A composite emulsifiable concentrate containing fluridone and a method of preparing the same

Abstract

This application relates to the field of pesticide technology, specifically disclosing a compound emulsifiable concentrate containing clodinafop-propargyl and its preparation method. The compound emulsifiable concentrate of this application comprises the following components in parts by weight: 79.4-87.4 parts of clodinafop-propargyl technical, 18.7-22.7 parts of clodinafop-propargyl technical, 284-308 parts of thickener, 196-204 parts of emulsifier, 144-156 parts of vegetable oil, 8-12 parts of co-solvent, and 521.9-529.9 parts of solvent oil. The thickener in this application increases the total amount of clodinafop-propargyl retained on the leaf surface of the emulsion, helping to retain more clodinafop-propargyl molecules after high-pressure mercury lamp irradiation, thereby reducing the impact of high-pressure mercury lamps and improving the weed control efficacy of clodinafop-propargyl.

Description

Technical Field

[0001] This application relates to the field of pesticide technology, and more specifically, to a compound emulsifiable concentrate containing chlorpyrifos and a method for preparing the same. Background Technology

[0002] Emulsifiable concentrates (ECs) are one of the main formulations of pesticides. They are oily liquids made by dissolving the active ingredient of a pesticide in an organic solvent in a certain proportion, adding a certain amount of emulsifier, and then stirring with water to form a relatively stable emulsion. Clothiamethoxam is a herbicide mainly absorbed through the leaves and leaf sheaths of plants. It has a good killing effect on grass weeds and is often mixed with the safener chlorpyrifos to formulate ECs. Chlorpyrifos can reduce the toxicity of clothiamethoxam to cereal crops, thus achieving selective protection for cereal crops.

[0003] One related technology contains a compound emulsifiable concentrate containing clodinafop-propargyl, comprising the following components by weight: 79.4 parts clodinafop-propargyl technical grade, 18.7 parts clodinafop-propargyl technical grade, 196 parts emulsifier, 144 parts vegetable oil, 8 parts cosolvent, and 521.9 parts solvent oil. The vegetable oil is soybean oil, the cosolvent is anhydrous fast T, the solvent oil is 200# solvent oil, and the emulsifier is a mixture of lauryl polyoxyethylene ether and polyethylene glycol fatty acid ester in a 1:2 weight ratio.

[0004] Regarding the aforementioned technologies, the inventors believe that while emulsions formulated with emulsifiable concentrates can achieve a certain weed-control effect, the irradiation from high-pressure mercury lamps easily accelerates the degradation of clodinafop-propargyl. For farmland requiring high-pressure mercury lamps for insect control, the irradiation from these emulsions will increase the loss of clodinafop-propargyl, thus making it difficult to achieve the desired weed control effect. Summary of the Invention

[0005] In farmland where high-pressure mercury lamps are frequently used for pest control, the application of emulsions formulated with clodinafop-propargyl emulsifiable concentrates in related technologies results in the loss of clodinafop-propargyl due to the irradiation from the high-pressure mercury lamps, making it difficult to achieve the desired weed control effect. To overcome this deficiency, this application provides a compound emulsifiable concentrate containing clodinafop-propargyl and its preparation method.

[0006] In a first aspect, this application provides a compound emulsifiable concentrate containing methylparaben, employing the following technical solution:

[0007] A compound emulsifiable concentrate containing clodinafop-propargyl, the emulsifiable concentrate comprising the following components in parts by weight: 79.4-87.4 parts of clodinafop-propargyl technical, 18.7-22.7 parts of clodinafop-propargyl technical, 284-308 parts of thickener, 196-204 parts of emulsifier, 144-156 parts of vegetable oil, 8-12 parts of cosolvent, and 521.9-529.9 parts of solvent oil, wherein the thickener is composed of wollastonite whiskers and a thickening copolymer, and the monomers for preparing the thickening copolymer include acrylamide and sodium 2-acrylamido-2-phenylethanesulfonate.

