Antimicrobial composition

Abstract

An antimicrobial composition comprising water; an alcohol; a cationic polymer; and an anti-sticking agent.

Description

Technical Field

[0001] This document discloses an antimicrobial composition, particularly a transparent antimicrobial composition. The antimicrobial composition comprises water, an alcohol, a cationic polymer, and a detackifying agent. Background Technology

[0002] Consumers are increasingly concerned about microbial and viral contamination. Therefore, hygiene remains one of the most important attributes consumers expect. Consumers desire products that provide the hygiene performance they require. Consumers worldwide use different types of antimicrobial compositions to disinfect a wide variety of surfaces, including hard surfaces such as countertops, floors, and furniture; soft and porous surfaces such as clothing, carpets, and upholstery; and personal surfaces such as skin and hair. Numerous microorganisms, such as bacteria and viruses, are found on these surfaces. The goal is to keep these surfaces free of pathogenic microorganisms to minimize the risk of illness.

[0003] Furthermore, respiratory infections are considered one of the most common causes of disease worldwide. Scientific research has identified respiratory syncytial virus (RSV) as the most common viral cause of death from this infection; other prominent viruses include human metapneumovirus, parainfluenza virus, influenza A and B viruses, adenovirus, and recently developed coronaviruses.

[0004] Besides viral infections, bacterial infections also account for a significant proportion of morbidity and mortality worldwide. Bacteria found on the skin can be divided into two categories: resident bacteria and transient bacteria. Resident bacteria are Gram-positive bacteria that form permanent small colonies on the skin surface and outermost layer, playing an important and beneficial role in preventing the colonization of other, more harmful bacteria and fungi. Transient bacteria are bacteria that are not part of the normal resident flora of the skin, but may accumulate when airborne pollutants land on the skin or when pollutants come into physical contact with the skin. Transient bacteria are generally also divided into Gram-positive and Gram-negative subclasses. Gram-positive bacteria include pathogens such as Staphylococcus aureus, Streptococcus pyogenes, and Clostridium botulinum. Gram-negative bacteria include pathogens such as Salmonella, Escherichia coli, Klebsiella pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa, Proteus mirabilis, and Shigella dysenteriae. Gram-negative bacteria are distinguished from Gram-positive bacteria by an additional protective cell membrane, which usually makes Gram-negative bacteria less sensitive to local antimicrobial active substances.

[0005] Studies have shown that the viruses and bacteria described above can be transmitted through contact with infected hands, or even through inanimate surfaces (including mobile phones). Therefore, hand hygiene is generally recommended as a method to kill these pathogenic microorganisms, thereby reducing not only the risk of respiratory infections but also the risk of gastrointestinal diseases. Hand hygiene involves washing hands with soap and running water, which removes dirt and kills pathogenic microorganisms, including bacteria and viruses. Alternatively, alcohol-based hand sanitizers containing very little water can be applied to hands as another effective way to remove viruses and bacteria. While these methods excel at instantly killing pathogenic microorganisms, they do not provide long-lasting wash- or post-application protection against viruses that can penetrate surfaces for several hours after surface cleaning. Long-lasting protection against pathogenic microorganisms requires the additional step of applying a rinse-free composition to the surface.

[0006] Therefore, there is a ongoing need to develop an antimicrobial composition containing antimicrobial active substances that not only kills pathogenic microorganisms but also deposits sufficient amounts of the active substances on the skin to ensure effective killing of pathogenic microorganisms within hours after washing. Summary of the Invention

[0007] This article discloses antimicrobial compositions in various aspects.

[0008] An antimicrobial composition comprises water; an alcohol; a cationic polymer; and an anti-sticking agent.

[0009] These and other features and characteristics will be described in more detail below. Detailed Implementation

[0010] This invention discloses an antimicrobial composition having desirable (e.g., non-sticky) sensory properties and durable antimicrobial efficacy. The antimicrobial composition comprises water, an alcohol, a cationic polymer, and an anti-stick agent. While the cationic polymer contributes to the durable antimicrobial efficacy of the antimicrobial composition, it can also provide an unpleasant or sticky feeling to the user after application. The anti-stick agent helps to reduce the stickiness associated with the cationic polymer, thereby providing an antimicrobial composition with durable pathogenic microorganism killing and a non-sticky feel after application. The antimicrobial composition can be transparent or translucent, preferably transparent. For transparent antimicrobial compositions, the inclusion of an anti-stick agent is expected to negatively impact transparency. However, it has been unexpectedly found that the inclusion of the anti-stick agent disclosed herein does not negatively impact the transparency of the antimicrobial composition.

[0011] The disinfectant or antimicrobial composition used herein refers to a composition capable of killing or inhibiting the growth of bacteria, as well as fungi, parasites, algae, dust mites, and certain viruses. The antimicrobial composition used herein refers to a composition that continuously inhibits the growth of microorganisms on a surface over a long period of time. The antimicrobial composition may be substantially emulsifier-free. "Substantially emulsifier-free" means that the composition contains less than 2% by weight of emulsifier, preferably less than 1% by weight, more preferably less than 0.5% by weight, even more preferably less than 0.1% by weight, and even more preferably 0% by weight.

[0012] The antimicrobial composition comprises a cationic polymer. The cationic polymer provides the antimicrobial composition with long-term pathogenic microbial killing efficacy. The cationic polymer can generally be any cationic polymer, but is preferably selected from polyquaternium-6 (polydiallyl dimethylammonium chloride) (PDADMAC), poly-N-[3-(dimethylamino)propyl]methacrylamide (PDMAPMA), poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA), polyethyleneimine (PEI), chitosan, or combinations thereof. Preferably, the cationic polymer is polyquaternium-6.

[0013] The cationic polymer used in the compositions disclosed herein is preferably a homopolymer / polymer having at least one nitrogen atom as a repeating unit. The presence of nitrogen results in a nitrogen content greater than or equal to 5% by weight of the cationic polymer. Preferably, the amount of nitrogen present is 5-45% by weight of the cationic polymer, more preferably 6-40% by weight, and most preferably 6-35% by weight.

[0014] The weight percentage of nitrogen is calculated using the following formula:

[0015] The weight percentage of N = (weight of N in the repeating unit / total molecular weight of the repeating unit) * 100

[0016] Therefore, the weight percentage of nitrogen does not change with the degree of polymerization / molecular weight of the polymer.

