Indole diterpene compounds, methods of making and use in the preparation of neuroprotective agents
CN117427063BActive Publication Date: 2026-08-28UNIV OF JINAN
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Patent Information
- Application Number
- CN202311401919.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2023-10-27
- Publication Date
- 2026-08-28
- Estimated Expiration
- 2043-10-27
AI Technical Summary
Technical Problem
[0002]神经退行性疾病多发于老年群体，因病情发展缓慢、发病率高、治愈率低等特点严重影响患者的健康生活，目前尚无有效的治疗方法或者治疗药物
Benefits of technology
本发明的吲哚二萜类化合物可以通过Penicilliumsp. UJNMF 0740的发酵提取分离获得，具有神经保护活性，在制备神经保护类药物、药物中间体方面具有应用潜力。
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Abstract
The present application provides indole diterpenoid compounds, a preparation method thereof and an application thereof in preparing neuroprotective agents. The indole diterpenoid compounds I and II with neuroprotective activity are separated from a Penicillium sp. UJNMF0740 fermentation product with a preservation number of CGMCC No: 40521 Penicillium Activity tests find that the indole diterpenoid compounds I and II have obvious protective effects on H2O2-induced Schwann cell (RSC96) damage and no toxicity, and have good application prospects in developing drugs and drug intermediates with neuroprotective effects.
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