A terahertz refractive index-rotational power co-optical path combined detection method, system and application based on quantum weak value amplification effect

The terahertz refractive index-optical rotation co-path joint detection method based on the quantum weak value amplification effect solves the problem of the inability to measure chiral drugs with high sensitivity in the existing technology, realizes the joint high-sensitivity measurement of refractive index and optical rotation, and improves the detection sensitivity.

CN117347315BActive Publication Date: 2026-07-21SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
Filing Date
2023-08-23
Publication Date
2026-07-21

AI Technical Summary

Technical Problem

Existing terahertz time-domain spectroscopy systems cannot achieve highly sensitive joint measurement of the refractive index and optical rotation of chiral drugs in biomedical detection due to insufficient sensitivity.

Method used

A terahertz refractive index-optical rotation joint detection method based on the quantum weak value amplification effect is adopted. By utilizing first and second polarizers, terahertz time-domain spectral unit, joint optical path measurement unit and quantum weak value joint detection calculation unit, a quantum weak measurement frequency domain transfer model is constructed through quantum before and after state selection and secondary joint optical path weak coupling to realize the joint measurement of refractive index and optical rotation.

Benefits of technology

Without changing the optical path, the detection sensitivity is significantly improved, enabling highly sensitive measurement of the refractive index and optical rotation of the analyte. The sensitivity is increased by 2-3 orders of magnitude, enabling trace detection.

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Abstract

The application discloses a terahertz refractive index-rotatory power common-path joint detection method and system based on a quantum weak value amplification effect and application, the detection method comprises the following steps: front selection, an incident terahertz wave emitted by a terahertz time-domain spectrum unit is selected by a first polarizer to be a quantum front selection state; back selection, a polarization state selected by a second polarizer is a quantum back selection state; before measurement, the quantum back selection state and the quantum front selection state are orthogonal to each other; twice common-path joint weak coupling, the terahertz wave and a sample to be measured on a common-path joint measurement unit are sequentially weakly coupled twice; the application utilizes the high-sensitivity characteristics of the quantum weak measurement amplification signal without amplifying technical noise, utilizes a common-path joint measurement mode, refractive indexes and rotatory powers of the measured chiral drugs can be jointly high-sensitivity measured without changing an optical path, and high-sensitivity conformation identification of the chiral drugs is realized.
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