Sample injection control method, device, computer equipment and storage medium

Abstract

The application relates to a sample injection control method and device, computer equipment, a storage medium and a computer program product. The method comprises the following steps: first, when it is determined that a plurality of chromatograph mass spectrometers are in a ready state, sending a ready signal of the plurality of chromatograph mass spectrometers to a control device; the control device responds to each ready signal and sends a first running signal to each chromatograph mass spectrometer through a plurality of output interfaces to control each chromatograph mass spectrometer to enter a pre-running state; then, samples of each chromatograph mass spectrometer are respectively sucked and injected into each chromatograph mass spectrometer; after the injection of each chromatograph mass spectrometer is completed, an injection completion signal is sent to the control device; the control device responds to the injection completion signal and sends a second running signal to each chromatograph mass spectrometer through the plurality of output interfaces to control each chromatograph mass spectrometer to enter a sample analysis state. The method can realize that one pretreatment injection platform simultaneously injects samples into a plurality of chromatograph mass spectrometers.

Description

Technical Field

[0001] This application relates to the field of control engineering technology, and in particular to control methods, devices, computer equipment, storage media and computer program products for sample injection. Background Technology

[0002] With the development of control engineering technology, a sample pretreatment platform has emerged that uses chromatography-mass spectrometry (GC-MS) injection technology. This technology enables multiple GC-MS instruments to analyze samples using different injection methods.

[0003] In traditional techniques, it usually takes ten to several tens of minutes to analyze a sample by chromatography-mass spectrometry. The time for the injector to complete the injection of a sample is about three to five minutes. Therefore, when analyzing samples by chromatography-mass spectrometry, the injector is idle and waiting most of the time.

[0004] However, currently, a single sample pretreatment platform can only inject samples for one chromatography-mass spectrometer, resulting in low injector efficiency and wasted resources. Summary of the Invention

[0005] Therefore, it is necessary to provide a sample injection control method, device, computer equipment, computer-readable storage medium, and computer program product that can simultaneously inject samples from multiple chromatography-mass spectrometers using a single sample pretreatment platform, thereby improving the efficiency of sample injector usage, in order to address the aforementioned technical problems.

[0006] In a first aspect, this application provides a method for controlling sample injection, including:

[0007] Once it is determined that multiple chromatography-mass spectrometers are in a ready state, a ready signal for the multiple chromatography-mass spectrometers is sent to the control device; the control device is used to respond to each ready signal and send a first operating signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter the pre-operation state.

[0008] Samples were aspirated from each chromatography-mass spectrometer and injected into each of the chromatography-mass spectrometers respectively;

[0009] After sample injection is completed for each of the chromatography-mass spectrometers, an injection completion signal is sent to the control device. The control device is used to respond to the injection completion signal by sending a second operating signal to each of the chromatography-mass spectrometers through the multiple output interfaces, so as to control each of the chromatography-mass spectrometers to enter the sample analysis state.

[0010] In one embodiment, the sample injection control method further includes receiving the operating status information of each chromatograph-mass spectrometer returned by the control device; and determining whether each chromatograph-mass spectrometer is in a ready state based on the operating status information.

[0011] In one embodiment, sending the readiness signals of the plurality of chromatography-mass spectrometers to the control device includes: simultaneously sending the readiness signals of the plurality of chromatography-mass spectrometers to the control device; or sequentially sending the readiness signals of the plurality of chromatography-mass spectrometers to the control device.

[0012] In one embodiment, the sample injection control method further includes: after completing the sample injection into any one of the chromatography-mass spectrometers, sending an injection completion signal to the control device; the control device is used to respond to the injection completion signal by sending a second operating signal to the chromatography-mass spectrometer through the output interface corresponding to the chromatography-mass spectrometer, so as to control the chromatography-mass spectrometer to enter the sample analysis state.

[0013] In one embodiment, the control device further includes a set of serial interfaces; the serial interfaces are used to replace the faulty output interface when any output interface of the control device fails.

[0014] Secondly, this application also provides a sample injection control device, comprising:

[0015] The first signal transmitting module is used to send a readiness signal of the multiple chromatography-mass spectrometers to the control device when it is determined that the multiple chromatography-mass spectrometers are in a ready state; the control device is used to respond to each ready signal and send a first running signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter a pre-running state.

[0016] The sample aspiration module is used to aspirate samples from each chromatography-mass spectrometer and inject them into each of the chromatography-mass spectrometers.

