一种4,7-二氮杂螺[2.5]辛烷-4-甲酸叔丁酯的制备方法

By optimizing the synthetic route of tert-butyl 4,7-diazaspiro[2.5]octane-4-carboxylate, this key intermediate was prepared through a six-step reaction based on inexpensive and readily available raw materials and reagents, solving the problems of high cost and low yield in the existing technology, and realizing efficient and environmentally friendly industrial production.

CN117343019BActive Publication Date: 2026-07-17JIAOZUO WOEN BIOTECHNOLOGY CO LTD
View PDF 6 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIAOZUO WOEN BIOTECHNOLOGY CO LTD
Filing Date
2022-06-29
Publication Date
2026-07-17

Smart Images

  • Figure QLYQS_1
    Figure QLYQS_1
  • Figure BDA0003721106270000011
    Figure BDA0003721106270000011
  • Figure BDA0003721106270000021
    Figure BDA0003721106270000021
Patent Text Reader

Abstract

本发明实施例提供了一种4,7‑二氮杂螺[2.5]辛烷‑4‑甲酸叔丁酯的制备方法，该方法是一种新的Risdiplam关键中间体的制备方法，以α‑溴‑γ‑丁内酯为起始物料，经过成环、脱保护、溴化、关环、还原以及脱苄，共经过六步反应最后得到该Risdiplam关键中间体，该制备路线原料便宜易得，工艺操作简单，收率高，适合商业化生产。
Need to check novelty before this filing date? Find Prior Art