Radio frequency ablation measurement and control system and measurement and control method

Abstract

The present application relates to a kind of radio frequency ablation measurement and control system and measurement and control method, it is related to radio frequency ablation technical field, for more accurately control the temperature of radio frequency ablation needle, avoid the temperature of ablation area edge position too low and the phenomenon of thermal field inhomogeneity.The radio frequency ablation measurement and control system of the present application, after being specified main needle as temperature control element to adjust its operating parameter, again specify sub needle as temperature control element to adjust its operating parameter, to avoid the temperature of edge position too low and the problem of thermal field inhomogeneity and cannot completely kill the cell activity in this place;Or radio frequency ablation instrument directly specifies sub needle as temperature control element to adjust its operating parameter, the temperature of edge position too low and the problem of thermal field inhomogeneity and cannot completely kill the cell activity in this place can also be solved.

Description

[0001] This application is a divisional application of application number CN202310395470.1 entitled "Radio Frequency Ablation Measurement and Control System and Measurement and Control Method". Technical Field

[0002] This invention relates to the field of radiofrequency ablation technology, and particularly to a radiofrequency ablation measurement and control system and method. Background Technology

[0003] Currently, radiofrequency ablation technology used for minimally invasive tumor treatment has a wide range of indications, is safe and reliable, and its frequency range is generally between 200 and 500 kHz. Radiofrequency energy is transmitted through radiofrequency cable connectors and surgical electrodes to the site where the surgical electrodes are inserted into the tissue under percutaneous puncture or laparoscopic guidance, and forms a circuit with the negative electrode plate connected externally, forming a high-frequency electric field. Under the action of the high-frequency electric field, the conductive particles and polarized molecules in the tissue around the surgical electrodes are excited to rotate at high speed, generating frictional heat. When the tissue temperature reaches above 60°C, the proteins in the tissue will coagulate, lose their activity, and undergo irreversible necrosis, thereby achieving the therapeutic effect.

[0004] The current in the ablation area is generally most concentrated near the center of the electrode, which is also the highest temperature point. As the current extends radially outward from the center of the electrode from both sides (e.g., left and right sides or top and bottom sides), the temperature gradually decreases. If the temperature at the edge is too low, the cells in that area will still be active, resulting in missed ablation and postoperative recurrence. If the temperature is further increased at this point, the temperature in the central area will become too high, causing the tissue in that area to form a scab and carbonize, which is not conducive to the smooth progress of the operation. Summary of the Invention

[0005] This invention provides a radiofrequency ablation measurement and control system and method for more accurately controlling the temperature of the radiofrequency ablation needle, avoiding excessively low temperatures at the edge of the ablation area and uneven thermal field temperature.

[0006] According to a first aspect of the present invention, the present invention provides a radiofrequency ablation measurement and control system, including a radiofrequency ablation device and a radiofrequency ablation needle, wherein the radiofrequency ablation needle includes a main needle and at least one sub-needle, and the sub-needle can be deployed or retracted from the periphery of the main needle; The radiofrequency ablation device is connected to the main needle and the sub-needle respectively to receive signals fed back by the main needle and the sub-needle; The radiofrequency ablation device is configured such that, after designating the main needle as the temperature control element to adjust the operating parameters of the radiofrequency ablation device, the sub-needle is designated as the temperature control element to adjust the operating parameters of the radiofrequency ablation device; or The radiofrequency ablation device is configured to use only the sub-needle as a temperature control element to adjust the operating parameters of the radiofrequency ablation device.

[0007] In one embodiment, the radiofrequency ablation device is configured to designate the main needle as a temperature control element and adjust the temperature based on the current temperature of the main needle. T 主 ( t i ) and the target temperature of the main needle T s主 After adjusting the operating parameters of the radiofrequency ablation device, the sub-needle is designated as the temperature control element, and the temperature of the sub-needle at the current moment is used as the control factor. T 子 ( t i ) and the target temperature of the needle T s子 The operating parameters of the radiofrequency ablation device were adjusted again.

[0008] In one embodiment, the radiofrequency ablation device is configured to designate only the sub-needle as the temperature control element, and to adjust the temperature based on the current temperature of the sub-needle. T 子 ( t i ) and the target temperature of the sub-needle T s子 Adjust the operating parameters of the radiofrequency ablation device.

[0009] In one embodiment, the operating parameters of the radiofrequency ablation device include the power output from the radiofrequency ablation device to the radiofrequency ablation needle at the current moment. P ( t i When the radiofrequency ablation device designates the main needle as the temperature control element, the power at the current moment... P ( t i The temperature of the main needle and the main needle satisfy the following relationship: P ( t i )= P ( t i-1 )+Δ P ; Δ P =K p [ T e ( t i )- T e ( t i-1 )]+ K j T e ( ti )+ K d [ T e ( t i )-2 T e ( t i-1 )+ T e ( t i-2 )]; T e ( t i )= T 主 ( t i )- T s主 ; T e ( t i-1 )= T 主 ( t i-1 )- T s主 ; T e ( t i-2 )= T 主 ( t i-2 )- T s主 ; Where ΔP is the power value that needs to be adjusted; t i The working time of the master pointer at the current moment. i It is a natural number greater than or equal to 2; P ( t i-1 ) is the first i -1 is the power output from the radiofrequency ablation device to the radiofrequency ablation needle; T e ( t i-1 ) is the first i The temperature deviation of the main needle at time -1; T e (t i-2 ) is the first i The temperature deviation of the main needle at time -2; K p This is the scaling factor for temperature adjustment, with a value range of 0.4 to 1. K j The integration time is 0.4 to 1. K d The time interval is the differential time, and its value ranges from 0.5 to 1.