[0017] The second signal transmitting module is used to send an injection completion signal to the control device after the sample injection to each of the chromatography-mass spectrometers is completed; the control device is used to respond to the injection completion signal and send a second running signal to each of the chromatography-mass spectrometers through the multiple output interfaces to control each of the chromatography-mass spectrometers to enter the sample analysis state.

[0018] Thirdly, this application also provides a control device, characterized in that the control device includes multiple output interfaces and one input interface, the input interface being connected to a pretreatment injection platform circuit, and the multiple output interfaces being respectively connected to a chromatography-mass spectrometer circuit; the control device is used to receive ready signals from multiple chromatography-mass spectrometers sent by the pretreatment injection platform through the input interface, and in response to each ready signal, to send a first running signal to each chromatography-mass spectrometer through the multiple output interfaces to control each chromatography-mass spectrometer to enter a pre-running state; the ready signal is sent by the pretreatment injection platform when it determines that multiple chromatography-mass spectrometers are in a ready state; the control device is also used to receive an injection completion signal sent by the pretreatment injection platform through the input interface, and in response to the injection completion signal, to send a second running signal to each chromatography-mass spectrometer through the multiple output interfaces to control each chromatography-mass spectrometer to enter a sample analysis state; the injection completion signal is sent by the pretreatment injection platform after completing sample injection into each chromatography-mass spectrometer.

[0019] Fourthly, this application also provides a computer device, the computer device including a memory and a processor, the memory storing a computer program, and the processor executing the computer program to implement the sample injection control of the method described in any one of the embodiments of this application.

[0020] Fifthly, this application also provides a computer-readable storage medium having a computer program stored thereon, wherein the computer program, when executed by a processor, implements the sample injection control of the method described in any one of the embodiments of this application.

[0021] Sixthly, this application also provides a computer program product, which includes a computer program that, when executed by a processor, implements the sample injection control of the method described in any one of the embodiments of this application.

[0022] The above-mentioned sample injection control method, apparatus, computer equipment, storage medium, and computer program product have the following beneficial effects when controlling sample injection: First, after determining that multiple chromatograms and mass spectrometers are in a ready state, a ready signal for each of the multiple chromatograms and mass spectrometers is sent to the control device. The control device, in response to each ready signal, sends a first running signal to each chromatogram and mass spectrometer through multiple output interfaces to control each chromatogram and mass spectrometer to enter a pre-running state. Then, samples are aspirated from each chromatogram and mass spectrometer and injected into each chromatogram and mass spectrometer. Finally, after completing the sample injection into each chromatogram and mass spectrometer, an injection completion signal is sent to the control device. The control device, in response to the injection completion signal, sends a second running signal to each chromatogram and mass spectrometer through multiple output interfaces to control each chromatogram and mass spectrometer to enter the sample analysis state. By sending confirmation messages about the readiness of multiple chromatography-mass spectrometers to the control device, the pre-operation status of each chromatography-mass spectrometer is initiated. Then, the sample is injected into each chromatography-mass spectrometer, and the injection information is sent to the control device. This allows the control device to promptly control each chromatography-mass spectrometer to enter the sample analysis state, enabling a single sample pretreatment platform to simultaneously inject samples from multiple chromatography-mass spectrometers, thus improving the efficiency of the injectors. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments or related technologies of this application, the accompanying drawings used in the description of the embodiments or related technologies will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0024] Figure 1 This is an application environment diagram of a sample injection control method in one embodiment;

[0025] Figure 2 This is a flowchart illustrating a sample injection control method in one embodiment;

[0026] Figure 3 This is a schematic diagram of the structure of a sample injection control device in one embodiment;

[0027] Figure 4 This is a schematic diagram of the external structure of a sample injection control device in one embodiment;

[0028] Figure 5 This is a schematic diagram of the internal structure of a sample injection control device in one embodiment;

[0029] Figure 6 This is a schematic diagram of the steps of a sample injection control method in one embodiment;

[0030] Figure 7 This is a structural block diagram of a sample injection control device in one embodiment;

[0031] Figure 8 This is an internal structural diagram of a computer device in one embodiment. Detailed Implementation

[0032] To make the objectives, technical solutions, and advantages of this application clearer, the following detailed description is provided in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this application.

