一种具有取向仿生、自供能特性的双层神经导管及其制备方法
The bilayer nerve conduit formed by electrospun PCL/CNTs and PVA/Gly hydrogel modified with tannic acid solves the problems of inflammation and external power dependence of existing materials, and achieves self-powered and directional nerve regeneration.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- FUZHOU UNIV
- Filing Date
- 2023-10-12
- Publication Date
- 2026-07-17
AI Technical Summary
Existing nerve repair materials have problems such as inflammation caused by implanted electrodes, the need for secondary surgery to remove them, and dependence on external power stimulation. In addition, there is a lack of catheter materials with self-powered characteristics.
Electrospun membranes PCL/CNTs are used as the inner conduit, and the outer layer is a tannic acid-modified barium titanate PVA/Gly hydrogel. A double-layer nerve conduit is formed through physical entanglement and non-covalent bonds. The conductive material in the inner layer can transmit electrical signals, and the hydrogel in the outer layer generates electrical stimulation under nerve contraction and muscle compression.
It achieves self-powered characteristics without external power supply, promotes nerve regeneration, provides directional guidance, improves biocompatibility and electrical signal output performance, supports nerve cell adhesion and climbing, and prevents scaffold collapse.
Smart Images
Figure CN117323467B_ABST