Absorbable oral barrier film

Abstract

The application provides an absorbable oral cavity barrier film, which comprises a bone plug and a barrier film, the bone plug is provided with a containing cavity and a plurality of first micropores, the size of the first micropores is greater than the size of a single bone cell, the first micropores are communicated with the containing cavity to allow bone cells to migrate and grow into the containing cavity, the circumferential wall of the first end of the bone plug is provided with a filling hole, the filling hole is communicated with the containing cavity to allow bone powder or bone blocks to be manually filled, the size of the filling hole is greater than the size of the first micropores, the second end of the bone plug is tapered, the barrier film is saddle-shaped to match the shape of the alveolar ridge, the middle part of the inner concave side of the barrier film is arranged at the first end of the bone plug, and the bone plug and the barrier film are both made of a medical degradable high polymer material. After implantation, the application can ensure biocompatibility, the bone plug can also provide sufficient support strength for the barrier film, wrinkles are avoided, and the application is easy to operate. After a period of implantation, the bone plug and the barrier film can be degraded into carbon dioxide and water, secondary removal is not needed, and secondary trauma to the patient is avoided.

Description

Technical Field

[0001] This application relates to the field of dental instrument technology, and in particular to an absorbable oral barrier membrane. Background Technology

[0002] In bone regeneration technology, the barrier membrane can be used in conjunction with guided bone regeneration (GBR) to effectively increase bone volume, restore the height and fullness of the alveolar ridge, and effectively prevent soft tissue retraction.

[0003] Barrier membranes can be divided into absorbable and non-absorbable barrier membranes. Absorbable barrier membranes exhibit good biocompatibility, controllable degradation time, and can guide tissue growth. They possess excellent tear resistance, are completely degraded and absorbed in vivo without tissue irritation or cytotoxicity, and effectively function as a barrier to assist in the alveolar bone regeneration process. Non-absorbable barrier membranes effectively isolate the bone graft area, possess good mechanical strength, and prevent membrane collapse. By using implants and additional membrane staples for fixation, they provide a stable space for bone regeneration and repair in the defect area, ensuring ideal osteogenic results.

[0004] Currently, absorbable barrier membranes are mainly represented by collagen membranes. Collagen membranes are obtained from specific animal-derived tissues and organs, posing animal-related risks. They also suffer from drawbacks such as insufficient mechanical support, easy wrinkling during surgery, and difficulty in intraoperative shaping. Non-absorbable barrier membranes are mainly represented by titanium membranes, which require secondary removal after surgery, causing significant trauma to the patient. Therefore, this application proposes an absorbable barrier membrane that possesses sufficient mechanical support, eliminates the need for secondary surgery, and exhibits excellent biocompatibility. Summary of the Invention

[0005] This application provides an absorbable barrier membrane that ensures biocompatibility after implantation. The bone plug provides sufficient support and strength to prevent wrinkling and facilitates handling. Furthermore, after a period of time, both the bone plug and the barrier membrane degrade into carbon dioxide and water, eliminating the need for secondary removal and preventing secondary trauma to the patient.

[0006] To solve the above-mentioned technical problems, this application adopts the following technical solution:

[0007] An absorbable oral barrier membrane includes a bone plug and a barrier membrane. The bone plug has a receiving cavity and a plurality of first micropores, the size of which is larger than the size of a single bone cell. The first micropores communicate with the receiving cavity to allow bone cell migration and ingrowth into the receiving cavity. The circumferential wall of a first end of the bone plug has a filling hole, which communicates with the receiving cavity to allow manual filling with bone powder or bone blocks. The size of the filling hole is larger than the size of the first micropores. The second end of the bone plug is tapered. The barrier membrane is saddle-shaped to match the shape of the alveolar ridge. The middle part of the concave side of the barrier membrane is located at the first end of the bone plug. Both the bone plug and the barrier membrane are made of medical biodegradable polymer material.

[0008] During use, the dentist first creates an implant socket in the alveolar bone, then inserts a bone plug into the socket. A saddle-shaped barrier membrane adheres to the alveolar ridge, achieving the implantation of this absorbable oral barrier membrane. Bone cells can migrate and grow into the cavity of the bone plug through micropores in the plug, and after a period of time, the bone cells can fill the cavity. Before implantation, the dentist can also fill the cavity with bone powder or bone blocks through filling holes to accelerate bone cell growth. The bone plug is connected to the concave side of the barrier membrane, allowing the barrier membrane to conform to the shape of the alveolar ridge after implantation. Both the bone plug and the barrier membrane are made of medical-grade biodegradable polymer materials, which degrade into carbon dioxide and water over time.

