一种盐酸达泊西汀片及其制备方法

By combining corn cob microcrystalline cellulose and inorganic disintegrants into dapoxetine hydrochloride tablets, and utilizing the swelling properties of sodium bicarbonate and illite bentonite loaded onto silicate adsorbents, the problem of excessively long disintegration time of dapoxetine hydrochloride tablets was solved, and rapid drug dissolution was achieved.

CN117414341BActive Publication Date: 2026-07-17NANJING ZENKOM PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING ZENKOM PHARMA
Filing Date
2023-11-15
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

The existing dapoxetine hydrochloride tablets have a long disintegration time, which affects the full dissolution of the drug.

Method used

The tablet composition was optimized by combining corn cob microcrystalline cellulose with an inorganic disintegrant, using a silicate adsorbent to load sodium bicarbonate, generating carbon dioxide expansion pressure under the action of gastric acid, and combining the expansion properties of illite and bentonite.

Benefits of technology

It shortens the disintegration time of dapoxetine hydrochloride tablets and improves the drug's dissolution efficiency.

✦ Generated by Eureka AI based on patent content.

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Abstract

本申请涉及医药技术领域，具体公开了一种盐酸达泊西汀片及其制备方法。盐酸达泊西汀片包括片芯以及包衣膜。本申请将玉米芯微晶纤维素与无机崩解剂混合使用，无机崩解剂中吸附的碳酸氢钠在胃酸作用下能够产生二氧化碳，并产生额外的膨胀压力，从而能够克服玉米芯微晶纤维素对片剂的崩解产生的负面影响，缩短了盐酸达泊西汀片·的崩解时间，有利于盐酸达泊西汀的充分溶出。
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