refers to methods that measure a person's blood glucose level without the need for puncture to collect a blood sample. Traditional blood glucose testing usually requires the use of a needle or pulse oximeter to collect a drop of blood for measurement. Non-invasive blood glucose testing technology avoids this uncomfortable and painful process, achieving blood glucose monitoring through a non-invasive method.

[0064] Currently, most non-invasive blood glucose monitoring technologies measure blood glucose levels by measuring the temperature of the finger skin or the oral cavity. However, measuring blood glucose levels by measuring the temperature of the finger skin is often easily affected by the external temperature environment, leading to inaccurate measurements. On the other hand, measuring blood glucose levels by measuring the temperature of the oral cavity is cumbersome, requiring frequent opening of the mouth to measure oral temperature, which is not user-friendly in terms of monitoring comfort.

[0065] Based on this, this application provides a blood glucose measurement method. First, the target tympanic membrane temperature is obtained. Then, the target oral temperature is estimated by establishing a pre-established temperature correspondence between the tympanic membrane and the oral cavity. Next, a temperature correspondence between the blood glucose increment and the oral temperature increment is established by establishing a pre-calibrated invasive blood glucose value and the oral temperature calibration value, thereby enabling the calculation of the target blood glucose increment. Finally, the target blood glucose value is calculated based on the target blood glucose increment and the pre-calibrated invasive blood glucose value, thereby improving the sensory experience of the blood glucose measurement process and reducing the influence of other factors on blood glucose measurement.

[0066] The blood glucose measurement method provided in this application is specifically illustrated through the following embodiments. First, the tympanic membrane temperature measuring device in this application embodiment is described.

[0067] Reference Figure 1 As shown, Figure 1 This is a flowchart of a blood glucose measurement method provided in some other embodiments of this application. The blood glucose measurement method may include, but is not limited to, steps S110, S120, S130 and S140.

[0068] Step S110: Obtain the target tympanic membrane temperature and the target ambient temperature;

[0069] It should be noted that both the target tympanic membrane temperature and the target ambient temperature need to be obtained under constant ambient temperature conditions. The duration of this constant temperature condition can be 1 hour, 2 hours, or 5 hours.

[0070] Step S120: Based on the relationship between the ambient temperature and the temperature difference between the tympanic membrane and the oral cavity, perform a relationship conversion on the target ambient temperature to obtain the temperature difference between the tympanic membrane and the oral cavity at the target ambient temperature.

[0071] It should be noted that, based on the relationship between the ambient temperature and the temperature difference between the tympanic membrane and the oral cavity, the temperature difference under the current target ambient temperature is fitted and predicted to obtain the temperature difference between the tympanic membrane and the oral cavity under the target ambient temperature. The relationship between the ambient temperature and the temperature difference between the tympanic membrane and the oral cavity is fitted using calibration data.

[0072] Step S130: Based on the temperature difference, perform temperature conversion on the target tympanic membrane temperature to obtain the target oral cavity temperature;

[0073] It should be noted that the target tympanic membrane temperature is obtained by summing the target temperature and the temperature difference.

[0074] Step S140: Based on the relationship between oral temperature and blood glucose, the target oral temperature is converted to the corresponding blood glucose value to obtain the target blood glucose value.

[0075] It should be noted that the relationship between oral temperature and blood glucose was fitted using calibration data.

[0076] Reference Figure 2 As shown, Figure 2 This is a flowchart of a blood glucose measurement method provided in other embodiments of this application. The blood glucose measurement method may include, but is not limited to, steps S210, S220, S230 and S240.

[0077] Step S210: Obtain multiple environmental calibration temperatures, and their corresponding tympanic membrane calibration temperature and oral cavity calibration temperature;

[0078] It should be noted that multiple environmental calibration temperatures can be obtained within 24 hours. These temperatures can be obtained around times when there are significant differences in environmental temperature, such as the time range of 5:30 to 6:30 in the morning, 12:30 to 13:30 in the afternoon, 16:30 to 18:30 in the afternoon, or 22:30 to 25:00. This application does not make any specific limitations.

[0079] Furthermore, oral temperature calibration requires the use of an oral temperature measuring device to calibrate and test the oral cavity.

