Magnetic fluorescent functional microspheres, preparation method and application thereof

By preparing microspheres containing magnetic and fluorescent materials and grafting phase-transformation lysozyme onto their surface, the sensitivity and stability problems of existing CTC enrichment methods have been solved, achieving efficient and simple CTC separation and enrichment.

CN117304917BActive Publication Date: 2026-07-03SHANGHAI YIFEI BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI YIFEI BIOTECHNOLOGY CO LTD
Filing Date
2023-09-27
Publication Date
2026-07-03

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Abstract

This application relates to a magnetic fluorescent functional microsphere, its preparation method, and its application. The magnetic fluorescent functional microsphere includes a core and a shell covering the surface of the core. The core contains a magnetic material, and the shell contains silica and a fluorescent material. A phase-inversion lysozyme is grafted onto the surface of the shell. The magnetic fluorescent functional microsphere can capture different subtypes of circulating tumor cells from peripheral blood with higher separation efficiency, regardless of antigen-antibody recognition strategies.
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