An acne-removing spray and a preparation method thereof

Abstract

The application discloses a kind of acne-removing sprays and preparation method thereof, the acne-removing spray includes but is not limited to the following mass percentage components: white willow bark extract 0.3%~3.0%, Sophora flavescens extract 0.5%~5.0%, Huangqi extract 0.5%~5.0%, South China honeysuckle flower extract 0.5%~5.0%, glycerol 5%~10%, linear aspirin extract 0.3%~3.0%, sodium hyaluronate 0.1%~1.0%, Shuzhuhun Miaosu active oxygen essence 0.5%~1.0%, and the balance is water.The application is prepared by selecting a variety of traditional Chinese medicine extracts and Shuzhuhun Miaosu active oxygen essence to compound acne-removing spray, which can not only achieve deep anti-inflammatory effect, has good acne-removing effect, but also has anti-aging, exfoliation, anti-allergy, anti-aging and improving blood circulation of skin, promoting skin metabolism, inhibiting the activity of tyrosinase and melanin deposition effect.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically, it relates to an acne-removing spray and its preparation method. Background Technology

[0002] Acne, also known as pimples, is a multifactorial skin disease characterized by polymorphic lesions, including comedones, papules, pustules, and nodules, primarily affecting the face. Its pathogenesis is mainly related to factors such as sex hormone levels, excessive sebum secretion, proliferation of Propionibacterium acnes, abnormal keratinization of the pilosebaceous duct, and inflammation. It is most common in adolescent males and females. Acne not only affects appearance but can also pose certain health risks; therefore, acne treatment is crucial.

[0003] In modern life, besides controlling acne through diet, appropriate acne-removing products can also be used. Acne-removing cosmetics are undoubtedly the first choice for many consumers. However, most acne-treating cosmetics on the market currently contain chemical bactericides, hormones, astringents, and anti-inflammatory agents, which are highly irritating to the skin, easily causing scarring or pigmentation, and in severe cases, even skin allergies. Furthermore, because pathogens easily develop drug resistance, the effects are often unsatisfactory. Therefore, the development of a safer, gentler, and longer-lasting acne-removing cosmetic has become an urgent need. Summary of the Invention

[0004] This invention aims to at least partially solve one of the technical problems in related technologies. To this end, embodiments of this invention propose an acne-removing spray and a method for its preparation.

[0005] One embodiment of the present invention provides an acne-removing spray, including but not limited to the following components in weight percentage: 0.3%–3.0% white willow bark extract, 0.5%–5.0% sophora flavescens extract, 0.5%–5.0% scutellaria baicalensis extract, 0.5%–5.0% honeysuckle flower extract, 5%–10% glycerin, 0.3%–3.0% linear asparagus extract, 0.1%–1.0% sodium hyaluronate, 0.5%–1.0% bamboo red fungus active oxygen essence, and the balance being water.

[0006] This invention provides an acne-removing spray prepared by compounding various Chinese herbal extracts and bamboo red fungus active oxygen essence. This acne-removing spray not only achieves deep anti-inflammatory effects and has a good acne-removing effect, but also has anti-aging, exfoliating, anti-allergic, and skin-improving effects, as well as improving skin blood circulation, promoting skin metabolism, inhibiting tyrosinase activity and melanin deposition. Moreover, it is safe, gentle and does not harm the skin, and is safer and more reliable than other chemically synthesized cosmetics.

[0007] In some embodiments, the molecular weight of the sodium hyaluronate is 3000 to 4000.

[0008] In some embodiments, the spatial structural formula of the bamboo red fungus active oxygen essence is:

[0009] , The bamboo red fungus active oxygen essence has a hollow capsule structure; the bamboo red fungus active oxygen essence is composed of triangular blocks B and olefin-containing chains A, and the structural unit is shown below: , The structural unit consists of a triangular block B and an olefin-containing chain A; each structural unit has three Si-containing branches; the Si-containing branches between different structural units are connected to form a hollow capsule structure; wherein, the value of n is 4 to 80, preferably 22 to 68, and more preferably 45.

[0010] In some embodiments, the bamboo red fungus active oxygen essence is prepared by a method comprising the following steps: S1: Covalent organic polyhedral cage compound COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide were mixed, and ultra-dry tetrahydrofuran was added to the mixture and stirred at room temperature for 40-60 h; then polyethylene glycol was added and the reaction was continued for 60-80 h; after the reaction was completed, the filtrate was evaporated to dryness to obtain a solid. S2: The solid obtained in step S1 is placed into a cellulose dialysis bag for dialysis treatment to obtain a suspension; S3: Dissolve and filter the suspension obtained in step S2. The filtrate is the active oxygen essence of bamboo red fungus A.

