基于碘海醇的两亲性自组装聚合物及其制备方法
By designing an amphiphilic self-assembling polymer based on iohexol, the problems of rapid metabolism and short retention time of small molecule iodine contrast agents in clinical applications have been solved, achieving longer lesion retention time and lower kidney damage, making it suitable for CT imaging and integrated diagnosis and treatment.
CN117285715BActive Publication Date: 2026-07-17FUJIAN NORMAL UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- FUJIAN NORMAL UNIV
- Filing Date
- 2023-03-01
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing small-molecule iodine contrast agents have problems in clinical application, such as rapid metabolism, large dosage, and short retention time at the lesion site, resulting in poor contrast effect and potential damage to the kidneys.
Method used
Design an amphiphilic self-assembling polymer based on iohexol, which forms a network structure by polymerizing with functional compounds and self-assembling with hydrophilic molecules to enhance imaging effects and prolong residence time.
Benefits of technology
It achieves longer lesion retention time, reduces the frequency of administration, lowers the renal clearance rate, reduces kidney damage, has low toxicity and biocompatibility, and is suitable for CT imaging and integrated diagnosis and treatment.
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Figure CN117285715B_ABST
Abstract
本发明公开了一种基于碘海醇的可人体降解的两亲性自组装聚合物及其合成与应用，其属于有机药物合成技术领域。本发明是采用含有功能团（单硫键、单硒键、单碲键、二硫键、双硒键、二碲键等）的化合物对小分子碘海醇进行聚合修饰，再将所得产物与亲水性分子进行自组装，获得所述聚合物。本发明合成路径简单高效，合成所用原料碘海醇易于降解且无毒，所得聚合物具有良好的生物相容性，可作为CT成像造影剂，并具有较长的成像时间窗和足够的对比度，可增强对患者病灶CT成像的精准度，还有望被开发为高效的纳米药物载体用于疾病的个性化诊疗。
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