[0010] In one embodiment, the operating parameters of the radiofrequency ablation device include the power output from the radiofrequency ablation device to the radiofrequency ablation needle at the current moment. P ( t i When the radiofrequency ablation device designates the sub-needle as the temperature control element, the power at the current moment... P ( t i The temperature of the needle satisfies the following relationship: P ( t i )= P ( t i-1 )+Δ P ; Δ P =K p [ T e ( t i )- T e ( t i-1 )]+ K j T e ( t i )+ K d [ T e ( t i )-2 T e ( t i-1 )+ T e ( t i-2 )]; Te ( t i )= T 子 ( t i )- T s子 ; T e ( t i-1 )= T 子 ( t i-1 )- T s子 ; T e ( t i-2 )= T 子 ( t i-2 )- T s子 ; Where ΔP is the power value that needs to be adjusted; t i The working time of the sub-needle at the current moment. i It is a natural number greater than or equal to 2; P ( t i-1 ) is the first i -1 is the power output from the radiofrequency ablation device to the radiofrequency ablation needle; T e ( t i ) is the first i Temperature deviation of the sub-needle at the specified time; T e ( t i-1 ) is the first i The temperature deviation of the sub-needle at time -1; T e ( t i-2 ) is the first i The temperature deviation of the sub-needle at time -2; K p This is the scaling factor for temperature adjustment, with a value range of 0.4 to 1. K jThe integration time is 0.4 to 1. K d The time interval is the differential time, and its value ranges from 0.5 to 1.

[0011] According to a second aspect of the present invention, the present invention provides a radiofrequency ablation measurement and control system, including a radiofrequency ablation instrument and a radiofrequency ablation needle, wherein the radiofrequency ablation needle includes a main needle and at least one sub-needle, and the sub-needle can be deployed or retracted from the periphery of the main needle; The radiofrequency ablation device is connected to the main needle and the sub-needle respectively to receive signals fed back by the main needle and the sub-needle; The radiofrequency ablation device can specify the main needle and the main needle as temperature control elements, or only specify the sub-needle as temperature control elements to adjust the operating parameters of the radiofrequency ablation device; When the radiofrequency ablation device designates the sub-needle as the temperature control element, the radiofrequency ablation device is configured to operate according to the target temperature of the sub-needle. T s子 Controlling the unfolding diameter of the sub-needle D .

[0012] In one embodiment, the target temperature of the main needle T s主 With the target temperature of the sub-needle T s子 The following relationship must be satisfied: T s子 ≤ T s主 ≤ T s子 +20. In one embodiment, the radiofrequency ablation device is configured to designate the main needle as a temperature control element and adjust the temperature based on the current temperature of the main needle. T 主 ( t i ) and the target temperature of the main needle T s主 After adjusting the operating parameters of the radiofrequency ablation device, the sub-needle is designated as the temperature control element, and the temperature of the sub-needle at the current moment is used as the control factor. T 子 ( t i ) and the target temperature of the needle T s子 The operating parameters of the radiofrequency ablation device were adjusted again.

[0013] In one embodiment, when the radiofrequency ablation device designates the sub-needle as the temperature control element, the sub-needle with the lowest temperature is preferentially set as the temperature control element, and the power at the current moment is adjusted according to the temperature of the sub-needle with the lowest temperature. P ( t i Subsequently, the radiofrequency ablation device locates and identifies the other sub-needle with the lowest current temperature and sets it as the temperature control element to adjust the power at the current moment. P ( t i Continue until the temperature of each needle reaches its target temperature. T s子 .

[0014] In one embodiment, the operating parameters of the radiofrequency ablation device include the power output from the radiofrequency ablation device to the radiofrequency ablation needle at the current moment. P ( t i When the radiofrequency ablation device designates the main needle as the temperature control element, the power at the current moment... P ( t i The temperature of the main needle and the main needle satisfy the following relationship: P ( t i )= P ( t i-1 )+Δ P ; Δ P =K p [ T e ( t i )- T e ( t i-1 )]+ K j T e ( t i )+ K d [ T e ( t i )-2 T e ( t i-1 )+ T e ( t i-2 )]; T e ( t i )= T 主 ( t i )- T s主 ; T e ( t i-1 )= T 主 ( t i-1 )- T s主 ; T e ( t i-2 )= T 主 ( t i-2 )- T s主 ; Where ΔP is the power value that needs to be adjusted; t i The working time of the master pointer at the current moment. i It is a natural number greater than or equal to 2; P ( t i-1 ) is the first i -1 is the power output from the radiofrequency ablation device to the radiofrequency ablation needle; T e ( t i-1 ) is the first i The temperature deviation of the main needle at time -1; T e ( t i-2 ) is the first i The temperature deviation of the main needle at time -2; K p This is the scaling factor for temperature adjustment, with a value range of 0.4 to 1. K j The integration time is 0.4 to 1. K dThe time interval is the differential time, and its value ranges from 0.5 to 1.

