Chitosan composite hemostatic microspheres, preparation method and device thereof, and application thereof

CN117299016BActive Publication Date: 2026-06-23HANGZHOU ZHONGKE PHYSICOCHEMICAL BIOMEDICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HANGZHOU ZHONGKE PHYSICOCHEMICAL BIOMEDICAL TECH CO LTD
Filing Date
2022-06-22
Publication Date
2026-06-23

AI Technical Summary

Technical Problem

Existing chitosan microsphere preparation processes are complex, have long production cycles, low yields, large microsphere sizes, limited liquid absorption, limited hemostatic effects from single materials, large morphological variations, and difficulty in controlling reproducibility.

Method used

A preparation device combining dynamic ultrasonic emulsification and parallel cross-quenching processes was used to prepare chitosan composite hemostatic microspheres with a double-layer core-shell structure by forming a nanosphere emulsion through a dynamic ultrasonic emulsification component and performing precise on-off atomization quenching using a parallel cross-quenching component, combined with a phase inversion process.

Benefits of technology

Nanoscale chitosan composite hemostatic microspheres with uniform size, large specific surface area, excellent hemostatic performance, good biocompatibility, and high reproducibility were prepared, which are suitable for rapid hemostasis and promoting wound healing.

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Abstract

The application discloses chitosan composite hemostatic microspheres, a preparation method and a preparation device thereof and application thereof. The preparation device combines a dynamic ultrasonic emulsification process with a parallel cross quenching process, and can continuously and uninterruptedly produce nanoscale composite hemostatic microspheres in a large quantity, the nanoscale composite hemostatic microspheres are uniform in size, good in biocompatibility, safe and non-toxic, good in hemostatic effect and high in repeatability, and are especially suitable for sudden trauma requiring rapid hemostasis.
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