[0017] The nitrogen weight percentage of the cationic polymer used here is:

[0018] PQ-6 (8.7%), PQ-37 (7.2%), and PQ-16 (16%). Cationic polymers outside the scope of disclosure include PQ-10 (1.5-2.2% N) and PQ-67 (1.3% N).

[0019] The preferred PDADMAC molecular weight (weight average molecular weight) for use in the antimicrobial compositions disclosed herein is from 200,000 to 2000,000, more preferably from 400,000 to 600,000. It is a cationic polymer with a viscosity of 10,000-20,000 mPa·s. This polymer is available from Lubrizol, Inc. under the trade name Merquat-100 (INCI: polyquaternium-6).

[0020] The cationic polymer may be present in an amount of 0.1-5.0% by weight of the total antimicrobial composition, preferably 0.25-4.0% by weight, more preferably 0.5-2.0% by weight, including all values ​​and ranges contained therein.

[0021] The antimicrobial composition comprises 8-40% by weight, preferably 10-35% by weight, and more preferably 12-30% by weight of water, of the total antimicrobial composition, including all values ​​and ranges contained herein.

[0022] Alcohols can be used as antimicrobial agents in compositions. When an alcohol is used as an antimicrobial agent, the antimicrobial composition contains 30-80% by weight, preferably 40-78% by weight, more preferably 55-75% by weight, and even more preferably 60-70% by weight of alcohol, including all values ​​and ranges contained therein. The alcohol may include a variety of alcohols, including but not limited to ethanol, propanol (n-propanol), isopropyl alcohol (isopropanol), butanol, or combinations thereof. The content of alcohol present in the antimicrobial composition may be adjusted based on the percentage of alcohol purity. For example, if 92% pure ethanol is used, the amount of ethanol may be 70-80% by weight, for example, 75% by weight. Optionally, the alcohol may contain chloromethylphenol. A preferred alcohol may be denatured SD-40 ethanol.

[0023] The antimicrobial composition may optionally contain one or more additional antimicrobial agents. Optional additional antimicrobial agents may be selected from terpenes, essential oils, or cationic oils with a solubility in water of less than 2000 parts per million (ppm) at 25°C. Examples of aromatic essential oils that may be used in the antimicrobial compositions disclosed herein include amyl salicylate, carvacrol, cymenes such as p-cymenes, dihydroeugenol, eugenol, hexyleugenol, hexyl salicylate, isoeugenol, methyleugenol, methyl isoeugenol, methyl salicylate, tert-butylcresol, thymol, and vanillin. Examples of non-aromatic essential oils containing terpenoids include juniperane, eucalyptol, citral (including geranialdehyde and nerol), citronellol, nitronelol, eucalyptol (i.e., 1,8-eucalyptol), p-dihydrolinalool, dihydromyrcenol (DH myrcenol), farnesol, geraniol, hexylcinnamaldehyde, hydroxycitronellol, hydroxycitronellol, isocitral, limonene, preferably d-limonene, linalool, linalool, menthol, nerolidiol, pinene, such as α-pinene, phellendrene, terpinene, such as α-terpinene and γ-terpinene, terpineol, such as γ-terpineol and 4-terpineol, and tetrahydromyrcenol (THM).

[0024] Preferred cationic oils include quaternary ammonium cationic vegetable oils and charged amino polydimethylsilanes having the formula (CH3)3-Si[Si(CH3)2-O]-[Si(CH3)-((CH2)3-NH-(CH2)2-NH2)-O]2-Si-(CH3)3. Preferably, these additional antimicrobial agents have a solubility of less than 2000 ppm at 25°C. For example, additional antimicrobial agents may be terpineol, thymol, eugenol, borneol, limonene, or combinations thereof. Preferred additional antimicrobial agents may be terpineol, thymol, or eugenol, or combinations thereof.

[0025] Other optional antimicrobial agents include silver compounds. Silver compounds may contain silver ions. For example, silver ions may be selected from silver nitrate, silver acetate, silver oxide, silver sulfate, or combinations thereof. Silver nitrate is preferred as the silver compound.

[0026] More specifically, the silver compound optionally used in the composition is one or more water-soluble silver (I) compounds having a silver ion solubility of at least 1.0 × 10⁻⁶. -4 The solubility of silver ions, as referred to herein, is a value derived from the solubility product (Ksp) in water at 25°C, a well-known parameter reported in many sources. More specifically, the solubility of silver ions [Ag+] (given in mol / L) can be calculated using the following formula:

[0027] [Ag+] = (Ksp x) (1 / (x+1)) ,

[0028] Where Ksp is the solubility product of the target compound in water at 25°C, and x represents the number of moles of silver ions per mole of the compound. It has been found that the solubility of silver ions is at least 1 × 10⁻⁶. -4 A mol / L silver(I) compound is desirable for use in this invention.

[0029] The silver compounds desired to be used in this invention include silver oxide, silver nitrate, silver acetate, silver sulfate, silver benzoate, silver salicylate, silver carbonate, silver citrate, and silver phosphate, or combinations thereof, preferably wherein the silver compound is silver nitrate, silver acetate, silver oxide, silver sulfate, or combinations thereof.

[0030] When present, the additional antimicrobial agent may be included in an amount of 0.05-2% by weight of the total antimicrobial composition, including all values ​​and ranges contained herein, such as 0.1-2% by weight.

[0031] An anti-adhesive agent may be used in the antimicrobial composition to help reduce any stickiness / stickiness remaining on the skin after application of an antimicrobial composition containing a cationic polymer. The antimicrobial composition contains an anti-adhesive agent in an amount of 0.01-15% by weight (including all values ​​and ranges contained therein) of the total antimicrobial composition, preferably 0.01-10% by weight (including all values ​​and ranges contained therein), more preferably 0.5-10% by weight (including all values ​​and ranges contained therein), and even more preferably 0.5-5% by weight (including all values ​​and ranges contained therein) of the total antimicrobial composition.

[0032] The anti-sticking agent intended for use in the antimicrobial compositions disclosed herein must meet the following criteria: the anti-sticking agent must be a liquid; the anti-sticking agent must be soluble in an ethanol / water ratio of at least 75 / 25 or higher (EtOH / water), which is a reflection of the solubility that produces a clear (i.e. transparent) final antimicrobial composition in the final composition; and the anti-sticking agent must not have water solubility.

[0033] The anti-stick agent may contain a soluble anti-stick agent. Solubility helps ensure the formation of a transparent antimicrobial composition. The soluble anti-stick agent may contain dicarboxylic acid esters, lactic acid esters (e.g., C12 / 14 / 16 lactic acid esters), (poly)propylene glycol fatty ethers, or combinations thereof.

