Prosthesis with elastic conduit and method for manufacturing same

Abstract

The present application discloses a kind of prosthesis with elastic pipeline and its manufacturing method, manufacturing method includes: according to the three-dimensional image of organ, the first tissue mold and the second tissue mold with elasticity are made;First false tissue material is coated on the surface of the first tissue mold, and the first false tissue with closed end and elasticity is made;The first false tissue is correctly positioned in the second tissue mold;Gelatinous second false tissue material is injected into the second tissue mold, and the first false tissue is covered;The interior of the first false tissue has first pressure value;Negative pressure defoaming step is applied to the second false tissue material;Freezing and thawing step is applied to the second false tissue material, to be shaped as second false tissue, in the thawing process in the freezing and thawing step, the interior of the first false tissue is repeatedly applied to decompression and pressurization step, and the decompression and pressurization step is executed below the first pressure value;The second tissue mold is removed, and the manufacturing of the prosthesis with elastic pipeline is completed.

Description

Technical Field

[0001] This invention relates to a prosthesis with an elastic conduit and a method for manufacturing the same, and more particularly to a prosthesis comprising an elastic hollow vasculature and a vasculature organ body and a method for manufacturing the same, wherein the hollow vasculature is elastic and can be used to simulate blood vessels with blood pressure. Background Technology

[0002] Chinese Invention Patent Announcement CN105719550B discloses a tumor resection surgery practice model and its manufacturing method. The manufacturing method of the tumor resection surgery practice model includes the following steps: Step 1: Acquire CT or MR images of the patient and perform stereoscopic reconstruction; Step 2: Obtain a stereoscopic model of the surgical organ; Step 3: Hollow out the stereoscopic model of the surgical organ; Step 4: Obtain a stereoscopic model of the tumor inside the surgical organ; Step 5: Construct a surgical organ practice mold; Step 6: 3D print the surgical organ practice mold; Step 7: Fabricate the surgical organ practice model. This creates a realistic model simulating a patient's surgical organ tumor, facilitating teaching and operational practice.

[0003] However, while the aforementioned patent applies to the manufacture of prostheses with tumors for teaching and practical training, the prosthesis models produced by this patent focus on establishing tumor models and do not address the formation of blood vessels in the prosthesis models, especially the formation of elastic blood vessels, nor does it propose specific technical means. Taking liver surgery practice as an example, in actual simulated surgical practice, surgeons must practice operating on a prosthesis, and during practice, they especially need to practice avoiding accidentally cutting blood vessels. Therefore, the prosthesis manufacturing method provided by the aforementioned patent cannot produce prostheses with realistic blood vessels.

[0004] Japanese Patent Publication No. JP2016139069 discloses an organ model with high biocompatibility and expected high learning efficiency. This model is applicable to preoperative procedures, surgeon simulation, and the selection of clamps to be used. This patent describes an organ model simulating a biological part, characterized by its composition of an addition-reactive silicone resin using a platinum-based catalyst. In this organ model, the addition-reactive silicone resin is applied to a replica surface made of a solvent-soluble resin to mimic a biological part of a predetermined thickness. The addition-reactive silicone resin is then cured, and the replica mold is dissolved and removed using a solvent.

[0005] However, the aforementioned patents also do not disclose how to manufacture elastic vascular prostheses. Summary of the Invention

[0006] Given the deficiencies in existing technologies, the purpose of this invention is to provide a prosthesis with an elastic conduit and a method for manufacturing the same.

[0007] To achieve the above objectives, the present invention employs the following technical means:

[0008] This invention provides a method for manufacturing a prosthesis with an elastic conduit, comprising the following steps:

[0009] Based on a three-dimensional image of an organ, a first tissue mold and a second tissue mold with elasticity are made.

[0010] A first pseudo-tissue material is coated onto the surface of the first tissue mold to create a first pseudo-tissue with closed ends and elasticity.

[0011] The first dummy tissue is correctly positioned in the second tissue mold;

[0012] A gel-like second pseudo-tissue material is injected into a second tissue mold to cover the first pseudo-tissue.

[0013] This gives the internal structure of the first dummy organization a first pressure value;

[0014] A negative pressure defoaming step was applied to the second spur tissue material;

[0015] A freeze-thaw process is applied to the second pseudo-tissue material to form a second pseudo-tissue, wherein during the thawing process in the freeze-thaw process, a depressurization and pressurization process is repeatedly applied to the interior of the first pseudo-tissue, the depressurization and pressurization process being performed below the first pressure value;

[0016] Remove the second tissue mold to complete the fabrication of the prosthesis with elastic tubing.