[0015] In one embodiment, the operating parameters of the radiofrequency ablation device include the power output from the radiofrequency ablation device to the radiofrequency ablation needle at the current moment. P ( t i When the radiofrequency ablation device designates the sub-needle as the temperature control element, the power at the current moment... P ( t i The temperature of the needle satisfies the following relationship: P ( t i )= P ( t i-1 )+Δ P ; Δ P =K p [ T e ( t i )- T e ( t i-1 )]+ K j T e ( t i )+ K d [ T e ( t i )-2 T e ( t i-1 )+ T e ( t i-2 )]; T e ( t i )= T 子 ( t i )- T s子 ; T e ( t i-1 )= T 子 (t i-1 )- T s子 ; T e ( t i-2 )= T 子 ( t i-2 )- T s子 ; Where ΔP is the power value that needs to be adjusted; t i The working time of the sub-needle at the current moment. i It is a natural number greater than or equal to 2; P ( t i-1 ) is the first i -1 is the power output from the radiofrequency ablation device to the radiofrequency ablation needle; T e ( t i ) is the first i Temperature deviation of the sub-needle at the specified time; T e ( t i-1 ) is the first i The temperature deviation of the sub-needle at time -1; T e ( t i-2 ) is the first i The temperature deviation of the sub-needle at time -2; K p This is the scaling factor for temperature adjustment, with a value range of 0.4 to 1. K j The integration time is 0.4 to 1. K d The time interval is the differential time, and its value ranges from 0.5 to 1.

[0016] According to a third aspect of the present invention, the present invention provides a measurement and control method for a radio frequency ablation measurement and control system, comprising the following operation steps: After designating the main needle of the radiofrequency ablation device as a temperature control element to adjust the operating parameters of the radiofrequency ablation device, the sub-needles of the radiofrequency ablation device are then designated as temperature control elements to adjust the operating parameters of the radiofrequency ablation device; or The radiofrequency ablation device designates the sub-needle of the radiofrequency ablation needle as a temperature control element to adjust the operating parameters of the radiofrequency ablation device.

[0017] Compared with the prior art, the advantages of the present invention are that the radiofrequency ablation device, after designating the main needle as the temperature control element to adjust its operating parameters, designates the sub-needle as the temperature control element to adjust its operating parameters again, thereby avoiding the problem of excessively low temperature (e.g., below 60°C) and uneven thermal field at the edge position, which prevents the complete elimination of cell activity at that location; or the radiofrequency ablation device can directly designate the sub-needle as the temperature control element to adjust its operating parameters, which can also solve the problem of excessively low temperature (e.g., below 60°C) and uneven thermal field at the edge position, which prevents the complete elimination of cell activity at that location. Attached Figure Description The invention will now be described in more detail with reference to embodiments and the accompanying drawings.

[0018] Figure 1 This is a block diagram showing the connection relationship of each component of the radiofrequency ablation device in an embodiment of the present invention; Figure 2 This is a front view of the radiofrequency ablation needle in an embodiment of the present invention; Figure 3 This is a schematic diagram of the temperature field of the radiofrequency ablation needle in an embodiment of the present invention; Figure 4 This is a schematic diagram of the ablation region in an embodiment of the present invention.

[0019] Figure label: 100. Radiofrequency ablation needle; 110. Main needle; 120. Sub-needle; 130. Handle; 140. Main needle temperature sensing element; 150. Sub-needle temperature sensing element; 160. Insulating layer; 170. Scale tube; 180. Ablation electrode; 190. Neutral electrode; 200. Radiofrequency ablation device; 210. Main control unit; 220. Measurement and control unit; 230. Switching power supply (digital-to-analog converter); 240. Power source; 250. Filter; 260. Power switch; Detailed Implementation The invention will now be further described with reference to the accompanying drawings.

[0020] like Figure 1 and Figure 2 As shown, this invention provides a radiofrequency ablation monitoring and control system, including a radiofrequency ablation device 200 and a radiofrequency ablation needle 100. As... Figure 2 As shown, the radiofrequency ablation needle 100 includes a main needle 110 and at least one sub-needle 120. The radiofrequency ablation device 200 is connected to the main needle 110 and the sub-needle 120 respectively to receive signals fed back from the main needle 110 and the sub-needle 120. For example, when the main needle 110 and the sub-needle 120 feed back temperature signals, the radiofrequency ablation device 200 can determine whether the current temperature of the main needle 110 and / or the sub-needle 120 has reached the target temperature based on the temperature signals fed back by the main needle 110 and / or the sub-needle 120. If not, the device adjusts its operating parameters accordingly based on the difference between the current temperature of the main needle 110 and / or the sub-needle 120 and the target temperature, such as increasing or decreasing its power, so that the temperature of the main needle 110 and / or the sub-needle 120 changes accordingly in order to reach its target temperature.

[0021] Example 1 In this embodiment 1, the radiofrequency ablation device 200 is configured such that the main needle 110 is designated as the temperature control element to adjust the operating parameters of the radiofrequency ablation device 200, and the sub-needle 120 is designated as the temperature control element to adjust the operating parameters of the radiofrequency ablation device 200.

[0022] Specifically, the radiofrequency ablation device 200 is constructed by first designating the main needle 110 as the temperature control element, and then controlling the temperature of the main needle 110 at the current moment. T 主 ( t i ) and the target temperature of the main needle 110 T s主 After adjusting the operating parameters of the radiofrequency ablation device 200, designate the sub-needle 120 as the temperature control element, and adjust the temperature of the sub-needle 120 according to its current value. T 子 ( t i ) and the target temperature of the needle T s子 The operating parameters of the radiofrequency ablation device 200 were readjusted.

[0023] When the radiofrequency ablation device 200 designates the main needle 110 as the temperature control element, although the radiofrequency ablation device 200 receives temperature signals from both the main needle 110 and the sub-needle 120, the radiofrequency ablation device 200 only determines the current temperature of the main needle 110. T 主 ( t i Has the target temperature been reached? T s主Instead of determining the relationship between the temperature of the sub-needle 120 and its target temperature, the radiofrequency ablation device 200, when designating the sub-needle 120 as the temperature control element, receives temperature signals from both the main needle 110 and the sub-needle 120, but only determines the current temperature of the sub-needle 120. T 子 ( t i Has the target temperature been reached? T s子 Instead of focusing on the relationship between the temperature of the main needle 110 and its target temperature.

