Fully automatic chemiluminescence immunoassay analyzer

Abstract

An automatic chemiluminescence immunoassay analyzer includes a sample and reagent dispensing assembly, a mixing and cleaning assembly, a magnetic separation assembly, an incubation and detection assembly, a waste liquid discharge assembly, a reaction vessel grabbing assembly, and a control assembly. The control assembly is configured to obtain action timing of a plurality of sub-actions of the reaction vessel grabbing assembly. If the action timing of any adjacent sub-actions in the plurality of sub-actions satisfies a preset condition, the control assembly controls the reaction vessel grabbing assembly to run to an intermediate position after the reaction vessel grabbing assembly executes a previous sub-action or before the reaction vessel grabbing assembly executes a next sub-action. The intermediate position is arranged in a region surrounded by the sample and reagent dispensing assembly, the mixing and cleaning assembly, the magnetic separation assembly, the incubation and detection assembly, the waste liquid discharge assembly, and the reaction vessel grabbing assembly.

Description

Technical Field

[0001] This invention relates to the field of chemiluminescence detection technology, and in particular to a fully automated chemiluminescence immunoassay analyzer. Background Technology

[0002] Chemiluminescence immunoassay is a highly sensitive and specific analytical instrument that has developed rapidly worldwide in the last decade. It is used in clinical laboratories to detect various immune indicators in blood, urine or other body fluids. The principle is to combine antibody-antigen reaction with chemiluminescence technology to achieve high specificity and high sensitivity.

[0003] In the chemiluminescence analyzer, the reaction container needs to be transferred through the reaction container gripping component when testing the sample. Since it is a fully automatic method, the action that the reaction container gripping component needs to perform is different for each test item, which causes problems with the smoothness of the transfer process. Summary of the Invention

[0004] This invention provides a fully automated chemiluminescence immunoassay analyzer. By controlling the timing of the reaction container gripping component and analyzing it, an improved timing sequence is presented, which can solve the problem of insufficient smoothness of the reaction container gripping component during the transfer process, making the timing of the reaction container gripping component's action simpler and smoother.

[0005] This invention provides a fully automated chemiluminescence immunoassay analyzer, comprising:

[0006] The sample and reagent dispensing assembly is used to load samples and reagents into the reaction vessel to form the test sample;

[0007] A mixing and cleaning assembly is used to mix the sample and reagents in the reaction vessel to allow the sample and reagents to react and form a test sample.

[0008] A magnetic separation assembly is used to perform magnetic separation cleaning on the test sample in the reaction vessel after adding magnetic bead reagent, and to add substrate;

[0009] The incubation photometric component is used to incubate and photometrically measure the test sample containing the substrate in order to obtain the test results;

[0010] A waste liquid discharge assembly is used to discharge the waste liquid from the sample container after incubation and photometry.

[0011] A reaction vessel grasping assembly for dispatching the reaction vessel to at least one of the sample and reagent dispensing assembly, the magnetic separation assembly, the incubation photometric assembly, and the waste liquid discharge assembly;

[0012] A control component is used to acquire the timing sequence of multiple sub-actions of the reaction container gripping component. If the timing sequence of any adjacent sub-actions among the multiple sub-actions meets a preset condition, the reaction container gripping component is controlled to run to the intermediate position after the preceding sub-action and before the following sub-action in the adjacent sub-actions. The intermediate position is located within the area enclosed by the sample and reagent dispensing component, the mixing and washing component, the magnetic separation component, the incubation and photometry component, the waste liquid discharge component, and the reaction container gripping component.

[0013] In an analyzer according to one embodiment of the present invention, an identification code is provided on the reaction vessel, the analyzer includes a scanning device, and the control component is further configured to: obtain the action timing sequence of multiple sub-actions of the reaction vessel grasping component by scanning the identification code through the scanning device.

[0014] In an analyzer according to one embodiment of the present invention, the timing of actions of any adjacent sub-actions among the plurality of sub-actions satisfies a preset condition, including: the timing of actions of any adjacent sub-actions among the plurality of sub-actions is different from the preset timing of actions; wherein, the preset timing of actions includes the timing of actions of the plurality of sub-actions pre-configured.

[0015] In an analyzer according to an embodiment of the present invention, the multiple sub-action timing sequence includes N consecutive timing cycles, each timing cycle corresponds to several sub-actions among the multiple sub-actions, and all the sub-actions corresponding to the N consecutive timing cycles form the multiple sub-actions; wherein, the duration of any timing cycle is the same, and the number of sub-actions included and their order are the same or different.

[0016] The timing of actions of any adjacent sub-actions among the multiple sub-actions meets preset conditions, including:

[0017] In any of the sub-actions corresponding to any given timing period, the timing sequence of any adjacent sub-actions differs from the preset timing sequence; and / or,

[0018] Between two adjacent timing cycles, the timing sequence of the actions corresponding to the last sub-action in the earlier timing cycle and the first sub-action in the later timing cycle is different from the preset timing sequence.

[0019] In an analyzer according to one embodiment of the present invention, after determining that the reaction vessel gripping component has completed the plurality of sub-actions, the reaction vessel gripping component is controlled to run to the intermediate position.

[0020] In the analyzer according to one embodiment of the present invention, the sub-action includes a set of multiple motion actions, the last motion action in the set being a lifting action; before controlling the reaction vessel gripping component to run to the intermediate position, the control component is further configured to: when controlling the reaction vessel gripping component to perform the lifting action, control the reaction vessel gripping component to rise to a preset position, the preset position being the same as the intermediate position in the vertical direction.

[0021] In an analyzer according to one embodiment of the present invention, the analyzer includes a liquid path system and a sample and reagent loading assembly for loading samples and reagents. The sample and reagent loading assembly is connected to a waste tank of a waste liquid discharge assembly through the liquid path system for discharging gas and liquid from the sample and reagent loading assembly. The liquid path system includes a discharge pipe, a discharge sensor, and a discharge power source. The discharge sensor is disposed in the discharge pipe. The sample and reagent loading assembly is connected to the waste tank through the discharge pipe. The control assembly is used to control the power source to discharge the gas and liquid from the sample and reagent loading assembly to the waste tank.

[0022] The control component is further configured to generate alarm information based on the pressure difference and / or flow difference between the discharge sensor and the discharge power source.

[0023] In an analyzer according to one embodiment of the present invention, the discharge sensor includes a pressure sensor, the discharge power source includes a diaphragm pump, and the pressure sensor is disposed between the sample reagent loading assembly and the diaphragm pump; or, the discharge sensor includes a flow sensor, and the flow sensor is disposed between the sample reagent loading assembly and the diaphragm pump.