[0017] Preferably, the first pressure value is between 9 and 11 mmHg.

[0018] Preferably, the negative pressure defoaming step involves placing the second tissue mold, the second dummy tissue material, and the first dummy tissue together in a negative pressure space, controlling the pressure value of the negative pressure space between -300 and -760 mmHg to remove air bubbles from the second dummy tissue material; the negative pressure defoaming step is a gradual pressure reduction, which involves sequentially controlling the pressure value of the negative pressure space to be -300 mmHg, -460 mmHg, -610 mmHg, and -760 mmHg; the running time of the negative pressure defoaming step is between 1 and 3 hours.

[0019] Preferably, before injecting the second dummy tissue material into the second tissue mold, a pre-debugging step is performed. The pre-debugging step involves placing the second dummy tissue material in a negative pressure space and controlling the pressure value of the negative pressure space between -72 and -800 mmHg to remove air bubbles from the second dummy tissue material. More preferably, the second dummy tissue material is injected into the second tissue mold in batches until the second tissue mold is filled.

[0020] Preferably, the freeze-thaw step involves freezing the second pseudo-tissue material for 20-28 hours, thawing it for 10-14 hours, freezing it again for 20-28 hours, and thawing it again for 10-14 hours.

[0021] Preferably, the pressure reduction and pressurization step involves first reducing the pressure value from 9-11 mmHg to 4-6 mmHg, and then increasing the pressure value from 4-6 mmHg to 9-11 mmHg.

[0022] Preferably, the first tissue image is a vascular image, and the first tissue model is made by 3D printing using a fusible material based on the first tissue image. The fusible material is polyvinyl alcohol (PVA).

[0023] Preferably, the first spurious tissue material is silicone. The first spurious tissue material is formed by coating the first tissue mold and then allowing it to stand at room temperature for 8 to 12 hours, or by soaking it in hot water at 80°C for 6 to 10 minutes.

[0024] Preferably, the thickness of the first pseudo-tissue (pseudo-blood vessel) is between 0.2 and 1.5 mm, and the first pseudo-tissue has an opening.

[0025] Preferably, the second tissue mold is provided with a second alignment unit, and the first dummy tissue is provided with a first alignment unit. By aligning the second alignment unit with the first alignment unit, the positioning step is performed so that the first dummy tissue is correctly positioned in the second tissue mold.

[0026] Preferably, the second tissue mold is a silicone mold.

[0027] The present invention also provides a prosthesis with an elastic conduit, comprising:

[0028] A first pseudo-tissue, a flexible tube with multiple branches formed to correspond to the shape of the internal blood vessels of an animal organ, the flexible tube having an opening and the ends of the multiple branches being closed;

[0029] A second pseudo-tissue is formed to correspond to the shape of the organ. The second pseudo-tissue is elastic and covers the first pseudo-tissue. After the first pseudo-tissue is injected with a fluid, it can expand and deform under the coverage of the second pseudo-tissue.

[0030] Preferably, the first pseudostructure is room temperature vulcanizing silicone rubber (RTV), and the Shore hardness of the first pseudostructure is 8-10, with a tensile strength between 33-41 kg / cm². 2 The elongation is between 400% and 600%, and the tear strength is between 21 and 25 kg / cm.

[0031] Preferably, the second pseudo-tissue is formed by gel formation, the gel comprising 2.5 to 15 parts by weight of polyvinyl alcohol (PVA), 2.5 to 15 parts by weight of glycerol, 69.5 to 94.5 parts by weight of water and 0.5 parts by weight of aqueous dye.

[0032] Based on the above technical features, the present invention can achieve the following effects:

[0033] 1. The liver vascular prosthesis is made of elastic silicone, while the liver body prosthesis is made of gel. During the molding process of the liver body prosthesis, a freeze-thaw process is used to further solidify the gel. In particular, during this freeze-thaw process, a pressure reduction and inflation process is repeatedly applied to the interior of the liver vascular prosthesis covered by the gel, causing the liver vascular prosthesis to continuously contract and expand. The liver prosthesis manufactured in this way, in addition to having a moderate firmness and extremely realistic appearance, also has appropriate extensibility. This allows the liver vascular prosthesis covered by the liver body prosthesis to expand and contract when fluid is injected, and this expansion and contraction is not restricted by the extensibility of the liver body prosthesis. Therefore, the liver vascular prosthesis can simulate blood vessels with blood pressure and is suitable as a target for surgical practice.