[0009] Compared to existing technologies, this absorbable oral barrier membrane can be installed onto the alveolar bone using a bone plug and a saddle-shaped barrier membrane. Bone cells continuously migrate and grow into the cavity of the bone plug, ultimately achieving implantation. Because both the bone plug and the barrier membrane are made of medical-grade biodegradable polymer materials, biocompatibility is guaranteed after implantation. The bone plug also provides sufficient support and strength for the barrier membrane, preventing wrinkles and facilitating manipulation. Furthermore, after a period of time, the bone plug and barrier membrane degrade into carbon dioxide and water, eliminating the need for secondary removal and preventing secondary trauma to the patient.

[0010] In one embodiment of this application, the medical biodegradable polymer material includes one or more of polycaprolactone, polyglycolic acid, polylactic acid, and polylactic acid-glycolic acid copolymer.

[0011] In one embodiment of this application, the thickness of the barrier membrane gradually decreases from the center to the edge.

[0012] In one embodiment of this application, the thickness of the barrier film is 0.5 mm to 2 mm.

[0013] In one embodiment of this application, the barrier membrane is provided with a second micropore, the size of which is smaller than the size of a single fibroblast, to prevent fibroblast migration and ingrowth.

[0014] In one embodiment of this application, the angle between the axis of the first micropore and the axis of the filling hole and the radial plane of the bone plug is 15 degrees to 30 degrees, and the openings of both are close to the first end of the bone plug.

[0015] In one embodiment of this application, the bone plug and the barrier membrane are integrally formed and manufactured by additive manufacturing.

[0016] In one embodiment of this application, the additive manufacturing method is fused deposition modeling.

[0017] In one embodiment of this application, the bone plug and the barrier membrane are manufactured separately, and the first end of the bone plug is bonded to the middle of the concave side of the barrier membrane.

[0018] In one embodiment of this application, the bone plug is manufactured by electrospinning, and the barrier membrane is manufactured by additive manufacturing. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 A three-dimensional structural diagram of an absorbable oral barrier membrane provided in an embodiment of this application;

[0021] Figure 2 A three-dimensional structural schematic diagram of an absorbable oral barrier membrane provided in another embodiment of this application;

[0022] Figure 3 A three-dimensional structural schematic diagram of an absorbable oral barrier membrane provided in another embodiment of this application;

[0023] Figure 4 A three-dimensional structural schematic diagram of an absorbable oral barrier membrane provided in another embodiment of this application;

[0024] Figure 5 A three-dimensional structural schematic diagram of an absorbable oral barrier membrane provided in another embodiment of this application;

[0025] Figure 6 A three-dimensional structural schematic diagram of the bone plug used in an absorbable oral barrier membrane provided in an embodiment of this application;

[0026] Figure 7 A three-dimensional structural schematic diagram of the bone plug used in an absorbable oral barrier membrane provided in another embodiment of this application;

[0027] Figure 8 A cross-sectional schematic diagram of the bone plug used in an absorbable oral barrier membrane provided in another embodiment of this application;

[0028] Figure 9 A three-dimensional structural schematic diagram of the barrier membrane used in an embodiment of this application for an absorbable oral barrier membrane;

[0029] Figure 10 A three-dimensional structural schematic diagram of the barrier membrane used in an absorbable oral barrier membrane provided in another embodiment of this application;

[0030] Figure 11 A three-dimensional structural schematic diagram of the barrier membrane used in an absorbable oral barrier membrane provided in another embodiment of this application.

[0031] Figure label:

[0032] 100, Bone plug; 110, Receiving cavity; 120, First micropore; 130, Filling pore; 200, Barrier membrane; 210, Second micropore. Detailed Implementation

[0033] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions in the embodiments of this application are described clearly and completely below. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort are also within the scope of protection of this application.

[0034] In the description of this application, it should be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.

[0035] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this application, unless otherwise stated, "a plurality of" means two or more.

