A multi-functional bath composition, its preparation method and application

Abstract

This invention relates to a multi-functional bath composition, its preparation method, and its applications. The multi-functional bath composition comprises separately packaged component A and component B. Component A includes magnesium chloride, potassium chloride, and calcium chloride; component B includes a moisturizer, antibacterial peptides, and vitamins. In this invention, component A of the multi-functional bath composition is a Dead Sea salt-like component, which has moisturizing effects on the skin and plays an important role in normal physiological activities, relieving fatigue, and enhancing physical strength. Component B, through the combination of moisturizer, antibacterial peptides, and vitamins, not only further enhances the moisturizing effect of the composition but also enables the composition to promote metabolism, condition the skin, and has antibacterial and anti-inflammatory effects.

Description

Technical Field

[0001] This invention belongs to the field of personal care technology, and in particular relates to a multifunctional bath composition, its preparation method and application. Background Technology

[0002] With increasing work pressure and a faster pace of life, more and more people are experiencing sub-health issues. In daily life, people often resort to medication to alleviate these conditions, but medications can also cause side effects. Bathing is a traditional way to relieve fatigue; it not only promotes metabolism and accelerates hormone secretion but also makes the skin supple and hydrated, without causing side effects, thus gaining increasing popularity.

[0003] CN101129322 discloses a multi-effect bath powder for skin care containing natural Chinese herbal extracts. Its composition includes: a sodium salt mixture, a tea saponin complex emollient, Chinese herbal extract powder, pearl powder, hydrochloric acid-based bactericides and antibacterial agents, and aromatherapy essential oils. All components of the provided bath powder are biodegradable, with a biodegradability rate approaching 99%. It has strong bactericidal and antibacterial effects, and all components are rapidly soluble in water, exhibiting a comprehensive synergistic effect, pharmacological effects, unique moisturizing effects, a smooth skin feel, and a long-lasting fragrance. It effectively promotes skin blood circulation and metabolism, regulates skin physiological balance, and leaves skin whiter, rosy, and delicate after bathing. It can significantly inhibit and alleviate skin odor, dermatitis, prickly heat, eczema, skin itching, and genital eczema and inflammation caused by excessive sweat gland secretion and sweat retention.

[0004] CN108159207A discloses a herbal medicinal stone bath liquid, prepared from the following raw materials: 20% medicinal stone, 9% saffron, 9% red peony root, 9% atractylodes rhizome, 9% salvia miltiorrhiza root, 9% sophora flavescens root, 9% saposhnikovia root, and the remainder is water. This invention optimizes the formula of Yuanyi medicinal stone and precious herbal medicinal materials such as saffron, fully leveraging the synergistic effects of each component. It not only restores the function of aging cells, promotes blood circulation, enhances metabolism, and eliminates waste products from the body, but also better meets the physical characteristics and physical and mental needs of modern people.

[0005] However, the above-mentioned bath products do not have a significant effect on skin care, and the Chinese herbal ingredients used are relatively expensive, increasing the cost of use. Therefore, there is an urgent need to develop a more effective product to care for the skin and maintain health to meet people's daily needs. Summary of the Invention

[0006] In view of the shortcomings of the prior art, the purpose of this invention is to provide a multi-functional bath composition, its preparation method and application.

[0007] To achieve this objective, the present invention adopts the following technical solution:

[0008] In a first aspect, the present invention provides a multi-functional bath composition, the multi-functional bath composition comprising separately packaged component A and component B;

[0009] Component A includes magnesium chloride, potassium chloride, and calcium chloride;

[0010] Component B includes moisturizers, antimicrobial peptides, and vitamins.

[0011] In the multi-functional bath composition of this invention, component A is a Dead Sea salt-like ingredient. It creates a water-permeable convection phenomenon on the skin's surface, inducing moisture from the subcutaneous layer to seep to the upper layer, thus promptly increasing the humidity of dehydrated skin. Simultaneously, the ingredient penetrates into the skin, adsorbing onto hair follicles, sweat glands, and positively charged oil, dirt, dead skin cells, and bacteria on the skin's surface. After deep cleansing, the released nutrients are more deeply absorbed by the skin, increasing cell activity and playing an important role in normal physiological activities, relieving fatigue, and enhancing physical strength. Component B, through the combination of moisturizers, antibacterial peptides, and vitamins, not only further enhances the moisturizing effect of the composition but also enables the composition to promote metabolism, condition the skin, whiten the skin, eliminate dryness and itching, have antibacterial and anti-inflammatory effects, help eliminate acne, improve eczema, and help treat acne.

