一类苯并噻唑吡喃衍生物及其制备方法与抗菌应用
By designing and synthesizing benzothiazolium pyran derivatives, the problems of synthesis complexity and stability of existing organic photothermal agents in the biomedical field have been solved, achieving efficient near-infrared photothermal conversion and drug-resistant bacteria killing effects, making it suitable for near-infrared photothermal therapy.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- CHINA PHARM UNIV
- Filing Date
- 2023-10-08
- Publication Date
- 2026-07-17
AI Technical Summary
Existing organic photothermal agents suffer from problems in the biomedical field, such as complex synthesis, low biocompatibility, low photothermal conversion efficiency, and poor photothermal stability. In particular, the lack of small molecule photothermal agents with near-infrared II response limits their practical application.
A class of benzothiazole pyran derivatives was developed. By introducing groups with strong electron-withdrawing properties, compounds with strong rigidity and conjugated systems were designed as photothermal agents in the NIR-II region. Taking advantage of their high efficiency in photothermal conversion in the near-infrared region, the preparation method includes a multi-step reaction carried out in an oxygen-free environment, and finally obtains deep red, deep blue or black solid compounds.
It achieves efficient photothermal conversion in the near-infrared region, can kill drug-resistant bacteria, and has excellent photothermal effect and thermal stability, making it suitable for near-infrared photothermal therapy.
Smart Images
Figure CN117430582B_ABST