[0008] By adopting the above technical solution, the difference between this application and related technologies lies in the fact that wollastonite whiskers and thickening copolymers are mixed to form a thickening agent, which is then added to the emulsifiable concentrate formulation. When the emulsifiable concentrate of this application is stirred with water, the sodium sulfonate groups on the side chains of the thickening copolymer ionize, generating sulfonate ions on the side chains. Sulfonate ions can electrostatically adsorb calcium ions on the surface of wollastonite whiskers. Since sulfonate ions exist in multiple side chains of the thickening copolymer, one molecule of the thickening copolymer can simultaneously adsorb onto multiple wollastonite whiskers, thereby forming a structure linked by thickening copolymer molecules between the suspended wollastonite whiskers. This thickens the emulsion and increases the total amount of clodinafop-propargyl retained on the leaf surface. Under the condition of constant high-pressure mercury lamp irradiation intensity and time, the increase in the total amount of clodinafop-propargyl retained allows more clodinafop-propargyl molecules to be retained after irradiation, thereby reducing the impact of high-pressure mercury lamps and improving the weed control efficacy of clodinafop-propargyl.

[0009] Preferably, the thickening copolymer is prepared according to the following method:

[0010] (1) Mix the monomer and deionized water and adjust the pH to 11 to obtain a monomer dispersion; the monomer dispersion contains 25% monomer by mass.

[0011] (2) Nitrogen gas is introduced into the monomer dispersion and an initiator is added. The mixture is heated at 55°C for 10 hours. After cooling down to 20°C, the mixture is discharged, cut, dried and pulverized to obtain the thickener.

[0012] By adopting the above technical solution, this application has optimized the preparation method of the tackifying copolymer, which can realize the preparation of the tackifying copolymer.

[0013] Preferably, the molar ratio of acrylamide to sodium 2-acrylamido-2-phenylethanesulfonate in the monomer is (6-7):1.

[0014] By adopting the above technical solution, the composition ratio of different components in the monomer is optimized, which helps to improve the tackifying effect of the tackifier as much as possible while saving sodium 2-acrylamido-2-phenylethanesulfonate.

[0015] Preferably, the initiator is potassium persulfate, and the amount of the initiator is 0.15% of the monomer weight.

[0016] By adopting the above technical solution, the type and amount of initiator were optimized. Potassium persulfate achieves the initiation effect through the free radicals generated by its own decomposition, and the copolymerization reaction can be fully carried out with a dosage of 0.15%.

[0017] Preferably, the weight ratio of the wollastonite whiskers to the tackifying copolymer is (2.2-2.6):10.

[0018] By adopting the above technical solution, the weight ratio of wollastonite whiskers to tackifying copolymer is optimized, which helps to improve the tackifying effect of the tackifier.

[0019] Preferably, the emulsifier comprises lauryl polyoxyethylene ether, polyethylene glycol fatty acid ester, and fatty acids, wherein the fatty acids are unsaturated fatty acids, and the weight ratio of lauryl polyoxyethylene ether, polyethylene glycol fatty acid ester, and fatty acids is 1:2:(0.5-1).

[0020] By employing the above-mentioned technical solution, the total amount of wax on the leaf surface of grasses such as barnyard grass and crabgrass increases after exposure to ultraviolet radiation from high-pressure mercury lamps, making it more difficult for droplets to adhere. The wax on the surface of grass leaves contains a certain proportion of fatty acids. Including fatty acids as a component of the emulsifier can improve the compatibility between the emulsion and the waxy layer. Furthermore, the carboxyl groups of fatty acids can form hydrogen bonds in the emulsion. Emulsifiers containing fatty acids can improve the adhesion of emulsion droplets to the leaf surface, thus contributing to increased efficacy of clodinafop-propargyl against weeds.

[0021] Preferably, the unsaturated fatty acid contains conjugated double bonds in its molecule.