[0036] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly, for example, they can refer to a fixed connection, a detachable connection, or an integral connection. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0037] First, let's explain the following terms:

[0038] Polycaprolactone (PCL) is a high-molecular-weight organic polymer synthesized by ring-opening polymerization of ε-caprolactone monomers under the catalysis of a metal anion complex catalyst. Different molecular weights can be obtained by controlling the polymerization conditions. PCL exhibits good biocompatibility, good compatibility with other organic polymers, and good biodegradability. It can be used as a cell growth support material, is compatible with a variety of conventional plastics, and completely degrades in natural environments within 6-12 months.

[0039] Polyglycolide (PGA), also known as polyhydroxyacetic acid, is a highly crystalline, biodegradable aliphatic polymer that degrades rapidly.

[0040] Polylactic acid (PLA), also known as polylactide, is a polyester polymerized from lactic acid. PLA possesses excellent biodegradability, compatibility, and absorbability. It is a non-toxic, non-irritating synthetic polymer material. Its raw material, lactic acid, primarily comes from the fermentation of starches (such as corn and rice), but can also be obtained from cellulose, kitchen waste, or fish waste. PLA has a wide range of raw material sources, and products made from it can be directly composted or incinerated after use, ultimately degrading completely into CO2 and H2O, meeting the requirements of sustainable development. PLA's good transparency, certain toughness, biocompatibility, and heat resistance are the main reasons for its widespread application.

[0041] Poly(lactide-co-glycolide acid) (PLGA) is a biodegradable functional polymer organic compound formed by the random polymerization of two monomers—lactic acid and glycolic acid. It has good biocompatibility, is non-toxic, and has good encapsulation and film-forming properties, and is widely used in pharmaceuticals, medical engineering materials, and modern industrial fields.

[0042] Additive manufacturing, also known as 3D printing, is a technology that uses digital model files as a basis and employs bondable materials such as powdered metal or plastic to construct objects by printing layer by layer.

[0043] Fused Deposition Modeling (FDM) is a laser-free machining process. Its principle is as follows: A nozzle, under computer control, moves in the x, y, and z directions. The filament is heated within the nozzle to a temperature slightly above its melting point and extruded through a nozzle with a micro-nozzle. The temperature of the molten material remains slightly above its curing temperature, while the temperature of the shaped portion is slightly below the curing temperature. After extrusion, the molten material fuses with the previous layer. Once one layer is deposited, the stage descends by a predetermined thickness increment, and the melt-blowing process continues until the entire solid part is completed.

[0044] Electrospinning is a special form of electrostatic atomization of polymer fluids. In this process, the atomized material is not split into tiny droplets, but rather into micro-jet streams of polymer that can travel considerable distances before solidifying into fibers. The polymer solution or melt is jet-spun in a strong electric field. Under the influence of the electric field, the droplets at the needle tip change from a spherical shape to a conical shape, extending from the tip of the cone to form fine filaments. This method can produce polymer filaments with diameters in the nanometer range.

[0045] Figure 1 This is a three-dimensional structural diagram of an absorbable oral barrier membrane provided in an embodiment of this application. Figure 2 This is a three-dimensional structural diagram of an absorbable oral barrier membrane provided in another embodiment of this application. Figure 3 This is a three-dimensional structural diagram of an absorbable oral barrier membrane provided in another embodiment of this application. Figure 4 This is a three-dimensional structural diagram of an absorbable oral barrier membrane provided in another embodiment of this application. Figure 5 This is a three-dimensional structural diagram of an absorbable oral barrier membrane provided in another embodiment of this application. Figure 6 This is a three-dimensional structural diagram of the bone plug used in an absorbable oral barrier membrane provided in an embodiment of this application. Figure 7 A three-dimensional structural schematic diagram of the bone plug used in an absorbable oral barrier membrane provided in another embodiment of this application. Figure 8 A cross-sectional schematic diagram of the bone plug used in an absorbable oral barrier membrane provided in another embodiment of this application. Figure 9 This is a three-dimensional structural diagram of the barrier membrane used in an embodiment of the absorbable oral barrier membrane provided in this application. Figure 10 A three-dimensional structural schematic diagram of the barrier membrane used in an absorbable oral barrier membrane provided in another embodiment of this application. Figure 11 A three-dimensional structural schematic diagram of the barrier membrane used in an absorbable oral barrier membrane provided in another embodiment of this application.

