一种嘧啶类衍生物在制备抗猪繁殖与呼吸综合征病毒的药物中的用途
By using the compound 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine to inhibit the -1Ribosomal Frameshifting process of PRRSV, the problem of viral replication and proliferation was solved, achieving effective viral blocking and therapeutic effects.
CN117379431BActive Publication Date: 2026-07-17WEST CHINA HOSPITAL SICHUAN UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- WEST CHINA HOSPITAL SICHUAN UNIV
- Filing Date
- 2023-11-08
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing technologies have failed to effectively inhibit the -1 Ribosomal Frameshifting process of porcine reproductive and respiratory syndrome virus (PRRSV), making viral replication and proliferation difficult to control and causing huge losses to the pig industry.
Method used
The 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine compound was used to block viral replication and proliferation by inhibiting the -1Ribosomal Frameshifting process of PRRSV.
Benefits of technology
It significantly inhibits the -1 Ribosomal Frameshifting process of PRRSV, effectively blocks viral replication and proliferation, provides a drug treatment option against PRRSV, and reduces the losses caused by the virus.
✦ Generated by Eureka AI based on patent content.
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Figure CN117379431B_ABST
Abstract
本发明提供了一种嘧啶类衍生物在制备抗猪繁殖与呼吸综合征病毒的药物中的用途，属于化学医药领域。该嘧啶类衍生物的结构如式I所示。实验结果表明，本发明化合物对猪繁殖与呼吸综合征病毒(PRRSV)的‑1位核糖体移码(‑1Ribosomal Frameshifting)过程具有显著的抑制、阻断效果，可有效抑制PRRSV的复制，抑制PRRSV的增殖，5‑(4‑氯苯基)‑6‑乙基嘧啶‑2,4‑二胺可以用于制备抗PRRSV的药物和治疗由PRRSV导致的蓝猪耳病的药物，应用前景广阔。
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