[0022] By adopting the above technical solution, the short-wave ultraviolet light generated by the high-pressure mercury lamp is the main reason why the high-pressure mercury lamp accelerates the degradation of clodinafop-propargyl. The unsaturated fatty acids containing conjugated double bonds have a good absorption effect on short-wave ultraviolet light, which helps to reduce the impact of high-pressure mercury lamp irradiation on the efficacy of clodinafop-propargyl.

[0023] Preferably, the unsaturated fatty acid is conjugated linoleic acid.

[0024] By adopting the above technical solution, conjugated linoleic acid has a maximum absorption wavelength at 232-234nm, while the maximum absorption wavelength of clodinafop-propargyl is 226nm, which is close to the maximum absorption wavelength of conjugated linoleic acid. Therefore, the use of conjugated linoleic acid helps to significantly reduce the absorption of short-wave ultraviolet light by clodinafop-propargyl, which is beneficial to improving the control efficacy of clodinafop-propargyl against weeds.

[0025] Preferably, the emulsifier further comprises calcium lignosulfonate, and the weight ratio of lauryl alcohol polyoxyethylene ether, polyethylene glycol fatty acid ester, fatty acid and calcium lignosulfonate is 1:2:0.5:0.5.

[0026] By adopting the above technical solution, calcium lignosulfonate has a certain absorption effect on short-wave ultraviolet light of 210-250nm. Moreover, calcium lignosulfonate can be recycled from papermaking waste. Using calcium lignosulfonate helps to reduce the impact of high-pressure mercury lamp irradiation on the efficacy of clodinafop-propargyl at a relatively low cost.

[0027] Secondly, this application provides a method for preparing a compound emulsifiable concentrate containing methyl methacrylate, using the following technical solution.

[0028] A method for preparing a compound emulsifiable concentrate containing chlorhexidine gluconate includes the following steps:

[0029] (1) Mix and stir the technical grade of clodinafop-propargyl, technical grade of clodinafop-propargyl, solubilizer, solvent oil and vegetable oil to obtain an oil-soluble solution;

[0030] (2) Mix the oil-soluble drug solution and emulsifier and continue stirring to obtain an emulsion base;

[0031] (3) Mix the thickener and the emulsion matrix to obtain a composite emulsifiable concentrate containing acetic acid ester.

[0032] By adopting the above technical solution, the method of this application first uses solvent oil and vegetable oil to dissolve the technical grade of clodinafop-propargyl and clodinafop-propargyl in the presence of a cosolvent to obtain an oil-soluble solution. Then, the oil-soluble solution is emulsified under the action of an emulsifier, and a thickener is added to obtain a composite emulsifiable concentrate containing clodinafop-propargyl.

[0033] In summary, this application has the following beneficial effects:

[0034] 1. This application introduces a thickener into the emulsifiable concentrate formulation system, which increases the total amount of clodinafop-propargyl in the emulsion and on the leaf surface. This helps to retain more clodinafop-propargyl molecules after high-pressure mercury lamp irradiation, thereby reducing the impact of high-pressure mercury lamps and improving the weed control efficacy of clodinafop-propargyl.

[0035] 2. In this application, fatty acids are preferred as emulsifiers. Using fatty acids as emulsifiers can improve the compatibility between the emulsion and the waxy layer, enhance the adhesion of emulsion droplets to the leaf surface, and help improve the weed control efficacy of clodinafop-propargyl. Detailed Implementation

[0036] The present application will be further described in detail below with reference to the embodiments, preparation examples and comparative examples. The raw materials involved in the present application can all be obtained commercially.

[0037] Preparation example of tackifying copolymer

[0038] The following explanation uses Preparation Example 1 as an example.

[0039] Preparation Example 1

[0040] In this preparation example, the tackifying copolymer was prepared according to the following method:

[0041] (1) Mix the monomer and deionized water and adjust the pH to 11 to obtain a monomer dispersion; the monomer dispersion contains 25% by mass; the monomer is a mixture of acrylamide and sodium 2-acrylamido-2-phenylethanesulfonate in a molar ratio of 7.5:1.

