High-safety vertebral artery drug stent

Abstract

The application discloses a high-safety vertebral artery drug stent which comprises a stent body and a drug coating, the drug coating is uniformly coated on the surface of the stent body, the stent body comprises a front end supporting part and a rear end supporting part, the front end supporting part and the rear end supporting part are distributed along the direction from narrow to wide of the vertebral artery, the front end supporting part and the rear end supporting part are respectively in tubular distribution, the front end supporting part comprises a front support body, a short connecting rib and a traction rib, the front support bodies are in longitudinal stacked distribution, the front support bodies are fixedly connected with the short connecting ribs between the front support bodies, the connecting ribs are fixedly connected with the traction ribs in the connecting ribs, and the rear end supporting part comprises a rear support body and a long connecting rib. The stent body is composed of the front end supporting part and the rear end supporting part with different densities, targeted support can be conveniently carried out according to the characteristics that the front end of the vertebral artery is relatively narrow and the rear end is relatively wide, and the surface of the stent body is uniformly coated with the drug, so that the excessive proliferation of vascular endothelial cells can be effectively inhibited, and the safety and long-acting property of treatment are improved.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a highly safe vertebral artery drug-eluting stent. Background Technology

[0002] Vascular disease is one of the three leading causes of death in humans. Among cerebrovascular diseases, ischemic stroke accounts for approximately 80%, and cerebral vascular stenosis is the most significant cause. The vertebral artery is one of the most important cerebral blood vessels, providing an indispensable blood supply to the brain. However, vertebral artery stenosis or occlusion can lead to cerebral ischemia, which can be life-threatening in severe cases. Traditional treatments include surgical resection or drug therapy, but these methods have certain risks and limitations. Stenosis at the origin of the vertebral artery accounts for 25% to 40% of all cerebral vascular stenosis cases. Drug therapy cannot reverse the morphological changes already caused, and this area is unsuitable for surgery due to the high technical difficulty and risks involved. With the development of stent technology, vertebral artery stenting has become an effective method for treating vertebral artery stenosis or occlusion.

[0003] Currently, vertebral artery stents on the market typically employ a uniform overall structural design, adjusting only according to variations in the width or shape of the vertebral artery. Because the anterior end of the vertebral artery is relatively narrow, the stent tip is easily subjected to significant compressive force during insertion. This can lead to deformation of the stent tip over prolonged use, affecting blood flow in the vertebral artery. Furthermore, the stent is prone to displacement under pressure, impacting the stability and long-term effectiveness of the treatment. Therefore, a highly safe vertebral artery drug-eluting stent is proposed. Summary of the Invention

[0004] (a) Technical problems to be solved

[0005] To address the shortcomings of existing technologies, this invention provides a high-safety vertebral artery drug-eluting stent that solves the problem that existing vertebral artery stents are prone to deformation and displacement due to excessive compressive force at the anterior end during use. The stent body is composed of an anterior and posterior support portion of different densities, allowing for targeted support tailored to the narrower anterior and wider posterior ends of the vertebral artery. This improves the stability and strength of the stent body's support for the vertebral artery. Furthermore, the stent body is uniformly coated with medication, which effectively inhibits excessive proliferation of vascular endothelial cells, enhancing the safety and long-term effectiveness of vertebral artery treatment.

[0006] (II) Technical Solution

[0007] To achieve the above objectives, the present invention is realized through the following technical solution: a high-safety vertebral artery drug-eluting stent, comprising a stent main body and a drug coating, wherein the drug coating is uniformly applied on the surface of the stent main body, the stent main body includes a front support portion and a rear support portion, the front support portion and the rear support portion are distributed along the direction from the narrow section to the wide section of the vertebral artery, the front support portion and the rear support portion are each distributed in a tubular shape, the front support portion includes front supports, short connecting ribs and traction ribs, the front supports are distributed in a longitudinally stacked manner, short connecting ribs are fixedly connected between the front supports, a traction rib is fixedly connected inside the short connecting ribs, the rear support portion includes rear supports and long connecting ribs, the rear supports are distributed in parallel, and the long connecting ribs are fixedly connected between the rear supports.

