A mouthwash for reducing dental plaque and its preparation method and application

Abstract

The embodiment of the present application discloses a mouthwash for reducing dental plaque and a preparation method and application thereof. The mouthwash comprises the following raw materials in percentage by weight: a complexing agent 0.5-20%, a foaming agent 0.1-10%, a soil dissolving agent 0.1-10%, an anti-redeposition agent 0.1-20%, and the balance is an oral cavity acceptable medium. The mouthwash can almost completely clean the soft dirt and most of the dental plaque on the tooth surface, and has important significance for maintaining the hygiene and health of the oral cavity. In addition, the mouthwash can be used for preparing a cleaning agent for removing dental plaque and a whitening tooth oral care product, and has a good application prospect.

Description

Technical Field

[0001] This invention relates to the field of oral care technology, specifically to a mouthwash and cleaning agent that reduces dental plaque. Background Technology

[0002] Currently available mouthwashes can only remove some tartar, and have almost no effect on removing dental plaque. In today's society, people are paying more and more attention to oral hygiene and health, making it particularly important to know how to remove both tartar and dental plaque simultaneously.

[0003] In view of this, the present invention is proposed. Summary of the Invention

[0004] Therefore, embodiments of the present invention provide a mouthwash and cleaning agent for reducing dental plaque, which can completely clean soft deposits and most plaque on the tooth surface.

[0005] To achieve the above objectives, the embodiments of the present invention provide the following technical solutions:

[0006] According to a first aspect of the present invention, the present invention provides a mouthwash for reducing dental plaque, the mouthwash comprising the following ingredients in weight percentages:

[0007] Complexing agent 0.5%-20%, foaming agent 0.1%-10%, scale remover 0.1%-10%, anti-redeposition agent 0.1%-20%, the balance being oral-acceptable mediators;

[0008] The complexing agent is selected from at least one of tartrate, phosphate, imide, sodium EDTA and potassium EDTA, zeolite, polyvinyl alcohol, and triethylamine;

[0009] The foaming agent is selected from surfactants and / or basic carbonates;

[0010] The scale solvent is selected from at least one of octyl glycol, butanediol, hexanediol, pentanediol, glutaraldehyde, phenoxyethanol, ethylhexylglycerin, benzyl alcohol, dichlorobenzyl alcohol, and cymene-5-ol;

[0011] The anti-redeposition agent is selected from at least one of PVA / MA copolymer, sodium carboxymethyl cellulose, sodium carboxyethyl cellulose, polyvinylpyrrolidone, acrylic homopolymer, and acrylic acid / maleic anhydride copolymer.

[0012] The inventors discovered that any one of the four raw materials—complexing agent, foaming agent, dissolving agent, and anti-redeposition agent—has some effect on reducing dental plaque. However, adding only one or more of them (less than four) limits their effectiveness to removing only loose, immature plaque. Even increasing the amount of each raw material to saturation (the maximum amount of solute that mouthwash can dissolve) does not achieve a significant breakthrough in efficacy. However, when the complexing agent, foaming agent, dissolving agent, and anti-redeposition agent are combined in the aforementioned proportions, a qualitative breakthrough is achieved, almost completely cleaning soft plaque and most of the dental plaque from the tooth surface. Therefore, the mouthwash provided by this invention can remove both dental plaque and dental plaque, which is of great significance for maintaining oral hygiene and health.

[0013] Dental plaque is mainly composed of bacteria encapsulated by polysaccharides. Complexing agents can destroy the polysaccharide structure, while dissolving agents can destroy the bacteria. The synergy between the two can more thoroughly clean dental plaque, achieving a 1+1 greater than 2 effect.