[0042] (2) Nitrogen gas is introduced into the monomer dispersion and an initiator is added. The mixture is heated at 55°C for 10 hours. After cooling down to 20°C, the mixture is discharged, cut, dried and crushed to obtain a thickener. The initiator is potassium persulfate and the amount of initiator is 0.15% of the monomer weight.

[0043] As shown in Table 1, the difference between Preparation Examples 1-5 lies in the different molar ratios of acrylamide and sodium 2-acrylamido-2-phenylethanesulfonate (hereinafter referred to as monomer molar ratios).

[0044] Table 1 Monomer Molar Ratio

[0045] sample Preparation Example 1 Preparation Example 2 Preparation Example 3 Preparation Example 4 Preparation Example 5 Monomer molar ratio 7.5:1 7:1 6.5:1 6:1 5.5:1 Example

[0046] Examples 1-5

[0047] The following description uses Example 1 as an example.

[0048] Example 1

[0049] This embodiment provides a compound emulsifiable concentrate containing clodinafop-propargyl, comprising the following components: 79.4 kg of clodinafop-propargyl technical, 18.7 kg of clodinafop-propargyl technical, 284 kg of thickener, 196 kg of emulsifier, 144 kg of vegetable oil, 8 kg of co-solvent, and 521.9 kg of solvent oil. The concentration of clodinafop-propargyl in the clodinafop-propargyl technical is 96%, and the concentration of clodinafop-propargyl in the clodinafop-propargyl technical is 97%. The thickener is a mixture of wollastonite whiskers and the thickening copolymer of Preparation Example 1 in a weight ratio of 2:10. The emulsifier is a mixture of lauryl polyoxyethylene ether, polyethylene glycol fatty acid ester, and fatty acid in a weight ratio of 1:2:1, and the fatty acid is (9Z,12Z)-9,12-octadecadienoic acid. The vegetable oil is soybean oil. The co-solvent is anhydrous fast T. The solvent oil is 200# solvent oil.

[0050] In this embodiment, the compound emulsifiable concentrate containing chlorhexidine gluconate was prepared according to the following steps:

[0051] (1) Mix and stir the technical grade of clodinafop-propargyl, technical grade of clodinafop-propargyl, solubilizer, solvent oil and vegetable oil to obtain an oil-soluble solution;

[0052] (2) Mix the oil-soluble drug solution and emulsifier and continue stirring to obtain an emulsion base;

[0053] (3) Mix the thickener and the emulsion matrix to obtain a composite emulsifiable concentrate containing acetic acid ester.

[0054] As shown in Table 2, the main difference between Examples 1-5 lies in the different raw material ratios.

[0055] Table 2

[0056] sample Clothiamethoxam technical grade / kg herbicides technical grade / kg Tackifier / kg Emulsifier / kg Vegetable oil / kg Cosolvent / kg Solvent oil / kg Example 1 79.4 18.7 284 196 144 8 521.9 Example 2 81.4 19.7 290 198 147 9 523.9 Example 3 83.4 20.7 296 200 150 10 525.9 Example 4 85.4 21.7 302 202 156 11 527.9 Example 5 87.4 22.8 308 204 156 12 529.9

[0057] Examples 6-9

[0058] As shown in Table 3, the difference between Examples 6-9 and Example 5 is that the preparation examples of the tackifying copolymers are different.

[0059] Table 3 Examples of preparation of tackifying copolymers

[0060] sample Example 5 Example 6 Example 7 Example 8 Example 9 Preparation Example Preparation Example 1 Preparation Example 2 Preparation Example 3 Preparation Example 4 Preparation Example 5

[0061] Examples 10-13

[0062] As shown in Table 4, the difference between Examples 10-13 and Example 9 is that the weight ratio of wollastonite whiskers to tackifying copolymer (hereinafter referred to as tackifier ratio) is different.