[0080] Step S220: Based on the environmental calibration temperature, calculate the difference between the tympanic membrane calibration temperature and the oral cavity calibration temperature at each environmental calibration temperature to obtain the temperature difference between the tympanic membrane and the oral cavity at multiple environmental calibration temperatures;

[0081] It should be noted that the difference between the tympanic membrane calibration temperature and the oral cavity calibration temperature can be calculated by taking the average of multiple tympanic membrane calibration temperatures and multiple oral cavity calibration temperatures at the same ambient temperature and then taking the difference between the two, or by calculating the difference between multiple tympanic membrane calibration temperatures and oral cavity calibration temperatures and then taking the average. This application does not make any specific limitation.

[0082] Step S230: Determine the target temperature difference relationship between the tympanic membrane and the oral cavity under different ambient temperatures based on multiple environmental calibration temperatures and their corresponding temperature differences;

[0083] It should be noted that in the fitting curve of the relationship between the target temperature difference between the tympanic membrane and the oral cavity under different ambient temperatures, the X-axis represents the ambient temperature and the Y-axis represents the target temperature difference between the tympanic membrane and the oral cavity. This curve can be a linear equation curve, a quadratic equation curve, or an Nth degree equation curve. This application does not make any specific limitation.

[0084] Step S240: Based on the target temperature difference relationship, perform a relationship conversion on the target ambient temperature to obtain the temperature difference between the tympanic membrane and the oral cavity at the target ambient temperature.

[0085] Furthermore, the Y value corresponding to the X-axis of the target ambient temperature on the fitted relationship curve is used as the temperature difference between the tympanic membrane and the oral cavity under the target ambient temperature.

[0086] Reference Figure 3 As shown, Figure 3 This is a flowchart of a blood glucose measurement method provided in some other embodiments of this application. The blood glucose measurement method may include, but is not limited to, steps S310, S320 and S330.

[0087] Step S310: Obtain the universal temperature difference relationship between the tympanic membrane and the oral cavity as the first temperature difference relationship;

[0088] It should be noted that because everyone's physical condition is different, the temperature difference between the tympanic membrane and the oral cavity is also different for each person. The universal temperature difference relationship is a relationship fitted by collecting the average temperature difference between the tympanic membrane and the oral cavity of the general public under different environmental temperatures. It represents the average level of the temperature difference between the tympanic membrane and the oral cavity of most people under different environmental temperatures.

[0089] Step S320: Based on multiple environmental calibration temperatures and corresponding temperature differences, determine the temperature difference relationship between the tympanic membrane and the oral cavity under different environmental temperatures as the second temperature difference relationship;

[0090] It should be noted that the second temperature difference relationship is the temperature difference relationship between the tympanic membrane and the oral cavity under different ambient temperatures, which is fitted by the user through the ambient calibration temperature, tympanic membrane calibration temperature and oral cavity calibration temperature.

[0091] Step S330: Under the same ambient temperature, the difference between the first temperature difference relationship and the second temperature difference relationship is compared with a preset threshold to obtain the target temperature difference relationship.

[0092] Specifically, because individuals are easily affected by the external environment during the measurement process, there are certain errors in the measured ambient temperature, tympanic membrane temperature, and oral cavity temperature. Consequently, the fitted relationship between the temperature difference between the tympanic membrane and oral cavity under different ambient temperatures for an individual may have some errors. It is necessary to correct the individual temperature difference relationship through a universal temperature difference relationship to make the fitted result more accurate, thereby improving the accuracy of subsequent blood glucose conversion.

[0093] Reference Figure 4 As shown, Figure 4 This is a flowchart of a blood glucose measurement method provided in other embodiments of this application, which may include, but is not limited to, steps S410 and S420.

[0094] Step S410: If the absolute value of the relationship difference is less than a preset threshold, then the second temperature difference relationship is taken as the target temperature difference relationship;

[0095] It should be noted that if the absolute value of the first temperature difference relationship is less than the preset threshold under the same ambient temperature, the second temperature difference relationship is within a reasonable error range, and the second temperature difference relationship is taken as the target temperature difference relationship.

[0096] Step S420: Alternatively, if the absolute value of the relationship difference is greater than or equal to a preset threshold, the relationship curve of the first temperature difference relationship is shifted up and down in the corresponding direction according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is taken as the target temperature difference relationship.

[0097] It should be noted that if the absolute value of the relationship difference is greater than or equal to the preset threshold, the second temperature difference relationship is outside the reasonable error range. The relationship curve of the first temperature difference relationship needs to be shifted vertically in the corresponding direction according to the relationship difference. The amount of displacement is determined by the magnitude of the difference, and the direction of displacement is determined by the sign of the difference.