[0024] In other words, in this embodiment 1, the radiofrequency ablation device 200 operates by replacing the temperature control element. The reason for replacing the temperature control element in the radiofrequency ablation device 200 is that during treatment, the ablation area formed by the main needle 110 (e.g., Figure 3 The circle shown (approximately 4 cm in radius) exhibits an energy field that gradually decreases outward from the location of the main needle 110. This is because the electrode used to receive the radiofrequency energy from the radiofrequency ablation device 200 is located on the main needle 110, which is the center of the ablation area. Therefore, the energy is most concentrated closer to the electrode (e.g., the center), and correspondingly, this area has the highest temperature. The temperature decreases by approximately 10°C for every 1 cm of radial extension outward from the center (e.g., the left and right sides or the top and bottom sides). Figure 3 As shown, the temperature is highest at the center of a circle with a radius of approximately 4 cm, around 95°C, while the temperature is lowest at the outermost edge, around 55°C. This means that the energy and temperature are highest at the center of the main needle 110; the further away from the main needle 110, the lower the energy and temperature. This phenomenon causes the temperature at the center of the main needle 110 to be excessively high (e.g., above 90°C), while the temperature at the edge of the ablation area has not yet reached the target temperature. Conversely, if the temperature at the edge is too low (e.g., below 60°C), the cells in that area may still be active, resulting in missed ablation and incomplete surgery. Therefore, in this case, the energy input to the main needle 110 is usually increased, which in turn causes the temperature at the center of the main needle 110 to become excessively high, leading to scab formation and carbonization, which is detrimental to the normal progress of the surgery. Therefore, based on the above problems, the present invention addresses these issues by replacing the temperature control element to adjust the current temperature of the main needle 110. T 主 ( t i It has reached its target temperature. T s主When the sub-needle 120 is used as a temperature control element, its temperature is controlled. Since the sub-needle 120 is located circumferentially to the main needle 110, it is situated at the edge of the ablation zone formed by the main needle 110, away from the center. Therefore, by controlling the energy input to the sub-needle 120, its temperature can be adjusted to reach the target temperature. This ensures that the temperature at the edge reaches the target temperature, allowing for complete annihilation of cell activity and preventing incomplete ablation. On the other hand, when energy is input to the sub-needle 120, its energy field is superimposed on the energy field at the center of the main needle 110, further increasing the temperature of the main needle 110. At this point, the temperature of the main needle 110 can be further increased by adjusting the energy input to the sub-needle 120. T s主 Set to a temperature below its limit (e.g., below 90°C), and / or by using the sub-needle 110 T s子 Set it to a temperature below its limit (e.g., below 85°C) to avoid the problem of excessive temperature at the location (center position) where the main needle 110 is located.

[0025] The operating parameters of the radiofrequency ablation device 200 include the power output from the radiofrequency ablation device 200 to the radiofrequency ablation needle 100 at the current moment. P ( t i ), this power P ( t i This will affect the temperature of the main needle 110 and the sub-needle 120 of the radiofrequency ablation device 200. Generally, this power... P ( t i The larger the value, the higher the temperature of the main needle 110 and the daughter needle 120, and the greater the power. P ( t i The smaller the value, the lower the temperature of the main needle 110 and the daughter needle 120, and the lower the power. P ( t i When the temperature decreases to 0, the temperature of the main needle 110 and the daughter needle 120 can be temporarily maintained at the current temperature.

[0026] When the main needle 110 of the radiofrequency ablation device 200 is designated as the temperature control element, the power at the current moment... P ( t i The temperature of the main needle 110 and the main needle 110 satisfy the following relationship (1): P ( t i )= P ( ti-1 )+Δ P ; Δ P =K p [ T e ( t i )- T e ( t i-1 )]+ K j T e ( t i )+ K d [ T e ( t i )-2 T e ( t i-1 )+ T e ( t i-2 (1-1) T e ( t i )= T 主 ( t i )- T s主 (1-3) T e ( t i-1 )= T 主 ( t i-1 )- T s主 (1-4) T e ( t i-2 )= T 主 ( t i-2 )- T s主 (1-5) Where ΔP is the power value that needs to be adjusted. t i This is the working time of the main hand 110 at the current moment.i It is a natural number greater than or equal to 2; P ( t i-1 ) is the first i -1 moment, the power output from the radiofrequency ablation device 200 to the radiofrequency ablation needle 100; T e ( t i-1 ) is the first i -1 minute temperature deviation of the main needle 110; T e ( t i-2 ) is the first i -2°C temperature deviation of the main needle 110°C; K p This is the scaling factor for temperature adjustment, with a value range of 0.4 to 1. K j The integration time is 0.4 to 1. K d The time interval is the differential time, and its value ranges from 0.5 to 1.

[0027] In other words, the radiofrequency ablation device 200, based on the current moment of the main needle 110 (i.e., the... i The temperature at (time) and its target temperature T s主 The relationship between the two, the first i The previous time (i.e., the time before time) i The temperature at time -1 and its target temperature T s主 The relationship between the two and the first i The time before time -1 (i.e., the time before time -1) i The temperature at -2 (time) and its target temperature T s主 The relationship between the two factors determines the power that needs to be adjusted. P ( t i That is, the radiofrequency ablation device 200 uses an incremental PID control algorithm to compare the monitored temperature value (the current temperature) with the set target temperature, and adjusts the power based on the comparison result. P ( t i (For example, for power) P ( t i The temperature can be increased or decreased to reach the target temperature. This control method gradually achieves the preset target temperature, avoiding excessive temperature control oscillations.