[0063] Table 4 Tackifier Proportions

[0064] sample Example 9 Example 10 Example 11 Example 12 Example 13 Tackifier ratio 2:10 2.2:10 2.4:10 2.6:10 2.8:10

[0065] Example 14

[0066] The difference between this embodiment and Embodiment 11 is that the fatty acid used in the emulsifier is conjugated linoleic acid.

[0067] Example 15

[0068] The difference between this embodiment and Embodiment 14 is that the emulsifier is a mixture of lauryl alcohol polyoxyethylene ether, polyethylene glycol fatty acid ester, conjugated linoleic acid and calcium lignosulfonate in a weight ratio of 1:2:0.75:0.25.

[0069] Example 16

[0070] The difference between this embodiment and Embodiment 15 is that the emulsifier is a mixture of lauryl alcohol polyoxyethylene ether, polyethylene glycol fatty acid ester, conjugated linoleic acid and calcium lignosulfonate in a weight ratio of 1:2:0.5:0.5.

[0071] Example 17

[0072] The difference between this embodiment and Embodiment 1 is that the emulsifier is a mixture of lauryl alcohol polyoxyethylene ether and polyethylene glycol fatty acid ester in a weight ratio of 1:2. Comparative Example

[0073] Comparative Example 1

[0074] The difference between this comparative example and Example 1 is that the composite emulsion does not include a thickener.

[0075] Comparative Example 2

[0076] The difference between this comparative example and Example 1 is that, based on the formulation and dosage of Example 1, the wollastonite whiskers in the thickener are removed.

[0077] Comparative Example 3

[0078] The difference between this comparative example and Example 1 is that, based on the formulation and dosage of Example 1, the tackifying copolymer in the tackifier is removed.

[0079] Performance testing methods

[0080] I. Drug Retention Effect

[0081] The plants tested were tiger tail grass plants cultivated in a glass greenhouse with a daytime temperature of 30℃ and a nighttime temperature of 26℃. The average height of the tiger tail grass plants was 20.8cm. The tiger tail grass plants were irradiated with high-pressure mercury lamps starting 15 days before leaf collection. The emission spectrum range of the high-pressure mercury lamp was 190-1000nm, and the irradiation intensity of the high-pressure mercury lamp was set at an average daily irradiation of 8.5kJ per square meter. The daily irradiation time was from 9:00 to 16:00.

[0082] Test method:

[0083] (1) Dilute the compound emulsifiable concentrate with water, the amount of water being 2000 times the weight of clodinafop-propargyl to obtain an emulsion for later use; collect leaves from the tested plants, and use a leaf area meter to measure the leaf area S, weigh the collected leaves, and then number and record them.

[0084] (2) Use tweezers to pick up the leaf and immerse it in the emulsion. After soaking for 10 seconds, take the leaf out and weigh it again when no more liquid droplets fall from the edge of the leaf. Record the weight obtained.

[0085] Data processing:

[0086] First, calculate the difference m between the two weights of the blade, then calculate the ratio of m to S, and record this ratio as the amount of residue per unit area.

[0087] Calculate the ratio of the unit area retention of Examples 1-17 and Comparative Examples 1-3 to the unit area retention of Comparative Example 1. Record this ratio as the relative retention. The calculation results of the relative retention are shown in Table 5.

[0088] II. Prevention and efficacy testing

[0089] Test environment:

[0090] The experimental area has an average annual precipitation of 413.8 mm and the soil is chestnut calcareous soil. The density of *Gnaphalium affine* in the experimental area before application was 65 plants / m². 2 High-pressure mercury lamp irradiation was carried out on the test area 15 days before the application of pesticides. The emission spectrum range of the high-pressure mercury lamp is 190-1000nm. The irradiation lasted for 45 days. The irradiation intensity of the high-pressure mercury lamp was set at an average daily irradiation of 8.5kJ per square meter. The daily irradiation time was from 9:00 to 16:00.