[0034] 2. The manufactured prosthesis is covered with an elastic tube. When using the prosthesis, fluid is injected into the elastic tube and the fluid is kept under a certain pressure, or the fluid is repeatedly pressurized and depressurized. When the prosthesis is used for surgical practice or demonstration, the elastic tube can be cut by a scalpel. If the elastic tube is cut, the fluid inside the elastic tube can simulate the outflow or spurting of blood, which has an extremely realistic effect.

[0035] 3. The manufactured prosthesis is covered with an elastic tube, which simulates the blood vessels inside human organs, making it closer to the real organs. When performing surgical simulation with the prosthesis, the surgical trainee can fully experience the stress on the elastic tube, thereby mastering the correct application of force with the scalpel. Attached Figure Description

[0036] Figure 1 This is a flowchart of the manufacturing steps of the present invention.

[0037] Figure 2 This is a flowchart of the manufacturing steps according to an embodiment of the present invention.

[0038] Figure 3 This is a schematic diagram of the first tissue mold in an embodiment of the present invention.

[0039] Figure 4 This is a schematic diagram of the second dummy tissue mold in an embodiment of the present invention.

[0040] Figure 5This is a schematic diagram of the first dummy tissue material being coated onto the first tissue mold in an embodiment of the present invention.

[0041] Figure 6 This is a cross-sectional view of the first dummy tissue in an embodiment of the present invention.

[0042] Figure 7 This is a schematic diagram of the first dummy tissue being placed into the lower cavity of the second tissue mold in an embodiment of the present invention.

[0043] Figure 8 This is a schematic diagram of the operation of the negative pressure space in an embodiment of the present invention.

[0044] Figure 9 This is an external view of the prosthesis manufactured according to the present invention.

[0045] Reference numerals: 1-First mold; 11-Tongue; 12-Groove; 13-Main shaft; 2-Second mold; 21-Upper mold; 211-Upper mold cavity; 212-Upper mold injection channel; 213-Upper mold air channel; 214-Second upper alignment unit; 2141-Upper opening groove; 215-Guide post; 22-Lower mold; 221-Lower mold cavity; 222-Lower mold injection channel; 223-Lower mold air channel; 224-Second lower alignment unit; 2241-Lower opening groove; 225-Guide hole; 3-Silicone; 4-First dummy tissue; 41-First alignment unit; 42-Opening; 5-Negative pressure space; 51-First pipeline; 511-First pump; 52-Second pipeline; 521-Second pump; 6-Second dummy tissue; A-Film; B-Channel. Detailed Implementation

[0046] Based on the above technical features, the manufacturing method and the prosthesis of the elastic tube prosthesis of the present invention will be clearly presented in the following embodiments. The following embodiments will take the manufacturing of a human liver prosthesis as an example, but the prosthesis of the present invention is not limited to the human liver prosthesis. Other animal organ prostheses covered with blood vessels and the manufacturing methods of such organ prostheses are all within the scope of the present invention.

[0047] Please see Figure 1 and Figure 2 The manufacturing method of the elastic conduit prosthesis of the present invention includes the following steps:

[0048] Using computed tomography (CT) or other medical methods to obtain images or physical images of the human liver, a digital three-dimensional image of the human liver is constructed based on the images or physical images, which includes images of liver blood vessels and images of the liver itself.

[0049] Please see Figure 1 and Figure 2 In addition, Figure 3Based on the aforementioned liver vascular images, a solid first tissue mold 1 is output using 3D printing. This first tissue mold 1 can be 3D printed in one piece or 3D printed in segments and then assembled, depending on the branching pattern of the organ's blood vessels. For vessels with many or thin branches, 3D printing in segments and then assembling is more suitable. In this embodiment, the first tissue mold 1 is formed corresponding to the blood vessels of the inferior vena cava. For ease of explanation, this embodiment only uses the inferior vena cava as an example, ignoring other blood vessels of the liver, such as the hepatic artery and portal vein. The liver vascular mold 1 is 3D printed in segments and then assembled. Appropriate parts of the liver vascular mold 1 are segmented, and corresponding tenons 11 and grooves 12 are formed at the segmentation points. The first tissue mold 1 is completed by the combination of the tenons 11 and grooves 12. Additionally, the first tissue mold 1 includes a main trunk 13, which corresponds to the central main channel of the inferior vena cava. The material of the first mold 1 can be a soluble material, a vaporizable material, or a fusible material, etc. In this embodiment, it is water-soluble polyvinyl alcohol (PVA).