[0034] The anti-stick agent may also comprise a mixture of soluble and insoluble anti-stick agents, provided that the combination of soluble and insoluble anti-stick agents is soluble in the end-use antimicrobial composition. For example, soluble anti-stick agents may include diisopropyl adipate, diisopropyl sebacate, diethylhexyl malate, lauryl lactate, myristyl lactate, cetyl lactate, isostearyl alcohol, PPG15 stearyl ether, or combinations thereof.

[0035] Further combinations of the aforementioned anti-sticking agents with insoluble oils (such as triglycerides (e.g., caprylic / caprylic triglycerides), soybean oil, or fatty esters (e.g., isopropyl myristate or isopropyl palmitate)) are also within the scope of the disclosed antimicrobial compositions, provided that the oil is soluble and forms a transparent end-use antimicrobial composition. The latter does not imply a limitation to the selection of insoluble anti-sticking agents that can be used in the compositions disclosed herein. That is, other insoluble oils may be used, provided that when combined with the selected anti-sticking agents of the compositions of the present invention, the insoluble agents become soluble upon mixing into the end-use antimicrobial composition. Any combination of anti-sticking agents used in the antimicrobial composition should not affect the transparency of the antimicrobial composition.

[0036] Antimicrobial compositions can be in any form. For example, antimicrobial compositions can be in the form of liquids, gels, or sprays.

[0037] When the antimicrobial composition is in liquid or gel form, a structuring agent may be present in the composition. The structuring agent may include nonionic, cationic, or combinations thereof. It is undesirable to be limited by theory, as it is believed that anionic structuring agents react with cationic polymers and precipitate. Therefore, the use of anionic structuring agents in the disclosed antimicrobial compositions is undesirable.

[0038] Structurers can also be used to adjust the viscosity of antimicrobial compositions and to facilitate the formation of compositions in non-spray forms (e.g., to impart structure to them). When present, the amount of structurer can be from 0.01 wt% to 3 wt% of the total antimicrobial composition, including all values ​​and ranges contained therein, for example, from 0.1 wt% to 2.5 wt% of the total antimicrobial composition, for example, from 0.15 wt% to 2.0 wt%, for example, from 0.20 wt% to 1.5 wt%. The amount of structurer used can be adjusted according to the desired end-use viscosity.

[0039] The structuring agent may comprise cellulose, which may include hydroxypropyl cellulose (e.g., the Klucel series from Ashland) and hydroxypropyl methylcellulose (e.g., the BENECEL from Ashland). TM E10M), hydroxyethyl cellulose (e.g., the Natrosol series from Ashland), and cellulose (e.g., cellulose microfibers, cellulose nanocrystals, or microcrystalline cellulose).

[0040] Further nonionic structuring agents may include maltodextrin, pentaerythritol tetrastearate, or combinations thereof.

[0041] Cationic structurers, including cationic polymer structurers, are also applicable. Cationic polymer structurers include polymers classified as cationic guar gum derivatives, synthetic cationic polymers, and cationic starch derivatives. Those classified as partially cationic substituted quaternary ammonium salts are generally preferred.

[0042] Suitable polymers of this type conform to the following structures:

[0043]

[0044] Where x is 0-3, preferably 0-1; the y:n ratio is 0.01 to 0.5 (i.e., n:y = 100 to 2). It is desirable to exclude cationic polymers with fully quaternized sugar units (i.e., y = n).

[0045] The ratio (n:y) of unquaternized sugar units to quaternized sugar units is preferably 3-30, more preferably 4-25, and most preferably 5-20.

[0046] The polymer has a weight-average molecular weight in the range of 100 to 3,000,000 kilodaltons (kDa), preferably 500 to 1,000,000 kDa, more preferably 10,000 to 500,000 kDa, and mixtures of polymers may be used. In one embodiment, the polymer has a weight-average molecular weight of 150 to 100,000 kDa. In another embodiment, the polymer has a weight-average molecular weight of 200 to 3,000 kDa. In yet another embodiment, the polymer has a weight-average molecular weight of 250 to 2,500 kDa.

[0047] Preferred cationic polymer structuring agents are called quaternary nitrogen-containing polysaccharides, more preferably quaternary nitrogen-containing cellulose ethers, such as those described in U.S. Patent Nos. 3,472,840; 3,962,418; 4,663,159, U.S. Patent No. 5,407,919, and International Publication No. WO2005 / 000903A1, the disclosures of which are incorporated herein by reference. Particularly preferred cationic polymer structuring agents are quaternary nitrogen-containing hydroxyethyl cellulose. Suitable examples of cationic polymer structuring agents are salts of hydroxyethyl cellulose reacted with trimethylammonium-substituted epoxides, known in the industry by the Cosmetic, Toiletry, and Fragrance Association (CTFA) as polyquaternium salt-10 (PQ-10), which is commercially available from Amerchol Corporation, a subsidiary of Dow Chemical Company, such as UCARE. TM Polymer JR-125, UCARE TM Polymer JR-400, UCARE TM Polymer KF, UCARE TM Polymer JR-30M, UCARE TM Polymer LR-400, UCARE TM Polymer LR-30M, UCARE TM Polymer KG-30M and UCARE TM PolymerLK. Other commercially available PQ-10 materials are KG30 and SENSOMER from Lubrizol, Inc. TM .

[0048] Other preferred examples of cationic polymeric structuring agents are CTFA's polyquaternary ammonium salt-67. These can be used as SoftCAT. TM Polymers are purchased from Amerchol Corp., such as SoftCAT. TM SL 5, SoftCAT TM SL 30, SoftCAT TM SL 60, SoftCAT TM SL 100, SoftCAT TM SK-L, SoftCAT TM SK-M, SoftCAT TM SK-MH, SoftCAT TM SK-H, SoftCAT TMSX-400X, SoftCAT TM SX-400H, SoftCAT TM SX-1300X and SoftCAT TM SX-1300H. Other examples of preferred cationic polymer structuring agents are those referred to in the industry by the CTFA as polyquaternium-7 (CAS Registry No. 026590-05-6) and those referred to by the CTFA as polyquaternium-44. Other cationic polymer structuring agents include those commercially available from Solvay. C 13S, C14S and C17. Even other types of cationic cellulose ethers include polymeric quaternary ammonium salts of hydroxyethyl cellulose reacted with lauryl dimethylammonium-substituted epoxides, known in the industry (CTFA) as polyquaternary ammonium salt-24. Polyquaternary ammonium salt-32, polyquaternary ammonium salt-37, polyquaternary ammonium salt-16, polyquaternary ammonium salt-45, polyquaternary ammonium salt-28, and polyquaternary ammonium salt-53 may also be used. Any combination of the above-described cationic polymeric structuring agents may be used as structuring agents in the disclosed antimicrobial compositions.