[0091] Test method:

[0092] (1) Dilute the compound emulsifiable concentrate with water, the amount of water being 2000 times the weight of clodinafop-propargyl, to obtain an emulsion for later use;

[0093] (2) At 50 m 2 The emulsion was sprayed in the experimental area at a rate of 30g clodinafop-propargyl per acre. The density of surviving tiger tail grass in the experimental area was counted 30 days after application.

[0094] The compound emulsifiable concentrates of Examples 1-17 and Comparative Examples 1-3 were tested according to the above test methods. Each example / comparative example contained three sets of parallel tests.

[0095] Data processing:

[0096] The difference in density of *Hypericum perforatum* measured before and after application of the pesticide was calculated. Then, the ratio of this difference to the density of *Hypericum perforatum* before application was calculated, and this ratio was recorded as the *Hypericum perforatum* kill rate. For each example / comparative example, the average kill rate of *Hypericum perforatum* obtained from three parallel experiments was calculated and recorded as the average kill rate. Then, the ratio between the average kill rate of Examples 1-17 and Comparative Examples 1-3 and the average kill rate of Comparative Example 1 was calculated, and this ratio was recorded as the relative kill rate. The results are shown in Table 5.

[0097] Table 5 Data Summary

[0098] sample Relative retention / % Relative kill rate / % sample Relative retention / % Relative kill rate / % Example 1 144.8 124.3 Example 11 155.2 132.7 Example 2 145.3 124.4 Example 12 154.7 132.3 Example 3 145.7 124.7 Example 13 153.8 131.9 Example 4 146.0 124.9 Example 14 155.4 148.7 Example 5 146.4 125.1 Example 15 154.5 145.2 Example 6 148.1 127.1 Example 16 153.8 139.3 Example 7 149.8 128.7 Example 17 135.6 120.7 Example 8 150.7 129.5 Comparative Example 1 100.0 100.0 Example 9 150.9 129.7 Comparative Example 2 116.4 105.2 Example 10 152.6 131.4 Comparative Example 3 103.5 100.4

[0099] Combining Example 1 and Comparative Example 1 with Table 5, it can be seen that the relative retention and relative kill rate measured in Example 1 are higher than those in Comparative Example 1. This indicates that the emulsion prepared from the compound emulsifiable concentrate of the application is more likely to adhere to the leaf surface of *Gnaphalium affine*. Moreover, under the irradiation of a high-pressure mercury lamp, the emulsion prepared from the compound emulsifiable concentrate of this application can retain more clodinafop-propargyl molecules after irradiation, thereby improving the control efficacy of clodinafop-propargyl against weeds.

[0100] As can be seen from Example 3 and Comparative Examples 2-3 and Table 5, when wollastonite whiskers and tackifying copolymers are used separately, the emulsion has poor adhesion to the leaves of *Gnaphalium affine*, which also affects the weed control efficacy of clodinafop-propargyl.

[0101] Combining Examples 3 and 6-9 with Table 5, it can be seen that as the proportion of sodium 2-acrylamido-2-phenylethanesulfonate in the monomer increases, both the measured relative retention and relative kill rate increase. The values ​​measured in Examples 6-9 are higher than those in Example 3, while the value measured in Example 9 is closer to that in Example 8. Therefore, when the molar ratio of acrylamide to sodium 2-acrylamido-2-phenylethanesulfonate is (6-7):1, it helps to improve the tackifying effect of the tackifier as much as possible while saving sodium 2-acrylamido-2-phenylethanesulfonate. If cost factors are not considered, the scheme in Example 9 is better.

[0102] Based on Examples 9, 10-13 and Table 5, it can be seen that when the weight ratio of wollastonite whiskers to tackifying copolymer is in the range of (2.2-2.6):10, the relative retention and relative kill rate are relatively high, and the data of Example 11 is the best, indicating that the tackifiers of Examples 10-12 have a better tackifying effect.

[0103] Based on Examples 13 and 14 and Table 5, it can be seen that the relative kill rate measured in Example 14 is significantly higher than that in Example 13, while the relative retention is close to that in Example 13. This indicates that conjugated linoleic acid has a better absorption effect on short-wave ultraviolet light, which reduces the loss of clodinafop-propargyl and improves the control efficacy of clodinafop-propargyl against weeds.