[0014] Further, the basic carbonate is selected from at least one of sodium carbonate, sodium bicarbonate, potassium carbonate, and potassium bicarbonate; and / or,

[0015] The surfactant is selected from at least one of anionic surfactants, amphoteric surfactants, and nonionic surfactants with foaming function; preferably, the anionic surfactant is selected from carboxylate, sulfate, sulfate, sulfonate, or phosphate types; more preferably, the anionic surfactant is sodium dodecylbenzenesulfonate or sodium dodecyl sulfate; the amphoteric surfactant is selected from at least one of cocamidopropyl betaine, lauroamide propyl betaine, cocamidopropyl hydroxysulfonate betaine, lauroamide propyl hydroxysulfonate betaine, sodium lauroylamphoacetate, and sodium cocoylamphoacetate; the nonionic surfactant is selected from at least one of peg40 hydrogenated castor oil, Croduret 40, polysorbate 20, polysorbate 80, and poloxamer.

[0016] Further, the foaming agent has a weight percentage content of 1%-10%; the foaming agent is sodium dodecyl sulfate and / or sodium bicarbonate; and / or, the foaming agent is sodium dodecyl sulfate and / or PEG40 hydrogenated castor oil.

[0017] The inventors discovered that combining foaming agents with different foaming mechanisms produces better foaming results than using a single foaming agent alone. For example, combining a surfactant with a basic carbonate produces better foaming results than using the surfactant alone.

[0018] Further, the phosphate is selected from at least one of alkali metal hydrogen phosphate, alkali metal pyrophosphate, alkali metal phosphate, alkali metal metaphosphate, and phytate; preferably, the phosphate is selected from at least one of disodium hydrogen phosphate, dipotassium hydrogen phosphate, trisodium phosphate, tripotassium phosphate, sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, sodium metaphosphate, sodium phytate, and sodium ammonium phytate; and / or,

[0019] The tartrate is sodium tartrate or potassium tartrate; and / or...

[0020] The imine salt is ethyl ethylene imine hydrochloride.

[0021] Further, the complexing agent has a weight percentage of 0.5%-3%; the complexing agent is sodium tripolyphosphate and / or sodium phytate; and / or, the complexing agent is trisodium phosphate and / or sodium phytate.

[0022] Further, the scale solvent has a weight percentage of 0.2%-1%; the scale solvent is selected from at least one of phenoxyethanol, octyl glycol, and pentylene glycol; and / or, the scale solvent is selected from at least one of acetylene glycol, ethylhexylglycerin, and pentylene glycol.

[0023] Further, the anti-redeposition agent has a weight percentage content of 0.2%-10%; the anti-redeposition agent is a PVA / MA copolymer and / or polyvinylpyrrolidone.

[0024] Furthermore, the orally acceptable medium is selected from at least one of water, preservatives, taste modifiers, flavorings, and solubilizers.

[0025] Among them, taste improvers include, but are not limited to, various sweet substances such as maltitol, sodium saccharin, steviol glycosides, sucralose, sorbitol, glycerin, mogrosides, and dipotassium glycyrrhizate.

[0026] Flavorings include, but are not limited to, peppermint oil, wintergreen oil, and flavorings for food and daily chemical use.

[0027] Preservatives include, but are not limited to, potassium sorbate and sodium benzoate. In an alternative embodiment, preservatives may be omitted.

[0028] Solubilizers include, but are not limited to, polysorbate-60, polysorbate-80, polysorbate-85, polyglycerol-3-methylglucose distearate, polyglycerol-10 stearate, polyglycerol-10 myristate, polyglycerol-10 dioleate, polyglycerol-10 laurate, polyglycerol-10 isostearate, polyglycerol-10 oleate, polyglycerol-10 diisostearate, polyglycerol-6 laurate, and polyglycerol-6 myristate. In an optional embodiment, the solubilizer may be omitted.

[0029] According to a second aspect of the present invention, the present invention provides the application of the mouthwash as described above in (1) or (2) below,

[0030] (1) Used to prepare cleaning agents for removing bacterial plaque;

[0031] (2) Used to prepare teeth whitening oral care products.

