一种完全分离油酸和亚油酸的方法
By separating oleic acid and linoleic acid using high-speed countercurrent chromatography and a specific solvent system, the problem of achieving high-purity oleic acid using traditional methods has been solved, enabling efficient and environmentally friendly oleic acid preparation.
CN117209376BActive Publication Date: 2026-07-17SHANGHAI TAUTO BIOTECH CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANGHAI TAUTO BIOTECH CO LTD
- Filing Date
- 2019-09-11
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Traditional methods are insufficient to reduce the linoleic acid content to below 0.5%, which fails to meet the purity requirements for pharmaceutical-grade oleic acid.
Method used
High-purity oleic acid was prepared by using high-speed countercurrent chromatography, separating oleic acid and linoleic acid through a specific solvent system and phase inversion step, combined with ultrasonic degassing and rotary evaporation vacuum drying.
Benefits of technology
It achieves an oleic acid purity of over 99%, and the solvent is recyclable and reusable, making it environmentally friendly and highly efficient, while avoiding sample loss.
✦ Generated by Eureka AI based on patent content.
Abstract
本发明涉及一种完全分离油酸和亚油酸的方法，包括：将溶剂体系充分振摇，静置分相，分开收集上、下两相；将70～80％高纯油酸溶解于上相中，采用高速逆流色谱进行分离，从进样起，首先正接正转，以上相为固定相，下相为流动相，得到亚油酸与下相的混合液；然后改为反接正转，以下相为固定相，上相为流动相，得到油酸与上相的混合液，去除下相和上相，分别得到亚油酸和油酸。本发明首次利用高速逆流色谱技术从70～80％高纯油酸分离纯化得到＞99％纯度的油酸，溶剂体系的试剂皆可回收再利用，理论上油酸可实现100％回收。
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