[0104] Combining Examples 11 and 14-16 with Table 5, it can be seen that although replacing a portion of the conjugated linoleic acid with calcium lignin sulfonate resulted in a certain degree of decrease in efficacy and the retention effect of the emulsion on the leaf surface, the overall effect was still better than that of Example 11. Considering that the price of calcium lignin sulfonate is usually much lower than that of conjugated linoleic acid, the solutions in Examples 15-16, compared to Example 14, can reduce the impact of high-pressure mercury lamp irradiation on the efficacy of clodinafop-propargyl at a lower cost compared to Example 11.

[0105] As can be seen from Examples 1 and 17 and Table 5, when the emulsifier does not contain fatty acids, the emulsion has a relatively poor adhesion effect on the leaf surface, and this leads to a decrease in the control efficacy of clodinafop-propargyl.

[0106] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A compound emulsifiable concentrate containing chlorhexidine, characterized in that, The emulsifiable concentrate comprises the following components in parts by weight: 79.4-87.4 parts of clodinafop-propargyl technical grade, 18.7-22.7 parts of clodinafop-propargyl technical grade, 284-308 parts of thickener, 196-204 parts of emulsifier, 144-156 parts of vegetable oil, 8-12 parts of cosolvent, and 521.9-529.9 parts of solvent oil. The thickener is composed of wollastonite whiskers and a thickening copolymer. The monomers used to prepare the thickening copolymer include acrylamide and sodium 2-acrylamido-2-phenylethanesulfonate. The emulsifier comprises lauryl polyoxyethylene ether, polyethylene glycol fatty acid ester, and fatty acid. The fatty acid is an unsaturated fatty acid, and the unsaturated fatty acid is conjugated linoleic acid. The weight ratio of lauryl polyoxyethylene ether, polyethylene glycol fatty acid ester, and fatty acid is 1:2:(0.5-1). The thickening copolymer is prepared according to the following method: (1) Mix the monomer and deionized water and adjust the pH to 11 to obtain a monomer dispersion; the monomer dispersion contains 25% monomer by mass. (2) Nitrogen gas is introduced into the monomer dispersion and an initiator is added. The mixture is heated at 55°C for 10 hours. After cooling down to 20°C, the mixture is discharged, cut, dried and pulverized to obtain the thickener.

2. The compound emulsifiable concentrate containing chlorhexidine gluconate according to claim 1, characterized in that, In the monomer components, the molar ratio of acrylamide and sodium 2-acrylamido-2-phenylethanesulfonate is (6-7):

1.

3. The compound emulsifiable concentrate containing chlorhexidine according to claim 2, characterized in that, The initiator is potassium persulfate, and the amount of the initiator is 0.15% of the monomer weight.

4. The compound emulsifiable concentrate containing chlorhexidine according to claim 2, characterized in that, The weight ratio of the wollastonite whiskers to the tackifying copolymer is (2.2-2.6):

10.

5. The compound emulsifiable concentrate containing chlorhexidine according to claim 1, characterized in that, The emulsifier also includes calcium lignosulfonate, and the weight ratio of lauryl alcohol polyoxyethylene ether, polyethylene glycol fatty acid ester, fatty acid and calcium lignosulfonate is 1:2:0.5:0.

5.

6. The method for preparing the compound emulsifiable concentrate containing chlorhexidine according to any one of claims 1-5, characterized in that, Includes the following steps: (1) Mix and stir the technical grade of clodinafop-propargyl, technical grade of clodinafop-propargyl, solubilizer, solvent oil and vegetable oil to obtain an oil-soluble solution; (2) Mix the oil-soluble drug solution and emulsifier and continue stirring to obtain an emulsion base; (3) Mix the thickener and the emulsion matrix to obtain a composite emulsifiable concentrate containing acetic acid ester.