[0032] Specifically, this cleaning agent can be used to remove other types of plaque, such as plaque contamination on equipment prone to bacterial growth, such as water containers and medical devices.

[0033] The embodiments of the present invention have the following advantages:

[0034] This invention combines specific complexing agents, foaming agents, solvents, and anti-redeposition agents in a specific ratio to produce a mouthwash that can almost completely clean soft plaque and most of the dental plaque from the tooth surface, which is of great significance for maintaining oral hygiene and health. Furthermore, the mouthwash provided by this invention can be used to prepare plaque-removing cleaning agents and teeth-whitening oral care products, showing promising application prospects. Attached Figure Description

[0035] To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are merely exemplary, and those skilled in the art can derive other embodiments based on the provided drawings without creative effort.

[0036] Figure 1 This is a comparison image showing the results of mouthwash cleaning of bacterial plaque before and after in Example 4 of the present invention;

[0037] Figure 2 This is a comparison diagram of the results of mouthwash cleaning before and after the removal of bacterial plaque in Comparative Example 4 of the present invention.

[0038] Figure 3 This is a comparison image showing the results of mouthwash cleaning before and after the removal of bacterial plaque in Comparative Example 1 of the present invention. Detailed Implementation

[0039] The following specific embodiments illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer are followed. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased commercially.

[0040] Example 1

[0041] This embodiment provides a mouthwash for reducing dental plaque, comprising, by weight percentage: 1% complexing agent, 3% foaming agent, 1% scale solvent, 5% anti-redeposition agent, with the remainder being an oral-acceptable medium.

[0042] The complexing agent consists of trisodium phosphate and sodium phytate in a mass ratio of 1:1;

[0043] The foaming agent consists of sodium dodecyl sulfate and PEG40 hydrogenated castor oil in a mass ratio of 1:1;

[0044] The scale solvent is composed of hexanediol, ethylhexylglycerin, phenoxyethanol, octyl glycol and pentanediol in a mass ratio of 1:1:1:1:1;

[0045] The anti-redeposition agent is composed of a PVA / MA copolymer and polyvinylpyrrolidone in a mass ratio of 1:1;

[0046] The oral mediator consists of 0.04% sodium saccharin, 0.1% flavoring, and 99.86% water.

[0047] The preparation method of the above mouthwash is as follows: Mix the above materials evenly and sterilize.

[0048] Example 2

[0049] This embodiment provides a mouthwash for reducing dental plaque, which differs from Example 1 only in the chelating agent. The chelating agent used in this embodiment consists of sodium tripolyphosphate and sodium phytate in a mass ratio of 1:1.

[0050] Example 3

[0051] This embodiment provides a mouthwash for reducing dental plaque, comprising, by weight percentage: 1% complexing agent, 4% foaming agent, 0.5% scale solvent, 5% anti-redeposition agent, with the remainder being an oral-acceptable medium.

[0052] The complexing agent consists of trisodium phosphate and sodium phytate in a mass ratio of 1:1;

[0053] The foaming agent is composed of sodium bicarbonate and sodium dodecyl sulfate in a mass ratio of 1:1;

[0054] The scale solvent is composed of phenoxyethanol, octyl glycol and pentylene glycol in a mass ratio of 1:1:1;

[0055] The anti-redeposition agent is composed of a PVA / MA copolymer and polyvinylpyrrolidone in a mass ratio of 1:1;

[0056] The oral mediator consists of 0.04% sodium saccharin, 0.1% flavoring, and 99.86% water.

[0057] Example 4

[0058] This embodiment provides a mouthwash for reducing dental plaque, the raw materials of which, by weight percentage, are: 1% complexing agent, 4% foaming agent, 1% scale solvent, 5% anti-redeposition agent, and 89% oral-acceptable mediator.