[0050] Please see Figure 1 and Figure 2 In addition, Figure 4 Based on the aforementioned liver body image, a second tissue mold 2 is fabricated. In this embodiment, the second tissue mold 2 is a liver body mold. In this embodiment, the material of the second tissue mold 2 includes 88-98.5 parts by weight of silicone, 1.5-2 parts by weight of hardener, and 0-10 parts by weight of silicone oil can be added as needed to give the second tissue mold 2 characteristics such as low viscosity, moderate hardness, elasticity, and ductility. The second tissue mold 2 includes an upper mold 21 and a lower mold 22. The upper mold 21 includes an upper mold cavity 211, an upper mold injection channel 212, multiple lower mold air channels 213, a second upper alignment unit 214, and a plurality of guide posts 215. The second upper alignment unit 214 corresponds to half of the shape of the inferior vena cava of the liver. The end of the second upper alignment unit 214 away from the upper mold cavity 211 is provided with an upper opening groove 2141. The lower mold 22 includes a lower mold cavity 221, a lower mold injection channel 222, multiple lower mold air channels 223, a second lower alignment unit 224, and a plurality of guide holes 225. The multiple lower mold air channels 223 extend from the lower mold cavity 221 to the surface of the lower mold 22. The second lower alignment unit 224 corresponds to the other half of the shape of the inferior vena cava in the liver. The end of the second lower alignment unit 224 away from the lower mold cavity 221 is further provided with a lower opening groove 2241. The aforementioned second upper alignment unit 214 and the second lower alignment unit 224 together form a second alignment unit of the present invention, which corresponds to the inferior vena cava (IVC) in the aforementioned liver vascular image.

[0051] Please see Figure 1 and Figure 2 In addition, Figure 5 and Figure 6Silicone 3, such as room temperature vulcanizing silicone rubber (RTV), is coated onto the first tissue mold 1. The thickness of the coated silicone 3 is controlled between 0.2 and 1.5 mm to simulate the wall thickness of liver blood vessels. An opening 42 is reserved at the end of the main trunk 13 of the coated silicone 3. It is then molded at room temperature for 8 to 12 hours, or rapidly molded by immersion in 80°C hot water for 6 to 10 minutes. In this embodiment, immersion in 80°C hot water for 6 to 10 minutes is chosen to obtain a faster molding speed. At this temperature, the first tissue mold 1 made of water-soluble polyvinyl alcohol will be melted, so that the silicone 3 is molded into a first pseudo-tissue 4. The first pseudo-tissue 4 is a hollow liver blood vessel prosthesis. The first pseudo-tissue 4 includes a first alignment unit 41, which corresponds to the inferior vena cava (IVC) in the aforementioned liver blood vessel image. The first pseudostructure 4 is hollow, with all branches closed at the ends, except for the aforementioned opening 42 formed only in the first aligning unit 41, which is located at the free end of the first aligning unit 41. The formed first pseudostructure 4 has a Shore hardness of 8-10 and a tensile strength between 33-41 kg / cm². 2 Its elongation ranges from 400% to 600%, and its tear strength ranges from 21 to 25 kg / cm.

[0052] Please see Figure 1 and Figure 2 In addition, Figure 4 , Figure 7 and Figure 8 The first dummy tissue 4 is placed in the lower mold cavity 221 of the second tissue mold 2. Then, the upper mold 21 and the lower mold 22 are aligned and closed together by means of the guide post 215 and the guide hole 225. The closed upper mold 21 and the lower mold 22 are wrapped with adhesive film A to maintain the closed state of the upper mold 21 and the lower mold 22. To enhance the sealing effect of the upper mold 21 and the lower mold 22, a fixture can also be used. Figure 7 (Not shown) The upper mold 21 and the lower mold 22 are clamped together. After the upper mold 21 closes onto the lower mold 22, the first alignment unit 41 of the first dummy tissue 4 is located in the second alignment unit formed by the aforementioned second upper alignment unit 214 and second lower alignment unit 224. The opening 42 of the first dummy tissue 4 is aligned with a channel B formed by the upper opening groove 2141 and the lower opening groove 2241. By aligning the first alignment unit 41 with the second alignment unit, the first dummy tissue 4 will be located in the correct position in the second tissue mold 2.