[0046] Embodiments of this application provide an absorbable oral barrier membrane, such as... Figures 1 to 5As shown, it includes a bone plug 100 and a barrier membrane 200. The bone plug 100 is a supporting structure with a certain structural strength, and the barrier membrane 200 can seal the planting hole for planting and play a barrier role.

[0047] like Figure 6 As shown, the bone plug 100 is generally cylindrical in structure. The bone plug 100 has a receiving cavity 110 and multiple first micropores 120, with the receiving cavity 110 located inside the bone plug 100. The size of the first micropores 120 is larger than the size of a single bone cell. The size (diameter) of a single bone cell is approximately 15 micrometers; therefore, the size of the first micropores 120 can be designed to be at least 18 micrometers. The first micropores 120 communicate with the receiving cavity 110, allowing bone cells to migrate into the receiving cavity 110 through the first micropores 120 and continuously grow, eventually filling the receiving cavity, thus realizing the migration of bone cells into the receiving cavity 110.

[0048] like Figure 6 As shown, the circumferential wall of the first end of the bone plug 100 is provided with a filling hole 130, which is connected to the receiving cavity 110. Before implantation, the doctor can manually fill the receiving cavity 110 with bone powder or bone blocks through the filling hole 130 until the receiving cavity 110 is full.

[0049] The size of the filling hole 130 is larger than the size of the first micropore 120, which facilitates the filling of bone powder and bone blocks into the receiving cavity 110. The size of the bone powder and bone blocks is larger than the size of the first micropore 120 to prevent the filled bone powder and bone blocks from leaking out of the first micropore 120.

[0050] The second end of the bone plug 100 is tapered, which makes it easy to insert the bone plug 100 into the implantation hole and facilitates the operation.

[0051] In the actual manufacturing process, multiple bone plugs of different models and specifications can be made according to the different implant sites. Doctors can choose to use them according to the actual situation of the implant site to meet a variety of usage needs.

[0052] like Figure 9 As shown, the barrier membrane 200 is saddle-shaped to match the shape of the alveolar ridge. The saddle shape refers to the U-shape formed by the concave inner diameter of the barrier membrane 200, with the opening side of the U-shape being larger than the bending side, facilitating adhesion to the alveolar ridge. After implantation, the barrier membrane 200 can adhere to the alveolar ridge. The saddle-shaped barrier membrane 200, after fitting well to the implant site with no obvious gaps, can prevent the migration and ingrowth of oral fibroblasts, thus providing a protective barrier function.

[0053] like Figures 1 to 4 As shown, the middle part of the concave side of the barrier membrane 200 is located at the first end of the bone plug 100, so that after the bone plug 100 is inserted into the implant socket, the barrier membrane 200 can fit against the alveolar ridge.

[0054] Both the bone plug 100 and the barrier membrane 200 are made of medical biodegradable polymer materials. After implantation, and after a period of time, both the bone plug 100 and the barrier membrane 200 can be completely degraded into carbon dioxide and water, which are harmless to the human body and do not require secondary removal.

[0055] In use, the dentist first creates an implant socket in the alveolar bone, then inserts the bone plug 100 into the socket. The saddle-shaped barrier membrane 200 adheres to the alveolar ridge, thus implanting the absorbable oral barrier membrane. Bone cells can migrate and grow into the receiving cavity 110 of the bone plug 100 through the micropores on the bone plug 100. After a period of implantation, the bone cells can fill the receiving cavity 110. Before implantation, the dentist can also fill the receiving cavity 110 with bone powder or bone blocks through the filling hole 130 to accelerate the filling of the receiving cavity 110 by bone cells. The bone plug 100 is connected to the concave side of the barrier membrane 200, allowing the barrier membrane 200 to conform to the shape of the alveolar ridge after implantation. Both the bone plug 100 and the barrier membrane 200 are made of medical biodegradable polymer materials, which can degrade into carbon dioxide and water after a period of time.

[0056] Compared to existing technologies, this absorbable oral barrier membrane can be installed onto the alveolar bone via a bone plug 100 and a saddle-shaped barrier membrane 200. Bone cells continuously migrate and grow into the receiving cavity 110 of the bone plug 100, ultimately achieving implantation. Since both the bone plug 100 and the barrier membrane 200 are made of medical-grade biodegradable polymer materials, biocompatibility is guaranteed after implantation. The bone plug 100 also provides sufficient support strength for the barrier membrane 200, preventing wrinkles and facilitating manipulation. Furthermore, after a period of time, the bone plug 100 and barrier membrane 200 degrade into carbon dioxide and water, eliminating the need for secondary removal and preventing secondary trauma to the patient. The degradation cycle meets clinical needs, maintaining over 80% of its mechanical support strength within the oral cavity for 6 months. The bone plug 100 effectively guides bone tissue regeneration, providing initial mechanical support and cell adhesion, thus facilitating bone defect repair.