[0028] Therefore, the power of the radiofrequency ablation device 200 at the current moment P ( t i The power at the current moment is related to the previous two temperature values ​​because the temperature changes over time. P ( t i Iterative calculations are performed based on the two most recent temperature values ​​to avoid introducing more irrelevant temperature data and to reduce the amount of computation.

[0029] Furthermore, as described above, when the temperature of the main needle 110 reaches the target temperature value, the radiofrequency ablation device 200 will stop or reduce the power output; in order to avoid the temperature at the edge of the ablation area not reaching the target temperature, the radiofrequency ablation device 200 will designate the sub-needle 120 as the temperature control element.

[0030] When the radiofrequency ablation device 200 uses the designated sub-needle 120 as the temperature control element, the power at the current moment... P ( t i The current temperature of the sub-needle 120. T 子 ( t i ) and the target temperature of the sub-needle 120 T s子 The following relationship must be satisfied: P ( t i )= P ( t i-1 )+ΔP; Δ P =K p [ T e ( t i )- T e ( t i-1 )]+ K j T e ( t i )+ K d [ T e ( t i )-2 T e ( t i-1 )+ Te ( t i-2 (1-2) T e ( t i )= T 子 ( t i )- T s子 ; T e ( t i-1 )= T 子 ( t i-1 )- T s子 ; T e ( t i-2 )= T 子 ( t i-2 )- T s子 ; Where ΔP is the power value that needs to be adjusted. t i This is the working time of the sub-hand pointer at the current moment, 120. i It is a natural number greater than or equal to 2; P ( t i-1 ) is the first i -1 moment, the power output from the radiofrequency ablation device 200 to the radiofrequency ablation needle 100; T e ( t i ) is the first i Temperature deviation of the sub-needle (120) at the specified time; T e ( t i-1 ) is the first i -1 hour hand temperature deviation 120; T e ( t i-2 ) is the first i -2 o'clock hour hand temperature deviation 120; K p This is the scaling factor for temperature adjustment, with a value range of 0.4 to 1. Kj The integration time is 0.4 to 1. K d The time interval is the differential time, and its value ranges from 0.5 to 1.

[0031] The radiofrequency ablation device 200 can adjust the power output to the sub-needle 120 according to the control method of adjusting the main needle 110 as described above. When the temperature of the sub-needle 120 reaches its target temperature, the temperature control timing starts to reach the expected ablation range.

[0032] When the radiofrequency ablation device 200 designates a sub-needle 120 as a temperature control element, it prioritizes setting the sub-needles 120 with the lowest temperature (which can be one or more) as temperature control elements, that is, it adjusts the power at the current moment according to the temperature of the sub-needle 120 with the lowest temperature. P ( t i This is done in anticipation that the temperature of the sub-needle 120 will reach its target temperature. T s子 Subsequently, locate and identify the other sub-needle 120 (which can be one or more) with the lowest current temperature, and set it as the temperature control element to adjust the power at the current moment. P ( t i By repeating the above process, the temperature of each sub-needle 120 can reach its target temperature. T s子 .

[0033] After obtaining the power output to the radiofrequency ablation needle 100 based on the temperatures of the main needle 110 and the daughter needle 120, the current output voltage of the radiofrequency ablation device 200 can be adjusted. U ( t i The method is to make its output power reach the power at the current moment. P ( t i ).

[0034] When the temperature of the sub-needle 120 reaches the target temperature, the radiofrequency ablation device 200 maintains the current output power. P ( t i For a certain period of time (e.g., 5-20 minutes), the thermal deposition effect can be achieved to consolidate the therapeutic effect.

[0035] When the radiofrequency ablation device 200 specifies the sub-needle 120 as the temperature control element, the radiofrequency ablation device 200 is also configured to adjust the temperature based on the target temperature of the sub-needle 120. T s子 Control the unfolding diameter of the sub-needle 120 D .

[0036] like Figure 4 As shown, the shape of the ablation zone formed in the unfolding direction of the sub-needle 120 is as follows: diameter AD The circle (the thermal field distribution in three-dimensional space presents an oblate spheroid shape). The upper ablation height of the plane where the sub-needle 120 is located is... AH 1. The ablation height at the lower part of the plane where the sub-needle 120 is located is AH2 Among them, the upper ablation height AH 1 represents a quantity that varies with power P and time t, and its range can be 0-20 mm; lower ablation height. AH2 It is a quantity that varies with power P and time t, and its range can be 0-10 mm.

[0037] The target temperature of the main needle is 110. T s主 The target temperature of the needle 120 T s子 The following relationship must be satisfied: T s子 ≤ T s主 ≤ T s子 +20. Sub-needle 120 target temperature T s子 It can be 54~100℃, D t The coefficients are (ablation diameter and temperature control time coefficients), where the temperature control time is generally 5-10 minutes, meaning the radiofrequency ablation device 200 mentioned above maintains the current output power. P ( t i (a certain period of time)

[0038] In other embodiments, the protruding diameter of the sub-needle 120 of the radiofrequency ablation needle 100 can be determined based on the size of the designated area to be ablated. D .like Figure 4 As shown, the diameter of the unfolded sub-needle is D The ablation range can be adjusted according to the power output from the radiofrequency ablation device 200 to the radiofrequency ablation needle 100 at the current moment. P ( t i ) and time t It changes with the changes.

[0039] The overall morphological distribution of the thermal field is as follows: the ablation morphology along the unfolding direction of the sub-needle 120 is a diameter... AD The circular shape, the ablation height of the upper part of the plane where the sub-needle 120 is located is AH 1. The lower ablation height of the plane where the sub-needle 120 is located is AH 2.