[0024] The step of generating alarm information based on the pressure difference and / or flow difference between the discharge sensor and the discharge power source includes:

[0025] An alarm message is generated when the pressure sensor detects that the pipeline resistance on the discharge pipeline is greater than or equal to the discharge resistance of the diaphragm pump during operation; or, an alarm message is generated when the flow sensor detects that the pipeline flow rate on the discharge pipeline is less than the minimum flow rate of the diaphragm pump during operation.

[0026] In the analyzer according to one embodiment of the present invention, the control component is further configured to:

[0027] The discharge resistance is corrected based on the ratio of the first ultimate vacuum pressure of the diaphragm pump at a preset altitude to the second ultimate vacuum pressure at the current altitude, and the corrected discharge resistance is obtained.

[0028] In an analyzer according to one embodiment of the present invention, the mixing and cleaning assembly stores an enhanced cleaning agent for intensive cleaning of the needle bar, enabling the needle bar to undergo intensive cleaning after testing; before testing the sample, the control assembly is used to:

[0029] Based on the historical operating parameters of the needle bar, determine whether the needle bar came into contact with maintenance fluid, sample and / or reagent in previous tests; if the needle bar came into contact with maintenance fluid, sample and / or reagent in previous tests, control the mixing and cleaning assembly to perform a second enhanced cleaning of the needle bar.

[0030] In the analyzer according to one embodiment of the present invention, the control component is further configured to: determine whether the next test item of the needle bar is a sensitive item; and if the next test item of the needle bar is determined to be a sensitive item, control the mixing and cleaning component to perform a second enhanced cleaning on the needle bar.

[0031] In an analyzer according to one embodiment of the present invention, the control component is further configured to: obtain the required amount of the enhanced cleaning agent for the needle bar based on the contact height and time between the needle bar and the maintenance fluid, sample and / or reagent.

[0032] In an analyzer according to one embodiment of the present invention, the analyzer includes a sample and reagent loading assembly for loading samples and reagents, the sample and reagent loading assembly further includes a reagent pot and a cooling structure, the cooling structure being disposed below the reagent pot for cooling the contents of the reagent pot;

[0033] The refrigeration structure includes a refrigeration component, a heat insulation plate, a cold-end radiator, a hot-end heat sink, a cold-end sealing ring, a hot-end sealing ring, and a reagent pot sealing ring. The cold-end heat sink is attached to the heat insulation plate via the cold-end sealing ring, and the hot-end heat sink is attached to the heat insulation plate via the hot-end sealing ring. The cold end of the refrigeration component is connected to the cold-end radiator, and the hot end of the refrigeration component is connected to the hot-end heat sink. The reagent pot is located above the cold-end radiator, and the reagent pot sealing ring is disposed between the bottom of the outer side of the reagent pot and the heat insulation plate.

[0034] In an analyzer according to one embodiment of the present invention, the heat insulation plate is provided with a non-irregular hot end mounting groove, and the hot end sealing ring is installed in the hot end mounting groove; and / or, the heat insulation plate is a heat insulation plate made of bakelite material, and / or, the side of the heat insulation plate facing the hot end heat sink has a plurality of clearance grooves.

[0035] In an analyzer according to one embodiment of the present invention, the cooling structure includes a wire-concealing sleeve and a signal connector. The hot end heat sink is provided with a connector receiving hole. One end of the wire-concealing sleeve is connected to the cooling component and housed in the connector receiving hole. The signal connector is disposed on the other end of the wire-concealing sleeve, so that the wires on the cooling structure can pass through the wire-concealing sleeve and connect to the signal connector.

[0036] In an analyzer according to one embodiment of the present invention, the refrigeration structure includes an airtight connector and a sleeve sealing ring. The sleeve sealing ring is disposed between the cable sleeve and the refrigeration component, and the airtight connector is fixed on the hot end heat sink for airtightness testing of the refrigeration structure.

[0037] In an analyzer according to one embodiment of the present invention, a heat insulation fixing part is provided on the heat insulation plate, and the refrigeration structure is fixed below the reagent pot by the heat insulation fixing part, and the operating end of the heat insulation fixing part is exposed on the periphery of the heat insulation plate.

[0038] In an analyzer according to one embodiment of the present invention, the analyzer includes a frame, and the sample and reagent dispensing component, mixing and washing component, magnetic separation component, incubation and photometric component, waste liquid discharge component, reaction vessel gripping component and control component are all mounted on the frame. The bottom of the frame is provided with support feet and auxiliary feet. The support feet are located at the ends of the frame, and the auxiliary feet are located between the support feet to assist in supporting the frame.

[0039] In an analyzer according to one embodiment of the present invention, the number of support feet is four, the number of auxiliary feet is one, the four support feet are disposed at the four ends of the bottom surface of the frame, the auxiliary foot is disposed at the middle of the bottom surface of the frame, and the height of the auxiliary foot is lower than the height of the four support feet; and / or, the support feet and the auxiliary foot are made of elastic material.

[0040] The technical solution provided in this application embodiment can include the following beneficial effects: This application designs a fully automated chemiluminescence immunoassay analyzer, including a sample and reagent dispensing component, a mixing and washing component, a magnetic separation component, an incubation and photometric component, a waste liquid discharge component, a reaction container gripping component, and a control component. The reaction container gripping component can be used to schedule the reaction container to at least one of the sample and reagent dispensing component, the mixing and washing component, the magnetic separation component, the incubation and photometric component, and the waste liquid discharge component. The control component is used to acquire and analyze the action timing of the reaction container gripping component, thereby providing an improved action timing and ensuring the smoothness of the reaction container gripping component during the transfer process.

[0041] Specifically, the control component is used to acquire the timing sequence of multiple sub-actions of the reaction container grasping component, and then determine whether the timing sequence of any adjacent sub-actions among the multiple sub-actions meets the preset conditions. If it does, the control component is controlled to run to the middle position after the reaction container grasping component executes the previous sub-action or before the next sub-action among the adjacent sub-actions. This makes the timing sequence of the reaction container grasping component smoother and reduces the phenomenon of the reaction container grasping component getting stuck during the transfer process.

