一种稠环化合物、其制备方法和应用
Fused-ring compounds were prepared by extraction from Aspergillus pseudomorphus fermentation broth and separation by high-performance liquid chromatography, which solved the problem of the single structure of existing anti-colorectal cancer compounds and achieved effective inhibition and apoptosis induction of colorectal cancer cells, showing broad prospects for drug application.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- WUHAN UNIV OF SCI & TECH
- Filing Date
- 2023-09-06
- Publication Date
- 2026-07-17
AI Technical Summary
Existing compounds for treating colorectal cancer have relatively simple structures, exhibit severe chemotherapy resistance, and lack effective new drugs.
A fused-ring compound and its pharmaceutically acceptable salt are provided, which are prepared by extraction from Aspergillus pseudoepiplo fermentation broth, silica gel column chromatography and high performance liquid chromatography. The preparation method is convenient and has high purity. It can be used to inhibit the proliferation and migration of colorectal cancer cells and induce apoptosis.
Compound 1 or its pharmaceutically acceptable salt can significantly inhibit the proliferation and migration of colorectal cancer cells and induce apoptosis, exhibiting good anti-colorectal cancer activity and is suitable for new drug development.
Smart Images
Figure CN117384181B_ABST