[0049] Regarding the percentage of nitrogen substitution in the cationic polymer (by weight) (i.e., cationic substitution), based on the total weight of the cationic polymer, the nitrogen percentage is typically 0.1-4% by weight, preferably 0.3-3.5% by weight, and most preferably 1-2.8% by weight.

[0050] Cationic surfactants that may be included in antimicrobial compositions include hexadecyltrimethylammonium chloride (CTAC), hexadecyltrimethylammonium bromide (CTAB), dodecyltrimethylammonium chloride (DTAC), or combinations thereof.

[0051] The antimicrobial composition may additionally contain other components besides those described herein, including but not limited to skin-beneficial agents, fragrances, preservatives, surfactants, fixatives, opacifiers, chelating agents, structuring agents, humectants, dyes or colorants, or combinations thereof. For example, various colorants may optionally be used in the antimicrobial composition. When present, the amount of colorant may be 0.00001-0.005% by weight of the total antimicrobial composition, including all values ​​and ranges contained therein, such as 0.0001-0.003% by weight, for example, 0.001% by weight.

[0052] For example, a moisturizer may optionally be used in the antimicrobial composition to provide additional moisturizing properties to the composition. Such moisturizers desired for use in the antimicrobial composition may include water-soluble polyols such as propylene glycol, dipropylene glycol, polypropylene glycol (e.g., PPG-9), polyethylene glycol, hydroxypropyl sorbitol, sorbitol, hexanediol, 1,3-butanediol, 1,4-butanediol, 1,2-octanediol, 1,2-hexanediol, isopentyl glycol, 1,2,6-hexanetriol, ethoxylated glycerin, propoxylated glycerin, and combinations thereof. Most preferably are glycerin, butylene glycol, propylene glycol, polyethylene glycol, sorbitol, polyglycerol, isopentyl glycol, hyaluronic acid, or combinations thereof. The amount of the moisturizer may be 1-15% by weight of the antimicrobial composition, preferably 2-10% by weight, more preferably 3-8% by weight (including any and all combinations contained therein).

[0053] The antimicrobial composition may optionally contain a surfactant, such as a cationic surfactant. When used, the limitation of the cationic surfactant is only that it should be suitable for topical application on human skin. The cationic surfactant may contain branched or linear alkyl trimethylammonium compounds, alkanol trimethylammonium compounds, or combinations thereof. Alkanol trimethylammonium compounds include lauroyl ethyl trimethylmethyl ammonium sulfate, palmitoyl ethyl trimethylmethyl ammonium sulfate, stearoyl ethyl trimethylmethyl ammonium sulfate, carnitine, palmitoyl carnitine, and combinations thereof, etc. The trimethylammonium compound used may be an alkyl trimethylammonium compound, which includes hexadecyl trimethylammonium chloride, hexadecyl trimethylammonium bromide, tetradecyl trimethylammonium chloride, tetradecyl trimethylammonium bromide, behenyl trimethylmethylammonium sulfate, cocoyl trimethylmethylammonium sulfate, behenyl trimethylammonium chloride, behenyl trimethylammonium bromide, stearyl trimethylammonium chloride, stearyl trimethylammonium bromide, lauryl trimethylammonium chloride, lauryl trimethylammonium bromide, and combinations thereof, etc. For the avoidance of doubt, when used, the cationic surfactants used in the antibacterial compositions disclosed herein may consist substantially of or be composed of any combination of the aforementioned surfactants.

[0054] As for cationic surfactants containing dimethylammonium compounds, such compounds include dialkyldimethylammonium compounds, such as distearyldimethylammonium chloride, dialcyldimethylammonium chloride, discocarbamateldimethylammonium chloride, and combinations thereof. Other suitable dimethylammonium compounds include benzyl chloride and / or benzalkonium chloride. The terms dimethylammonium and trimethylammonium compounds used herein refer to compounds including their salts, especially their chlorides and bromides.

[0055] The amount of cationic surfactants (i.e., cationic trimethylammonium, dimethylammonium) and / or polyquaternary ammonium salt materials used in the composition is typically 0.007-5% by weight of the total antimicrobial composition, preferably 0.01-3% by weight, most preferably 0.05-2% by weight, including all values ​​and ranges contained therein.

[0056] When using trimethylammonium and dimethylammonium surfactants, they are typically used in a weight ratio of 1:99 to 99:1, preferably 30:70 to 70:30, and most preferably 40:60 to 60:40.

[0057] The antimicrobial composition may optionally include a sunscreen agent and a light stabilizer, provided that the type and amount of the sunscreen agent and light stabilizer used do not affect the transparency and antimicrobial efficacy of the composition. Sunscreen agents and light stabilizers used include, for example, octyl methoxycinnamate (OMC), ethylhexyl salicylate, phenylbenzimidazole sulfonic acid (Ensulizole), and ethylhexyl p-methoxycinnamate (which can be used as...). MCX obtained), Avobenzene (butyl methoxydibenzoylmethane) (can be used as) Materials including benzophenone-3 (also known as oxybenzone) and benzophenone-4 (also known as sulphone) can be used. Other materials may include bis(ethylhexyloxyphenol) methoxyphenol triazine, 2-ethylhexyl-2-cyano-3,3-diphenyl-2-propionic acid, cresoltrazol trisiloxane, 3,3,5-trimethylcyclohexyl-2-hydroxybenzoate, 2-ethylhexyl-2-hydroxybenzoate, or combinations thereof. Inorganic sunscreen active ingredients may be used, such as fine titanium dioxide (preferably having a particle diameter of less than 150 nanometers (nm), most preferably less than 100 nm), and zinc oxide, polyethylene, and various other polymers are also suitable sunscreen agents. Other suitable sunscreen agents include para-aminobenzoic acid (PABA), octyl dimethyl-PABA, 2-ethoxyethyl-p-methoxycinnamate, benzophenone-1, benzophenone-2, benzophenone-6, benzophenone-8, benzophenone-9, benzophenone-12, homomethyl salicylate, menthyl anthranilate, benzophenone-4, triethanolamine salicylic acid, terephthalimide dicamphenone sulfonic acid, bisoctriazole, bisethylhexyloxyphenol methoxyphenyl triazine, disodium bisdisulizole, diometriazole trisiloxane, octyl triazinone, iscotrizinol, polysiloxane-15, isopentenyl-4-methoxycinnamate, or combinations thereof. Octocrylene can also be used. The amount of sunscreen or light stabilizer (when present) may be 0.001-20% by weight of the total antimicrobial composition (including all values ​​and ranges contained therein), preferably 0.005-15% by weight, more preferably 0.01-0.2% by weight, and even more preferably 0.1% by weight.