[0042] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit this application. Attached Figure Description

[0043] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the following description of the embodiments will be briefly introduced. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0044] Figure 1 This is a schematic diagram of the structure of a fully automated chemiluminescence immunoassay analyzer according to an embodiment of the present invention;

[0045] Figure 2 yes Figure 1 A schematic diagram of the fully automated chemiluminescence immunoassay analyzer from another angle;

[0046] Figure 3 yes Figure 1 A schematic diagram of the reagent loading component. Detailed Implementation

[0047] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0048] It should also be understood that the terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to limit the invention. As used in this specification and the appended claims, the singular forms “a,” “an,” and “the” are intended to include the plural forms unless the context clearly indicates otherwise.

[0049] It should also be further understood that the term "and / or" as used in this specification and the appended claims refers to any combination of one or more of the associated listed items and all possible combinations, and includes such combinations.

[0050] like Figures 1 to 3 As shown, this application provides a fully automated chemiluminescence immunoassay analyzer, including a sample and reagent dispensing component 30, a mixing and washing component 40, a magnetic separation component 50, an incubation and photometric component 60, a waste liquid discharge component, a reaction vessel gripping component 80, and a control component. The sample and reagent dispensing assembly 20 is used to load samples and reagents into the reaction container to form a test sample; the mixing and washing assembly 30 is used to mix the samples and reagents in the reaction container to allow them to react and form a test sample; the magnetic separation assembly 50 is used to add magnetic beads to the test sample in the reaction container, perform magnetic separation and washing, and add substrate; the incubation and photometric assembly 60 is used to incubate and photometrically measure the test sample with added substrate to obtain detection results; the waste liquid discharge assembly is used to discharge the waste liquid from the sample container after incubation and photometrically measuring; the reaction container gripping assembly 80 is used to dispatch the reaction container to at least one of the sample and reagent dispensing assembly 30, the mixing and washing assembly 40, the magnetic separation assembly 50, the incubation and photometric assembly 60, and the waste liquid discharge assembly; and the control assembly is used to control the reaction container gripping assembly 80 to transfer the reaction container between the sample and reagent dispensing assembly 30, the mixing and washing assembly 40, the magnetic separation assembly 50, the incubation and photometric assembly 60, and the waste liquid discharge assembly.

[0051] Specifically, after the sample and reagent dispensing component 30 loads the sample and reagent into the reaction container, the mixing and cleaning component 30 mixes the sample and reagent evenly. The reaction container grasping component 80 transfers the reaction container to the incubation photometric component 60 for incubation. Then, the reaction container grasping component 80 transfers the incubated reaction container to the magnetic separation component 50 for separation and cleaning. Finally, the separated and cleaned reaction container is transferred to the incubation photometric device 60 for luminescence detection to obtain various parameters of the sample.

[0052] Since fully automated chemiluminescence immunoassay analyzers operate on a fully automated basis, and given that the actions required for the reaction container gripping component differ for each sample during testing, following the analyzer's built-in action sequence can easily lead to sluggish movement of the reaction container gripping component, or even jamming or stalling. Therefore, this application proposes an improved action sequence that ensures the smoothness of the reaction container gripping component during reaction container transfer.

[0053] Specifically, the control component acquires the timing sequence of multiple sub-actions of the reaction container gripping component 80. If the timing sequence of any adjacent sub-actions among the multiple sub-actions meets the preset conditions, the reaction container gripping component 80 is controlled to run to the intermediate position after the previous sub-action and before the next sub-action in the adjacent sub-actions. The intermediate position is set in the area enclosed by the sample and reagent dispensing component 30, the mixing and washing component 40, the magnetic separation component 50, the incubation and photometry component 60, the waste liquid discharge component, and the reaction container gripping component 80.

[0054] The timing sequence of multiple sub-actions includes the actions that the reaction container grasping component 80 needs to complete during the process of the analyzer detecting all samples. That is, the set of all actions of the reaction container grasping component 80 from the first sample to the last sample during the testing process, including the sub-actions generated by the reaction container grasping component 80 moving the reaction container from each starting position to the target position.

[0055] For example, the reaction container gripping component 80 places the reaction container in the position of the mixing and cleaning component 30, the sample and reagent dispensing component 30 loads the sample and reagent into the reaction container, and then the mixing and cleaning component 30 mixes the sample and reagent evenly; then the reaction container gripping component 80 transfers the reaction container to the incubation photometric component 60 for incubation, and then the reaction container gripping component 80 transfers the incubated reaction container to the magnetic separation component 50 for separation and cleaning, and then transfers the separated and cleaned reaction container to the incubation photometric device 60 for luminescence detection, etc., which is a collection of all actions.

[0056] Alternatively, taking one of the sub-actions required for one of the actions as an example, after the arm of the reaction container grasping component 80 moves along the XY axis to above the starting position, the fingers of the reaction container grasping component 80 open, the arm of the reaction container grasping component 80 descends along the Z axis, the fingers of the reaction container grasping component 80 close to grasp the reaction container, then the arm of the reaction container grasping component 80 rises along the Z axis, and after moving along the XY axis to above the target position, the arm of the reaction container grasping component 80 descends along the Z axis, then the fingers of the reaction container grasping component 80 open to release the reaction container, and finally the arm of the reaction container grasping component 80 rises along the Z axis to reset.

[0057] Generally, to ensure the smooth movement of the reaction container gripping component 80, the analyzer sorts the actions required for the reaction container gripping component 80 to complete the target test, making the movement of the reaction container gripping component 80 smoother. However, the actions required for each sample during the test are different. Therefore, the control component matches the acquired action sequence with preset conditions. If the current action sequence meets the preset conditions, the reaction container gripping component 80 moves to the middle position and waits after the reaction container has completed the corresponding test item in the previous sub-action and before the next sub-action. After the reaction container has completed the corresponding test item in the previous sub-action, the reaction container gripping component 80 moves to the position of the previous sub-action, grips the reaction container, and transports it to the position where the next sub-action needs to complete the test item.

[0058] For example, during the testing of the reaction vessel gripping component 80, it generally needs to go through the sequence of actions one, two, three, four, five, six, seven, and eight. However, for the test of the first sample, the reaction vessel gripping component 80 only needs to complete actions one, two, and three, omitting actions four, five, six, seven, and eight. For the test of the second sample, the reaction vessel gripping component 80 needs to complete actions one, three, and five, omitting actions two, four, six, seven, and eight. For the test of the third sample, the reaction vessel gripping component 80 needs to complete actions six, seven, and eight, omitting actions one, two, three, four, and five.