[0033] The sample injection control method provided in this application embodiment can be applied to, for example, Figure 1 In the application environment shown, the sample pretreatment platform 102 communicates with multiple chromatography-mass spectrometers via a control device 104. First, upon determining that the multiple chromatography-mass spectrometers are in a ready state, the sample pretreatment platform 102 sends ready signals from the multiple chromatography-mass spectrometers to the control device 104. The control device 104, in response to each ready signal, sends a first running signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter a pre-running state. Then, samples are aspirated from each chromatography-mass spectrometer and injected into each spectrometer. Finally, after completing sample injection into each chromatography-mass spectrometer, an injection completion signal is sent to the control device 104. The control device 104, in response to the injection completion signal, sends a second running signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter the sample analysis state.

[0034] In one exemplary embodiment, such as Figure 2 As shown, a sample injection control method is provided, which can be applied to... Figure 1 The following steps are used as an example of the pretreatment sample introduction platform 102, including steps 202 to 206. Wherein:

[0035] Step 202: After determining that multiple chromatography-mass spectrometers are in a ready state, send a ready signal of the multiple chromatography-mass spectrometers to the control device; the control device is used to respond to each ready signal and send a first running signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter the pre-running state.

[0036] In this context, the control equipment refers to the central control device or system used to control and manage multiple chromatography-mass spectrometers, typically including a computer or controller. Determining that multiple chromatography-mass spectrometers are in a ready state means that they are prepared to proceed to the next step of the operation. The first operating signal refers to the signal that controls each chromatography-mass spectrometer to enter the pre-operation state, i.e., ready to begin sample analysis. The pre-operation state refers to the state the chromatography-mass spectrometer enters after receiving the first operating signal, including self-testing, calibration, and preparation.

[0037] Specifically, the sample pretreatment platform first confirms that multiple chromatography-mass spectrometers have completed self-tests and preparations and are ready to begin sample analysis. It then sends a ready signal to the control device, indicating the readiness status of each spectrometer, so that the control device can proceed with subsequent operations. Next, the control device responds to the ready signals; upon receiving the ready signals from each spectrometer, it takes corresponding actions. Finally, the control device sends a first operating signal to each spectrometer through multiple output interfaces, initiating pre-operation.

[0038] Step 204: Samples from each chromatography-mass spectrometer are aspirated and injected into each of the aforementioned chromatography-mass spectrometers.

[0039] Specifically, in the pre-running state, each chromatography-mass spectrometer is ready to receive samples. Samples can be extracted from the sample container by aspiration and injected into each chromatography-mass spectrometer.

[0040] Step 206: After completing the sample injection for each chromatography-mass spectrometer, an injection completion signal is sent to the control device. The control device is used to respond to the injection completion signal by sending a second operating signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter the sample analysis state.

[0041] Sample injection refers to introducing the sample to be analyzed into the injection port or system of the chromatography-mass spectrometer for subsequent analysis and detection. The second operating signal controls each chromatography-mass spectrometer to enter sample analysis mode, i.e., to begin analyzing and detecting the sample. Sample analysis mode refers to the state the chromatography-mass spectrometer enters after receiving the second operating signal, including processes such as sample separation, detection, and data acquisition.

[0042] Specifically, after each chromatography-mass spectrometer completes sample injection, the sample pretreatment platform sends an injection completion signal to the control device. Upon receiving the injection completion signal, the control device responds accordingly. Finally, the control device sends a second operating signal to each chromatography-mass spectrometer through multiple output interfaces, instructing them to enter sample analysis mode and begin sample analysis and detection.

[0043] In the above-described sample injection control method, firstly, after confirming that multiple chromatography-mass spectrometers are in a ready state, a ready signal for each of the multiple chromatography-mass spectrometers is sent to the control device. The control device, in response to each ready signal, sends a first operating signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter a pre-operation state. Then, samples are aspirated from each chromatography-mass spectrometer and injected into each of the spectrometers. Finally, after completing the sample injection into each chromatography-mass spectrometer, an injection completion signal is sent to the control device. The control device, in response to the injection completion signal, sends a second operating signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter the sample analysis state. By sending confirmation messages about the readiness of multiple chromatography-mass spectrometers to the control device, the pre-operation status of each chromatography-mass spectrometer is initiated. Then, the sample is injected into each chromatography-mass spectrometer, and the injection information is sent to the control device. This allows the control device to promptly control each chromatography-mass spectrometer to enter the sample analysis state, enabling a single sample pretreatment platform to simultaneously inject samples from multiple chromatography-mass spectrometers, thus improving the efficiency of the injectors.

[0044] In one embodiment, the sample injection control method further includes:

[0045] Step 1: Receive the operating status information of each chromatography-mass spectrometer returned by the control equipment.