[0058] Ideally, optional skin-beneficial agents used in the antimicrobial compositions disclosed herein include niacinamide (vitamin B3), tocopherol (vitamin E), aloe vera, α-hydroxy acids and esters, β-hydroxy acids and esters, hydroxyethyl urea, polyhydroxy acids and esters, creatine, hydroquinone, tert-butylhydroquinone, mulberry, hyaluronic acid and its salts (including, but not limited to, their Na+ and K+ salts), extracts, licorice extract, resorcinol derivatives, or combinations thereof. For example, the skin-beneficial agent may be sodium hyaluronate. The amount of these beneficial agents (including sodium hyaluronate) may be from 0.0001 to 10%, for example 0.001 to 6.5%, for example 0.01 to 3.5%, and for example 0.01% (by weight), based on the total weight of the antimicrobial composition, and includes all values ​​and ranges contained therein.

[0059] Further optional water-soluble skin-benefiting agents include acids, such as amino acids like arginine, valine, or histidine. Other vitamins can be used, such as vitamin B2, pyridinecarboxamide, panthenol (vitamin B5), vitamin B6, vitamin C, and combinations thereof. Derivatives of these vitamins (generally referring to substances developed or obtained from other substances), especially water-soluble derivatives, can also be used. For example, vitamin C derivatives such as ascorbate tetraisopalmitate, magnesium ascorbate phosphate, and ascorbate glycoside can be used alone or in combination. Niacinamide derivatives such as nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) can be used alone or in combination. Other skin-benefiting agents that can be used include 4-ethylresorcinol, extracts (such as sage, aloe vera, green tea, sugarcane, citrus, grape seed, thyme, chamomile, yarrow, cucumber, licorice, rosemary extracts), or combinations thereof. Electrolytes such as NaCl and / or KCl and / or MgCl2 can also be used. When present in the compositions disclosed herein, the total amount of the optional water-soluble beneficial agent (including mixtures) may be from 0.0001 to 10% by weight, preferably from 0.001 to 6.5% by weight, and most preferably from 0.01 to 3.5% by weight (including all values ​​and ranges contained herein) based on the total weight of the antimicrobial composition.

[0060] Optional inclusion of oil-soluble beneficial agents is also within the scope of antimicrobial compositions. Illustrative examples of types of oil-soluble beneficial agents that may be optionally used in the antimicrobial compositions disclosed herein include components such as stearic acid, vitamins such as vitamins A, D, E, and K (and their oil-soluble derivatives).

[0061] Other optional oil-soluble beneficial agents used include resorcinols and resorcinol derivatives, such as 4-hexylresorcinol, 4-phenylethylresorcinol, 4-cyclopentylresorcinol, 4-cyclohexylresorcinol, 4-isopropylresorcinol, or combinations thereof. Additionally, 5-substituted resorcinols, such as 4-cyclohexyl-5-methylphenyl-1,3-diol, 4-isopropyl-5-methylphenyl-1,3-diol, or combinations thereof, can be used. 5-substituted resorcinols and their synthesis are described in commonly assigned U.S. Patent Application Publication No. 2016 / 000669A1.

[0062] Other oil-soluble beneficial agents that may be used include ω-3 fatty acids, ω-6 fatty acids, clomiphene, magnolol, and honokiol, farnesol, ursolic acid, myristic acid, geraniol, oil-based betaine, cocoyl hydroxyethyl imidazoline, hexanoyl sphingosine, 12-hydroxystearic acid (12HSA), phellandrene, conjugated linoleic acid, stearic acid, palmitic acid, lauric acid, terpineol, thymol, and essential components of solubilizers selected from limonene, pinene, camphene, cymene, citronellol, citronellol, geraniol, nerol, linalool, rose alcohol, borneol, isoborneol, menthone, camphor, safrole, isosafrole, eugenol, isoeugenol, tea tree oil, eucalyptus oil, peppermint oil, neem oil, lemongrass oil, orange oil, bergamot oil, or combinations thereof.

[0063] Another optional oil-soluble beneficial agent that can be used is a retinoic acid precursor. The retinoic acid precursor can be retinol, retinaldehyde, retinyl ester, retinyl propionate, retinyl palmitate, retinyl acetate, or combinations thereof. Retinyl propionate, retinyl palmitate, and combinations thereof are generally preferred. Yet another retinoic acid precursor used is provided by Molecular Design International. The product is commercially available as hydroxyanasatil retinoate. It can be used in combination with any oil-soluble beneficial agents described herein.

[0064] When an optional (i.e., 0.0 to 1.5% by weight) oil-soluble beneficial agent is used in an antimicrobial composition, it is typically present in an amount of 0.001 to 1.5% by weight of the total antimicrobial composition (including all values ​​and ranges contained therein), and for example, 0.05 to 1.2% by weight of the total weight of the end-use composition, such as 0.2 to 0.5% by weight.

[0065] Film-forming agents may be used in antimicrobial compositions. Although optional, these agents can help the composition adhere to the surface on which it is applied. Film-forming agents include those with hydrophilic properties, and they include materials comprising polyvinylpyrrolidone (PVP), acrylates, acrylamide, and copolymers thereof. Organosiloxanes and polyquaternium-7 (from Lubrizol's Merquat) may also be used. TM S Polymer) depositing agents. When used, such agents comprise 0.001-1% by weight of the antimicrobial composition, including all values ​​and ranges contained herein.

[0066] Other optional ingredients that may be used in the composition are mosquito repellents such as eucalyptus oil, lavender oil, citronella oil, N,N-diethyl-m-toluamide (DEET), combinations thereof, etc. Even other ingredients that may be used include oxymethopyrone (pyrrolidone), zinc pyrithione, xylenol, triclosan, hexadecylpyridine chloride, and silver compounds, including silver oxides, nitrates, sulfates, phosphates, carbonates, acetates, benzoates, combinations thereof, etc. If used, these other components typically comprise 0.001-1.6% by weight of the total antimicrobial composition, including all values ​​and ranges contained therein, and preferably 0.01-1.2% by weight.

