用于抑杀革兰氏阴性菌的抗菌肽组合物及其应用
The chemically synthesized antimicrobial peptides Thanatin and BF-15a3 combination solves the problems of antibiotic resistance and limited application of antimicrobial peptides, achieving highly efficient inhibition and killing of Gram-negative bacteria and food preservation, with good biosafety and application prospects.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- JIANGSU ACAD OF AGRI SCI
- Filing Date
- 2022-07-22
- Publication Date
- 2026-07-17
AI Technical Summary
The overuse of existing antibiotics has led to serious problems of bacterial resistance, and there is an urgent need for new antimicrobial agents to address Gram-negative bacterial infections, especially the threat of Escherichia coli O157:H7. Furthermore, the application of antimicrobial peptides in the food and pharmaceutical fields is limited by issues such as cost, toxicity, and stability.
A chemically synthesized antimicrobial peptide Thanatin and BF-15a3 composition in a mass ratio of 1:1.5-3 is used to prepare antibacterial agents, pharmaceuticals, and food preservatives. Through synergistic effects, the bactericidal effect is improved while reducing the dosage and maintaining biosafety.
This composition exhibits excellent antibacterial activity against Gram-negative bacteria, effectively inhibits and kills multidrug-resistant bacteria, reduces the amount of antimicrobial peptides used, maintains bactericidal effect, and does not lead to bacterial resistance. It is suitable for food and pharmaceuticals and has broad application prospects.
Smart Images
Figure CN117430673B_ABST