Bing-bor-san and a method of preparing the same

Abstract

The application discloses Bingboran and a preparation method thereof. The formula of the Bingboran is improved, and Qingdai extract, dandelion extract and the like are added to improve the heat-clearing and detoxicating capacity. Erythromycin is added to improve the anti-inflammatory capacity. Clove oil is added to help pain relief. Bee glue is added to help form a protective film layer on the ulcer and help rapid recovery. Huangqi extract is added to provide the body immunity. In cooperation with the traditional formula, the Bingboran can help rapidly relieve and treat symptoms such as oral ulcer.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, specifically to Bingpengsan and its preparation method. Background Technology

[0002] Ulcers are generally localized skin tissue erosions caused by trauma, microbial infection, tumors, circulatory disorders, neurological dysfunction, immune dysfunction, or congenital skin defects. The affected area is often accompanied by necrotic tissue, pus, scabs, etc., and is often complicated by chronic infection, which can easily lead to stubborn ulcers that do not heal for a long time.

[0003] Currently, the most common Chinese patent medicine for treating ulcers is Bingpengsan, which is composed of borneol, borax, cinnabar, and sodium sulfate mixed in a predetermined ratio. It has a certain therapeutic effect on ulcers in some patients, but its disadvantages are that it takes effect slowly and has poor efficacy, and needs to be improved. Summary of the Invention

[0004] To address at least one of the aforementioned technical deficiencies, the present invention provides the following technical solution:

[0005] This application discloses Bingpengsan, which includes 6-8 parts of indigo extract, 1-2 parts of astragalus extract, 3-8 parts of clove oil, 10-15 parts of propolis, 2-2.5 parts of erythromycin, 1-3 parts of dandelion extract, 5.5-6.5 parts of borneol, 46-53 parts of borax, 5.8-6.2 parts of cinnabar, 49-52 parts of sodium sulfate, and 5-7 parts of sodium carboxymethyl cellulose.

[0006] Furthermore, the indigo extract is a powder formed by reflux extraction of indigo with ethanol, followed by solid-liquid separation and spray drying of the ethanol extract.

[0007] Furthermore, the reflux temperature is 60-68℃, and the mass ratio of indigo to ethanol is 1:10-15.

[0008] Furthermore, the Astragalus extract was prepared by adding water to Astragalus, adjusting the pH to 2.8±0.3, and extracting at 55±10℃. After solid-liquid separation, filtrate A was reserved. The filter residue was then added to water again and the pH was adjusted to 9.2±0.6. The extraction temperature was 55±10℃, and solid-liquid separation was performed to obtain filtrate B. Filtrate A and filtrate B were mixed, the pH was adjusted to 7.0±0.5, and the mixture was concentrated under reduced pressure to obtain the Astragalus extract.

[0009] Furthermore, the dandelion extract was obtained by ethanol extraction of dandelion medicinal material at 65±5℃ followed by vacuum concentration.

[0010] A second aspect of this invention discloses a method for preparing boric acid powder, comprising the above-mentioned boric acid powder, including the following steps:

[0011] First, the preparation of extracts: extracts were prepared from indigo naturalis, astragalus membranaceus, and dandelion.

[0012] Second, mix the components evenly according to the component ratio of claim 1;

[0013] Third, weigh and package the mixed materials.

[0014] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0015] 1. This invention improves the formula of Bingpengsan by adding indigo extract, dandelion extract and other ingredients to enhance its heat-clearing and detoxifying abilities, adding erythromycin and other ingredients to enhance its anti-inflammatory abilities, adding clove oil to help relieve pain, adding propolis to help form a protective film layer at the ulcer site to help with rapid recovery, and adding astragalus extract to provide the body's immunity. When combined with the traditional formula, it helps to quickly relieve and treat symptoms such as oral ulcers. Detailed Implementation

[0016] The present invention will be further described below with reference to specific embodiments.

[0017] Example 1

[0018] The preparation method of borax powder includes the following steps:

[0019] First, the preparation of the extract

[0020] Preparation of Indigo Extract:

[0021] The prepared indigo was mixed with 12 times its weight of ethanol and refluxed at 65°C for 2 hours. After filtration, the ethanol extract was spray-dried to obtain a powder, which is the indigo extract.

[0022] Preparation of Astragalus extract:

[0023] Mix the prepared Astragalus membranaceus with 10 times its weight of water, adjust the pH to 2.8, heat to 60℃, keep warm for 3 hours, filter, and retain the resulting filtrate A. Mix the filter residue with 5 times its weight of water, adjust the pH to 9.2, heat to 58℃, keep warm for 3 hours, filter to obtain filtrate B. Mix filtrate A and filtrate B, adjust the pH to 7.0, concentrate under reduced pressure at -0.05 MPa, temperature 35℃, and time 1 hour to obtain the Astragalus membranaceus extract.