[0046] The operating status information refers to the current status of the chromatography-mass spectrometer, which can include real-time monitoring data of parameters such as the working status, temperature, pressure, and flow rate of the chromatography-mass spectrometer. The control equipment can obtain the current operating status of each chromatography-mass spectrometer by analyzing and processing this information.

[0047] Step 2: Based on the operating status information, determine whether each chromatography-mass spectrometer is in a ready state.

[0048] Specifically, the ready state means that the chromatography-mass spectrometer has completed initialization, the temperature and pressure have stabilized, and all components and systems are functioning normally.

[0049] In this embodiment, by monitoring and judging the operating status of the chromatography-mass spectrometer through control equipment, it is possible to ensure that sample analysis is performed at the appropriate time, realize intelligent management and control of the chromatography-mass spectrometer, and improve the efficiency and performance of the entire system.

[0050] In one embodiment, sending readiness signals for multiple chromatography-mass spectrometers to a control device includes:

[0051] Scenario 1: Simultaneously sending ready signals from multiple chromatography-mass spectrometers to the control equipment.

[0052] Simultaneous transmission refers to the process where the sample pretreatment platform can send a ready signal to the control device when the current sample pretreatment platform determines that multiple chromatography-mass spectrometers are in a ready state.

[0053] Specifically, after receiving the ready signals from multiple chromatography-mass spectrometers, the control equipment can immediately proceed to the next step, such as sending the first run signal to each chromatography-mass spectrometer to start sample analysis.

[0054] Scenario 2: Sequentially send ready signals from multiple chromatography-mass spectrometers to the control equipment.

[0055] In this context, sequential transmission refers to the pretreatment injection platform sending the readiness signals of each chromatography-mass spectrometer to the control device in a specific order.

[0056] For example, a priority order is set, where the chromatograph-mass spectrometer that sends its ready signal first in the sample pretreatment platform has a higher priority, and the chromatograph-mass spectrometer that sends its ready signal later has a lower priority. When the control device receives the first ready signal, it will perform the corresponding operation and then wait to receive the next ready signal, thereby controlling the operation of each chromatograph-mass spectrometer in sequence.

[0057] In this embodiment, by simultaneously or sequentially sending readiness signals from multiple chromatography-mass spectrometers to the control device, the transmission and reception of readiness signals from multiple chromatography-mass spectrometers are achieved. This ensures that the control device proceeds to the next step only after all chromatography-mass spectrometers are in a ready state, thereby improving the overall efficiency and accuracy of the system.

[0058] In one embodiment, the sample injection control method further includes:

[0059] Step 1: After completing the sample injection for any one of the chromatography-mass spectrometers, send an injection completion signal to the control device.

[0060] Specifically, the injection completion signal can be sent to the control device via the pretreatment injection platform. After receiving the injection completion signal, the control device will perform corresponding processing and judgment.

[0061] Step 2: The above-mentioned control device is used to respond to the injection completion signal by sending a second operating signal to any one of the chromatographs / mass spectrometers through the corresponding output interface, so as to control any one of the chromatographs / mass spectrometers to enter the sample analysis state.

[0062] Specifically, according to the operating procedures and experimental requirements, the control equipment sends a second operating signal to any one of the chromatography-mass spectrometers, starting the chromatography-mass spectrometer to begin analyzing the sample.

[0063] In the above embodiments, intelligent control of the chromatography-mass spectrometer is achieved by sending and receiving control signals. The control device can determine the operating status of each chromatography-mass spectrometer based on the injection completion signal, and send corresponding operating signals according to experimental requirements to control the chromatography-mass spectrometer to perform sample analysis. This ensures that the sample is analyzed in a timely manner after injection, improving the efficiency and accuracy of the system.

[0064] In one embodiment, the control device further includes a set of serial interfaces; the serial interfaces are used to replace the faulty output interface when any output interface of the control device fails.

[0065] In this embodiment, by reserving an additional set of interfaces, when the original contact closure fails or other problems occur, this set of backup interfaces can be used to send operation signals to ensure the normal operation of the equipment, thereby enhancing the reliability and stability of the equipment.