[0098] Furthermore, the value of the relationship difference can be the difference between the average temperature difference of the first temperature difference relationship and the average temperature difference of the second temperature difference relationship, or it can be the difference between the temperature difference of the first temperature difference relationship and the temperature difference of the second temperature difference relationship at the same temperature, or it can be the average difference between the temperature difference of the first temperature difference relationship and the temperature difference of the second temperature difference relationship at multiple temperatures.

[0099] Reference Figure 5 As shown, Figure 5 This is a flowchart of a blood glucose measurement method provided in other embodiments of this application, which may include, but is not limited to, steps S510 and S520.

[0100] Step S510: When the relationship difference is positive, the relationship curve of the first temperature difference relationship is shifted downward according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is taken as the target temperature difference relationship.

[0101] It should be noted that when the relationship difference is positive, the relationship curve of the first temperature difference relationship is above the coordinate axis of the relationship curve of the second temperature difference relationship. It is necessary to shift the relationship curve of the first temperature difference relationship downward by the displacement of the relationship difference, and then use the shifted first temperature difference relationship as the target temperature difference relationship.

[0102] Step S520: Alternatively, when the relationship difference is negative, the relationship curve of the first temperature difference relationship is shifted upward according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is taken as the target temperature difference relationship.

[0103] It should be noted that when the relationship difference is negative, the relationship curve of the first temperature difference relationship is below the coordinate axis of the relationship curve of the second temperature difference relationship. It is necessary to shift the relationship curve of the first temperature difference relationship upward by the displacement of the relationship difference, and then use the shifted first temperature difference relationship as the target temperature difference relationship.

[0104] Reference Figure 6 As shown, Figure 6 This is a flowchart of a blood glucose measurement method provided in other embodiments of this application. The blood glucose measurement method may include, but is not limited to, steps S610, S620, S630 and S640.

[0105] Step S610: Obtain multiple ambient temperatures, and the corresponding ambient tympanic membrane temperature and oral cavity temperature under these multiple ambient temperatures;

[0106] Specifically, the above universal parameters require multiple users to perform multiple measurements of tympanic membrane temperature and oral cavity temperature under different ambient temperatures within the same preset ambient temperature range in the same area. Furthermore, users need to maintain a constant state under the same ambient temperature for a period of time, and temperature measurement is only performed when the preset time measurement threshold is exceeded.

[0107] Furthermore, the aforementioned preset ambient temperature range can be 5°C to 30°C, 10°C to 35°C, 5°C to 35°C, or 8°C to 37°C; this application does not impose any specific limitations.

[0108] Furthermore, the aforementioned preset time measurement threshold can be 10 minutes, 15 minutes, 30 minutes, or 1 hour; this application does not impose any specific limitation.

[0109] Step S620: Based on the ambient temperature, calculate the difference between the ambient temperature and the oral cavity temperature under each ambient temperature to obtain the first ambient temperature difference between the tympanic membrane and the oral cavity under multiple ambient temperatures.

[0110] It should be noted that the first universal temperature difference between the tympanic membrane and the oral cavity under multiple environmental universal temperatures is the first universal temperature difference between the tympanic membrane and the oral cavity under multiple environmental universal temperatures for multiple users.

[0111] Step S630: Perform dimensionality reduction on the first universal temperature difference under different environmental universal temperatures to obtain the second universal temperature difference under different environmental universal temperatures;

[0112] It should be noted that since the first universal temperature difference includes the first universal temperature difference of multiple users, there are multiple temperature difference relationship curves for individual users. It is necessary to reduce the first universal temperature difference from two-dimensional parameters to one-dimensional parameters to obtain the corresponding universal temperature difference relationship curve. The dimensionality reduction method can be to take the average value of the temperature difference between the tympanic membrane and oral cavity of multiple users under the same ambient temperature, or to take the median value of the temperature difference between the tympanic membrane and oral cavity of multiple users under the same ambient temperature, so that each ambient temperature on the X-axis of the coordinate axis has only one corresponding universal temperature difference between the tympanic membrane and oral cavity.

[0113] Step S640: Based on multiple universal environmental temperatures and their corresponding second universal temperature differences, determine the universal temperature difference relationship between the tympanic membrane and the oral cavity under different universal environmental temperatures and use it as the first temperature difference relationship.