[0012] Preferably, component A comprises 40-70 parts by weight of magnesium chloride, 5-20 parts by weight of potassium chloride, and 1-5 parts by weight of calcium chloride.

[0013] Preferably, component B comprises, by weight, 1-40 parts of moisturizer, 1-50 parts of antibacterial peptide, and 0.1-15 parts of vitamin.

[0014] Preferably, the moisturizer includes any one or a combination of at least two of NMF-50, erythritol, or hyaluronic acid.

[0015] Preferably, the humectant is a combination of NMF-50 and erythritol.

[0016] In this invention, the moisturizer is a combination of NMF-50 and erythritol, which not only enhances the moisturizing effect of the composition but also reduces the irritation of component A.

[0017] Preferably, the mass ratio of NMF-50 to erythritol is (1-3):(1-2).

[0018] The values ​​“1-3” can be 1.2, 1.4, 1.6, 1.8, 2, 2.2, 2.4, 2.6, or 2.8, etc.

[0019] “1-2” can be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8 or 1.9, etc.

[0020] Other specific point values ​​within the range of the above values ​​can be selected, and will not be elaborated on here.

[0021] Preferably, the antimicrobial polypeptide includes any one or a combination of at least two of lysozyme, nisin, or cephalosporin.

[0022] Preferably, the antimicrobial polypeptide is a combination of lysozyme, nisin, and cephalosporin.

[0023] The multi-functional bath composition of this invention uses a combination of lysozyme, nisin, and cephalosporin as antibacterial peptides. Lysozyme breaks down the β-1,4 glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in the cell wall, causing the insoluble mucopolysaccharides in the cell wall to decompose into soluble glycopeptides. This leads to cell wall rupture, release of contents, and bacterial lysis. Lysozyme can also directly bind to negatively charged viral proteins, forming complexes with DNA, RNA, and apoproteins, thus inactivating viruses. Nisin effectively kills pathogens, bacteria, and fungi, inhibiting most Gram-positive bacteria and strongly inhibiting Bacillus spores. Cephalosporin has a broad-spectrum antibacterial effect, exhibiting strong killing power against Gram-positive bacteria and some Gram-negative bacteria, while being non-toxic to fungi and eukaryotic cells. These three components have a synergistic effect in antibacterial and anti-inflammatory properties, not only enhancing the antibacterial and anti-inflammatory efficacy of the multi-functional bath composition but also reducing the risk of skin infection, making it safer and more reliable.

[0024] Preferably, the mass ratio of lysozyme, nisin, and cephalosporin is (1-2):(0.5-1.5):(1-2).

[0025] The first "1-2" can be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, or 1.9, etc.;

[0026] "0.5-1.5" can be 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3 or 1.4, etc.;

[0027] The second "1-2" can be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8 or 1.9, etc.

[0028] Other specific point values ​​within the range of the above values ​​can be selected, and will not be elaborated on here.

[0029] Preferably, the vitamins include B vitamins.

[0030] Preferably, the B vitamins include any one or a combination of at least two of vitamin B3, vitamin B6, or biotin.

[0031] Preferably, component A further includes any one or a combination of at least two of sodium chloride, magnesium bromide, silver chloride, zinc chloride, copper sulfate, dipotassium hydrogen phosphate, or ferrous sulfate heptahydrate.

[0032] Preferably, component A comprises, by weight, 40-70 parts magnesium chloride, 5-20 parts potassium chloride, 1-5 parts calcium chloride, 1-10 parts sodium chloride, 0.1-1 parts magnesium bromide, 0.0001-0.01 parts silver chloride, 0.01-0.1 parts zinc chloride, 0.01-0.1 parts copper sulfate, 0.01-0.1 parts dipotassium hydrogen phosphate, or 0.01-0.1 parts ferrous sulfate heptahydrate.

[0033] The amount of magnesium chloride added in component A of the multi-functional bath composition of the present invention can be 42 parts, 45 parts, 48 ​​parts, 50 parts, 52 parts, 55 parts, 58 parts, 60 parts, 62 parts, 65 parts or 68 parts, etc.

[0034] The amount of potassium chloride added can be 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 or 19 parts, etc.