[0059] Therefore, when the analyzer tests three samples, the sequence of actions it needs to complete is as follows: Action 1, Action 2, Action 3, Action 1, Action 3, Action 5, Action 6, Action 7, and Action 8. After the reaction vessel gripping component 80 completes Action 1, since Action 1 and Action 2 are adjacent actions, the reaction vessel gripping component 80 does not need to move to the middle position. After the reaction vessel gripping component 80 completes Action 2, since Action 2 and Action 3 are also adjacent actions, the reaction vessel gripping component 80 does not need to move to the middle position. After the reaction vessel gripping component 80 completes Action 3, since Action 3 and Action 1 are not adjacent, the reaction vessel gripping component 80 needs to move to the middle position. After Action 3 is completed, the reaction vessel gripping component 80 then moves to Action 1. Similarly, the reaction vessel gripping component 80 needs to move to the middle position between Action 3 and Action 5, and between Action 5 and Action 6, and so on. By adopting the above technical solutions, the smoothness of the reaction vessel gripping component 80 during movement can be effectively ensured, and the phenomenon of jamming during the transfer of the reaction vessel gripping component 80 can be avoided.

[0060] In an optional implementation, an identification code is provided on the reaction vessel, the analyzer includes a scanning device, and the control component is further configured to: obtain the timing sequence of multiple sub-actions of the reaction vessel grasping component by scanning the identification code with the scanning device.

[0061] Specifically, an identification code is affixed or printed on the reaction vessel to identify the category of the test items to be performed on the reaction vessel. When the reaction vessel is placed in the analyzer, the scanning device on the analyzer can scan the identification code and send the scanned result to the control component, so that the control component can obtain the action sequence of multiple sub-actions of the reaction vessel grasping component by scanning the identification code through the scanning device.

[0062] For example, the sample in the reaction vessel requires the reaction vessel gripping component 80 to perform a sequence of actions including action one, action three, and action five. The control component judges the sequence of actions with actions one, three, and five to determine whether it meets preset conditions. Through the above analysis, it can be seen that actions one and three meet the preset conditions. Therefore, after executing action one, the control component controls the reaction vessel gripping component 80 to run to the intermediate position. Similarly, actions three and five also meet the preset conditions; therefore, the reaction vessel gripping component 80 needs to run to the intermediate position.

[0063] By employing a scanning device to scan the identification code on the reaction vessel and combining it with control components, the analyzer can be effectively automated without requiring manual input. For example, each sample test requires inputting the corresponding test item into the analyzer. Of course, this application does not exclude this approach, but using a scanning device enables fully automated control of the analyzer.

[0064] In an optional implementation, the timing of actions of any adjacent sub-actions among the multiple sub-actions satisfies a preset condition, including: the timing of actions of any adjacent sub-actions among the multiple sub-actions is different from the preset timing of actions; wherein, the preset timing of actions includes the timing of actions of the multiple sub-actions that are pre-configured.

[0065] For example, during sample testing, the reaction container grasping component 80 needs to execute actions one, three, and five in a specific sequence, while the preset action sequence is actions one, two, three, four, and five. Therefore, the action sequence and the preset action sequence are different. The preset action sequence includes a pre-configured sequence of multiple sub-actions, referring to the predefined actions and their order performed by the user before sample testing.

[0066] In one optional implementation, the multiple sub-action timing sequence includes N consecutive timing cycles, each timing cycle corresponds to several sub-actions among the multiple sub-actions, and all the sub-actions corresponding to the N consecutive timing cycles form multiple sub-actions; wherein, the duration of any timing cycle is the same, and the number of sub-actions it contains and their order are the same or different.

[0067] For example, each time cycle lasts 20 seconds, and each sample test requires one time cycle. When the analyzer performs tests on multiple samples, the reaction vessel gripping component 80 needs to go through multiple time cycle sub-action sequences, meaning multiple sub-action sequences include N consecutive time cycles. Simultaneously, after completing the test of each sample item, the reaction vessel gripping component 80 will move on to the next sample item test. However, the sub-actions and their order within each sample item may be the same or different, while the time cycle duration remains the same. By determining whether multiple adjacent sub-actions meet preset conditions, the reaction vessel gripping component 80 is controlled to run to the intermediate position. The main purpose is to make the operation of the reaction vessel gripping component 80 smoother.

[0068] In an optional implementation, the timing of actions of any adjacent sub-actions among multiple sub-actions satisfies a preset condition, including: the timing of actions of any adjacent sub-actions among several sub-actions corresponding to any timing period is different from the preset timing; and / or, between two adjacent timing periods, the timing of actions corresponding to the last sub-action in the earlier timing period and the first sub-action in the later timing period is different from the preset timing.

[0069] Specifically, the timing of any adjacent sub-actions differs from the preset timing of actions, including two adjacent sub-actions within the same cycle; and the timing of the last sub-action in the first cycle and the first sub-action in the second cycle between two adjacent cycles.

[0070] For example, when the analyzer tests two samples, the corresponding time periods for the two samples are the first time period and the second time period, respectively. The first time period includes actions one, two, and three; the second time period includes actions four, five, and six; and the preset action sequence includes actions one, two, three, four, five, and six. Therefore, determining the action sequence of any adjacent sub-actions involves matching actions one, two, and three in the first time period with actions one, two, three, four, five, and six in the preset action sequence, and matching the last action (action three) of the first time period with the first action (action four) of the second time period with actions one, two, three, four, five, and six in the preset action sequence to determine whether the two actions are adjacent, thereby deciding whether the reaction vessel gripping component 80 needs to run to the middle position.

[0071] In an alternative implementation, after determining that the reaction vessel gripping component has completed multiple sub-actions, the reaction vessel gripping component is controlled to run to the intermediate position. When the analyzer restarts to test other samples, it only needs to move from the intermediate position to the target position, which can shorten the running time of the reaction vessel gripping component.

[0072] In an optional implementation, the sub-action includes a set of multiple motion actions, the last motion action in the set being a lifting action; before controlling the reaction container gripping component to run to the intermediate position, the control component is also used to: control the reaction container gripping component to rise to a preset position when the reaction container gripping component performs the lifting action, the preset position being the same as the intermediate position in the vertical direction.

[0073] Specifically, when the reaction vessel gripping component is gripping the reaction vessel, the arm of the reaction vessel gripping component 80 descends vertically, then the fingers of the reaction vessel gripping component 80 open and release the reaction vessel, and then the arm of the reaction vessel gripping component 80 rises vertically to reset. Normally, the arm of the reaction vessel gripping component 80 rising vertically to reset means that the arm of the reaction vessel gripping component 80 is raised to the highest position. However, this application can control the reaction vessel gripping component to rise to a preset position and then move to the middle position according to the timing of the actions to be completed in the next sub-action of the reaction vessel gripping component. That is, the preset position and the middle position are the same in the vertical direction.