[0057] In some embodiments, the medical biodegradable polymeric material includes one or more of polycaprolactone, polyglycolic acid, polylactic acid, and polylactic-co-glycolic acid copolymer. Polycaprolactone, polyglycolic acid, polylactic acid, and polylactic-co-glycolic acid copolymer all possess biocompatibility and biodegradability. Bone plugs 100 and barrier membranes 200 made from these materials exhibit good biocompatibility with the oral cavity. Furthermore, after a period of implantation, bone plugs 100 and barrier membranes 200 can be degraded into small molecules or monomers by the action of acids, alkalis, or enzymes in the body, or metabolized into carbon dioxide (CO2) and water (H2O), achieving self-degradation after implantation in the oral cavity, thus eliminating the need for secondary removal.

[0058] In some embodiments, such as Figure 9 and Figure 10 As shown, the thickness of the barrier membrane 200 gradually decreases from the center to the edges, specifically from the connection point between the barrier membrane 200 and the bone plug 100 towards both sides. The connection point between the barrier membrane 200 and the bone plug 100 is generally located above the implant socket and is thicker to improve structural strength and prevent damage during tooth occlusion. The thickness of the barrier membrane 200 gradually decreases on both sides, facilitating shaping by the dentist. The greater thickness in the central area helps improve the protective mechanical strength during occlusion, while the thinner edge provides greater flexibility, aiding in bending, fitting, and shaping. By designing the thickness of different areas, the desired mechanical strength and degradation cycle can be controlled. This barrier membrane 200 has a dense, fully curved surface, effectively serving as a barrier.

[0059] In some embodiments, the barrier membrane 200 has a thickness of 0.5 mm to 2 mm, with the central region having a thickness of approximately 2 mm to provide sufficient structural strength, and the edge region having a thickness of approximately 0.5 mm to facilitate shaping by the physician.

[0060] In the actual fabrication process, the saddle-shaped barrier membrane 200 can be designed according to the matching requirements of different peripheral geometric structures of dental implants. Multiple models and specifications of saddle-shaped barrier membranes 200 can be prepared, allowing dentists to select the appropriate one based on their specific oral conditions, thus meeting diverse usage needs. Once the saddle-shaped barrier membrane 200 adheres well to the implant socket, there are no obvious gaps, and it can prevent the migration and ingrowth of oral fibroblasts, providing a protective barrier function.

[0061] In some embodiments, such as Figure 10 As shown, the barrier membrane 200 has second micropores 210. The size of the second micropores 210 is smaller than that of a single fibroblast, yet they can still prevent the migration and ingrowth of oral fibroblasts, thus playing a protective barrier role and realizing the barrier function of the barrier membrane 200. The density of the second micropores 210 varies in different regions of the barrier membrane 200. By adjusting the pore density arrangement in different regions, the mechanical properties and degradation cycle are regulated.

[0062] In specific implementation, the second micropore 210 can be a polygonal structure such as a circle, triangle, quadrilateral, pentagon, hexagon, heptagon, or octagon.

[0063] In addition, such as Figure 5 and Figure 11 As shown, the barrier membrane 200 can also be a porous mesh structure, composed of lattice units of different shapes. The size of the pores on the surface is smaller than the size of a single fibroblast, preventing the migration and ingrowth of oral fibroblasts, thus playing a protective barrier role and realizing the barrier function of the barrier membrane 200. During the sculpting process, the membrane can be... Figure 5 and Figure 11 The barrier membrane 200 is shaped into a saddle shape.

[0064] In some embodiments, such as Figure 8 As shown, the angle between the axis of the first micropore 120 and the axis of the filling hole 130 and the radial plane of the bone plug 100 is 15 degrees to 30 degrees, and the openings of both are close to the first end of the bone plug 100. That is to say, from the inner wall to the outer wall of the bone plug 100, the first micropore 120 and the filling hole 130 extend from the second end of the bone plug 100 to the first end. In this way, the migrating and ingrowth of bone cells, as well as the manually filled bone powder and bone blocks, are less likely to overflow.