[0114] It should be noted that the universal temperature difference relationship curve can be a quadratic equation curve, a cubic equation curve, or even an Nth degree equation curve.

[0115] The blood glucose measurement method of this application will be further described in detail below with another example.

[0116] Multiple volunteers were gathered in the same room equipped with an air conditioning system. The air conditioning system controlled the blood glucose monitoring temperature within the range of 5℃ to 30℃. Multiple indoor ambient temperatures were set at 5℃, 10℃, 15℃, 20℃, 25℃, and 30℃. Each volunteer was then kept at each temperature test point for at least 15 minutes. The universal oral temperature and universal tympanic membrane temperature of each volunteer were measured at the above ambient temperatures. The universal difference between the two was calculated and the average value was taken. Based on the average value of the universal difference between oral temperature and tympanic membrane temperature and the corresponding ambient temperature, a relationship curve equation was constructed to obtain the relationship between the universal temperature difference between the tympanic membrane and the oral cavity. Figure 7 This is a graph showing the universal relationship between the ambient temperature and the difference between the tympanic membrane temperature and the oral cavity temperature of multiple volunteers provided in some embodiments of this application. The universal relationship curve between oral cavity temperature and tympanic membrane temperature is as follows:

[0117] (1)DT=-0.0008Th2+0.05Th+0.225;

[0118] Where DT represents the temperature difference between the tympanic membrane and the oral cavity, and Th represents the ambient temperature.

[0119] The blood glucose measurement method of this application will be further described in detail below with another example.

[0120] Volunteer B obtained the difference between tympanic membrane calibration temperature and oral cavity calibration temperature at 11 different ambient temperatures during the calibration process before blood glucose monitoring. Three times with significant ambient temperature differences were selected: 6:30 AM before breakfast (ambient temperature 13.3℃), 11:50 AM before lunch (ambient temperature 16.6℃), and 3:25 PM 2 hours after lunch (ambient temperature 23.2℃). The differences between the three sets of tympanic membrane calibration temperature and oral cavity calibration temperature were 0.611℃, 0.670℃, and 0.753℃, respectively. Figure 8 As shown, Figure 8 This is a comparison graph showing the equations of the relationship curves between the ambient temperature and the differences between the tympanic membrane temperature and the oral cavity temperature of volunteer B provided in some embodiments of this application, and the equation of the relationship curve between the ambient temperature and the differences between the tympanic membrane temperature and the oral cavity temperature of volunteer B:

[0121] (2) DT = -0.0007T h 2 +0.0385T h +0.2212;

[0122] Where DT represents the temperature difference between the tympanic membrane and oral cavity of volunteer B, and T... h Represents ambient temperature.

[0123] Comparing equations (1) and (2) above, it can be seen that the coefficients of the relationship curve of volunteer B are not significantly different from the average coefficients of the universal relationship curve, indicating that the difference between the tympanic membrane temperature and oral cavity temperature obtained by volunteer B during the calibration process is reasonable. Through mathematical simulation, the relationship can be extended to lower or higher ambient temperatures, such as as low as 5℃ or as high as 30℃, which can be used as a difference equation suitable for volunteer B.

[0124] The blood glucose measurement method of this application will be further described in detail below with another example.

[0125] The ambient temperature for volunteer C during the calibration process was concentrated around 25℃, with an average of 25.2℃. The tympanic membrane temperature and oral temperature of volunteer C were measured over 25 hours before breakfast, lunch, dinner, and after dinner. Figure 9 As shown, Figure 9This is a comparison graph of the equations for the relationship curves between the ambient temperature and the difference between the tympanic membrane temperature and the oral cavity temperature of volunteer C provided in some embodiments of this application, and a universal relationship curve. It can be seen that the average difference between the tympanic membrane temperature and the oral cavity temperature of volunteer C at an ambient temperature of 25.2℃ is 0.651℃, which is 0.1092℃ lower than the average difference of 0.7502℃ at the same ambient temperature on the universal relationship curve. The universal curve needs to be shifted downwards by 0.1092℃ to obtain a difference curve suitable for volunteer C. The equation for the relationship curve between the ambient temperature and the difference between the tympanic membrane temperature and the oral cavity temperature of volunteer C is as follows:

[0126] (3) DT = -0.008T h 2 +0.051T h +0.1158;

[0127] Where DT represents the temperature difference between the tympanic membrane and oral cavity of volunteer C, and T... h Represents ambient temperature.