[0066] In one exemplary embodiment, such as Figure 3 As shown, a control device is provided, comprising multiple output interfaces and one input interface. The input interface is connected to a sample pretreatment injection platform circuit, and the output interface is connected to a chromatography-mass spectrometer circuit. The control device is configured to receive readiness signals from multiple chromatography-mass spectrometers sent by the sample pretreatment injection platform via the input interface, and in response to each readiness signal, send a first operating signal to each chromatography-mass spectrometer via the multiple output interfaces to control each chromatography-mass spectrometer to enter a pre-operation state. The readiness signals are sent by the sample pretreatment injection platform when it determines that multiple chromatography-mass spectrometers are in a readiness state. The control device is also configured to receive an injection completion signal from the sample pretreatment injection platform via the input interface, and in response to the injection completion signal, send a second operating signal to each chromatography-mass spectrometer via the multiple output interfaces to control each chromatography-mass spectrometer to enter a sample analysis state. The injection completion signal is sent by the sample pretreatment injection platform after completing sample injection into each chromatography-mass spectrometer.

[0067] In the above embodiments, multiple output interfaces allow for the simultaneous control of multiple chromatography-mass spectrometers, improving analytical efficiency and sample processing capabilities. Input interfaces enable the control device to receive ready and injection completion signals from the pretreatment injection platform, facilitating information exchange with the platform. The control device also responds promptly to these signals, ensuring that the chromatography-mass spectrometers enter pre-running and sample analysis states at appropriate times. Multiple output interfaces allow the control device to send first and second running signals to each chromatography-mass spectrometer, enabling independent control and operation of each instrument, improving sample analysis efficiency and accuracy, and achieving collaborative and automated operation of multiple chromatography-mass spectrometers.

[0068] In one embodiment, to facilitate understanding of the embodiments of this application by those skilled in the art, the following description will take the example of a control device including one input interface and two output interfaces.

[0069] refer to Figure 4 and Figure 5 The diagrams show the external and internal structures of the control device, respectively. Figure 4 As shown, the control device includes one input interface 41 and two output interfaces, namely a first output interface 42 and a second output interface 43. The input interface 41 is connected to the sample pretreatment platform circuit and is used to receive signals sent by the sample pretreatment platform. The first output interface 42 is connected to the first chromatography-mass spectrometer and is used to send operating signals to the first chromatography-mass spectrometer. The second output interface 43 is connected to the second chromatography-mass spectrometer and is used to send operating signals to the second chromatography-mass spectrometer.

[0070] Specifically, such as Figure 6 As shown, application Figure 4 The sample injection control method of the control device shown includes the following steps:

[0071] Step 602: The sample pretreatment platform confirms that multiple chromatography-mass spectrometers are in a ready state.

[0072] Specifically, the signal trigger line of the interface (interface signal, which refers to the signal used for communication and data transmission between different hardware devices in a computer system, and can be an electrical signal, optical signal or wireless signal) of the sample pretreatment platform is connected to the wiring port of the control device, and the chromatogram 1 interface (i.e. the first output interface) and chromatogram 2 interface (i.e. the second output interface) in the control device are connected to the first chromatogram-mass spectrometer and the second chromatogram-mass spectrometer, respectively.

[0073] Step 604: The sample pretreatment platform sends ready signals from multiple chromatography-mass spectrometers to the control device, which then converts one set of synchronization signals into two sets of synchronization signals.

[0074] The pretreatment injection platform consists of a set of synchronization signals, which are composed of a set of input signals (TTL-In digital I / O, 5V) and two sets of output signals (SWOut-1 / SWOut-2 contact closure). The input signal (TTL-In digital I / O, 5V) is used to receive the ready signal from the chromatography-mass spectrometer.

[0075] Specifically, after the control equipment connects to a single set of synchronization signals from the pretreatment sample injection platform, it converts one set of synchronization signals into two sets of synchronization signals.

[0076] Step 606: In response to each ready signal, the control device sends the first running signal to each chromatography-mass spectrometer through multiple output interfaces, thereby controlling each chromatography-mass spectrometer to enter the pre-running state.

[0077] Specifically, after the sample pretreatment platform receives the chromatogram and mass spectrometer ready status, it sends out the SWOut-2 signal to put the chromatogram and mass spectrometer into the pre-running state.

[0078] Step 608: The sample pretreatment platform picks up samples from multiple chromatography-mass spectrometers, injects them into the multiple chromatography-mass spectrometers, sends an injection completion signal to the control device, sends a second running signal to each chromatography-mass spectrometer, and controls each chromatography-mass spectrometer to enter the sample analysis state.