[0059] The complexing agent consists of sodium tripolyphosphate and sodium phytate in a mass ratio of 1:1;

[0060] The foaming agent is composed of sodium bicarbonate and sodium dodecyl sulfate in a mass ratio of 1:1;

[0061] The scale solvent is composed of hexanediol, ethylhexylglycerin, phenoxyethanol, octyl glycol and pentanediol in a mass ratio of 1:1:1:1:1;

[0062] The anti-redeposition agent is composed of a PVA / MA copolymer and polyvinylpyrrolidone in a mass ratio of 1:1;

[0063] The oral mediator consists of 0.04% sodium saccharin, 0.1% flavoring, and 99.86% water.

[0064] Comparative Example 1

[0065] This comparative example provides a mouthwash for reducing dental plaque, which, by weight percentage, comprises: 1% complexing agent, 3% foaming agent, 20% scale solvent, 5% anti-redeposition agent, and the remainder being an oral-acceptable medium.

[0066] The scale solvent consists of PEG400, propylene glycol, and glycerin in a mass ratio of 1:1:1;

[0067] The remaining raw materials are the same as in Example 2.

[0068] Comparative Example 2

[0069] This comparative example provides a mouthwash for reducing dental plaque, whose ingredients, by weight percentage, are: 1% complexing agent, 3% foaming agent, 20% scale solvent, 5% anti-redeposition agent, and 71% oral-acceptable mediator.

[0070] The scale solvent is composed of PEG400, propylene glycol, and glycerin in a mass ratio of 1:1:1;

[0071] The remaining raw materials are the same as in Example 1.

[0072] Comparative Example 3

[0073] This comparative example provides a mouthwash for reducing dental plaque, whose ingredients, by weight percentage, are: 7% foaming agent, 1% scale solvent, 5% anti-redeposition agent, and 87% oral-acceptable mediator.

[0074] The foaming agent consists of sodium dodecyl sulfate, PEG40 hydrogenated castor oil, and sodium bicarbonate in a mass ratio of 1:1:1.

[0075] The scale solvent is composed of hexanediol, ethylhexylglycerin, phenoxyethanol, octyl glycol and pentanediol in a mass ratio of 1:1:1:1:1;

[0076] The anti-redeposition agent is composed of a PVA / MA copolymer and polyvinylpyrrolidone in a mass ratio of 1:1.

[0077] Comparative Example 4

[0078] The mouthwash provided in this comparative example for reducing dental plaque does not contain an anti-redeposition agent, and the solvent is different from that in Example 3. The solvent used in this comparative example consists of hexanediol, ethylhexylglycerin, phenoxyethanol, octyl glycol, and pentanediol in a mass ratio of 1:1:1:1:1.

[0079] Comparative Example 5

[0080] The plaque-reducing mouthwash provided in this comparative example differs from Example 1 only in that it does not contain a foaming agent.

[0081] Comparative Example 6

[0082] The mouthwash provided in this comparative example for reducing dental plaque differs from that in Example 1 only in that it does not contain a plaque solvent.

[0083] Comparative Example 7

[0084] The mouthwash provided in this comparative example for reducing dental plaque differs from that in Example 3 in that it does not contain a complexing agent.

[0085] Comparative Example 8

[0086] The mouthwash provided in this comparative example for reducing dental plaque differs from that in Example 1 only in that it does not contain an anti-redeposition agent.

[0087] Experimental Example 1

[0088] The plaque-removing effects of the mouthwashes in Examples 1-4 and Comparative Examples 1-8 were tested.

[0089] Testing Method: Efficacy was verified through human trials. The specific method was as follows: Before brushing teeth morning and night, teeth were stained with a plaque indicator and the plaque condition was recorded as w1. Then, the mouthwash was rinsed for 1 minute, and the plaque indicator was used again to stain the teeth, recording the plaque condition as w2. w1-w2 represents the plaque cleanliness index.

[0090] The method for judging the condition of dental plaque is as follows: observe the 12 central teeth, deduct 1 point for each tooth with plaque, and the total score is 12 points.