[0035] The amount of calcium chloride added can be 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, or 4.5 parts, etc.

[0036] The amount of sodium chloride added can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, or 9 parts, etc.

[0037] The amount of magnesium bromide added can be 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, or 0.9 parts, etc.;

[0038] The amount of silver chloride added can be 0.002 parts, 0.003 parts, 0.004 parts, 0.005 parts, 0.006 parts, 0.007 parts, 0.008 parts, or 0.009 parts, etc.;

[0039] The amount of zinc chloride added can be 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, or 0.09 parts, etc.;

[0040] The amount of copper sulfate added can be 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, or 0.09 parts, etc.;

[0041] The amount of dipotassium hydrogen phosphate added can be 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, or 0.09 parts, etc.;

[0042] The amount of ferrous sulfate heptahydrate added can be 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts, 0.08 parts, or 0.09 parts, etc.

[0043] Other specific point values ​​within the range of the above values ​​can be selected, and will not be elaborated on here.

[0044] Preferably, component B further includes any one or a combination of at least two of the following: a soothing and repairing composition, a plant-based acaricide, or an adjuvant.

[0045] Preferably, component B comprises, by weight, 1-40 parts of moisturizer, 1-50 parts of antibacterial peptide, 0.1-15 parts of vitamin, 0.1-10 parts of soothing and repairing composition, 0.1-5 parts of plant-based acaricide, and 0-3 parts of adjuvant.

[0046] The amount of moisturizer added to component B of the multifunctional bath composition of the present invention can be 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts or 35 parts, etc.

[0047] The amount of the antimicrobial peptide added can be 5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts or 45 parts, etc.

[0048] The amount of vitamins added can be 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, or 14 parts, etc.

[0049] The amount of the soothing and repairing composition can be 0.5 parts, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, or 9 parts, etc.

[0050] The amount of the plant-based acaricide added can be 0.5 parts, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, or 4.5 parts, etc.;

[0051] The amount of the additive can be 0.1 parts, 0.5 parts, 1 part, 1.5 parts, 2 parts, or 2.5 parts, etc.

[0052] Preferably, the soothing and repairing composition comprises any one or a combination of at least two of dipotassium glycyrrhizate, asiaticoside, or oligopeptides.

[0053] Preferably, the soothing and repairing composition is a combination of dipotassium glycyrrhizate, asiaticoside, and oligopeptides.

[0054] As a preferred technical solution of the present invention, the multi-functional bath composition uses a combination of dipotassium glycyrrhizate, asiaticoside and oligopeptides as soothing and repairing ingredients. The three work synergistically to effectively repair the skin barrier function, better repair damaged cells, reduce skin sensitivity and improve skin comfort.

[0055] Preferably, the mass ratio of dipotassium glycyrrhizate, asiaticoside, and oligopeptide is (1-2):(2-3):(0.1-1).

[0056] "1-2" can be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, or 1.9, etc.

[0057] “2-3” can be 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, or 2.9, etc.;

[0058] "0.1-1" can be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8 or 0.9, etc.

[0059] Other specific point values ​​within the range of the above values ​​can be selected, and will not be elaborated on here.

[0060] Preferably, the plant acaricide includes any one or a combination of at least two of matrine, osthol, or xanthocyanin.

[0061] Preferably, the additives include any one or a combination of at least two of the following: preservatives, fragrances, or essential oils.

[0062] In a second aspect, the present invention provides a method for preparing the multi-functional bath composition according to the first aspect, the method comprising:

[0063] (1) Component A is obtained by mixing magnesium chloride, potassium chloride and calcium chloride;

[0064] (2) Then, the moisturizer, antimicrobial peptides and vitamins are mixed to obtain component B.

[0065] Preferably, step (1) further includes adding any one or a combination of at least two of sodium chloride, magnesium bromide, silver chloride, zinc chloride, copper sulfate, dipotassium hydrogen phosphate, or ferrous sulfate heptahydrate.

[0066] Preferably, the humidity during mixing in step (1) is <75%, for example, the humidity can be 65%, 60%, 55%, 50%, 45% or 40%, etc.

[0067] Preferably, step (2) further includes the addition of any one or a combination of at least two of the following: a soothing and repairing composition, a plant acaricide, or an adjuvant.

[0068] Preferably, component A and component B are packaged separately.

