一种管式连续亚微通道微气泡生物反应器

By using a tubular continuous submicrochannel microbubble bioreactor, microbubbles are prepared using a rotating impeller and a fluid oscillator, which solves the problems of large-scale bioreactors and low mass and heat transfer efficiency, achieving continuous and miniaturized production, reducing production costs and improving safety.

CN117343835BActive Publication Date: 2026-07-17NANJING TECH UNIV

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING TECH UNIV
Filing Date
2023-11-08
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing bioreactors are large-scale and have low mass and heat transfer efficiency, resulting in high production costs and safety hazards, making it difficult to achieve continuous and miniaturized production.

Method used

A tubular continuous submicrochannel microbubble bioreactor, combined with a rotating impeller, a fluid oscillator, and a submicrochannel static mixer, is used to prepare microbubbles and enhance fluid mixing, prevent backmixing, and improve mass and heat transfer efficiency.

Benefits of technology

It enables continuous and miniaturized bioreactors, reduces production costs, and improves safety and mass transfer efficiency, and is suitable for gas-liquid two-phase and gas-liquid-solid three-phase reactions.

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Abstract

本发明提供了一种管式连续亚微通道微气泡生物反应器,包括依次连接的控制罐、料液循环蠕动泵、微气泡发生器、流体振荡器、亚微管道静态混合器,微气泡发生器包括旋转叶轮,旋转叶轮包括叶轮盖和叶轮主体,叶轮主体包括一体成型的微气泡发生板和环形侧板,微气泡发生板的上端面上设有气液流道,在气液流道外周侧设有填料槽,填料槽与气液流道连通,环形侧板箍设在微气泡发生板上,在环形侧板上均布有多个通孔,通孔与填料槽连通;在微气泡发生板和叶盖上相对设有多个螺栓孔,叶轮盖和叶轮主体通过螺栓连接,叶轮盖的中部向上凸起形成环形凸台,在环形凸台中部设有与气体或蒸汽进口。本发明提的生物反应器体量小,制造成本低且安全性能高。
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