硼酸功能化共价三嗪框架的光电化学传感器制备方法

By fabricating a boric acid-functionalized covalent triazine framework photoelectrochemical sensor, the problems of low sensitivity and narrow detection range of existing dopamine detection methods have been solved, achieving rapid and accurate dopamine detection, reducing costs and simplifying sample processing.

CN117368278BActive Publication Date: 2026-07-17ANALYSIS & TESTING CENT CHINESE ACADEMY OF TROPICAL AGRI SCI

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ANALYSIS & TESTING CENT CHINESE ACADEMY OF TROPICAL AGRI SCI
Filing Date
2023-10-11
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing methods for dopamine detection suffer from low sensitivity, narrow detection range, expensive instruments, and complex sample processing, making it difficult to quickly and accurately determine the dopamine content in serum.

Method used

A photoelectrochemical sensor based on a boric acid-functionalized covalent triazine framework was fabricated by ultrasonically dispersing a solution of 2,4,6-tris(4-aldehydephenyl)-1,3,5-triazine, anthracene-2,6-diamine, n-butanol, o-dichlorobenzene, acetic acid, and boric acid in a high-pressure reactor, followed by vacuum degassing to form a COFB-TFPT-AD precipitate. This precipitate was then coated onto the surface of an ITO glass electrode to prepare an ON-type DA-PEC photoelectrochemical sensor. Detection was performed using the direct proportionality between photocurrent and dopamine content.

Benefits of technology

It enables rapid and accurate measurement of dopamine levels in serum, with high sensitivity and a wide detection range, reducing detection costs and simplifying sample processing.

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Abstract

本发明涉及一种硼酸功能化共价三嗪框架的光电化学传感器制备方法,包括以下步骤:S1.将2,4,6‑三(4‑醛基苯基)‑1,3,5‑三嗪、蒽‑2,6‑二胺、正丁醇、邻二氯苯、乙酸溶液按照0.08mmol:0.12mmol:1.2ml:1.2ml:0.18ml的比例以及硼酸溶液加入至高压反应釜中,超声分散后真空脱气循环;S2.将脱气循环后的溶液放入至烘箱中加热形成COFB‑TFPT‑AD沉淀;S3.将COFB‑TFPT‑AD沉淀通过DMF和甲醇洗涤后添加至甲醇溶液中静置,超声振动后分离出COFB‑TFPT‑AD溶液;S4.将ITO玻璃依次用丙酮、乙醇和纯水洗涤,然后将ITO玻璃浸入1:1(v / v)乙醇 / NaOH(1M)的溶液中静置,再用纯水冲洗;S5.将步骤S3中分离出的COFB‑TFPT‑AD溶液涂覆在ITO玻璃电极表面,干燥后形成COFB‑TFPT‑AD修饰电极制备成ON型DA‑PEC光电传感器。本发明制备的光电化学传感器能快速检测血清中多巴胺的含量。
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