[0091] The formulations and plaque removal index results of Examples 1-4 and Comparative Examples 1-8 are shown in Table 1.

[0092]

[0093] Comparing the data from Examples 1 and 2 in Table 1, it can be seen that when the complexing agent is placed within the range of complexing agents provided by this invention, simply replacing the complexing agent within this range has little impact on the plaque cleaning effect. Comparing Example 1 and Comparative Example 2, it can be seen that reducing the phenoxyethanol content in the solvent, removing octyl glycol and pentylene glycol, and using PEG400, propylene glycol, and glycerin as solvents has little impact on the plaque cleaning index. However, comparing Example 2 and Comparative Example 1, it can be seen that completely replacing the solvent with PEG400, propylene glycol, and glycerin leads to a sharp drop in the plaque cleaning index, resulting in a very poor plaque cleaning index, indicating that it has almost no effect and demonstrating that the solvent is an important component for cleaning plaque.

[0094] In the absence of complexing agents, anti-redeposition agents, and foaming agents, the plaque cleanliness index decreased slightly in all three groups, namely Comparative Examples 3, 4, and 5.

[0095] Using a combination of sodium bicarbonate and sodium dodecyl sulfate, two foaming agents with different mechanisms, results in better foaming performance than using surfactants alone. Examples 3 and 4, for instance, are superior to Examples 1 and 2.

[0096] The comparison results of mouthwash plaque removal before and after in Example 4 are shown in the figure. Figure 1 As shown (left: before cleaning, right: after cleaning), the cleanliness level is 12. Before use, almost every tooth had plaque; after use, it was almost completely clean. See the comparison image for Example 4 showing the before-and-after plaque removal results. Figure 2As shown (left: before cleaning, right: after cleaning), the cleanliness level is 9. Before use, almost every tooth had plaque; after use, plaque residue remained in the gaps between 3 teeth. See the comparison image for Example 1 showing the before-and-after plaque removal results. Figure 3 As shown (left: before cleaning, right: after cleaning), the cleanliness level is 5. Before use, almost every tooth had plaque, and after use, plaque remained on 6 teeth. This indicates that the mouthwash provided in Example 4 has a better cleaning effect than Comparative Examples 1 and 4. (Comparative Example 1 and Example 4) The plaque remover used in the control group could not effectively remove plaque; (Comparative Example 4 and Example 4) The absence of an anti-settling agent led to a decrease in plaque removal effectiveness.

[0097] Although the present invention has been described in detail above with general descriptions and specific embodiments, modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention fall within the scope of protection claimed by the present invention.

Claims

1. A mouthwash for reducing dental plaque, characterized in that, By weight percentage, its raw materials are: 1% complexing agent, 4% foaming agent, 1% scale solvent, 5% anti-redeposition agent, and 89% oral-acceptable mediator; among which, The complexing agent consists of sodium tripolyphosphate and sodium phytate in a mass ratio of 1:1; The foaming agent is composed of sodium bicarbonate and sodium dodecyl sulfate in a mass ratio of 1:1; The scale solvent is composed of hexanediol, ethylhexylglycerin, phenoxyethanol, octyl glycol and pentanediol in a mass ratio of 1:1:1:1:1; The anti-redeposition agent is composed of a PVA / MA copolymer and polyvinylpyrrolidone in a mass ratio of 1:1; The oral mediator consists of 0.04% sodium saccharin, 0.1% flavoring, and 99.86% water.

2. The method for preparing the mouthwash for reducing dental plaque according to claim 1, characterized in that, The method includes: weighing the complexing agent, foaming agent, scale solvent, anti-redeposition agent and oral acceptable medium according to the weight ratio, then mixing the above raw materials evenly and sterilizing to obtain the mouthwash.

3. The use of the mouthwash according to claim 1 in (1) or (2) below, (1) Used to prepare cleaning agents for removing bacterial plaque; (2) Used to prepare teeth whitening oral care products.

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