一种治疗奶牛乳房炎的硫酸头孢喹肟缓释制剂及其制备方法
By preparing cefquinoxime sulfate solid lipid nanoparticles and combining them with specific suspending agents and emulsifiers, the stability problem of cefquinoxime sulfate intravenous injection under high temperature and high humidity conditions was solved, achieving long-term storage stability and rapid in vitro dissolution of the drug, thus prolonging its efficacy.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- CAHIC ZENOAQ ANIMAL PHARM CO LTD
- Filing Date
- 2023-09-27
- Publication Date
- 2026-07-17
AI Technical Summary
Existing cefquinoxime sulfate intramuscular injection formulations exhibit poor stability under high temperature and humidity conditions, are prone to sedimentation and stratification, leading to increased toxic side effects in animals and making long-term storage and redispersibility difficult.
Cefquinoxime sulfate solid lipid nanoparticles were prepared by cooling homogenization and combined with suspending agents, hygroscopic agents and emulsifiers to prepare a sustained-release formulation. The formulation was then subjected to vacuum emulsification dispersion and cobalt-60γ irradiation sterilization to form a stable oil suspension.
It improves the quality and physical stability of cefquinoxime sulfate, ensuring that the drug does not separate into layers after long-term storage and is easy to redisperse, with a faster in vitro dissolution rate and sustained-release effect, thus prolonging the duration of efficacy.
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Figure CN117281796B_ABST