[0069] Other specific point values ​​within the range of the above values ​​can be selected, and will not be elaborated on here.

[0070] Thirdly, the present invention provides an application of the multifunctional bath composition according to the first aspect in a bath, wherein the application method is: adding component A and component B to the water simultaneously during bathing;

[0071] Preferably, the mass percentage of component A in water is 0.1-3%, for example, it can be 0.3%, 0.5%, 0.8%, 1%, 1.5%, 1.8%, 2%, 2.5% or 2.8%, etc.

[0072] Preferably, the mass ratio of component A to component B is 1:(0.1-1), for example, it can be 1:0.2, 1:0.3, 1:0.4, 1:0.5, 1:0.6, 1:0.7, 1:0.8 or 1:0.9, etc.

[0073] Other specific point values ​​within the range of the above values ​​can be selected, and will not be elaborated on here.

[0074] Compared with the prior art, the present invention has the following beneficial effects:

[0075] In the multi-functional bath composition of this invention, component A is a Dead Sea salt-like ingredient. It creates a water-permeable convection phenomenon on the skin's surface, inducing moisture from the subcutaneous layer to seep to the upper layer, thus promptly increasing the humidity of dehydrated skin. Simultaneously, the ingredient penetrates into the skin, adsorbing onto hair follicles, sweat glands, and positively charged oil, dirt, dead skin cells, and bacteria on the skin's surface. After deep cleansing, the released nutrients are more deeply absorbed by the skin, increasing cell activity and playing an important role in normal physiological activities, relieving fatigue, and enhancing physical strength. Component B, through the combination of moisturizers, antibacterial peptides, and vitamins, not only further enhances the moisturizing effect of the composition but also enables it to promote metabolism, condition the skin, whiten the skin, eliminate dryness and itching, provide antibacterial and anti-inflammatory effects, help eliminate acne, improve eczema, and aid in the treatment of acne. Since magnesium chloride, potassium chloride, and calcium chloride in component A are hygroscopic, packaging components A and B separately can prevent the active substances in component B, such as lysozyme, nisin, cephalosporin, asiaticoside, and oligopeptides, from deteriorating and becoming inactive. Detailed Implementation

[0076] To further illustrate the technical means and effects of the present invention, the following describes the technical solution of the present invention in conjunction with preferred embodiments of the present invention. However, the present invention is not limited to the scope of the embodiments.

[0077] Example 1

[0078] This embodiment provides a multi-functional bath composition, the components of which are:

[0079]

[0080]

[0081] The preparation method is as follows:

[0082] (1) Magnesium chloride, potassium chloride, calcium chloride, sodium chloride, magnesium bromide, silver chloride, zinc chloride, copper sulfate, dipotassium hydrogen phosphate and ferrous sulfate heptahydrate were mixed at 50% humidity to obtain component A, which was then packaged in plastic bags.

[0083] (2) NMF-50, erythritol, lysozyme, nisin, cephalosporin, vitamin B3, vitamin B6, biotin, dipotassium glycyrrhizate, asiaticoside, oligopeptide, and matrine moisturizer were mixed at room temperature to obtain component B, which was then packaged in aluminum foil bags.

[0084] Example 2

[0085] This embodiment provides a multi-functional bath composition, the components of which are:

[0086]

[0087]

[0088] The preparation method is as described in Example 1.

[0089] Example 3

[0090] This embodiment provides a multi-functional bath composition, the components of which are:

[0091]

[0092]

[0093] The preparation method is as described in Example 1.

[0094] Example 4

[0095] This embodiment provides a multi-functional bath composition. The only technical difference between this composition and that of Example 1 is that component A does not include magnesium bromide, silver chloride, zinc chloride, copper sulfate, dipotassium hydrogen phosphate, and ferrous sulfate heptahydrate. These components are added to sodium chloride in reduced quantities, while the remaining raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0096] Example 5

[0097] This embodiment provides a multi-functional bath composition. The only technical difference between this composition and Example 1 is that component B does not include the soothing and repairing composition; its amount is reduced and added to the moisturizer. The ratio of NMF-50 and erythritol remains unchanged, while the remaining ingredients and their contents remain the same. The preparation method is the same as in Example 1.