[0067] Optionally, preservatives may be used in the antimicrobial compositions disclosed herein. When used, illustrative preservatives include sodium benzoate, iodopropynyl butylcarbamate, phenoxyethanol, hydroxyacetophenone, ethylhexylglycerin, methylparaben, propylparaben, imidazolidinyl urea, sodium dehydroacetate, dimethyl dimethyl (DMDM) hydantoin, and benzyl alcohol, or combinations thereof. Other suitable preservatives include sodium dehydroacetate, chlorophenesin, and decanediol. The amount of preservative used is preferably 0.01% to 2.0% by weight (inclusive of all values ​​and ranges contained therein) of the total weight of the antimicrobial composition. Preservative systems containing hydroxyacetophenone alone or in mixtures with other preservatives are also preferred.

[0068] The antimicrobial composition may optionally contain a fragrance, a fixative, a light-blocking agent (such as titanium dioxide or distearate), and a chelating agent. Possible chelating agents include, but are not limited to, ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), ethylenediaminedisuccinic acid (EDDS), pentasodium diethylenetriaminepentaacetic acid, trisodium N-(hydroxyethyl)-ethylenediaminetetraacetic acid, the acidic form of EDTA, sodium thiocyanate, trisodium salt of methylglycine diacetic acid, tetrasodium glutamate diacetate, and phytic acid, preferably wherein the chelating agent is ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), ethylenediaminedisuccinic acid (EDDS), or a combination thereof. The amount of each of these substances may be from about 0.03 to about 3% by weight of the total antimicrobial composition (including all values ​​and ranges contained therein), preferably from about 0.1 to about 2.6% by weight.

[0069] Another preferred optional additive includes hemp oil containing 2.5-25% by weight of cannabidiol and / or 0.5-10% by weight of cannabidiol. When used, this oil constitutes 0.0001-1.5% by weight of the total antimicrobial composition, including all values ​​and ranges contained herein, preferably 0.01-1% by weight.

[0070] The antimicrobial composition may optionally include an emulsifier. The emulsifier may be selected from C2 to about 100 moles of ethylene oxide or propylene oxide condensed with a hydrophobic compound. 10 -C 20 Fatty alcohols or acidic hydrophobic compounds; C2-C condensed with 2-20 moles of epoxides 10 Alkylphenols; mono- and di-fatty acid esters of ethylene glycol; f; sorbitol, mono- and di-C8-C 20 Fatty acids; and polyoxyethylene sorbitol, or combinations thereof. Alkyl polyglycosides and glycofatty amides (e.g., methylglucamide) may also be used as nonionic emulsifiers.

[0071] Preferred emulsifiers typically have an HLB (hydrophilic-lipophilic balance) of 7.5 to 20, preferably 8 to 18, and most preferably 9 to 15, including all ranges contained herein. For example, nonionic emulsifiers may include polysorbate 20 (Tween 20) or polyoxyethylene (20) dehydrated sorbitan monooleate (Tween 80). When present, the amount of emulsifier may be 0-1% by weight of the total antimicrobial composition, including all values ​​and ranges contained herein, such as 1% by weight.

[0072] In terms of packaging, antimicrobial compositions can be packaged in pump bottles, spray bottles, squeeze bottles, or provided as impregnating wetting agents for cotton swabs, tissues, wet wipes, cosmetic substrate sheets (such as those described in US 6,294,182B1), etc. Due to the increased viscosity with the structuring agent, the antimicrobial composition gels and can be provided to consumers as a gel composition in squeeze bottles. Spray bottles can also be metal, and the antimicrobial composition can be provided using conventional aerosol packaging techniques, including those using bag-in-bag air discharge canisters, mechanisms, and actuators. The inclusion of foaming agents (e.g., zwitterionic and / or amphoteric surfactants) is also within the scope of antimicrobial compositions so that the antimicrobial composition can be expelled as foam.

[0073] The antimicrobial composition should be provided with instructions for applying the composition (e.g., by squeezing or spraying) to a surface (e.g., skin) to kill bacteria and reduce viral activity. The antimicrobial composition may be provided in biodegradable packaging, preferably refillable or reusable, biodegradable, and / or at least 50%, preferably at least 100%, made from post-consumer recycled resin. The antimicrobial composition may be in liquid or gel form.

[0074] As used herein, skin refers to the skin on the arms (including armpits), face, feet, neck, chest, hands, legs, buttocks, and scalp (including hair). Disinfectant, as used herein, refers to the killing of at least 2 logarithmic bacteria and the inactivation of at least 2 logarithmic viruses (both achieved) within less than 3 minutes after topical application to a surface. Preferably, it refers to the killing of at least 3 logarithmic bacteria and the inactivation of at least 3 logarithmic viruses. As used herein, combination refers to, for example, the total weight of cetyltrimethylammonium chloride and benzalkonium chloride. Skin beneficiaries refer to ingredients suitable for improving skin properties. Surfaces, as used herein, include skin or inanimate objects such as desktops, computer monitors, door handles, toilet seats, shopping cart handles, or even clothing surfaces. Surfaces are also intended to include animal fur, such as dog and cat fur. As used herein, surface preferably refers to human skin, especially the skin on the face and hands.

[0075] The antimicrobial composition can be a home care composition, such as a clothing spray composition suitable for spraying on clothing and interior decorations requiring disinfection. The home care composition can also be an antimicrobial kitchen or bathroom spray composition. Preferably, the antimicrobial composition is a topical composition applied to the skin for disinfection by significantly reducing the amount of bacteria and viruses on the skin. The composition may optionally contain skin-beneficial ingredients incorporated therein, such as emollients, vitamins and / or their derivatives, resorcinols, retinoic acid precursors, colorants, humectants or moisturizers, fragrances, sunscreens, combinations thereof, etc., as previously described herein. The skin-beneficial ingredients may be water-soluble or oil-soluble.