[0008] As a further preferred embodiment of the present invention, the front supports extend sequentially in a sine wave shape, and the rear supports extend sequentially in a cosine wave shape.

[0009] As a further preferred embodiment of the present invention, connecting portions are respectively provided on both sides of the traction rib, and the connecting portions are respectively and fixedly connected to the short connecting ribs on both sides.

[0010] As a further preferred embodiment of the present invention, the short connecting ribs are V-shaped and fixedly connected between two adjacent front supports, and both ends of each short connecting rib are respectively and fixedly connected to the wave peak of a front support and the wave trough of the adjacent front support.

[0011] As a further preferred embodiment of the present invention, elastic connecting portions are respectively provided at the vertexes of the front supports, and the elastic connecting portions are distributed in a semicircular shape.

[0012] As a further preferred embodiment of the present invention, the long connecting rib is composed of a deformable portion and a tension portion, the deformable portion is distributed in an "ω" shape, and the tension portion is in a straight line shape with both ends fixedly connected to the deformable portion and the rear support.

[0013] As a further preferred embodiment of the present invention, the stent main body is made of a material with high biocompatibility and high mechanical strength, and the stent main body is made of one of titanium alloy, cobalt-chromium alloy or stainless steel.

[0014] As a further preferred embodiment of the present invention, the drug coating is nifedipine or atorvastatin.

[0015] (3) Beneficial Effects

[0016] The present invention provides a high-safety vertebral artery drug-eluting stent. The following beneficial effects are achieved:

[0017] 1. This invention utilizes front-end and rear-end support parts of different densities to form the stent body, which facilitates targeted support based on the characteristics of the vertebral artery, which is narrower at the front end and wider at the rear end. This improves the stability and strength of the stent body in supporting the vertebral artery. Furthermore, the stent body is uniformly coated with medication, which can effectively inhibit the excessive proliferation of vascular endothelial cells and improve the safety and long-term effectiveness of vertebral artery treatment.

[0018] 2. The present invention provides traction ribs in the front support section, which facilitates the increase of tension on the short connecting ribs in the front support section after the rear support section is deployed, thereby making the front support section more compact and avoiding deformation of the front support section due to large compression force from blood vessels, thus improving the stability of the stent body.

[0019] 3. The present invention provides a relatively stable elastic support between the rear supports by providing an “ω”-shaped deformation part and an “I”-shaped tension part inside the rear support part, ensuring the stability of the connection between the rear supports. Moreover, by using a self-expanding elastic structure, it can ensure that the rear support part fits tightly with the inner wall of the blood vessel, preventing the stent body from shifting. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the overall structure of the high-safety vertebral artery drug-eluting stent of the present invention;

[0021] Figure 2 This is a side view of the main body of the bracket of the present invention;

[0022] Figure 3 This is a schematic diagram of the front support portion of the present invention;

[0023] Figure 4 This is a schematic diagram of the structure of the front support body of the present invention;

[0024] Figure 5 This is a schematic diagram of the structure of the rear support part of the present invention.

[0025] In the diagram: 1. Scaffold body - 2. Drug coating - 3. Front support - 4. Rear support - 5. Front support - 6. Short connecting rib - 7. Traction rib - 8. Rear support - 9. Long connecting rib - 10. Connecting part - 11. Elastic connecting part - 12. Deformation part - 13. Tension part - 14. Detailed Implementation

[0026] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0027] Please see Figure 1-5 This invention provides a technical solution: a high-safety vertebral artery drug-eluting stent, comprising a stent body 1 and a drug coating 2. The drug coating 2 is uniformly applied to the surface of the stent body 1. The stent body 1 includes a front support portion 3 and a rear support portion 4, which are distributed along the vertebral artery from narrow to wide. The front support portion 3 and the rear support portion 4 are respectively tubularly distributed. The front support portion 3 includes an anterior support body 5, short connecting ribs 6, and traction ribs 7. The anterior support bodies 5 are longitudinally stacked, and short connecting ribs 6 are fixedly connected to each other. Traction ribs 7 are fixedly connected inside the short connecting ribs 6. The rear support portion 4 includes a posterior support body 8 and long connecting ribs 9, which are parallel to each other. The long connecting ribs 9 are fixedly connected to each other in the posterior support body 8.