[0128] Reference Figure 10 As shown, Figure 10 This is a flowchart of a blood glucose measurement method provided in some other embodiments of this application. The blood glucose measurement method may include, but is not limited to, steps S1010, S1020, S1030 and S1040.

[0129] Step S1010: Obtain the calibrated blood glucose value and oral calibrated temperature before the time of oral temperature measurement. The calibrated blood glucose value is calibrated in an invasive manner.

[0130] Specifically, the calibration process requires measuring blood glucose levels over a 24-hour period. The measurement points are: before breakfast, 1 hour after breakfast, 2 hours after breakfast, before lunch, 1 hour after lunch, 2 hours after lunch, before dinner, 1 hour after dinner, 2 hours after dinner, before bedtime, and when you wake up at midnight, for a total of 11 blood glucose measurements.

[0131] Furthermore, the blood glucose level can be calibrated in an invasive manner, such as by fingertip blood collection, by arm vein blood collection, or by back of hand vein blood collection; this application does not impose any limitations on this method.

[0132] Step S1020: Obtain the target oral temperature increment based on the target oral temperature and the oral calibration temperature;

[0133] It should be noted that the oral calibration temperature is the oral calibration temperature measured at the time when the target tympanic membrane is measured, relative to the closest of the aforementioned calibration times. The difference between the target oral temperature and the oral calibration temperature is calculated to obtain the target oral temperature increment.

[0134] Step S1030: Based on the relationship between oral temperature increment and blood glucose increment, perform a relationship conversion on the target oral temperature increment to obtain the target blood glucose increment;

[0135] It should be noted that in the fitting curve of the relationship between oral temperature increment and blood glucose increment, the X-axis represents the oral temperature increment and the Y-axis represents the blood glucose increment. This curve can be a linear equation curve, a quadratic equation curve, or an Nth degree equation curve. This application does not make any specific limitation.

[0136] To elaborate further, the target blood glucose increment can be positive, negative, or zero.

[0137] Step S1040: Obtain the target blood glucose value based on the calibrated blood glucose value and the target blood glucose increment.

[0138] It should also be noted that the calibrated blood glucose value is the calibrated blood glucose value measured at the time closest to the target tympanic membrane measurement time among the aforementioned calibration times. The calibrated blood glucose value and the target blood glucose increment are added together to obtain the target blood glucose value.

[0139] Reference Figure 11 As shown, Figure 11 This is a flowchart of a blood glucose measurement method provided in some other embodiments of this application. The blood glucose measurement method may include, but is not limited to, steps S1110, S1120, S1130, S1140 and S1150.

[0140] Step S1110: Obtain multiple oral calibration temperatures and multiple calibration blood glucose values;

[0141] Specifically, the multiple oral temperature calibrations and multiple blood glucose calibrations were oral temperatures and invasive blood glucose values ​​obtained at the above 11 time points.

[0142] Step S1120: Based on multiple oral calibration temperatures, calculate the difference between oral calibration temperatures at adjacent times to obtain multiple oral calibration temperature increments;

[0143] Specifically, when the oral calibration temperature is the oral temperature obtained at the above 11 times, 10 oral calibration temperature increments are obtained by calculating the difference between the oral calibration temperatures at adjacent times.

[0144] Step S1130: Based on multiple calibrated blood glucose values, calculate the difference between calibrated blood glucose values ​​at adjacent times to obtain multiple calibrated blood glucose value increments;

[0145] Specifically, when the calibrated blood glucose value is the invasive blood glucose value obtained at the above 11 time points, the difference between the calibrated blood glucose values ​​at adjacent time points will yield 10 calibrated blood glucose value increments.

[0146] Step S1140: Determine the relationship between oral temperature increment and blood glucose increment based on multiple oral temperature increments and corresponding blood glucose increments;

[0147] It should be noted that in the fitting curve of the relationship between oral temperature increment and blood glucose increment, the X-axis represents the oral temperature increment and the Y-axis represents the blood glucose increment. This curve can be a linear equation curve, a quadratic equation curve, or an Nth degree equation curve. This application does not make any specific limitation.

[0148] Step S1150: Based on the relationship between oral temperature increment and blood glucose increment, perform a relationship conversion on the target oral temperature increment to obtain the target blood glucose increment.

[0149] It should be noted that the target oral temperature is used as the Y value corresponding to the X-axis of the fitted curve as the target blood glucose increment.