[0065] In some embodiments, the bone plug 100 and the barrier membrane 200 are integrally molded and manufactured together, eliminating the need for doctors to connect them during implantation, thus facilitating use. The bone plug 100 and the barrier membrane 200 can be manufactured using additive manufacturing methods. Additive manufacturing is a technology that constructs objects by printing layer by layer using powdered metals or plastics based on digital model files. In this application, the aforementioned medical biodegradable polymer material (one or more of polycaprolactone, polyglycolic acid, polylactic acid, and polylactic acid-glycolic acid copolymer) is used for manufacturing.

[0066] In some embodiments, the additive manufacturing method is fused deposition modeling, which is the most commonly used additive manufacturing method. The process is mature and suitable for the manufacture of the aforementioned medical biodegradable polymer materials (one or more of polycaprolactone, polyglycolic acid, polylactic acid, and polylactic acid-glycolic acid copolymer).

[0067] In some embodiments, the bone plug 100 and the barrier membrane 200 are manufactured separately, and the bone plug 100 and the barrier membrane 200 are two independent parts, which can be manufactured separately. When using it, the doctor attaches the first end of the bone plug 100 to the middle of the concave side of the barrier membrane 200 to connect the two and realize the implantation of the entire absorbable oral barrier membrane.

[0068] In some embodiments, the bone plug 100 is fabricated by electrospinning, and the barrier membrane 200 is fabricated by additive manufacturing. For example... Figure 7 As shown, in the fabrication of bone plug 100, different porous densities and structures can be achieved internally and externally by controlling process parameters such as wire diameter, wire angle, wire spacing, and wire direction. By controlling the internal and external wire winding process parameters, different degradation rates can be achieved internally and externally, with the internal degradation rate being faster than the external one. Figure 9 , Figure 10 and Figure 11 As shown, when manufacturing the barrier membrane 200, it can be made into a dense surface, a surface with second micropores 210, or a porous mesh structure by additive manufacturing.

[0069] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

Claims

1. An absorbable oral barrier membrane, characterized in that, include: A bone plug, wherein the bone plug has a receiving cavity and a plurality of first micropores, the size of the first micropores being larger than the size of a single bone cell, the first micropores communicating with the receiving cavity to allow bone cells to migrate and grow into the receiving cavity, the circumferential wall of the first end of the bone plug having a filling hole, the filling hole communicating with the receiving cavity to allow manual filling of bone powder or bone blocks, the size of the filling hole being larger than the size of the first micropores, and the second end of the bone plug being tapered; A barrier membrane, which is saddle-shaped to match the shape of the alveolar ridge, has its concave side connected to the first end of the bone plug at its midpoint. Both the bone plug and the barrier membrane are made of medical biodegradable polymer materials; The barrier membrane is provided with a second micropore, the size of which is smaller than the size of a single fibroblast, to prevent fibroblast migration and ingrowth; The angle between the axis of the first micropore and the axis of the filling hole and the radial plane of the bone plug is 15 to 30 degrees, and the openings of both are close to the first end of the bone plug.

2. The absorbable oral barrier membrane according to claim 1, characterized in that, The medical biodegradable polymeric material includes one or more of polycaprolactone, polyglycolic acid, polylactic acid, and polylactic acid-glycolic acid copolymer.

3. The absorbable oral barrier membrane according to claim 2, characterized in that, The thickness of the barrier membrane gradually decreases from the center to the edge.

4. The absorbable oral barrier membrane according to claim 3, characterized in that, The thickness of the barrier membrane is 0.5 mm to 2 mm.

5. The absorbable oral barrier membrane according to any one of claims 1 to 4, characterized in that, The bone plug and the barrier membrane are integrally formed and manufactured by additive manufacturing.

6. The absorbable oral barrier membrane according to claim 5, characterized in that, The additive manufacturing method is fused deposition modeling.

7. The absorbable oral barrier membrane according to any one of claims 1 to 4, characterized in that, The bone plug and the barrier membrane are manufactured separately, and the first end of the bone plug is bonded to the middle of the concave side of the barrier membrane.

8. The absorbable oral barrier membrane according to claim 7, characterized in that, The bone plug is manufactured by electrospinning, and the barrier membrane is manufactured by additive manufacturing.

Images