[0024] Preparation of dandelion extract:

[0025] Dandelion was mixed with 10 times its weight of ethanol and heated to 65°C for 3 hours. The filtrate was then concentrated under reduced pressure (-0.06 MPa) for 2 hours to obtain dandelion extract.

[0026] Second, mix all components thoroughly. The component ratios are as follows:

[0027] Indigo extract 6 parts, Astragalus extract 1 part, clove oil 3 parts, propolis 10 parts, erythromycin powder 2 parts, dandelion extract 1.5 parts, borneol 5.5 parts, borax 46 parts, cinnabar 5.8 parts, sodium sulfate 50 parts, sodium carboxymethyl cellulose 6 parts.

[0028] Third, weigh and package the mixed materials.

[0029] Example 2

[0030] The preparation method of borax powder includes the following steps:

[0031] First, the preparation of the extract

[0032] Preparation of Indigo Extract:

[0033] The prepared indigo was mixed with 10 times its weight of ethanol and refluxed at 68°C for 2.5 hours. After filtration, the ethanol extract was spray-dried to obtain a powder, which is the indigo extract.

[0034] Preparation of Astragalus extract:

[0035] Mix the prepared Astragalus membranaceus with 12 times its weight of water, adjust the pH to 2.9, heat to 63℃, keep warm for 2.5 hours, filter, and retain the resulting filtrate A. Mix the filter residue with 6 times its weight of water, adjust the pH to 9.5, heat to 60℃, keep warm for 3 hours, filter to obtain filtrate B. Mix filtrate A and filtrate B, adjust the pH to 6.5, concentrate under reduced pressure at -0.05 MPa, temperature 35℃, and time 1 hour to obtain the Astragalus membranaceus extract.

[0036] Preparation of dandelion extract:

[0037] Dandelion was mixed with 12 times its weight of ethanol and heated to 68°C for 2.5 hours. The filtrate was then concentrated under reduced pressure (-0.06 MPa) for 2 hours to obtain dandelion extract.

[0038] Second, mix all components thoroughly. The component ratios are as follows:

[0039] 7 parts of indigo extract, 1.2 parts of astragalus extract, 6 parts of clove oil, 10 parts of propolis, 2 parts of erythromycin powder, 1.8 parts of dandelion extract, 6 parts of borneol, 48 parts of borax, 6 parts of cinnabar, 50 parts of sodium sulfate, and 5 parts of sodium carboxymethyl cellulose.

[0040] Third, weigh and package the mixed materials.

[0041] Example 3

[0042] The preparation method of borax powder includes the following steps:

[0043] First, the preparation of the extract

[0044] Preparation of Indigo Extract:

[0045] The prepared indigo was mixed with 14 times its weight of ethanol and refluxed at 65°C for 3 hours. After filtration, the ethanol extract was spray-dried to obtain a powder, which is the indigo extract.

[0046] Preparation of Astragalus extract:

[0047] Mix the prepared Astragalus membranaceus with 8 times its weight of water, adjust the pH to 3.0, heat to 65℃ and keep warm for 2.6 hours, filter, and retain the resulting filtrate A. Mix the filter residue with 10 times its weight of water, adjust the pH to 8.8, heat to 63℃ and keep warm for 2.6 hours, filter to obtain filtrate B. Mix filtrate A and filtrate B, adjust the pH to 6.6, concentrate under reduced pressure at -0.05 MPa, temperature 35℃, and time 1 hour to obtain the Astragalus membranaceus extract.

[0048] Preparation of dandelion extract:

[0049] Dandelion was mixed with 8 times its weight of ethanol and heated to 70°C for 2 hours. The filtrate was then concentrated under reduced pressure (-0.06 MPa) for 2 hours to obtain dandelion extract.

[0050] Second, mix all components thoroughly. The component ratios are as follows:

[0051] Indigo extract 6 parts, Astragalus extract 1.6 parts, clove oil 7 parts, propolis 14 parts, erythromycin powder 2.5 parts, dandelion extract 2 parts, borneol 6.5 parts, borax 52 parts, cinnabar 6.2 parts, sodium sulfate 52 parts, sodium carboxymethyl cellulose 7 parts.

[0052] Third, weigh and package the mixed materials.

[0053] Example 4

[0054] The preparation method of borax powder includes the following steps:

[0055] First, the preparation of the extract

[0056] Preparation of Indigo Extract:

[0057] The prepared indigo was mixed with 15 times its weight of ethanol and refluxed at 68°C for 2 hours. After filtration, the ethanol extract was spray-dried to obtain a powder, which is the indigo extract.