[0028] The present invention provides a traction rib 7 in the front support part 3, which facilitates the increase of tension on the short connecting rib 6 in the front support part 3 after the rear support part 4 is unfolded, thereby making the front support part 3 more compact, avoiding deformation of the front support part 3 due to large compression force from blood vessels, and improving the stability of the stent body 1 in use.

[0029] Further improvements include the front support 5 extending in a sinusoidal wave pattern and the rear support 8 extending in a cosine wave pattern. By adopting a sinusoidal distribution for the front support 5 and a cosine wave distribution for the rear support 8, it is convenient to align the peaks of the front support 5 with the troughs of the rear support 8. This facilitates the use of the elastic support of the rear support 8 to pull the traction ligament 7, thereby ensuring the stability of the front support 3 and preventing the narrower segment of the vertebral artery from compressing and deforming the stent body 1.

[0030] In a further improvement, the traction rib 7 is provided with connecting parts 10 on both sides, and the connecting parts 10 are fixedly connected to the short connecting ribs 6 on both sides. By providing connecting parts 10 fixedly connected to the short connecting ribs 6 on both sides of the traction rib 7, it is convenient to push the short connecting ribs 6 to move to both sides when the traction rib 7 is pulled, so that the front support body 5 can squeeze each other, thereby ensuring the tightness of the front support part 3 and enhancing the support strength of the bracket body 1.

[0031] In a further improvement, the short connecting rib 6 is V-shaped and fixedly connected between two adjacent front support bodies 5. The two ends of the short connecting rib 6 are fixedly connected to the crest of the front support body 5 and the trough of the adjacent front support body 5, respectively. By providing V-shaped short connecting ribs 6 at the crest and trough of the two adjacent front support bodies 5, the tightness of the front support part 3 is improved, and the support stability of the front support part 3 at the narrow vertebral artery is enhanced.

[0032] Further improvements include providing elastic connecting portions 11 at the apex of the front support body 5. The elastic connecting portions 11 are distributed in a semi-circular shape. By providing semi-circular elastic connecting portions 11 at the apex of the front support body 5, the elasticity of the front support body 5 is improved, which facilitates the storage of greater elastic potential energy when the main body 1 of the stent is contracted, greatly enhancing the stability of the front support after expansion and facilitating effective support for the vertebral artery.

[0033] In a further improvement, the long connecting rib 9 is composed of a deformable part 12 and a tensile part 13. The deformable part 12 is distributed in a "ω" shape, and the tensile part 13 is in a "I" shape with both ends fixedly connected to the deformable part 12 and the rear support body 8. By providing the "ω" shaped deformable part 12 and the "I" shaped tensile part 13, it is convenient to provide elastic support for the rear support body 8, ensuring the stability of the connection of the rear support part 4, while ensuring the looseness of the rear support part 4, increasing the tension at the connection between the rear support part 4 and the blood vessel, and facilitating the effective fixation of the stent body 1.

[0034] Further improvements include the use of a biocompatible and mechanically strong material for the support body 1. The support body 1 is made of a material selected from titanium alloy, cobalt-chromium alloy, or stainless steel. By using a biocompatible and mechanically strong material to make the support body 1, the structural strength and stability of the support body 1 are improved.

[0035] Specifically, the drug coating 2 is nifedipine or atorvastatin, which inhibits the excessive proliferation of vascular endothelial cells, reduces the risk of excessive endothelial growth of the stent body 1, and improves the stability of the stent body 1 in supporting the vertebral artery.

[0036] In use, the stent body 1 is contracted and stretched to fix it to the surface of the guidewire. The stent body 1 is then inserted into the vertebral artery using the guidewire. After the stent body 1 detaches from the guidewire, it automatically expands under the elastic force of the anterior support 5 and the posterior support 8. The elastic potential energy stored in the long connecting rib 9 provides stable support to the posterior support 4. As the posterior support 4 expands, the short connecting rib 6 in the anterior support 3 is pulled by the traction rib 7, causing the anterior support 5 to be squeezed together and brought closer, leaving a small gap in the anterior support 3. This ensures the compressive strength of the anterior support 3 and improves the stability of the stent body 1 installed in the vertebral artery. Furthermore, the drug coating 2 on the surface of the stent body 1 can effectively inhibit the excessive proliferation of vascular endothelial cells, improving the safety and long-term effectiveness of vertebral artery treatment.