[0150] The blood glucose measurement method of this application will be further described in detail below with another example.

[0151] Volunteer D performed continuous glucose monitoring after the method calibration in the above embodiments was completed, such as... Figure 12 As shown, Figure 12 The figure shows the dynamic curve of tympanic membrane temperature of volunteer D over 25 hours according to some embodiments of this application. It can be seen that the curve has three peaks, which correspond to the increase in tympanic membrane temperature caused by the increase in metabolic heat due to the increase in blood sugar after three meals (meal times are 6:53, 12:55 and 18:50 respectively). This reflects the positive correlation between tympanic membrane temperature and blood sugar, that is, the tympanic membrane temperature will also increase when blood sugar increases.

[0152] This application also provides an electronic device, which includes a memory and a processor. The memory stores a computer program, and the processor executes the computer program to implement the above-described blood glucose measurement method and temperature curve relationship calibration method. This electronic device can be any smart terminal, including mobile phones, tablets, and in-vehicle computers.

[0153] Please see Figure 13 , Figure 13 This illustration shows the hardware structure of an electronic device provided in some embodiments. The electronic device includes:

[0154] The processor 1301 can be implemented using a general-purpose CPU (Central Processing Unit), microprocessor, application-specific integrated circuit (ASIC), or one or more integrated circuits, and is used to execute relevant programs to implement the tympanic membrane temperature measurement method, blood glucose measurement method, and temperature curve relationship calibration method provided in the embodiments of this application.

[0155] The memory 1302 can be implemented as a read-only memory (ROM), a static storage device, a dynamic storage device, or a random access memory (RAM). The memory 1302 can store the operating system and other application programs. When the technical solutions provided in the embodiments of this specification are implemented through software or firmware, the relevant program code is stored in the memory 1302 and is called and executed by the processor 1301 to execute the blood glucose measurement method provided in the embodiments of this application.

[0156] The input / output interface 1303 is used to implement information input and output;

[0157] The communication interface 1305 is used to enable communication and interaction between this device and other devices. Communication can be achieved through wired means (such as USB, network cable, etc.) or wireless means (such as mobile network, WIFI, Bluetooth, etc.).

[0158] Bus 1305 transmits information between various components of the device (e.g., processor 1301, memory 1302, input / output interface 1303, and communication interface 1305);

[0159] The processor 1301, memory 1302, input / output interface 1303 and communication interface 1305 are connected to each other within the device via bus 1305.

[0160] This application also provides a computer-readable storage medium storing a computer program, which, when executed by a processor, provides the blood glucose measurement method of this application.

[0161] Memory, as a non-transitory computer-readable storage medium, can be used to store non-transitory software programs and non-transitory computer-executable programs. Furthermore, memory may include high-speed random access memory, and may also include non-transitory memory, such as at least one disk storage device, flash memory device, or other non-transitory solid-state storage device. In some embodiments, memory may optionally include memory remotely located relative to the processor, and these remote memories can be connected to the processor via a network. Examples of such networks include, but are not limited to, the Internet, intranets, local area networks, mobile communication networks, and combinations thereof.

[0162] The embodiments described in this application are for the purpose of more clearly illustrating the technical solutions of the embodiments of this application, and do not constitute a limitation on the technical solutions provided by the embodiments of this application. As those skilled in the art will know, with the evolution of technology and the emergence of new application scenarios, the technical solutions provided by the embodiments of this application are also applicable to similar technical problems.

[0163] Those skilled in the art will understand that the technical solutions shown in the figures do not constitute a limitation on the embodiments of this application, and may include more or fewer steps than shown, or combine certain steps, or different steps.

[0164] The device embodiments described above are merely illustrative. The units described as separate components may or may not be physically separate; that is, they may be located in one place or distributed across multiple network units. Some or all of the modules can be selected to achieve the purpose of this embodiment according to actual needs.

[0165] Those skilled in the art will understand that all or some of the steps in the methods disclosed above, as well as the functional modules / units in the systems and devices, can be implemented as software, firmware, hardware, or suitable combinations thereof.

[0166] The terms “first,” “second,” “third,” “fourth,” etc. (if present) in the specification and accompanying drawings of this application are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that the embodiments of this application described herein can be implemented in orders other than those illustrated or described herein. Furthermore, the terms “comprising” and “having,” and any variations thereof, are intended to cover non-exclusive inclusion; for example, a process, method, system, product, or apparatus that comprises a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units not explicitly listed or inherent to such processes, methods, products, or apparatus.