[0058] Preparation of Astragalus extract:

[0059] Mix the prepared Astragalus membranaceus with 15 times its weight of water, adjust the pH to 2.5, heat to 57℃ and keep warm for 4 hours, filter, and retain the resulting filtrate A. Mix the filter residue with 10 times its weight of water, adjust the pH to 9.0, heat to 50℃ and keep warm for 4 hours, filter to obtain filtrate B. Mix filtrate A and filtrate B, adjust the pH to 7.5, concentrate under reduced pressure at -0.05 MPa, temperature 35℃, and time 1 hour to obtain the Astragalus membranaceus extract.

[0060] Preparation of dandelion extract:

[0061] Dandelion was mixed with 10 times its weight of ethanol and heated to 65°C for 3 hours. The filtrate was then concentrated under reduced pressure (-0.06 MPa) for 2 hours to obtain dandelion extract.

[0062] Second, mix all components thoroughly. The component ratios are as follows:

[0063] 8 parts of indigo extract, 2 parts of astragalus extract, 8 parts of clove oil, 10 parts of propolis, 2 parts of erythromycin powder, 2.2 parts of dandelion extract, 6.3 parts of borneol, 53 parts of borax, 6.0 parts of cinnabar, 49 parts of sodium sulfate, and 5 parts of sodium carboxymethyl cellulose.

[0064] Third, weigh and package the mixed materials.

[0065] Comparative Example 1

[0066] The ice-borax powder was prepared according to the traditional method, with the following component ratios: 6.3 parts borneol, 53 parts borax, 6.0 parts cinnabar, and 49 parts sodium sulfate.

[0067] The clinical trial is as follows:

[0068] Eighty-six patients with recurrent oral ulcers were randomly divided into two groups of 43 each (26 males and 17 females, aged 26-55 years, with a mean age of 34±3 years and a disease duration of 1-6 months, with a mean of 4.2±0.8 months). One group was the experimental group, and the other was the control group.

[0069] Before treatment, the wound was rinsed with physiological saline to remove rotten and necrotic tissue. The control group was treated with the ice-boron powder prepared in Comparative Example 1, while the experimental group was treated with the ice-boron powder prepared in Example 1, with the same usage and dosage.

[0070] The efficacy evaluation criteria are as follows:

[0071] Significant effect: Ulcers heal and symptoms disappear after 2 days of treatment; Effective: Ulcers are basically healed and symptoms are significantly improved after 3-5 days of treatment; Ineffective: Ulcers show no change or even enlarge after 3-5 days of treatment, and symptoms remain unchanged.

[0072] The comparison between the control group and the experimental group is shown in Table 1:

[0073] Table 1

[0074]

[0075]

[0076] It can be seen that the efficacy of the ice-boron powder prepared in this method is significantly higher than that of the traditional ice-boron powder, and it has the advantages of rapid onset of action and wide applicability.

[0077] The above are merely preferred embodiments of the present invention. The scope of protection of the present invention is not limited to the above embodiments. All technical solutions falling within the scope of the present invention's concept are within the scope of protection of the present invention. It should be noted that for those skilled in the art, any improvements and modifications made without departing from the principle of the present invention should also be considered within the scope of protection of the present invention.

Claims

1. Borax Powder, characterized in that, The product is prepared from 6-8 parts of indigo extract, 1-2 parts of astragalus extract, 3-8 parts of clove oil, 10-15 parts of propolis, 2-2.5 parts of erythromycin, 1-3 parts of dandelion extract, 5.5-6.5 parts of borneol, 46-53 parts of borax, 5.8-6.2 parts of cinnabar, 49-52 parts of sodium sulfate, and 5-7 parts of sodium carboxymethyl cellulose. Indigo extract is a powder formed by reflux extraction of indigo with ethanol, solid-liquid separation, and spray drying of the ethanol extract. The reflux temperature was 60-68℃, and the mass ratio of indigo naturalis to ethanol was 1:10-15; the dandelion extract was obtained by ethanol extraction of dandelion medicinal material at 65±5℃ and concentration under reduced pressure.

2. The ice-boron powder as described in claim 1, characterized in that: Astragalus extract is obtained by adding water to Astragalus, adjusting the pH to 2.8±0.3, and extracting at 55±10℃. After solid-liquid separation, filtrate A is reserved. The residue is then added to water again and the pH is adjusted to 9.2±0.

6. The extraction temperature is 55±10℃, and solid-liquid separation is performed to obtain filtrate B. Filtrate A and filtrate B are mixed, the pH is adjusted to 7.0±0.5, and the mixture is concentrated under reduced pressure to obtain the Astragalus extract.

3. The method for preparing the ice-boron powder according to claim 1 or 2, characterized in that: Includes the following steps: First, the preparation of extracts: extracts were prepared from indigo naturalis, astragalus membranaceus, and dandelion. Second, mix the components evenly according to the component ratio of claim 1; Third, weigh and package the mixed materials.

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