A hydrogel coating with underwater stability and drag reduction for implantable / interventional medical devices and its preparation method and application

Abstract

The present invention provides a hydrogel coating with underwater stability and drag reduction for implantable / interventional medical devices, and a preparation method and application thereof. The hydrogel coating of the present invention is prepared by cross-linking polymerization of water-soluble methacryloyl gelatin (GelMA), polyethylene glycol diacrylate (PEGDA), methacryloyloxyethyl trimethylammonium chloride (METAC) and a photoinitiator. An adhesive layer is also provided between the hydrogel coating of the present invention and the substrate, and the adhesive layer improves the bonding strength of the interface between the substrate and the hydrogel coating by co-deposition of PDA, PEI and grafting KH570. The hydrogel coating of the present invention can be prepared on the surface of artificial hip joints, endotracheal tubes, urinary catheters and titanium alloys, and has excellent underwater stability and drag reduction performance, and can controllably release drugs, which can well meet the application requirements on the surface of implantable / interventional devices.

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