[0167] It should be understood that in this application, "at least one (item)" means one or more, and "more than" means two or more. "And / or" is used to describe the relationship between related objects, indicating that three relationships can exist. For example, "A and / or B" can represent three cases: only A exists, only B exists, and both A and B exist simultaneously, where A and B can be singular or plural. The character " / " generally indicates that the preceding and following related objects are in an "or" relationship. "At least one (item) of the following" or similar expressions refer to any combination of these items, including any combination of single or plural items. For example, at least one (item) of a, b, or c can represent: a, b, c, "a and b", "a and c", "b and c", or "a and b and c", where a, b, and c can be single or multiple.

[0168] In the embodiments provided in this application, it should be understood that the disclosed systems and methods can be implemented in other ways. For example, the system embodiments described above are merely illustrative; for instance, the division of the units described above is only a logical functional division, and in actual implementation, there may be other division methods. For example, multiple units or components may be combined or integrated into another system, or some features may be ignored or not executed. Furthermore, the coupling or direct coupling or communication connection shown or discussed may be an indirect coupling or communication connection through some interfaces, devices, or units, and may be electrical, mechanical, or other forms.

[0169] The units described above as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the units can be selected to achieve the purpose of this embodiment according to actual needs.

[0170] Furthermore, the functional units in the various embodiments of this application can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit. The integrated unit can be implemented in hardware or as a software functional unit.

[0171] If the integrated unit is implemented as a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of this application, in essence, or the part that contributes to the prior art, or all or part of the technical solution, can be embodied in the form of a software product. This computer software product is stored in a storage medium and includes multiple instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute all or part of the steps of the methods of the various embodiments of this application. The aforementioned storage medium includes various media capable of storing programs, such as USB flash drives, portable hard drives, read-only memory (ROM), random access memory (RAM), magnetic disks, or optical disks.

[0172] The preferred embodiments of the present application have been described above with reference to the accompanying drawings, but this does not limit the scope of the claims of the present application. Any modifications, equivalent substitutions, and improvements made by those skilled in the art without departing from the scope and substance of the embodiments of the present application shall be within the scope of the claims of the present application.

Claims

1. A method for measuring blood glucose, characterized in that, include: Obtain the target tympanic membrane temperature and the target ambient temperature; Based on the relationship between ambient temperature and the temperature difference between the tympanic membrane and the oral cavity, the target ambient temperature is converted to obtain the temperature difference between the tympanic membrane and the oral cavity at the target ambient temperature. Based on the temperature difference, the target tympanic membrane temperature is converted to obtain the target oral cavity temperature; Based on the relationship between oral temperature and blood glucose, the target oral temperature is converted to a corresponding blood glucose value to obtain the target blood glucose value. The step of performing a relationship conversion on the target ambient temperature based on the relationship between the ambient temperature and the temperature difference between the tympanic membrane and the corresponding oral cavity temperature to obtain the temperature difference between the tympanic membrane and the oral cavity at the target ambient temperature includes: Obtain multiple environmental calibration temperatures, and their corresponding tympanic membrane calibration temperature and oral cavity calibration temperature; Based on the environmental calibration temperature, the difference between the tympanic membrane calibration temperature and the oral cavity calibration temperature at each of the environmental calibration temperatures is calculated to obtain the temperature difference between the tympanic membrane and the oral cavity at multiple environmental calibration temperatures; Based on multiple environmental calibration temperatures and their corresponding temperature differences, the target temperature difference relationship between the tympanic membrane and the oral cavity under different environmental temperatures is determined. Based on the target temperature difference relationship, the target ambient temperature is converted to obtain the temperature difference between the tympanic membrane and the oral cavity at the target ambient temperature; The step of determining the target temperature difference relationship between the tympanic membrane and the oral cavity under different ambient temperatures based on multiple environmental calibration temperatures and their corresponding temperature differences includes: The universal temperature difference relationship between the tympanic membrane and the oral cavity is obtained as the first temperature difference relationship. The first temperature difference relationship is a temperature difference relationship fitted by collecting the average temperature difference between the tympanic membrane and the oral cavity of the general public under different ambient temperatures. Based on multiple environmental calibration temperatures and corresponding temperature differences, the temperature difference relationship between the tympanic membrane and the oral cavity under different environmental temperatures is determined as a second temperature difference relationship. The second temperature difference relationship is the temperature difference relationship between the tympanic membrane and the oral cavity under different environmental temperatures that the user fits by the environmental calibration temperature, the tympanic membrane calibration temperature and the oral cavity calibration temperature. Under the same ambient temperature, the difference between the first temperature difference relationship and the second temperature difference relationship is compared with a preset threshold to obtain the target temperature difference relationship.

