One-pot two-step synthesis of lignin-based carbazole derivatives

CN117229194BActive Publication Date: 2026-07-24DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES
Filing Date
2022-06-08
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing methods for synthesizing carbazole derivatives have limitations such as heavy metal residues, low yields, and complex operations, and lack green and efficient synthetic routes.

Method used

A one-step method for synthesizing lignin-based carbazole derivatives involves reacting a lignin β-O-4 model compound, an N-methylindole-3-carboxaldehyde compound, and a base in a solvent with stirring. A Cu-based catalyst and TEMPO are then added, followed by reaction with a 3-chlorophenylacetone compound. The carbazole derivative is then separated and purified.

Benefits of technology

This approach achieves simple operation, mild reaction conditions, and high product selectivity, providing a new, green route for the synthesis of carbazole compounds.

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Patent Text Reader

Abstract

The application discloses a one-pot two-step synthesis method of a lignin-based carbazole derivative, and belongs to the technical field of compound synthesis. In the first step, a lignin beta-O-4 model compound and an N-methyl-3-indole formaldehyde compound are used as reaction raw materials, and are reacted in a solvent under the action of an alkali under an air atmosphere for a certain time; in the second step, a Cu-based catalyst, 2,2,6,6-tetramethylpiperidine oxide and a 3-chlorobenzene propiophenone compound are added into the system to be reacted, and finally a carbazole compound is obtained. The synthesis method for preparing the carbazole derivative has the advantages of simple operation, mild reaction condition, high product selectivity and the like, and provides a green new way for preparation of the carbazole compound.
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