[0098] Example 6

[0099] This embodiment provides a multi-functional bath composition. The only technical difference between this composition and Example 1 is that the soothing and repairing composition in component B does not include oligopeptides, and the reduced amount is allocated to dipotassium glycyrrhizate and asiaticoside in proportion to the amount of oligopeptides. The remaining raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0100] Example 7

[0101] This embodiment provides a multi-functional bath composition. The only technical difference between this composition and Example 1 is that the soothing and repairing composition in component B does not include asiaticoside, and its reduced amount is allocated to dipotassium glycyrrhizate and oligopeptides in proportion to the amount of asiaticoside. The remaining raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0102] Example 8

[0103] This embodiment provides a multi-functional bath composition. The only technical difference between this composition and that of Example 1 is that the soothing and repairing composition in component B does not include dipotassium glycyrrhizate. The reduced amount of dipotassium glycyrrhizate is allocated to asiaticoside and oligopeptides in proportion to the amount of glycyrrhizin. The remaining raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0104] Example 9

[0105] This embodiment provides a multi-functional bath composition. The only technical difference between this composition and Example 1 is that the antibacterial polypeptide in component B does not include lysozyme. The reduced amount of lysozyme is allocated to nisin and cephalosporin in a proportional ratio, while the remaining raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0106] Example 10

[0107] This embodiment provides a multi-functional bath composition. The only technical difference between this composition and Example 1 is that the antibacterial polypeptide in component B does not include nisin, and its reduced amount is allocated to lysozyme and cephalosporin in proportion to the proportions. The remaining raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0108] Example 11

[0109] This embodiment provides a multi-functional bath composition. The only technical difference between this composition and Example 1 is that the antibacterial polypeptide in component B does not include cephalosporin, and its reduced amount is allocated to lysozyme and nisin in proportion to the proportions. The remaining raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0110] Example 12

[0111] This embodiment provides a multi-functional bath composition. The only technical difference between this composition and Example 1 is that the moisturizer in component B does not include NMF-50, and its amount is reduced and added to erythritol. The remaining raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0112] Example 13

[0113] This embodiment provides a multi-functional bath composition. The only technical difference between this composition and Example 1 is that the moisturizer in component B does not include erythritol, and its amount is reduced and added to NMF-50. The remaining raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0114] Comparative Example 1

[0115] This comparative example provides a multi-functional bath composition, which differs from Example 1 only in that it does not include component A, while the other raw materials and their contents remain unchanged. Its preparation method is the same as in Example 1.

[0116] Comparative Example 2

[0117] This comparative example provides a multi-functional bath composition, which differs from Example 1 only in that it does not include component B; all other raw materials and their contents remain unchanged. Its preparation method is the same as in Example 1.

[0118] Comparative Example 3

[0119] This comparative example provides a multi-functional bath composition, which differs from Example 1 only in that component A does not include magnesium chloride, and its reduced amount is increased proportionally in potassium chloride and calcium chloride, while the other raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0120] Comparative Example 4

[0121] This comparative example provides a multi-functional bath composition, which differs from Example 1 only in that component A does not include potassium chloride, and its reduced amount is increased proportionally in magnesium chloride and calcium chloride, while the other raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0122] Comparative Example 5

[0123] This comparative example provides a multi-functional bath composition, which differs from Example 1 only in that component A does not include calcium chloride, and its reduced amount is increased proportionally in magnesium chloride and potassium chloride, while the other raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0124] Comparative Example 6

[0125] This comparative example provides a multi-functional bath composition, which differs from Example 1 only in that component B does not include antibacterial peptides, and the reduced amount is increased in the moisturizer and vitamins according to the proportions. The other raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0126] Comparative Example 7

[0127] This comparative example provides a multi-functional bath composition, which differs from Example 1 only in that component B does not include vitamins, and its reduced amount is increased proportionally in the moisturizer and antibacterial peptides, while the other raw materials and their contents remain unchanged. The preparation method is the same as in Example 1.

[0128] Test Example 1: Skin Irritation Evaluation

[0129] The specific method is as follows: the samples of Examples 1-13 and Comparative Examples 3-7 (the mass ratio of component A to component B is 1:1) are prepared into a 3% aqueous solution, and the samples of Comparative Examples 1-2 are prepared into a 3% aqueous solution. Forty volunteers (20 males and 20 females) are used as test subjects, and all of them try the above samples.