[0074] In one optional embodiment, the analyzer includes a liquid path system and a sample reagent loading assembly 20 for loading reagents. The sample reagent loading assembly 20 is connected to a waste tank 90 of a waste liquid discharge assembly via the liquid path system for discharging the gas and liquid on the sample reagent loading assembly 20. In this embodiment, the liquid path system includes a discharge pipe, a discharge sensor, and a discharge power source. The discharge sensor is disposed in the discharge pipe. The sample reagent loading assembly 20 is connected to the waste tank 90 via the discharge pipe. A control assembly controls the power source to discharge the gas and liquid on the sample reagent loading assembly 20 to the waste tank 90. ​​The control assembly is also used to generate alarm information based on the pressure difference and / or flow difference between the discharge sensor and the discharge power source, enabling the analyzer to comprehensively monitor the discharge status of condensate on the sample reagent loading assembly 20 and prevent electrical safety hazards caused by condensate accumulation in the sample reagent loading assembly 20.

[0075] Specifically, the sample reagent loading assembly 20 has a reagent pot with a drainage channel at the bottom. A drain pipe is connected between the drainage channel and the waste bin 90 to drain condensate from the reagent pot. A drain sensor is installed on the drain pipe, and a drain power source provides the power to drain the condensate from the reagent pot.

[0076] In this embodiment, the sample loading assembly 20 includes a sample loading assembly for loading samples and a reagent loading assembly 20 for loading reagents. The sample loading assembly is sleeved on the outside of the reagent loading assembly 21, and the sample loading assembly and the reagent loading assembly 20 rotate independently of each other.

[0077] Specifically, the sample loading assembly includes a chassis, and the reagent loading assembly includes a reagent container 212. The chassis is used to store samples, and the reagent container 212 is used to store reagents. The chassis is coaxially fitted onto the outside of the reagent container 212, and the chassis and the reagent container 212 rotate independently of each other.

[0078] In one optional embodiment, the discharge sensor includes a pressure sensor, and the discharge power source includes a diaphragm pump, with the pressure sensor disposed between the sample reagent loading assembly and the diaphragm pump; or, the discharge sensor includes a flow sensor, with the flow sensor disposed between the sample reagent loading assembly and the diaphragm pump. The generation of alarm information based on the pressure difference and / or flow difference between the discharge sensor and the discharge power source includes: generating an alarm when the pressure sensor detects that the pipeline resistance in the discharge line is greater than or equal to the discharge resistance of the diaphragm pump during operation; or, generating an alarm when the flow sensor detects that the pipeline flow rate in the discharge line is less than the minimum flow rate of the diaphragm pump during operation.

[0079] Specifically, a diaphragm pump is used as the power source. The diaphragm pump performs gas-liquid suction and discharge actions by moving its diaphragm up and down. Under the same voltage and resistance, the volume of gas suction and discharge per diaphragm movement is constant, i.e., the flow rate is constant. However, the flow rate of the diaphragm pump varies under the same voltage and different resistances. Therefore, the discharge resistance during operation can be determined by the flow-resistance curve of the diaphragm pump. This discharge resistance serves as the blockage resistance threshold for incomplete condensate drainage. When the discharge pipeline is draining condensate, the pressure sensor compares the pipeline resistance with the discharge resistance. If the discharge resistance is less than or equal to the pipeline resistance, it is determined that the discharge pipeline cannot completely drain the condensate from reagent pot 212, thus generating an alarm message.

[0080] In addition, the discharge sensor can also be a flow sensor. The flow sensor collects the flow rate in the discharge pipeline and compares it with the minimum flow rate when the diaphragm pump is working. If the pipeline flow rate is less than the minimum flow rate when the diaphragm pump is working, an alarm message is generated.

[0081] It should be noted that the alarm information can be from the device's alarm, which may include indicator lights or buzzers, etc., and this application does not impose any restrictions.

[0082] In an optional implementation, the control component is further configured to: adjust the discharge resistance based on the ratio of the first ultimate vacuum pressure of the diaphragm pump at a preset altitude to the second ultimate vacuum pressure at the current altitude.

[0083] The force is corrected to obtain the corrected drainage resistance, which can identify the decline in altitude and pump capacity in real time, and correct the blockage resistance in real time, so as to ensure that the discharge status of condensate can be monitored correctly and stably under different altitudes and pump capacity decline conditions.

[0084] In an optional embodiment, the mixing and cleaning assembly 40 stores an enhanced cleaning agent for intensive cleaning of the needle bar, enabling the needle bar to undergo intensive cleaning after testing. Before testing a sample, the control assembly determines whether the needle bar has come into contact with maintenance fluid, sample, and / or reagent in a previous test based on its historical operating parameters. If the needle bar has come into contact with maintenance fluid, sample, and / or reagent in a previous test, the mixing and cleaning assembly 40 performs a second intensive cleaning of the needle bar. This reduces the number of cleaning cycles and the amount of intensive cleaning agent, while also preventing residual sample from the previous test from affecting the accuracy of the next test.

[0085] The needle components include, but are not limited to, sampling needles, dispensing needles, and draining needles. Their main purpose is to thoroughly clean the needle components to prevent residual samples on the needle components from affecting the accuracy of the next test item. For example, residual protein impurities on the surface of the dispensing needle.

[0086] In an optional implementation, the control component is further configured to: determine whether the next test item for the needle bar is a sensitive item; and, if the next test item for the needle bar is determined to be a sensitive item, control the mixing and cleaning component to perform a second enhanced cleaning of the needle bar to prevent residual sample and / or reagents on the needle bar from the previous test item from affecting the test of that item.

[0087] After sampling the above technical solutions, the contamination scenarios and degrees on the needle rods can be accurately identified. At the same time, compared with intensive cleaning after each test, the number of cleaning times and the amount of cleaning fluid can be effectively reduced, thereby reducing the consumable costs for the client and saving maintenance time and client consumable costs.

[0088] In an optional implementation, the control component is further configured to: determine the amount of enhanced cleaning agent required for the needle bar based on the contact height and time between the needle bar and the maintenance fluid, sample, and / or reagent.

[0089] Specifically, the diameter of the needle rod is fixed, while the amount of enhanced cleaning agent required for the needle rod is related to the diameter and height of the needle rod. Therefore, the amount of enhanced cleaning agent required for the needle rod can be calculated by the contact height and time between the needle rod and the maintenance solution, sample and / or reagent. This allows the amount of enhanced cleaning agent required to be controlled to meet the cleaning needs of the needle rod, without causing problems of too much or too little.

