具有干细胞募集和免疫调控功能的引导组织再生纳米纤维膜的制备方法
By preparing a bilayer nanofiber membrane and combining sequential electrospinning and co-spinning techniques, the problems of single function of traditional GTR membranes and the reduction of stem cells in periodontitis were solved, achieving stability and immune regulation of periodontal tissue regeneration and reducing material costs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JILIN UNIVERSITY
- Filing Date
- 2023-09-28
- Publication Date
- 2026-07-17
AI Technical Summary
Traditional guided tissue regeneration (GTR) membranes have limited functionality and short lifespan in the treatment of periodontal defects, making it difficult to achieve stable and ideal regeneration results. Furthermore, periodontitis reduces the number of stem cells in the lesion area, making it difficult to effectively regulate the inflammation of the local immune microenvironment.
A bilayer nanofiber membrane was prepared using sequential electrospinning technology. The inner layer was an immunomodulatory polysaccharide composite nanofiber membrane loaded with HMB-Ca, and the outer layer was an electrospun polymer fiber membrane. By combining these layers through co-spinning technology, stem cell recruitment and immune regulation functions were achieved, thereby promoting the regeneration of the periodontal complex.
It achieves long-term spatial maintenance, promotes stem cell homing and osteogenic differentiation, regulates the local immune microenvironment, reduces material costs, and is suitable for clinical translation.
Smart Images
Figure CN117298353B_ABST