[0079] Specifically, the sample preparation platform begins the sample preparation process, cleans the injection needle, aspirates the sample and injects it into the chromatography-mass spectrometer. After the injection is completed, it sends an injection completion signal to the control device. In response to the injection completion signal, the control device sends a second running signal to each chromatography-mass spectrometer to trigger the operation of the chromatography-mass spectrometer.

[0080] The control device connects to the pretreatment injection platform to split its synchronization signal. Specifically, one set of input signals (TTL-In digital I / O, 5V) from the pretreatment injection platform is output by the control device's logic circuit as two sets of input signals (TTL-In-1, TTL-In-2 digital I / O, 5V). The two sets of output signals SWOut-1 / SWOut-2 from the pretreatment injection platform are closed, and the control device's logic circuit outputs four sets of output signals SWOut-1 / SWOut-2, SWOut-3 / SWOut-4, with the contacts closed. The pretreatment injection platform's synchronization signal is connected to the control device's interface port, and the two sets of synchronization signals are output from the control device's Chromatography 1 and Chromatography 2 interfaces, respectively. The Chromatography 1 interface output signal is connected to the first chromatography-mass spectrometer, and the Chromatography 2 interface output signal is connected to the second chromatography-mass spectrometer. The control device is powered by a 24V power supply, which, after voltage conversion, outputs a 5V TTL-In signal. By ensuring that one set of TTL-In signals is split into two groups, the voltage and current are stable, and the triggering is stable. In addition, an extra DB9 (serial communication interface) interface needs to be reserved to provide two contact closures for backup.

[0081] In this embodiment, a single set of synchronization signals from the pretreatment injection platform is connected to a control device. The control device then splits this single set of synchronization signals into two sets, which are connected to multiple chromatography-mass spectrometers (GC-MS). The GC-MS operating status is read in real-time and fed back to the pretreatment injection platform. Upon receiving the GC-MS's ready status signal, the pretreatment injection platform first sends a ready signal to the control device. The control device then sends a first operating signal to each GC-MS. Simultaneously, the pretreatment injection platform picks up samples from each GC-MS and injects them into each GC-MS. After injection, it sends an injection completion signal to the control device, which then sends a second operating signal to each GC-MS, triggering the GC-MS to run. This method, by constructing a control device that acts as a communication relay between the pretreatment injection platform and the GC-MS, enables injection control for at least two GC-MS, overcoming the shortcomings of traditional methods that can only inject samples for one GC-MS, resulting in low injector efficiency and wasted resources.

[0082] It should be understood that although the steps in the flowcharts of the embodiments described above are shown sequentially according to the arrows, these steps are not necessarily executed in the order indicated by the arrows. Unless explicitly stated herein, there is no strict order restriction on the execution of these steps, and they can be executed in other orders. Moreover, at least some steps in the flowcharts of the embodiments described above may include multiple steps or multiple stages. These steps or stages are not necessarily completed at the same time, but can be executed at different times. The execution order of these steps or stages is not necessarily sequential, but can be performed alternately or in turn with other steps or at least some of the steps or stages of other steps.

[0083] In one embodiment, such as Figure 7 As shown, based on the same inventive concept, this application also provides a sample injection control device for implementing the sample injection control method described above. It includes: a first signal transmitting module 701, a sample aspiration module 702, and a second signal transmitting module 703, wherein:

[0084] The first signal transmitting module 701 is used to send readiness signals of multiple chromatography-mass spectrometers to the control device when it is determined that multiple chromatography-mass spectrometers are in a ready state; the control device is used to respond to each readiness signal and send a first running signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter the pre-running state.

[0085] The sample aspiration module 702 is used to aspirate samples from each chromatography-mass spectrometer and inject them into each chromatography-mass spectrometer.

[0086] The second signal transmitting module 703 is used to send an injection completion signal to the control device after the sample injection to each chromatography-mass spectrometer is completed; the control device is used to respond to the injection completion signal and send a second running signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter the sample analysis state.

[0087] In one embodiment, the first signal transmitting module 701 is further configured to receive the operating status information of each chromatography-mass spectrometer returned by the control device; and determine whether each chromatography-mass spectrometer is in a ready state based on the operating status information.

[0088] In one embodiment, the first signal transmitting module 701 is further configured to simultaneously transmit readiness signals of multiple chromatographs / mass spectrometers to the control device; or, sequentially transmit readiness signals of multiple chromatographs / mass spectrometers to the control device.