[0040] Under different power P and time t settings, the ablation diameter AD Satisfy the following definition: AD = D +2× SW ; in, SW The coefficient represents the ablation range extending outward from the sub-needle 120, which varies with power. P ( t i ) and time t The change in value is 0-10 mm.

[0041] The power P is typically set to 50-200W and the time t to 5-20 minutes. After ablation, a flattened spherical shape is formed. (Total) The ablation height above the plane where needle 120 is located is AH 1 represents power P ( t i ) and time t The amount of change ranges from 0 to 20 mm.

[0042] The ablation height above the plane where needle 120 is located is AH 2 represents power P ( t i ) and time t The amount of change ranges from 0 to 20 mm.

[0043] Example 2 The difference between this embodiment 2 and embodiment 1 is that the radiofrequency ablation device 200 is configured to designate only the sub-needle 120 as the temperature control element to adjust the operating parameters of the radiofrequency ablation device 200. In other words, the radiofrequency ablation device 200 can disregard the relationship between the temperature of the main needle 110 and its target temperature, and only determine the relationship between the temperature of the sub-needle 120 and its target temperature. Because, according to the above analysis, the temperature is highest at the center of the ablation area, as long as the temperature of the sub-needle 120 can reach the expected target, the temperature of the main needle 110, located at the center, will generally also reach the expected target.

[0044] Specifically, the radiofrequency ablation device 200 is configured to designate only the sub-needle 120 as the temperature control element, and to control the temperature based on the current temperature of the sub-needle 120. T 子 ( t i ) and the target temperature of the sub-needle 120 T s子 Adjust the operating parameters of the radiofrequency ablation device 200.

[0045] The operating parameters of the radiofrequency ablation device 200 include the power output from the radiofrequency ablation device 200 to the radiofrequency ablation needle 100 at the current moment. P ( t i When the radiofrequency ablation device 200 uses the sub-needle 120 as the temperature control element, the power at the current moment... P ( t i The current temperature of the sub-needle 120. T 子 ( t i ) and the target temperature of the sub-needle 120 T s子 The following relationship must be satisfied: P ( t i )= P ( t i-1 )+Δ P ; Δ P = K p [ T e ( t i )- T e ( t i-1 )]+ K j T e ( t i )+ K d [ T e ( t i )-2 T e ( t i-1 )+ T e ( t i-2 (2-1) T e ( t i )= T 子 ( t i )- T s子 ; Te ( t i-1 )= T 子 ( t i-1 )- T s子 ; T e ( t i-2 )= T 子 ( t i-2 )- T s子 ; in, t i This is the working time of the sub-hand pointer at the current moment, 120. i It is a natural number greater than or equal to 2; P ( t i-1 ) is the first i -1 moment, the power output from the radiofrequency ablation device 200 to the radiofrequency ablation needle 100; T e ( t i ) is the first i Temperature deviation of the sub-needle (120) at the specified time; T e ( t i-1 ) is the first i -1 hour hand temperature deviation 120; T e ( t i-2 ) is the first i -2 o'clock hour hand temperature deviation 120; K p This is the scaling factor for temperature adjustment, with a value range of 0.4 to 1. K j The integration time is 0.4 to 1. K d The time interval is the differential time, and its value ranges from 0.5 to 1.

[0046] In other words, the radiofrequency ablation device 200 adjusts according to the current time of the sub-needle 120 (i.e., the first... i The temperature at (time) and its target temperature T s子 The relationship between the two, the first i The previous time (i.e., the time before time) i The temperature at time -1 and its target temperatureT s子 The relationship between the two and the first i The time before time -1 (i.e., the time before time -1) i The temperature at -2 (time) and its target temperature T s子 The relationship between the two factors determines the power that needs to be adjusted. P ( t i That is, the radiofrequency ablation device 200 uses an incremental PID control algorithm to compare the monitored temperature value (the current temperature) with the set target temperature, and adjusts the power based on the comparison result. P ( t i (For example, for power) P ( t i The temperature can be increased or decreased to reach the target temperature. This control method gradually achieves the preset target temperature, avoiding excessive temperature control oscillations.

[0047] Furthermore, in this embodiment 2, the current output voltage from embodiment 1 can be used. U ( t i Power at the current moment P ( t i The power to be set at this moment can be obtained by using equation (1-3) or equation (1-5), that is, the power at the current moment. P ( t i The present invention will not elaborate on this point.

[0048] Understandably, in this embodiment 2, the unfolded diameter of the sub-needle 120 can be obtained using the relationship (1-7) in embodiment 1 above, and the present invention will not elaborate on this further.

[0049] Based on the above embodiments 1 and 2, as follows Figure 1 As shown, the radiofrequency ablation device 200 includes a main control unit 210, a measurement and control unit 220, a switching power supply (digital-to-analog converter) 230, a power source 240, a filter 250, and a power switch 260. Figure 1 The middle arrow indicates the direction of signal flow.

[0050] The main control unit 210 generates radio frequency (RF) energy based on preset parameters or parameters calculated and tuned by the measurement and control unit 220 based on the feedback temperature. The measurement and control unit 220 detects the switching status of the RF ablation electrode and the power source, and acquires the temperature measurement value fed back by the sub-needle 120 or the main needle 110. The main control unit 210 controls the output of the power source 240 based on the analog voltage generated according to the corresponding preset temperature value. The switching power supply (digital-to-analog converter) 230 converts the input AC power into DC power. The power source 240 generates the RF energy, for example, it can generate 470kHz RF energy.