[0076] Therefore, the antimicrobial composition is a water-alcohol based composition with a pH value of 3.0 to 8.2, and the composition is water / alcohol continuous. The viscosities used herein are at 25°C and at 20-second intervals, using a Brookfield viscometer (using a Spindle 4 at 10 rpm) or a Discovery HR-2 rheometer (using a blasting plate with a 1000-micron gap), and for the first viscosity V... A 0.4s -1 First shear rate S A , and for the second viscosity V B 10s -1 The second shear rate S B (Obtained)

[0077] Several units are known to be used for viscosity, but the most commonly used units are centipoise (cP), pascal-second (Pa*s), and millipascal-second (mPa*s), and these units are easily convertible to each other using publicly available resources (such as textbooks, encyclopedias, and the Internet). In yet another embodiment, the composition is a non-therapeutic and non-pharmaceutical composition that is an aqueous alcoholic solution with a viscosity of less than 30,000 centipoise (cps) (30 Pa*s), preferably less than 25,000 cps (25 Pa*s), preferably 2,000-25,000 cps (2-25 Pa*s), and more preferably 2,000-10,000 cps (2-10 Pa*s).

[0078] Typically, the viscosity of the antimicrobial composition is below 30,000 cps (30 Pa*s). The viscosity of the antimicrobial composition is typically 1-25,000 cps (0.001-25 Pa*s), preferably 1,500-25,000 cps (1.5-25 Pa*s), more preferably 2,000-20,000 cps (2-20 Pa*s), and even more preferably 2,000-10,000 cps (2-10 Pa*s), including all of the ranges contained herein.

[0079] Antimicrobial compositions can be prepared by any method for preparing antimicrobial compositions. In one embodiment, the method for preparing an antimicrobial composition may include: combining an anti-adhesive and a humectant to form a first phase; then combining water with an alcohol to form a second phase; combining the first and second phases to form a third phase; and adding a neutralizing agent to the third phase to form the antimicrobial composition.

[0080] Unless otherwise expressly stated, all scopes described herein are to be included within the scope covered herein. As used herein, "substantially non-existent" means less than 10% by weight, unless explicitly stated otherwise. Antimicrobial benefit refers to at least 2 logarithmic kills, preferably at least 3 logarithmic kills, within less than 3 minutes, as determined by ASTM International Standard Method E2783-11 (re-approved in 2016), which presents a procedure for measuring the antimicrobial activity of water-miscible compounds using a time-killing procedure. Viral (or viral) inactivation is determined by evaluating the effect of the antimicrobial agent on the virus, as described in ASTM International Standard Method 1052-20. The term "comprising" is intended to include both the terms "substantially composed of" and "composed of". For the avoidance of ambiguity, and for the purpose of clarification, a composition comprising water, a cationic surfactant, and a preservative means including compositions substantially composed of and compositions composed of.

[0081] Unless otherwise expressly stated, all figures indicating the amount of material or reaction conditions, physical properties of materials and / or uses in this specification shall be understood to be modified by the word “about”. Unless otherwise specified, all quantities are by weight of the final composition.

[0082] It should be noted that when specifying any concentration or amount range, any particular higher concentration can be associated with any particular lower concentration or amount and any subranges covered therein. In this regard, it should be noted that all ranges disclosed herein include endpoints, and endpoints can be combined independently of each other (e.g., up to 25% by weight, or more specifically, a range from 5% to 20% by weight, including the endpoints of the range from 5% to 25% by weight and all intermediate values, etc.). "Combination" includes blends, mixtures, alloys, reaction products, etc. Furthermore, the terms "first," "second," etc., used herein do not indicate any order, quantity, or importance, but are used to distinguish one element from another. Unless otherwise stated herein or the context clearly contradicts, the terms "a," "an," and "the" used herein do not indicate a limitation of quantity but should be interpreted to cover both singular and plural. The suffix "(s)" used herein is intended to include both the singular and plural of the item it modifies, thereby including one or more of the said items (e.g., membrane(s) includes one or more membranes). Throughout this specification, references to "an embodiment," "an aspect," "another embodiment," "another aspect," "an embodiment," "an aspect," etc., mean that a particular element (e.g., a feature, structure, and / or characteristic) described in connection with that embodiment or aspect is included in at least one embodiment or aspect described herein, and may or may not be present in other embodiments or aspects. Furthermore, it should be understood that the described elements can be combined in any suitable manner across various embodiments or aspects.

[0083] All cited patents, patent applications, and other references are incorporated herein by reference in their entirety. However, if any terminology in this application contradicts or conflicts with terminology in the incorporated references, the terminology in this application shall prevail over the conflicting terminology in the incorporated references. Although specific aspects have been described, unforeseen or currently unforeseen alternatives, modifications, variations, improvements, and substantial equivalents may arise in the applicant or others skilled in the art. Therefore, the appended claims and their possible modifications are intended to cover all such alternatives, modifications, variations, improvements, and substantial equivalents.

[0084] To avoid ambiguity, the word "comprise" is intended to mean "include," but not necessarily "compose of" or "consisting of." In other words, the steps, options, or alternatives listed need not be exhaustive.

[0085] The disclosure of the invention as set forth herein should be considered to cover all aspects present in claims that are mutually dependent, regardless of the fact that claims may exist without multiple dependencies or redundancy. Unless otherwise specified, numerical ranges expressed in the format “x to y” should be understood to include both x and y. When specifying a range of any value or quantity, any particular higher value or quantity may be associated with any particular lower value or quantity. Unless otherwise stated, all percentages and ratios contained herein are by weight. Where appropriate, various features of the invention referred to in the preceding individual sections may be applied to other sections with suitable modifications. Thus, a feature specified in one section may be combined (where appropriate) with features specified in other sections. The addition of any section headings is merely for convenience and is not intended to limit this disclosure in any way.

[0086] Example

[0087] The following examples are merely illustrative of the antimicrobial compositions disclosed herein and are not intended to limit their scope.

[0088] Example 1

[0089] Samples 1 to 9 are examples illustrating the composition of the antimicrobial compositions disclosed herein, while Comparative Examples 1 to 11 (CE1 to CE11) are examples illustrating compositions other than those disclosed herein. All viscosities were measured at 10 rpm using a Brookfield Spindle 4.

[0090] Samples were prepared by dispersing a cationic polymer in water to form phase A, under room temperature, atmospheric pressure, and standard shear. An alcohol was then added to form phase B. Any skin-beneficial agents, moisturizers, anti-adhesives, and structuring agents (when included) were then combined to form phase C.