[0089] In one embodiment, the first signal transmitting module 701 is further configured to send an injection completion signal to the control device after completing the sample injection to any one of the chromatography-mass spectrometers; the control device is configured to respond to the injection completion signal by sending a second operating signal to any one of the chromatography-mass spectrometers through the output interface corresponding to any one of the chromatography-mass spectrometers, so as to control any one of the chromatography-mass spectrometers to enter the sample analysis state.

[0090] In one embodiment, the first signal transmitting module 701 is further configured to control the device to reserve an additional set of interfaces for contact closure during the transmission of the first and second running signals.

[0091] Each module in the aforementioned sample injection control device can be implemented entirely or partially through software, hardware, or a combination thereof. These modules can be embedded in the processor of a computer device in hardware form or independent of it, or stored in the memory of a computer device in software form, so that the processor can call and execute the corresponding operations of each module.

[0092] In one exemplary embodiment, a computer device is provided, which may be a server, and its internal structure diagram may be as follows: Figure 8As shown, this computer device includes a processor, memory, input / output (I / O) interfaces, and a communication interface. The processor, memory, and I / O interfaces are connected via a system bus, and the communication interface is also connected to the system bus via the I / O interfaces. The processor provides computational and control capabilities. The memory includes non-volatile storage media and internal memory. The non-volatile storage media stores the operating system, computer programs, and a database. The internal memory provides the environment for the operation of the operating system and computer programs stored in the non-volatile storage media. The database stores control data for sample injection. The I / O interfaces are used for exchanging information between the processor and external devices. The communication interface is used for communication with external terminals via a network connection. When the computer program is executed by the processor, it implements a sample injection control method.

[0093] Those skilled in the art will understand that Figure 8 The structure shown is merely a block diagram of a portion of the structure related to the present application and does not constitute a limitation on the computer device to which the present application is applied. Specific computer devices may include more or fewer components than those shown in the figure, or combine certain components, or have different component arrangements.

[0094] In one exemplary embodiment, a computer device is provided, including a memory and a processor, wherein the memory stores a computer program, and the processor executes the computer program to implement the steps in the above-described method embodiments.

[0095] In one embodiment, a computer-readable storage medium is provided having a computer program stored thereon, which, when executed by a processor, implements the steps in the above method embodiments.

[0096] In one embodiment, a computer program product is provided, including a computer program that, when executed by a processor, implements the steps in the above method embodiments.

[0097] It should be noted that the user information (including but not limited to user device information, user personal information, etc.) and data (including but not limited to data used for analysis, data stored, data displayed, etc.) involved in this application are all information and data authorized by the user or fully authorized by all parties, and the collection, use and processing of the relevant data must comply with relevant regulations.

[0098] Those skilled in the art will understand that all or part of the processes in the above embodiments can be implemented by a computer program instructing related hardware. The computer program can be stored in a non-volatile computer-readable storage medium. When executed, the computer program can include the processes of the embodiments described above. Any references to memory, databases, or other media used in the embodiments provided in this application can include at least one of non-volatile and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory, optical memory, high-density embedded non-volatile memory, resistive random access memory (ReRAM), magnetic random access memory (MRAM), ferroelectric random access memory (FRAM), phase change memory (PCM), graphene memory, etc. Volatile memory can include random access memory (RAM) or external cache memory, etc. By way of illustration and not limitation, RAM can take many forms, such as Static Random Access Memory (SRAM) or Dynamic Random Access Memory (DRAM). The databases involved in the embodiments provided in this application may include at least one type of relational database and non-relational database. Non-relational databases may include, but are not limited to, blockchain-based distributed databases. The processors involved in the embodiments provided in this application may be general-purpose processors, central processing units, graphics processing units, digital signal processors, programmable logic devices, quantum computing-based data processing logic devices, etc., and are not limited to these.

[0099] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0100] The embodiments described above are merely illustrative of several implementation methods of this application, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of this patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these all fall within the protection scope of this application. Therefore, the protection scope of this application should be determined by the appended claims.