[0037] The problem addressed by this invention is that vertebral artery stents on the market typically employ a uniform overall structural design, adjusting only according to variations in the width or shape of the vertebral artery. Because the anterior end of the vertebral artery is relatively narrow, the anterior end is easily subjected to significant compressive force during stent placement. This can lead to deformation of the stent's anterior end over prolonged use, affecting blood flow in the vertebral artery. Furthermore, it can easily displace under pressure, impacting the stability and long-term effectiveness of the stent in vertebral artery treatment. This invention utilizes an anterior support portion 3 and a posterior support portion 4 of varying densities to form the stent body 1. This allows for targeted support based on the narrow anterior end and wide posterior end of the vertebral artery, improving the stability and strength of the stent body 1 in supporting the vertebral artery. Additionally, a drug coating 2 is uniformly applied to the surface of the stent body 1, effectively inhibiting excessive proliferation of vascular endothelial cells and enhancing the safety and long-term effectiveness of vertebral artery treatment.

[0038] In the description of this invention, it should be understood that the terms "coaxial," "bottom," "one end," "top," "middle," "other end," "upper," "side," "top," "inner," "front," "center," "both ends," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limiting this invention.

[0039] Furthermore, the terms "first," "second," "third," and "fourth" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first," "second," "third," or "fourth" may explicitly or implicitly include at least one of those features.

[0040] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "setting," "connection," "fixing," "screw connection," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal connection of two components or the interaction between two components. Unless otherwise explicitly limited, those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0041] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A high-safety vertebral artery drug-eluting stent, comprising a stent body (1) and a drug coating (2), characterized in that: The drug coating (2) is uniformly applied on the surface of the stent main body (1). The stent main body (1) comprises a front support portion (3) and a rear support portion (4), which are distributed along the direction of the vertebral artery from narrow to wide. The front support portion (3) and the rear support portion (4) are each distributed in a tubular shape. The front support portion (3) includes front supports (5), short connecting ribs (6) and traction ribs (7). The front supports (5) are distributed in a longitudinally stacked manner. Short connecting ribs (6) are fixedly connected between adjacent front supports (5). The traction ribs (7) are fixedly connected inside the short connecting ribs (6). The rear support portion (4) includes rear supports (8) and long connecting ribs (9). The rear supports (8) are distributed in parallel. The long connecting ribs (9) are fixedly connected between adjacent rear supports (8). The front supports (5) extend sequentially in a sinusoidal wave shape, and the rear supports (8) extend sequentially in a cosinusoidal wave shape. Two sides of the traction rib (7) are respectively provided with connecting portions (10), which are respectively and fixedly connected to the short connecting ribs (6) on both sides. The short connecting rib (6) is V-shaped and fixedly connected between two adjacent front supports (5), and two ends of the short connecting rib (6) are respectively and fixedly connected to the wave crest of a front support (5) and the wave trough of the adjacent front support (5).

2. The high-safety vertebral artery drug-eluting stent according to claim 1, characterized in that: Elastic connecting portions (11) are respectively provided at the vertexes of the front supports (5), and the elastic connecting portions (11) are distributed in a semicircular shape.

3. The high-safety vertebral artery drug-eluting stent according to claim 1, characterized in that: The long connecting rib (9) consists of a deformation portion (12) and a tension portion (13). The deformation portion (12) is distributed in an "ω" shape, and the tension portion (13) is in a straight line shape with two ends fixedly connected to the deformation portion (12) and the rear support (8).

4. The high-safety vertebral artery drug-eluting stent according to claim 1, characterized in that: The stent main body (1) is made of one of titanium alloy, cobalt-chromium alloy or stainless steel.

5. The high-safety vertebral artery drug-eluting stent according to claim 1, characterized in that: The drug coating (2) is nifedipine or atorvastatin.

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