[0091] First, phases A and B are combined and mixed using an overhead pneumatic mixer until a clear mixture is formed, at which point phase C is added. Then, a neutralizing agent is added as phase D, and a fragrance from phase E is added, thereby forming an antimicrobial composition. (BENECEL) TM E10M is a nonionic structuring agent, particularly hydroxypropyl methylcellulose. (KLUCEL) TM It is a nonionic structuring agent, especially hydroxypropyl cellulose. PQ-10 is a cationic structuring agent, especially polyquaternium-10. IPA refers to isopropanol, EDTA refers to ethylenediaminetetraacetic acid, B3 refers to nicotinamide, 12HSA refers to 12-hydroxystearic acid, and DC2501 wax refers to DOWSIL. TM2501 is a water-dispersible siloxane glycol copolymer wax with a low melting point. It offers several benefits, including moisturizing, reducing viscosity, and enhancing foam. PEG400 refers to low molecular weight polyethylene glycol. It is a clear, colorless, viscous liquid. PPG15 stearyl ether refers to a polypropylene glycol ether of stearyl ether. PPG-2 isocetyl ether-20 acetate refers to polypropylene glycol isocetyl ether acetate. IPM refers to isopropyl myristate.

[0092] Table 1 - All figures are shown as weight %

[0093]

[0094]

[0095] Table 2 - All figures are shown as weight %

[0096]

[0097]

[0098]

[0099] The alcohol content present in the antimicrobial composition can be adjusted based on the percentage of alcohol purity. For example, the ethanol purity should preferably be 92% w / w to 94% w / w, so that if 92% pure ethanol is used, the amount of ethanol used can be 70 to 80% by weight, for example 72% by weight.

[0100] The compositions in Tables 1 and 2 can be converted into low-viscosity spray formulations by simply removing the structuring agents Benecel E10m, Klucel, or cationic structured polymers. Table 4 shows anti-stick agents that can be used in antimicrobial compositions to design transparent hand sanitizer formulations with a non-sticky feel. The examples are not intended to limit the materials that can be used, but are merely illustrative of the type and amount of anti-stick agents selected based on three criteria. Preferred anti-stick agents are those with a solubility greater than 30% in at least a 75 / 25EtOH / water blend, reflecting the good solubility in the formulations in Table 1.

[0101] Furthermore, the anti-adhesive must be a liquid at room temperature so that the composition does not produce any negative (sticky / tacky) sensation once left as a film. Finally, the preferred anti-adhesive itself must not be water-soluble, allowing water to evaporate rapidly during application and during drying, leaving only oil and any skin-beneficial active substances / humectants (if present). It is not intended to be theoretically limited, but it is believed that when a hand sanitizer formulation having the preferred anti-adhesive disclosed herein is applied to the skin, and with the evaporation of water and ethanol, if the anti-adhesive has good water solubility, this will delay evaporation and result in an undesirable slower drying and stickier sensation.

[0102] Of the formulations listed in Table 2, the listed anti-adhesives do not meet one or more of these criteria and are therefore outside the scope of the antimicrobial compositions disclosed herein.

[0103] Sensory evaluations were performed on the selected compositions of the present invention and comparative compositions. Samples 1 and 4 were evaluated against a control formulation (CE1) without sensory oil and two other comparative compositions (CE3 and CE4). Small sample containers of each of the five compositions were given to seven individuals, who were then asked to rank the samples according to their viscosity. Sensory evaluation results showed that comparative examples CE1, CE2, and CE3 were all significantly more viscous than samples 1 and 4 (which included the samples of the present invention disclosed herein). This result indicates that the antimicrobial compositions containing anti-stick agents disclosed herein provide a non-sticky feel to the user.

[0104] Example 2

[0105] Samples 10-14 are further examples demonstrating the composition of the antimicrobial compositions disclosed herein. Samples 10-14 were prepared using the same method as described with respect to Samples 1-9.

[0106] Table 3 - All figures are shown as weight %

[0107]

[0108]

[0109] Table 4 lists examples of anti-sticking agents that meet and do not meet the three criteria, which include: (1) the oil must be a liquid; (2) the oil must be soluble in at least a 75 / 25 ethanol / water mixture; and (3) the oil must be insoluble in water and therefore desirable for use in the disclosed antimicrobial compositions. RT in Table 4 refers to room temperature.

[0110] Table 4

[0111]

[0112]

Claims

1. An antimicrobial composition comprising: water; 60 to 70% by weight of ethanol; 0.5 to 3.0% by weight of a cationic polymer of polydiallyldimethylammonium chloride; and 0.5 to 10% by weight of an anti-sticking agent, wherein the anti-sticking agent comprises a soluble anti-sticking agent selected from diisopropyl dicarboxylate, diisopropyl sebacate, or diethylhexyl malate, or combinations thereof, wherein the anti-sticking agent is a liquid, wherein the anti-sticking agent is soluble in at least a 75 / 25 ethanol / water mixture, and wherein the anti-sticking agent is not water-soluble; and Skin beneficial agents, wherein the skin beneficial agents comprise niacinamide, tocopherol, aloe vera, sodium or potassium hyaluronate, α-hydroxy acids and esters, hydroxystearic acid, β-hydroxy acids and esters, hydroxyethyl urea, polyhydroxy acids and esters, creatine, hydroquinone, tert-butylhydroquinone, mulberry extract, licorice extract, or combinations thereof; and The antimicrobial composition is transparent, and the addition of the anti-stick agent does not affect the transparency of the antimicrobial composition.

2. The antimicrobial composition according to claim 1, wherein the nitrogen percentage of the cationic polymer is greater than or equal to 5% by weight of the cationic polymer.

3. The antimicrobial composition according to claim 1 or 2, wherein the anti-sticking agent comprises a combination of a soluble anti-sticking agent and an insoluble anti-sticking agent, wherein the insoluble anti-sticking agent is an oil having a solubility of less than 10% in an ethanol / water mixture of at least 75 / 25 or higher, wherein the combined anti-sticking agent is a liquid at room temperature, soluble in at least a 75 / 25 ethanol / water mixture, and wherein the anti-sticking agent has no water solubility.

4. The antimicrobial composition according to claim 1 or 2, further comprising a humectant, wherein the humectant comprises glycerin, butylene glycol, propylene glycol, polyethylene glycol, sorbitol, polyglycerol, isopentyl glycol, hyaluronic acid, or a combination thereof.

5. The antimicrobial composition according to claim 1 or 2, wherein the antimicrobial composition is in the form of a liquid, gel or spray.

6. The antimicrobial composition according to claim 1 or 2, further comprising a viscosity-modifying structuring agent, wherein the structuring agent is selected from nonionic structuring agents, cationic structuring agents, or combinations thereof.

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