[0090] In an optional embodiment, the reagent loading assembly 21 includes a cooling structure 211, wherein the cooling structure 211 is disposed below the reagent pot 212 and offset from the center of the reagent pot 212, for cooling the interior of the reagent pot 212.

[0091] In this embodiment, the refrigeration structure 211 includes a refrigeration component 2111, a heat insulation plate 2116, a cold end radiator 2112, a hot end radiator 2113, a cold end sealing ring, a hot end sealing ring, and a reagent pot sealing ring. The cold end radiator 2112 is attached to the heat insulation plate 2116 via the cold end sealing ring, and the hot end radiator 2113 is attached to the heat insulation plate via the hot end sealing ring. The cold end of the refrigeration component 2111 is connected to the cold end radiator 2112, and the hot end of the refrigeration component 2111 is connected to the hot end radiator 2113. The reagent pot 212 is located above the cold end radiator 2112. The reagent pot sealing ring is disposed between the bottom of the outer side of the reagent pot 212 and the heat insulation plate 2116, which facilitates the assembly and disassembly of the heat insulation plate 2116 and the reagent pot.

[0092] After adopting the above technical solution, the adhesive seal between the cold end radiator 2112 and the heat insulation plate 2116 is changed to a cold end sealing ring, and the adhesive seal between the hot end radiator 2113 and the heat insulation plate 2116 is changed to a hot end sealing ring. By using the sealing ring, the problem of easy aging of glue and unreliability in long-term use can be avoided. At the same time, the reagent pot sealing ring is set between the bottom of the outside of the reagent pot 212 and the heat insulation plate 2116, which can facilitate the overall disassembly and assembly of the refrigeration structure 211.

[0093] In an alternative implementation, the reagent pot material is changed from ABS to a stronger glass fiber material to improve the strength of the reagent pot.

[0094] After adopting the above technical solution, since the reagent pot 212 is sealed to the heat insulation plate 2116 through the reagent pot sealing ring, it is not necessary to place the reagent pot 212 between the cold end radiator 2112 and the heat insulation plate 2116, nor is it necessary to set a sealing ring between the cold end radiator 2112 and the reagent pot 212. This allows the cold end radiator 2112, the heat insulation plate 2116, the refrigeration component 2111 and the hot end radiator 2113 to form a complete structure, which makes it convenient for the entire refrigeration structure 211 to be disassembled from the bottom of the reagent pot 212.

[0095] In an optional embodiment, the diameter of the hot-end sealing ring is increased from 3mm to 4mm, and the heat insulation plate 2116 is changed from bakelite to SMC material. SMC material is a sheet molding compound with good electrical insulation, mechanical properties, thermal stability, and chemical corrosion resistance. By adopting the above technical solutions, not only is the sealing performance of the refrigeration structure 211 ensured, but the strength of the heat insulation plate 2116 is also improved, and the dimensional expansion after water absorption is relatively low.

[0096] In this embodiment, the heat insulation plate 2116 is provided with a non-irregular hot end mounting groove, and the shape of the hot end sealing ring is adapted to the shape of the hot end mounting groove, that is, both are non-irregular structures. This not only allows the hot end sealing ring to be installed in the hot end mounting groove, but also ensures the sealing between the heat insulation plate 2116 and the hot end radiator 2113. It is not necessary to open irregular holes for wiring on the heat insulation plate, which would result in the hot end mounting groove and the hot end sealing ring being irregular structures.

[0097] In an alternative embodiment, the heat insulation plate 2116 has multiple clearance slots on the side facing the hot end heat sink, which can reduce heat conduction.

[0098] The vent groove can be set inside the heat insulation plate 2116 located in the hot end mounting groove, or it can be set outside the hot end mounting groove. Alternatively, the vent groove can be set inside and outside the hot end mounting groove. Its main purpose is to reduce heat conduction. As for whether the vent groove is inside or outside the hot end mounting groove, this application does not impose any restrictions.

[0099] In an optional embodiment, the cooling structure 211 includes a cable concealment sleeve 2115 and a signal connector 2114. The hot-end heat sink 2113 is provided with a connector receiving hole. One end of the cable concealment sleeve 2115 is connected to the cooling component 2111 and housed in the connector receiving hole. The signal connector 2114 is disposed on the other end of the cable concealment sleeve 2115, so that the wires on the cooling structure 211 can pass through the cable concealment sleeve 2115 and connect to the signal connector 2114. By using the cable concealment sleeve 2115 and the signal connector 2114, it is possible to avoid opening wire holes in the heat insulation plate 2116, and the wires can be directly passed through the cable concealment sleeve 2115 fixed to the hot-end heat sink 2113.

[0100] Specifically, the heat insulation plate 2116 has a wire clamping groove and a wire pressing plate on the inner side of the hot end mounting groove. The position of the wire pressing plate corresponds to the position of the wire hiding sleeve 2115. The wire clamping groove can straighten the wires on the cooling component 2111. Then, the wires are bent at the position of the wire pressing plate towards the end of the hot end heat sink 2113 that is away from the heat insulation plate 2116, so that the wires can be passed through the wire hiding sleeve 2115 and connected to the signal connector 2114 fixed on the wire hiding sleeve 2115. The wire hiding sleeve 2115 can accommodate excess wires and play the role of hiding wires.

[0101] In one optional embodiment, the refrigeration structure includes an airtight joint and a sleeve sealing ring. The sleeve sealing ring is disposed between the cable sleeve and the refrigeration component for sealing between the cable sleeve and the refrigeration component. The airtight joint is fixed on the hot end radiator 2113 for realizing the airtightness detection of the refrigeration structure.

[0102] Specifically, the airtight connector and the cable sleeve 2115 are fixed to the heat sink at the hot end by their own threads. The signal connector 2114 is an aviation connector, which is locked to the cable sleeve 2115 by screws. At the same time, the aviation connector and the airtight connector seal their openings with their own sealing rings to ensure the airtightness of the overall structure of the cooling structure 211.

[0103] In an optional embodiment, the heat insulation plate 2116 is provided with a heat insulation fixing part, so that the refrigeration structure 211 can be fixed to the bottom of the reagent pot 212 by the heat insulation fixing part. The operating end of the heat insulation fixing part is exposed on the periphery of the heat insulation plate 2116, so that the refrigeration structure 211 can be removed from the bottom of the reagent pot 212 from the outside of the heat insulation plate 2116.