Claims

1. A method for controlling sample injection, characterized in that, The method includes: The system receives the operating status information of each chromatography-mass spectrometer returned by the control device, and determines whether each chromatography-mass spectrometer is in a ready state based on the operating status information; the ready state includes that each chromatography-mass spectrometer has completed initialization, and that the temperature and pressure values ​​are stable. When multiple chromatography-mass spectrometers are confirmed to be in a ready state, a set of synchronization signals containing the ready information of the multiple chromatography-mass spectrometers is sent to the control device. The control device, in response to each ready signal, converts the received set of synchronization signals into multiple sets of synchronization signals and sends a first operating signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter a pre-operation state. The control device includes a set of serial interfaces; the serial interfaces are used to replace the faulty output interface when any output interface of the control device fails. Samples were aspirated from each chromatography-mass spectrometer and injected into each of the chromatography-mass spectrometers. After completing the sample injection into any one of the chromatography-mass spectrometers, an injection completion signal is sent to the control device. The control device is used to respond to the sample injection completion signal by sending a second operating signal to the chromatograph / mass spectrometer through the output interface corresponding to the chromatograph / mass spectrometer, so as to control the chromatograph / mass spectrometer to enter the sample analysis state.

2. The method according to claim 1, characterized in that, Sending a set of synchronization signals containing the readiness information of the multiple chromatography-mass spectrometers to the control device includes: Simultaneously, the readiness signals of the multiple chromatography-mass spectrometers are sent to the control device; Alternatively, the readiness signals of the multiple chromatography-mass spectrometers can be sent sequentially to the control device.

3. A sample injection control device, characterized in that, The device includes: A first signal transmitting module is used to send a set of synchronization signals containing the readiness information of multiple chromatography-mass spectrometers to a control device when it is determined that multiple chromatography-mass spectrometers are in a ready state. The control device is used to respond to each ready signal by converting the received set of synchronization signals into multiple sets of synchronization signals, and sending a first operating signal to each chromatography-mass spectrometer through multiple output interfaces to control each chromatography-mass spectrometer to enter a pre-operation state. The control device includes a set of serial interfaces; the serial interfaces are used to replace the faulty output interface when any output interface of the control device fails. The sample aspiration module is used to aspirate samples from each chromatography-mass spectrometer and inject them into each of the chromatography-mass spectrometers. The first signal transmitting module is further configured to send an injection completion signal to the control device after completing the sample injection to any one of the chromatography-mass spectrometers; the control device is configured to respond to the injection completion signal by sending a second operating signal to any one of the chromatography-mass spectrometers through the output interface corresponding to any one of the chromatography-mass spectrometers, so as to control any one of the chromatography-mass spectrometers to enter the sample analysis state.

4. The apparatus according to claim 3, characterized in that, The first signal transmitting module is also used to simultaneously transmit the readiness signals of multiple chromatographs and mass spectrometers to the control device; or, to sequentially transmit the readiness signals of multiple chromatographs and mass spectrometers to the control device.

5. The apparatus according to claim 3, characterized in that, The first signal transmitting module is further configured to send an injection completion signal to the control device after completing the sample injection to any one of the chromatography-mass spectrometers; the control device is configured to respond to the injection completion signal by sending a second operating signal to any one of the chromatography-mass spectrometers through the output interface corresponding to any one of the chromatography-mass spectrometers, so as to control any one of the chromatography-mass spectrometers to enter the sample analysis state.

6. The apparatus according to claim 3, characterized in that, The first signal transmitting module is also used to control the device to reserve an additional set of interfaces for contact closure during the transmission of the first and second operating signals.

7. A control device, characterized in that, The control device includes multiple output interfaces and one input interface. The input interface is connected to the sample pretreatment platform circuit, and the multiple output interfaces are respectively connected to a chromatography-mass spectrometer circuit. The control device is used to receive ready signals from multiple chromatography-mass spectrometers sent by the pretreatment injection platform through the input interface, and in response to each ready signal, send a first running signal to each chromatography-mass spectrometer through the multiple output interfaces to control each chromatography-mass spectrometer to enter the pre-running state; the ready signal is sent by the pretreatment injection platform when it determines that multiple chromatography-mass spectrometers are in the ready state. The control device is also used to receive the injection completion signal sent by the pretreatment injection platform through the input interface, and in response to the injection completion signal, send a second running signal to each of the chromatography-mass spectrometers through the multiple output interfaces to control each of the chromatography-mass spectrometers to enter the sample analysis state; the injection completion signal is sent by the pretreatment injection platform after completing the sample injection to each of the chromatography-mass spectrometers.

8. A computer device comprising a memory and a processor, wherein the memory stores a computer program, characterized in that, When the processor executes the computer program, it implements the steps of the method of claim 1 or 2.

9. A computer-readable storage medium having a computer program stored thereon, characterized in that, When the computer program is executed by a processor, it implements the steps of the method of claim 1 or 2.

10. A computer program product, comprising a computer program, characterized in that, When the computer program is executed by a processor, it implements the steps of the method of claim 1 or 2.

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