[0130] (1) A 24-hour closed patch test was conducted. 0.020 mL of the above aqueous solution was measured into the patch apparatus, and a blank control group (without any added substances) was set up at the same time;

[0131] (2) After cleaning the inside of the subject's arm, apply the patch applicator containing the sample to the selected location on the inside of the subject's arm using non-irritating adhesive tape. After applying, gently press with your fingers to make it evenly adhered to the skin, and leave it for 24 hours. Instruct the subject to keep the patch area dry for 24 hours and avoid strenuous exercise, scratching the patch area, prolonged sun exposure, etc.

[0132] (3) After 24 hours, remove the test apparatus and mark it. After 30 minutes, when the indentation disappears, make a judgment under sufficient light. Follow up and observe within 24 hours and 48 hours respectively.

[0133] The criteria for identifying skin irritation are shown in Table 1:

[0134] Table 1

[0135] 0 - Negative reaction: no irritation, no erythema 1 ± Suspected reaction: Mild erythema 2 + Weak positive reaction: erythema 3 ++ Strong positive reaction: erythema, papules, vesicles 4 +++ Extremely strong positive reaction: severe edema, large bullae

[0136] The experimental results are shown in Table 2:

[0137] Table 2

[0138]

[0139]

[0140] According to the test results in Table 2 above, the synergistic effect of components A and B in the multi-functional bath composition of the present invention does not irritate the skin and has no positive reaction, indicating that the product of the present invention is safe and mild. In Comparative Example 2, only component A caused an erythema reaction, indicating that component A is prone to causing skin sensitivity. Therefore, the combination of component A and component B can make the product milder.

[0141] Test Example 2

[0142] Antibacterial performance test:

[0143] Test samples: Samples of Examples 1-13 and Comparative Examples 3-7 (with a mass ratio of component A to component B of 1:1) were prepared into 3% aqueous solutions, and samples of Comparative Examples 1-2 were prepared into 3% aqueous solutions.

[0144] Test methods: The test was conducted in accordance with QB / T2738-2005. The test strains were Candida albicans (ATCC10231), Pseudomonas aeruginosa (ATC15442) and Staphylococcus aureus (ATCC27217).

[0145] The experimental results are shown in Table 3:

[0146] Table 3

[0147]

[0148]

[0149] As shown in Table 3, the multi-functional bath composition involved in this invention has significant antibacterial and antimicrobial effects. Lysozyme, nisin, and cephalosporin have a certain synergistic effect in improving the antibacterial effect of the product. At the same time, the formulation of component A also affects the antibacterial effect of the product.

[0150] Test Example 3

[0151] Transdermal moisture loss test

[0152] Testing instrument: Skin surface moisture loss tester (C&K, Germany, Tewameter TM300);

[0153] Test samples: Samples from Examples 1-4, 12-13 and Comparative Examples 1-5.

[0154] Test Principle: The skin surface moisture loss tester uses a specially designed cylindrical probe with open ends to create a relatively stable microenvironment on the skin surface. Two sets of temperature and humidity sensors measure the water vapor pressure gradient at two different points near the epidermis (within approximately 1 cm) caused by moisture loss from the stratum corneum. This directly measures the amount of water evaporated through the epidermis, thus assessing the degree of skin surface moisture loss. The unit is g / hm². 2 In particular, the less transepidermal water loss, the better the skin barrier function;

[0155] Subjects: 110 subjects were selected, including those with dry forearm skin (moisture content less than 45%), and randomly divided into 11 groups of 10 subjects each. Each group used the multi-functional bath composition of Examples 1-4, 12-13 and Comparative Examples 1-5 once a day (bath water composition: the samples of Examples 1-4, 12-13 and Comparative Examples 3-5 (component A and component B in a mass ratio of 1:1) were prepared into a 2% aqueous solution, and the sample of Comparative Example 1-2 was prepared into a 2% aqueous solution).

[0156] Test site: Inner forearm;

[0157] The experimental results are shown in Table 4:

[0158] Table 4

[0159]

[0160]

[0161] As shown in Table 4, after using the multi-functional bath composition described in Examples 1-3 of this invention for 4 weeks, the water loss was reduced to 18 g / hm. 2 The following comparison of Examples 1 and 4, as well as Comparative Examples 3-5, shows that the combination of components in Component A of the present invention can improve the moisturizing effect; and Examples 12-13, compared with Example 1, demonstrate that the combination of NMF-50 and erythritol can effectively improve the moisturizing ability.