[0104] Specifically, the heat insulation fixing part is connected to the four screws on the outside of the heat insulation plate 2116. The refrigeration structure 211 is fixed to the bottom of the reagent pot 212 by the four screws. When maintaining the reagent loading assembly 21, it is only necessary to tighten or loosen the screws to remove the entire refrigeration structure 211 from the reagent pot 212 or to install the refrigeration structure 211 on the reagent pot 212, making the maintenance of the reagent loading assembly 21 more time-saving and labor-saving.

[0105] In an optional embodiment, the analyzer includes a frame 10, wherein a sample and reagent dispensing assembly 30, a mixing and washing assembly 40, a magnetic separation assembly 50, an incubation and photometric assembly 60, a waste liquid discharge assembly, a reaction vessel gripping assembly 80, and a control assembly are all mounted on the frame 10. The bottom of the frame 10 is provided with support feet 11 and auxiliary feet 12. The support feet 11 are located at the ends of the frame 10, and the auxiliary feet 12 are located between the support feet 11 to assist in supporting the frame, so that the frame 10 can be placed more firmly on a horizontal surface. In particular, when the support feet 11 on one side of the frame 10 cannot provide support, the auxiliary feet 12 can provide support together with the support feet 11 on the other side of the frame 10.

[0106] For example, when the analyzer needs maintenance, it can be moved forward a short distance on the table. At this point, the support leg 11 on one side of the rack 10 will detach from the table, and the analyzer can then be supported on the table by the auxiliary leg 12 and the support leg 11 on the other side of the rack 10, forming a new support surface. The space at this point is sufficient to remove the analyzer's casing, facilitating the repair of its components. If the maintenance personnel feel the space is still insufficient, the analyzer needs to be moved from the table to the repair area. This can be done by two people lifting the analyzer or by four people moving it around its sides. During the repair process, convenience and safety are greatly improved.

[0107] In one optional embodiment, there are four support feet 11 and one auxiliary foot 12. The four support feet 11 are located at the four ends of the bottom surface of the frame 10, and the auxiliary foot 12 is located in the middle of the bottom surface of the frame, with its height lower than that of the four support feet 11. This ensures that when the analyzer is working normally on the table, only the four end support feet 11 at the bottom provide support. When the machine malfunctions and requires alignment for maintenance, the analyzer can be moved forward a short distance. At this time, the middle auxiliary foot 12 and the support feet 11 at two ends of the auxiliary foot 12 form a triangular support, allowing the analyzer to remain firmly placed on the table even when slightly tilted forward. This allows maintenance personnel to repair the analyzer or move it to a repair area for maintenance.

[0108] It should be noted that the number of supporting feet 11 can be three, five or more, and the number of auxiliary feet 12 can also be two, three or more, and this application does not impose any restrictions.

[0109] In one alternative implementation, the support foot 11 and auxiliary foot 12 are made of an elastic material. During normal use of the analyzer, the weight of the entire unit compresses the support foot 11 and auxiliary foot 12, and the analyzer is directly disconnected from the ground, with their surroundings only providing partial support. Alternatively, the support foot 11 and auxiliary foot 12 can be compressed to a rigid or stable position, so that the analyzer does not contact the ground and they provide the main support.

[0110] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection. They can refer to a mechanical connection or an electrical connection. They can refer to a direct connection or an indirect connection through an intermediate medium, and they can refer to the internal communication of two components or the interaction between two components. For those skilled in the art, the specific meaning of the above terms in this application can be understood according to the specific circumstances.

[0111] In this application, unless otherwise expressly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature being directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature being directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0112] The foregoing disclosure provides many different embodiments or examples for implementing different structures of this application. To simplify the disclosure, specific examples of components and arrangements are described above. Of course, these are merely examples and are not intended to limit the scope of this application. Furthermore, reference numerals and / or letters may be repeated in different examples; such repetition is for simplification and clarity and does not in itself indicate a relationship between the various embodiments and / or arrangements discussed. In addition, examples of various specific processes and materials are provided in this application, but those skilled in the art will recognize the application of other processes and / or the use of other materials.

[0113] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with an embodiment or example is included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

Claims

1. A fully automated chemiluminescence immunoassay analyzer, characterized in that, include: The sample and reagent dispensing assembly is used to load samples and reagents into the reaction vessel to form the test sample; A mixing and cleaning assembly is used to mix the sample and reagents in the reaction vessel to allow the sample and reagents to react and form a test sample. A magnetic separation assembly is used to perform magnetic separation cleaning on the test sample in the reaction vessel after adding magnetic bead reagent, and to add substrate; The incubation photometric component is used to incubate and photometrically measure the test sample containing the substrate in order to obtain the test results; A waste liquid discharge assembly is used to discharge the waste liquid from the sample container after incubation and photometry. A reaction vessel grasping assembly for dispatching the reaction vessel to at least one of the sample and reagent dispensing assembly, the mixing and washing assembly, the magnetic separation assembly, the incubation photometric assembly, and the waste liquid discharge assembly; A control component is used to acquire the timing sequence of multiple sub-actions of the reaction container gripping component. If the timing sequence of any adjacent sub-actions among the multiple sub-actions meets a preset condition, the reaction container gripping component is controlled to run to the intermediate position after the preceding sub-action and before the following sub-action in the adjacent sub-actions. The intermediate position is located within the area enclosed by the sample and reagent dispensing component, the mixing and washing component, the magnetic separation component, the incubation and photometry component, the waste liquid discharge component, and the reaction container gripping component. Wherein, the timing of any adjacent sub-actions among the plurality of sub-actions satisfies a preset condition, including: the timing of any adjacent sub-actions among the plurality of sub-actions is different from the preset timing of actions; wherein, the preset timing of actions includes the timing of actions of a plurality of pre-configured sub-actions.

2. The analyzer according to claim 1, characterized in that, The reaction vessel is provided with an identification code, the analyzer includes a scanning device, and the control component is further used to: scan the identification code through the scanning device to obtain the action timing of multiple sub-actions of the reaction vessel grasping component.

3. The analyzer according to claim 1, characterized in that, The multiple sub-action timing sequence includes N consecutive timing cycles, each timing cycle corresponds to several sub-actions in the multiple sub-actions, and all the sub-actions corresponding to the N consecutive timing cycles form the multiple sub-actions; wherein, the duration of any timing cycle is the same, and the number of sub-actions it contains and their order are the same or different. The timing of actions of any adjacent sub-actions among the multiple sub-actions meets preset conditions, including: In any of the sub-actions corresponding to any given timing period, the timing sequence of any adjacent sub-actions differs from the preset timing sequence; and / or, Between two adjacent timing cycles, the timing sequence of the actions corresponding to the last sub-action in the earlier timing cycle and the first sub-action in the later timing cycle is different from the preset timing sequence.

