藜芦胺在制备糖尿病及并发症药物中的应用
Veratridine is used to prepare drugs for the prevention and treatment of diabetes and diabetic nephropathy. By lowering fasting blood glucose and improving renal filtration function, it solves the problem that existing technologies cannot effectively stop the progression of diabetic nephropathy, and achieves safe and effective treatment results.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
- Filing Date
- 2023-11-06
- Publication Date
- 2026-07-17
AI Technical Summary
Existing diabetes treatments are ineffective in preventing the progression and worsening of diabetic nephropathy, and conventional hypoglycemic drugs may cause side effects or reduced efficacy, increasing diabetes-related morbidity and mortality.
Veratramine (VT) was used as the active ingredient to prepare drugs for the prevention and treatment of diabetes and diabetic nephropathy. In vitro and in vivo experiments showed that it can significantly reduce fasting blood glucose, reduce high glucose-induced glomerular mesangial cell inflammation, and improve renal filtration function.
Veratramine significantly reduced fasting blood glucose in diabetic model mice, weakened the expression of inflammation-related factors, and improved renal filtration function, demonstrating potential anti-diabetic and anti-diabetic nephropathy activities.
Smart Images
Figure CN117243961B_ABST