[0162] Test Example 4

[0163] Clinical sleep trial

[0164] Two hundred and ten female volunteers aged 20-40 were randomly divided into 21 groups of 10 each. Twenty groups used the multi-functional bath composition of Examples 1-13 and Comparative Examples 1-7 once a day (bath water composition: 2% aqueous solution of samples of Examples 1-13 and Comparative Examples 3-7 (component A and component B in a 1:1 mass ratio), and 2% aqueous solution of sample of Comparative Example 1-2). The remaining group was a control group (no bath product used). One course of treatment lasted 15 days. The efficacy was evaluated after two courses of treatment. During the treatment, no sleep aids or health products were taken. Changes in sleep time were measured using a Xiaomi Mi Band, which can measure deep sleep time and indirectly assess sleep improvement.

[0165] The specific test results are shown in Table 5:

[0166] Table 5

[0167]

[0168]

[0169] As shown in Table 5, after 15 days of continuous use of the multi-functional bath composition described in this invention, volunteers experienced an increase in sleep time of over 60 minutes, and after 14 days, an increase of over 90 minutes. This indicates that components A and B in the bath composition of this invention work synergistically, further enhancing the calming and sleep-inducing effects. Long-term use can improve sleep quality and, consequently, alleviate sub-health conditions.

[0170] The applicant declares that the present invention illustrates a multi-functional bath composition, its preparation method, and its application through the above embodiments. However, the present invention is not limited to the above embodiments, that is, it does not mean that the present invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvements to the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0171] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0172] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not describe the various possible combinations separately.

Claims

1. A multi-functional bath composition, characterized in that, The multi-functional bath composition includes separately packaged component A and component B; Component A, by weight, comprises 40-70 parts magnesium chloride, 5-20 parts potassium chloride, 1-5 parts calcium chloride, 1-10 parts sodium chloride, 0.1-1 parts magnesium bromide, 0.0001-0.01 parts silver chloride, 0.01-0.1 parts zinc chloride, 0.01-0.1 parts copper sulfate, 0.01-0.1 parts dipotassium hydrogen phosphate, and 0.01-0.1 parts ferrous sulfate heptahydrate. Component B, by weight, comprises 1-40 parts of moisturizer, 1-50 parts of antibacterial peptides, 0.1-15 parts of vitamins, 0.1-10 parts of soothing and repairing composition, 0.1-5 parts of plant-based acaricide, and 0-3 parts of adjuvants; the soothing and repairing composition is a combination of dipotassium glycyrrhizate, asiaticoside, and oligopeptides; the mass ratio of dipotassium glycyrrhizate, asiaticoside, and oligopeptides is (1-2):(2-3):(0.1-1). The moisturizer is a combination of NMF-50 and erythritol; the mass ratio of NMF-50 to erythritol is (1-3):(1-2). The antimicrobial polypeptide is a combination of lysozyme, nisin and cephalosporin; the mass ratio of lysozyme, nisin and cephalosporin is (1-2):(0.5-1.5):(1-2).

2. The multi-functional bath composition according to claim 1, characterized in that, The vitamins mentioned include B vitamins.

3. The multi-functional bath composition according to claim 2, characterized in that, The B vitamins include any one or a combination of at least two of vitamin B3, vitamin B6, or biotin.

4. The multi-functional bath composition according to claim 1, characterized in that, The plant-based acaricide includes any one or a combination of at least two of matrine, osthol, or xanthocyanin.

5. The multi-functional bath composition according to claim 1, characterized in that, The additives include any one or a combination of at least two of the following: preservatives, fragrances, or essential oils.

6. The method for preparing the multi-functional bath composition according to any one of claims 1-5, characterized in that, The preparation method includes: (1) Component A is obtained by mixing magnesium chloride, potassium chloride, calcium chloride, sodium chloride, magnesium bromide, silver chloride, zinc chloride, copper sulfate, dipotassium hydrogen phosphate and ferrous sulfate heptahydrate; (2) Then, the moisturizer, antimicrobial peptide, vitamin, soothing and repairing composition, plant acaricide and adjuvant are mixed to obtain component B.

7. The method for preparing the multi-functional bath composition according to claim 6, characterized in that, The humidity during mixing in step (1) is <75%.

8. The method for preparing the multi-functional bath composition according to claim 6, characterized in that, Component A and Component B are packaged separately.

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