[0051] The measurement and control unit 220 is communicatively connected to the radiofrequency ablation needle 100. More specifically, the measurement and control unit 220 is connected to the ablation electrode 180 (which can be used as the positive electrode, inserted into the target location in the body with the main needle 110) and the neutral electrode 190 (which can be considered as the negative electrode, forming a current loop with the ablation electrode 180 on the main needle 110, and can be attached to the human skin) on the main needle 110, and to the ablation electrode 180 (which can be used as the positive electrode, inserted into the target location in the body with the sub-needle 120) and the neutral electrode 190 (which can be considered as the negative electrode, forming a current loop with the ablation electrode 180 on the sub-needle 120, and can be attached to the human skin) on the sub-needle 120, to control their on / off states. In addition, the measurement and control unit 220 is also connected to the temperature sensing elements on the main needle 110 and the sub-needle 120, respectively, to acquire the temperature data of the main needle 110 and the sub-needle 120. The temperature sensing element on the main needle 110 can be disposed in the ablation electrode 180 on the main needle 110, and the temperature sensing element on the sub-needle 120 can be disposed in the ablation electrode 180 on the sub-needle 120.

[0052] The measurement and control unit 220 is connected to the main control unit 210 to feed back the temperature signal it acquires to the main control unit 210. The main control unit 210 determines the power that needs to be set this time based on judgment and calculation, and transmits the power signal to the measurement and control unit 220.

[0053] The main control unit 210 is also connected to the switching power supply (digital-to-analog converter) 230 and the power source 240 respectively. The switching power supply (digital-to-analog converter) 230 is connected to the power source 240. The main control unit 210 can obtain the current output voltage by modulating the switching power supply (digital-to-analog converter) 230 and finally obtain the power that needs to be set.

[0054] In addition, power switch 260 is connected to filter 250, which is used to filter fluctuations in the mains voltage of the input AC power supply. Filter 250 filters out and purifies the mains voltage fluctuations of the input AC power supply, making it stable and reliable. Filter 250 is connected to switching power supply (digital-to-analog converter) 230.

[0055] The measurement and control unit 220 has multiple switching devices and N relays to control the switching of radio frequency energy and electrode output. The main control unit 210 generates a corresponding analog voltage value based on the feedback temperature value and the preset target temperature value, thereby controlling the power output of the power source 240. That is, the main control unit 210 can control the output of the power source 240 according to the temperature value obtained by the measurement and control unit 220, and monitor the temperature values ​​at the center of the ablation area where the main needle 110 of the radio frequency ablation needle 100 is located and the edge of the ablation area where the sub-needle 120 is located in real time to determine the ablation duration.

[0056] The measurement and control unit 220 monitors the return impedance of the neutral electrode 190 when the radiofrequency ablation needle 100 is working, and determines whether it is disconnected or connected to avoid burning the skin and ensure the safety of the operation.

[0057] Based on the above embodiments 1 and 2, as follows Figure 2 As shown, the radiofrequency ablation needle 100 also includes a handle 130. Both the main needle 110 and the sub-needle 120 are connected to the handle 130. The sub-needle 120 can be extended or retracted from the outer periphery of the main needle 110. When extended, the sub-needle 120 extends from the gap between the tip of the main needle 110 and the needle tube; conversely, when retracted, the sub-needle 120 retracts from the gap. The radiofrequency ablation needle 100 can adopt an existing structure including a main needle and a sub-needle, such as the radiofrequency ablation electrode needle disclosed in Chinese Patent CN115444551A, the entire text of which is incorporated herein by reference.

[0058] Temperature sensing elements (such as thermocouples) can be installed on the main needle 110 and the sub-needle 120 to measure the temperature of the main needle 110 and the sub-needle 120 and feed the temperature signal back to the control unit 220 of the radiofrequency ablation device 200. Figure 2 As shown, the main needle temperature sensing element 140 on the main needle 110 can be located at the root of the main needle 110, and the sub-needle temperature sensing element 150 on the sub-needle 120 can be located at the tip of the sub-needle 120.

[0059] The number of sub-needles 120 can be one or more, and the multiple sub-needles 120 can surround the circumference of the main needle 110, so that the sub-needles 120 can be umbrella-shaped or other shapes when unfolded. When there are multiple sub-needles 120, a temperature sensing element can be provided on each sub-needle 120, or a temperature sensing element can be provided on only a portion of the sub-needles 120 (e.g., Figure 2 As shown, the sub-needle 120 with a temperature sensing element and the sub-needle 120 without a temperature sensing element are set at intervals, etc.

[0060] It should be noted that since the sub-needle 120 equipped with a temperature sensing element can feed back a temperature signal to the radiofrequency ablation device 200, it can be designated as a temperature control element by the radiofrequency ablation device 200; the sub-needle 120 without a temperature sensing element cannot be designated as a temperature control element.

[0061] In addition, an insulating layer 160 may be coated on the tube of the main needle 110 to partially insulate the tube. The tube is constructed in the form of a graduated tube 170, which indicates the depth at which the main needle 110 is inserted into the target position.

[0062] The tip of the main needle 110 can be a triangular tip with electrical conductivity. The tip of the main needle 110 is connected to the central tube in the scale tube 170. When the scale tube 170 moves, a gap is created between it and the central tube, through which the sub-needle 120 can extend and unfold.