[0053] Using a gel as the second spurious tissue material, a pre-defoaming step is first performed on the second spurious tissue material. This pre-defoaming step involves placing the second spurious tissue material in a negative pressure space, such as a vacuum chamber, and controlling the pressure value of the negative pressure space between -720 and -800 mmHg to remove air bubbles from the second spurious tissue material through negative pressure. During the pre-defoaming step, a large number of air bubbles will escape from the second spurious tissue material. When no more air bubbles escape, the pre-defoaming step is complete. The gel composition includes 2.5 to 15 parts by weight of polyvinyl alcohol (PVA), 2.5 to 15 parts by weight of glycerol, 69.5 to 94.5 parts by weight of water, and 0.5 parts by weight of an aqueous dye, wherein the aqueous dye is used to simulate organ color.

[0054] A first pipe 51 is connected to the opening 42 of the first dummy tissue 4 through the aforementioned channel B. The first pipe 51 is also connected to a first pump 511. The first pump 511 injects liquid or gas into the first dummy tissue 4, so that the first dummy tissue 4 has a first pressure value, which is between 9 and 11 mmHg.

[0055] After the upper mold 21 and lower mold 22 are closed, the aforementioned upper mold cavity 211 and lower mold cavity 222 together form a mold cavity, and the upper mold injection channel 212 and lower mold injection channel 212 together form an injection channel. After the aforementioned adhesive film A is wrapped around the upper mold 21 and lower mold 22, punch holes are punched at corresponding positions in the injection channel, lower mold air channel 223, and channel B to maintain the external connection of the injection channel, lower mold air channel 223, and channel B. The second dummy tissue material is injected into the mold cavity in batches or in parts through the aforementioned injection channel until the mold cavity is full.

[0056] Please see Figure 1 and Figure 2 In addition, Figure 8The upper mold 21 and lower mold 22, filled with the second dummy tissue material and closed to each other, are placed in a negative pressure space 5, such as a vacuum chamber. The negative pressure space 5 is connected to a second pump 521 via a second pipe 52. The pressure of the negative pressure space 5 is controlled by the second pump 521. The aforementioned first pipe 51 is connected to the opening 42 of the first dummy tissue 4. The second pump 512 controls the internal pressure of the first dummy tissue 4. In the negative pressure space 5, a negative pressure degassing step is performed. The negative pressure degassing step involves controlling the pressure value of the negative pressure space 5 between -300 and -760 mmHg for a running time of 1 to 3 hours to remove residual air bubbles in the second dummy tissue material. Preferably, a gradual depressurization is performed to remove air bubbles. The gradual depressurization involves controlling the pressure value of the negative pressure space 5 in stages: -300 mmHg, -460 mmHg, -610 mmHg, and -760 mmHg. The removed air bubbles can escape through the aforementioned multiple air channels. The second sham tissue material was subjected to a freeze-thaw process, which involved freezing it for 20–28 hours, thawing it for 10–14 hours, freezing it again for 20–28 hours, and thawing it again for 10–14 hours. During the thawing process, the first sham tissue 4 was subjected to a repeated depressurization and pressurization process, which involved decreasing the pressure from 9–11 mmHg to 4–6 mmHg and then increasing the pressure from 4–6 mmHg back to 9–11 mmHg.

[0057] Please see Figure 1 and Figure 2 In addition, Figure 4 , Figure 7 and Figure 9 Remove the upper mold 21 and the lower mold 22 to obtain a prosthesis with an elastic channel. The prosthesis with an elastic channel includes a first pseudo tissue 4 and a second pseudo tissue 6. The first pseudo tissue 4 is a liver blood vessel prosthesis, and the second pseudo tissue 6 is a liver body prosthesis. The first pseudo tissue 4 is covered by the second pseudo tissue 6, and the first alignment unit 41 simulating the inferior vena cava is exposed in the second pseudo tissue 6.

[0058] After the aforementioned second sham tissue 6 is formed through the freeze-thaw process, it possesses appropriate elasticity. During the freeze-thaw process of forming the second sham tissue 6, the present invention causes the first sham tissue 4 to repeatedly contract and expand through the aforementioned depressurization and pressurization steps. This allows the first sham tissue 4 to moderately expand and deform under the coverage of the second sham tissue 6 after it is formed. Therefore, the prosthesis with elastic channels manufactured by the present invention allows for controlled pressure manipulation of the interior of the first sham tissue 4, such as injecting a pressure-controlled fluid, so that the first sham tissue 4 simulates a blood vessel with diastolic and systolic blood pressure.