4. The analyzer according to any one of claims 1 to 3, characterized in that, After determining that the reaction vessel gripping component has completed the multiple sub-actions, the reaction vessel gripping component is controlled to run to the intermediate position.

5. The analyzer according to claim 1, characterized in that, The sub-action includes a set of multiple motion actions, the last motion action in the set being a lifting action; before controlling the reaction container gripping component to move to the intermediate position, the control component is further configured to: when controlling the reaction container gripping component to perform the lifting action, control the reaction container gripping component to rise to a preset position, the preset position being the same as the intermediate position in the vertical direction.

6. The analyzer according to claim 1, characterized in that, The analyzer includes a liquid path system and a sample and reagent loading assembly for loading samples and reagents. The sample and reagent loading assembly is connected to the waste tank of the waste liquid discharge assembly through the liquid path system for discharging the gas and liquid on the sample and reagent loading assembly. The liquid path system includes a discharge pipe, a discharge sensor, and a discharge power source. The discharge sensor is disposed in the discharge pipe. The sample and reagent loading assembly is connected to the waste tank through the discharge pipe. The control assembly is used to control the power source to discharge the gas and liquid on the sample and reagent loading assembly to the waste tank. The control component is further configured to generate alarm information based on the pressure difference and / or flow difference between the discharge sensor and the discharge power source.

7. The analyzer according to claim 6, characterized in that, The discharge sensor includes a pressure sensor, the discharge power source includes a diaphragm pump, and the pressure sensor is disposed between the sample reagent loading assembly and the diaphragm pump; And / or, the discharge sensor includes a flow sensor disposed between the sample reagent loading assembly and the diaphragm pump; The step of generating alarm information based on the pressure difference and / or flow difference between the discharge sensor and the discharge power source includes: An alarm message is generated when the pressure sensor detects that the pipeline resistance on the discharge pipeline is greater than or equal to the discharge resistance of the diaphragm pump during operation. And / or, when the flow sensor detects that the flow rate in the discharge pipeline is less than the minimum flow rate when the diaphragm pump is operating, an alarm message is generated.

8. The analyzer according to claim 7, characterized in that, The control component is also used for: The discharge resistance is corrected based on the ratio of the first ultimate vacuum pressure of the diaphragm pump at a preset altitude to the second ultimate vacuum pressure at the current altitude, and the corrected discharge resistance is obtained.

9. The analyzer according to claim 1, characterized in that, The mixing and cleaning assembly stores an enhanced cleaning agent for intensive cleaning of the needle bar, enabling the needle bar to undergo intensive cleaning after testing; before testing the sample, the control assembly is used to: Based on the historical operating parameters of the needle bar, determine whether the needle bar came into contact with maintenance fluid, sample and / or reagent in previous tests; if the needle bar came into contact with maintenance fluid, sample and / or reagent in previous tests, control the mixing and cleaning assembly to perform a second enhanced cleaning of the needle bar.

10. The analyzer according to claim 9, characterized in that, The control component is also used to: determine whether the next test item of the needle bar is a sensitive item, and if the next test item of the needle bar is determined to be a sensitive item, control the mixing and cleaning component to perform a second enhanced cleaning on the needle bar.

11. The analyzer according to claim 10, characterized in that, The control component is also used to: determine the required amount of the enhanced cleaning agent for the needle bar based on the contact height and time between the needle bar and the maintenance fluid, sample, and / or reagent.

12. The analyzer according to claim 1, characterized in that, The analyzer includes a sample and reagent loading assembly for loading samples and reagents. The sample and reagent loading assembly also includes a reagent pot and a cooling structure. The cooling structure is located below the reagent pot and is used to cool the contents of the reagent pot. The refrigeration structure includes a refrigeration component, a heat insulation plate, a cold-end radiator, a hot-end heat sink, a cold-end sealing ring, a hot-end sealing ring, and a reagent pot sealing ring. The cold-end heat sink is attached to the heat insulation plate via the cold-end sealing ring, and the hot-end heat sink is attached to the heat insulation plate via the hot-end sealing ring. The cold end of the refrigeration component is connected to the cold-end radiator, and the hot end of the refrigeration component is connected to the hot-end heat sink. The reagent pot is located above the cold-end radiator, and the reagent pot sealing ring is disposed between the bottom of the outer side of the reagent pot and the heat insulation plate.

13. The analyzer according to claim 12, characterized in that, The heat insulation board is provided with a non-irregularly shaped hot end mounting groove, and the hot end sealing ring is installed in the hot end mounting groove; and / or, the heat insulation board is a heat insulation board made of SMC material, and / or, the side of the heat insulation board facing the hot end radiator has multiple clearance grooves.

14. The analyzer according to claim 13, characterized in that, The cooling structure includes a cable sleeve and a signal connector. The hot end heat sink is provided with a connector receiving hole. One end of the cable sleeve is connected to the cooling component and is housed in the connector receiving hole. The signal connector is disposed on the other end of the cable sleeve, so that the wires on the cooling structure can pass through the cable sleeve and connect to the signal connector.

15. The analyzer according to claim 14, characterized in that, The refrigeration structure includes an airtight joint and a sleeve sealing ring. The sleeve sealing ring is disposed between the cable sleeve and the refrigeration component. The airtight joint is fixed on the hot end radiator and is used for airtightness testing of the refrigeration structure.

16. The analyzer according to claim 12, characterized in that, The heat insulation plate is provided with a heat insulation fixing part, and the refrigeration structure is fixed to the bottom of the reagent pot through the heat insulation fixing part. The operating end of the heat insulation fixing part is exposed on the periphery of the heat insulation plate.

17. The analyzer according to claim 1, characterized in that, The analyzer includes a frame, and the sample and reagent dispensing component, mixing and washing component, magnetic separation component, incubation and photometry component, waste liquid discharge component, reaction vessel gripping component and control component are all mounted on the frame. The bottom of the frame is provided with support feet and auxiliary feet. The support feet are located at the ends of the frame, and the auxiliary feet are located between the support feet to assist in supporting the frame.

18. The analyzer according to claim 17, characterized in that, The number of supporting feet is four, and the number of auxiliary feet is one. The four supporting feet are located at the four ends of the bottom surface of the frame, and the auxiliary foot is located in the middle of the bottom surface of the frame. The height of the auxiliary foot is lower than the height of the four supporting feet. And / or, the support feet and auxiliary feet are made of elastic material.

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