2. The blood glucose measurement method according to claim 1, characterized in that, Under the same ambient temperature, the difference between the first temperature difference relationship and the second temperature difference relationship is compared with a preset threshold to obtain a target temperature difference relationship, which includes: If the absolute value of the relationship difference is less than a preset threshold, then the second temperature difference relationship is taken as the target temperature difference relationship; or, If the absolute value of the relationship difference is greater than or equal to a preset threshold, the relationship curve of the first temperature difference relationship is shifted up and down in the corresponding direction according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is taken as the target temperature difference relationship.

3. The blood glucose measurement method according to claim 2, characterized in that, If the absolute value of the relationship difference is greater than or equal to a preset threshold, then the relationship curve of the first temperature difference relationship is shifted vertically in the corresponding direction according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is taken as the target temperature difference relationship, including: When the relationship difference is positive, the relationship curve of the first temperature difference relationship is shifted downward according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is taken as the target temperature difference relationship. or, When the relationship difference is negative, the relationship curve of the first temperature difference relationship is shifted upward according to the relationship difference, and the first temperature difference relationship after the relationship curve is shifted is taken as the target temperature difference relationship.

4. The blood glucose measurement method according to claim 1, characterized in that, The acquisition of the universal temperature difference relationship between the tympanic membrane and the oral cavity as the first temperature difference relationship includes: Obtain multiple environmental universal temperatures, and the corresponding tympanic membrane universal temperature and oral cavity universal temperature under these multiple environmental universal temperatures; Based on the ambient temperature, the difference between the ambient temperature and the oral cavity temperature under each ambient temperature is calculated to obtain the first ambient temperature difference between the tympanic membrane and the oral cavity under multiple ambient temperatures. The first universal temperature difference under different universal environmental temperatures is reduced in dimensionality to obtain the second universal temperature difference under different universal environmental temperatures. Based on multiple universal environmental temperatures and their corresponding second universal temperature differences, the universal temperature difference relationship between the tympanic membrane and the oral cavity under different universal environmental temperatures is determined and used as the first temperature difference relationship.

5. The blood glucose measurement method according to claim 1, characterized in that, The step of converting the target oral temperature to a corresponding blood glucose value based on the relationship between oral temperature and blood glucose to obtain the target blood glucose value includes: Acquire calibrated blood glucose and oral calibrated temperature prior to the time of oral temperature measurement, wherein the calibrated blood glucose is calibrated invasively; The target oral temperature increment is obtained based on the target oral temperature and the oral temperature calibration. Based on the relationship between oral temperature increment and blood glucose increment, the target oral temperature increment is converted to obtain the target blood glucose increment. The target blood glucose value is obtained based on the calibrated blood glucose value and the target blood glucose increment.

6. The blood glucose measurement method according to claim 5, characterized in that, The step of converting the target oral temperature increment to the target blood glucose increment based on the relationship between oral temperature increment and blood glucose increment includes: Obtain multiple oral calibrated temperatures and multiple calibrated blood glucose values; Based on the multiple oral calibration temperatures, the differences between the oral calibration temperatures at adjacent times are calculated sequentially to obtain multiple oral calibration temperature increments; Based on multiple calibrated blood glucose values, the differences between the calibrated blood glucose values ​​at adjacent time points are calculated sequentially to obtain multiple calibrated blood glucose value increments; The relationship between oral temperature increment and blood glucose increment is determined based on multiple oral temperature increments and corresponding blood glucose increments. Based on the relationship between oral temperature increment and blood glucose increment, the target oral temperature increment is converted to obtain the target blood glucose increment.

7. An electronic device, characterized in that, include: At least one processor; At least one memory for storing at least one program; The blood glucose measurement method as described in any one of claims 1 to 6 is implemented when at least one of the programs is executed by at least one of the processors.

8. A computer-readable storage medium, characterized in that: It contains a processor-executable program, which, when executed by a processor, is used to implement the blood glucose measurement method as described in any one of claims 1 to 6.

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