[0059] Based on the above description of the embodiments, the content and effects of the present invention can be fully understood. The above embodiments are only preferred embodiments of the present invention and should not be construed as limiting the scope of the present invention. Simple equivalent changes and modifications made in accordance with the claims and description of the present invention are all within the scope of the present invention.

Claims

1. A method for manufacturing an elastic conduit prosthesis, characterized in that, Includes the following steps: Based on a three-dimensional image of an organ, a first tissue mold and a second tissue mold with elasticity are made. A first pseudo-tissue material is coated onto the surface of the first tissue mold to create a first pseudo-tissue with closed ends and elasticity. The first dummy tissue is correctly positioned in the second tissue mold; A gel-like second pseudo-tissue material is injected into a second tissue mold to cover the first pseudo-tissue. This gives the internal structure of the first dummy organization a first pressure value; A negative pressure defoaming step was applied to the second spur tissue material; A freeze-thaw process is applied to the second pseudo-tissue material to form a second pseudo-tissue, wherein during the thawing process in the freeze-thaw process, a depressurization and pressurization process is repeatedly applied to the interior of the first pseudo-tissue, the depressurization and pressurization process being performed below the first pressure value; Remove the second tissue mold to complete the fabrication of the prosthesis with elastic tubing.

2. The method for manufacturing an elastic tube prosthesis as described in claim 1, characterized in that: The first pressure value is between 9 and 11 mmHg.

3. The method for manufacturing an elastic conduit prosthesis as described in claim 1, characterized in that: The negative pressure defoaming step involves placing the second tissue mold, the second dummy tissue material, and the first dummy tissue together in a negative pressure space, controlling the pressure value of the negative pressure space between -300 and -760 mmHg, in order to remove air bubbles from the second dummy tissue material.

4. The method for manufacturing an elastic conduit prosthesis as described in claim 3, characterized in that: The negative pressure defoaming step is a gradual pressure reduction, which is achieved by controlling the pressure values ​​of the negative pressure space in stages: -300 mmHg, -460 mmHg, -610 mmHg and -760 mmHg.

5. The method for manufacturing an elastic conduit prosthesis as described in claim 3, characterized in that: The negative pressure defoaming step takes between 1 and 3 hours to run.

6. The method for manufacturing an elastic conduit prosthesis as described in claim 1, characterized in that: Before the second dummy tissue material is injected into the second tissue mold, a pre-debugging step is performed. The pre-debugging step involves placing the second dummy tissue material in a negative pressure space and controlling the pressure value of the negative pressure space between -720 and -800 mmHg to remove air bubbles from the second dummy tissue material.

7. The method for manufacturing an elastic conduit prosthesis as described in claim 1, characterized in that: The second dummy tissue material is injected into the second tissue mold in batches until the second tissue mold is full.

8. The method for manufacturing an elastic conduit prosthesis as described in claim 1, characterized in that: The freezing and thawing process involves freezing the second pseudo-tissue material for 20–28 hours, thawing it for 10–14 hours, freezing it again for 20–28 hours, and thawing it again for 10–14 hours.

9. The method for manufacturing an elastic conduit prosthesis as described in claim 1, characterized in that: The pressure reduction and boosting process involves first lowering the pressure from 9–11 mmHg to 4–6 mmHg, and then raising the pressure from 4–6 mmHg back to 9–11 mmHg.

10. The method for manufacturing an elastic conduit prosthesis as described in claim 1, characterized in that: The first tissue image is a vascular image, and the first tissue mold is made by 3D printing using a fusible material based on the first tissue image. The fusible material is polyvinyl alcohol (PVA).

11. The method for manufacturing a flexible tube prosthesis as described in claim 1, characterized in that: The first spurious tissue material is silicone. The first spurious tissue material is formed by coating the first tissue mold and then molding it at room temperature for 8 to 12 hours, or by soaking it in hot water at 80°C for 6 to 10 minutes.

12. The method for manufacturing an elastic tube prosthesis as described in claim 1, characterized in that: The thickness of the first pseudo-tissue is between 0.2 and 1.5 mm, and the first pseudo-tissue has an opening.

13. The method for manufacturing a prosthetic tube with elasticity as described in claim 1, characterized in that: The second tissue mold is provided with a second alignment unit, and the first dummy tissue is provided with a first alignment unit. By aligning the second alignment unit with the first alignment unit, the positioning step is performed so that the first dummy tissue is correctly positioned in the second tissue mold.

14. The method for manufacturing an elastic conduit prosthesis as described in claim 1, characterized in that: The second tissue mold is a silicone mold.

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