[0063] The conductive portion at the end of the scale tube 170 is connected to a high-frequency line, which in turn is connected to a PCB adapter board. The PCB adapter board is connected to the control unit 220 of the radiofrequency ablation device 200 via an RF connector. The main needle temperature sensing element 140 is located within the central tube cavity, connecting to the tip of the main needle 110. The ends of the main needle temperature sensing element 140 are connected to both the PCB adapter board and the RF connector, thus enabling communication with the control unit 220 of the radiofrequency ablation device 200. The sub-needle temperature sensing element 150 is located at the top of the sub-needle 120 cavity, with its ends connected to both the PCB adapter board and the RF connector, thus enabling communication with the control unit 220 of the radiofrequency ablation device 200.

[0064] The tip of the main needle 110 can be made of an anti-adhesive material to prevent it from sticking to the tissue, thus ensuring stable conductivity and preventing scab formation and carbonization caused by excessively high center temperature.

[0065] Example 3 Based on the above embodiments 1 and 2, the present invention also provides a measurement and control method for a radio frequency ablation measurement and control system, comprising the following operation steps: After designating the main needle 110 of the radiofrequency ablation needle 100 as a temperature control element to adjust the operating parameters of the radiofrequency ablation device 200, the sub-needle 120 of the radiofrequency ablation needle 100 is designated as a temperature control element to adjust the operating parameters of the radiofrequency ablation device 200.

[0066] Alternatively, the radiofrequency ablation device 200 may designate the sub-needle 120 of the radiofrequency ablation needle 100 as a temperature control element to adjust the operating parameters of the radiofrequency ablation device 200.

[0067] For the specific adjustment process of the operating parameters of the radiofrequency ablation device 200, please refer to Embodiments 1 and 2 above. This invention will not repeat the process here.

[0068] The measurement and control method described in this invention is applied to the experimental or testing phase of a radiofrequency ablation measurement and control system.

[0069] Although the invention has been described with reference to preferred embodiments, various modifications can be made and components can be replaced with equivalents without departing from the scope of the invention. In particular, the technical features mentioned in the various embodiments can be combined in any manner as long as there is no structural conflict. The invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A radio frequency ablation measurement and control system, characterized in that, It includes a radiofrequency ablation device (200) and a radiofrequency ablation needle (100), the radiofrequency ablation needle (100) including a main needle (110) and a plurality of sub-needles (120), the sub-needles (120) being able to expand or retract from the periphery of the main needle (110); The radiofrequency ablation device (200) is connected to the main needle (110) and the sub-needle (120) respectively to receive signals fed back by the main needle (110) and the sub-needle (120); The radiofrequency ablation device (200) is configured to designate only the sub-needle (120) as a temperature control element to adjust the operating parameters of the radiofrequency ablation device (200); The radiofrequency ablation device (200) adjusts the temperature of the sub-needle (120) at the current moment. T 子 ( t i The target temperature of the sub-needle (120) T s子 Adjust the operating parameters of the radiofrequency ablation device (200); the radiofrequency ablation device (200) is configured such that the sub-needle (120) with the lowest temperature is first set as the temperature control element, and the power at the current moment is adjusted according to its temperature. P ( t i When the temperature of the sub-needle (120) reaches its target temperature T s子 Then, locate and determine the other sub-needle (120) with the lowest current temperature, and set it as the temperature control element to adjust the power at the current moment. P ( t i Repeat the above process to ensure that the temperature of each sub-needle (120) reaches its target temperature. T s子 ; The operating parameters of the radiofrequency ablation device (200) include the power output from the radiofrequency ablation device (200) to the radiofrequency ablation needle (100) at the current moment. P ( t i When the radiofrequency ablation device (200) designates the sub-needle (120) as the temperature control element, the power at the current moment... P ( t i The temperature of the sub-needle (120) and the temperature of the sub-needle satisfy the following relationship: P ( t i )= P ( t i-1 )+D P ; D P =K p [ T e ( t i )- T e ( t i-1 )]+ K j T e ( t i )+ K d [ T e ( t i )-2 T e ( t i-1 )+ T e ( t i-2 )]; T e ( t i )= T 子 ( t i )- T s子 ； T e ( t i-1 )= T 子 ( t i-1 )- T s子 ； T e ( t i-2 )= T 子 ( t i-2 )- T s子 ； Where ΔP is the power value that needs to be adjusted; t i The working time of the sub-needle (120) at the current moment. i It is a natural number greater than or equal to 2; P ( t i-1 ) is the first i The power output from the radiofrequency ablation device (200) to the radiofrequency ablation needle (100) at time -1; T e ( t i ) is the first i Temperature deviation of the sub-needle (120) at the specified time; T e ( t i-1 ) is the first i Temperature deviation of the sub-needle (120) at time -1; T e ( t i-2 ) is the first i -2 The temperature deviation of the sub-needle (120) at time -2; K p This is the scaling factor for temperature adjustment, with a value range of 0.4 to 1. K j The integration time is 0.4 to 1. K d The time interval is the differential time, and its value ranges from 0.5 to 1.

2. The radio frequency ablation measurement and control system according to claim 1, characterized in that, When the temperature of the sub-needle (120) reaches its target temperature T s子 At that time, the radiofrequency ablation device (200) maintains the current output power. P ( t i 5 min ~ 20 min.

3. The radio frequency ablation measurement and control system according to claim 1, characterized in that, The radiofrequency ablation device (200) also includes a temperature measuring element disposed on the sub-needle (120). The temperature measuring element is used to measure the temperature of the sub-needle (120) and feed back the temperature signal to the measurement and control unit (220) of the radiofrequency ablation device (200). The measurement and control unit (220) feeds back the acquired temperature signal to the main control unit (210) of the radiofrequency ablation device (200). The main control unit (210) determines the power to be set this time based on judgment and calculation, and transmits the power signal to the measurement and control unit (220).

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