一种改变四氢嘧啶晶型的方法
By altering the crystal form of tetrahydropyrimidine through vacuum concentration and acetone resuspension followed by centrifugal drying, the problems of poor flowability and low purity were solved, resulting in the preparation of clear crystals suitable for the high-purity pharmaceutical industry.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHANDONG FREDA BIOTECH
- Filing Date
- 2023-10-20
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for preparing tetrahydropyrimidine result in an amorphous powder that is prone to clumping, has poor flowability, slow dissolution rate, and affects processing and utilization, as well as low purity and recovery rate.
By mixing tetrahydropyrimidine with deionized water and dimethyl sulfoxide and concentrating under vacuum, followed by resuspending in acetone, centrifuging, and vacuum drying, moisture content and drying weight loss are controlled to form uniform, transparent crystals.
The prepared tetrahydropyrimidine crystals are light in color, have good fluidity, fast dissolution rate, high purity, high recovery rate, and low organic reagent residue, making them suitable for the pharmaceutical industry with high purity requirements.
Smart Images
Figure CN117384101B_ABST