[0011] In some embodiments, in step S1, the spatial structural formula of the covalent organic polyhedral cage compound COP2T is: , The covalent organic polyhedral cage compound COP2T has an open hollow capsule structure; the covalent organic polyhedral cage compound COP2T is composed of triangular blocks B and olefin-containing chains A, and the structural units are shown below: , The structural unit consists of a triangular block B and an olefin-containing chain A; each structural unit has three Si-containing branches; the Si-containing branches between different structural units are connected to form a hollow capsule structure.

[0012] In some embodiments, in step S1, the mass ratio of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide is (36-38):20:1:(18-20); And / or, the mass ratio of the mixture of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide to the polyethylene glycol is 1:(5-8); the molecular weight of the polyethylene glycol is 1000-3000, preferably 2000; And / or, the drying temperature is 30–50°C.

[0013] In some embodiments, in step S2, the molecular weight cutoff of the cellulose dialysis bag is 3000-6000; And / or, the dialysis treatment is performed 2 to 5 times, with each dialysis session lasting 5 to 10 hours.

[0014] The main active ingredient in the acne-removing spray of this invention, bamboo red fungus HA active oxygen essence, is prepared by cross-linking bamboo red fungus HA with polyethylene glycol (PEG) after loading the covalent organic polyhedral cage-like compound COP2T. Bamboo red fungus HA, a natural photosensitive pigment extracted from a parasitic fungus native to arrow bamboo in Yunnan, my country, possesses characteristics such as high singlet reactive oxygen quantum yield, non-toxic side effects on human skin tissue, and easy modification of its chemical structure. It shows promising potential in the development of photodynamic antibacterial drugs for treating acne, pimples, papules, pustules, and other skin diseases. COP2T, with its cage-like structure, readily undergoes a condensation reaction with the hydroxyl groups on bamboo red fungus HA, increasing the loading of bamboo red fungus HA and thus enhancing the acne-removing efficacy of the essence. Furthermore, this invention also utilizes polyethylene glycol to hydrophilically modify bamboo red fungus HA, generating active oxygen, which further enhances its effectiveness in killing Propionibacterium acnes.

[0015] Another aspect of this invention provides a method for preparing the above-mentioned acne spray, comprising the following steps: (1) Dissolve the extracts of white willow bark, sophora flavescens, scutellaria baicalensis, honeysuckle flower, glycerin and linear asparagine in water, stir and mix, and then heat and stir to react. (2) Add sodium hyaluronate and bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir and mix, and let stand to obtain a spray liquid; (3) Adjust the pH value of the spray obtained in step (2) to 5-7, and draw the spray into a vacuum spray bottle, seal and store it to obtain the acne-removing spray.

[0016] The features and advantages described above for acne sprays also apply to the preparation method of acne sprays, and will not be repeated here.

[0017] In some embodiments, in step (1), the stirring speed is 100-300 r / min and the stirring time is 10-60 min; And / or, the heating and stirring reaction is carried out under a nitrogen protective atmosphere, the reaction temperature is 60-80°C, and the reaction time is 0.5-3h.

[0018] In some embodiments, in step (2), the mixing time is 10 to 80 minutes; the settling time is 20 to 50 minutes.

[0019] In some embodiments, in step (3), the pH value of the spray liquid is adjusted using a citrate buffer solution. Attached Figure Description

[0020] Figure 1 This is a synthetic route diagram of the active oxygen essence of bamboo red fungus A-type agent according to the present invention.

[0021] Figure 2 Synthetic route diagram for COP2T, a covalent organic polyhedral cage compound. Detailed Implementation

[0022] The embodiments of the present invention are described in detail below. These embodiments are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention.

[0023] In this document, when values ​​are described as ranges, it should be understood that such disclosure includes disclosure of all possible subranges within that range, as well as the specific numerical values ​​falling within that range, regardless of whether the specific numerical value or specific subrange is explicitly specified.

[0024] In this article, the words “contain” and “include” and their various variations mean that other elements or wholes may be included but not specifically described.

[0025] In this article, the term "and / or" is merely a description of the relationship between related objects, indicating that there can be three kinds of relationships. For example, A and / or B can represent three cases: A exists alone, A and B exist simultaneously, and B exists alone.

[0026] One embodiment of the present invention provides an acne-removing spray, including but not limited to the following components in weight percentage: 0.3%–3.0% white willow bark extract, 0.5%–5.0% sophora flavescens extract, 0.5%–5.0% scutellaria baicalensis extract, 0.5%–5.0% honeysuckle flower extract, 5%–10% glycerin, 0.3%–3.0% linear asparagus extract, 0.1%–1.0% sodium hyaluronate, 0.5%–1.0% bamboo red fungus active oxygen essence, and the balance being water.

[0027] This invention provides an acne-removing spray prepared by compounding various Chinese herbal extracts and bamboo red fungus extract. The extracts of white willow bark, sophora flavescens, scutellaria baicalensis, honeysuckle, and linear asparagus extract primarily function for anti-aging and exfoliation, with acne removal being a secondary effect. In contrast, the bamboo red fungus extract is primarily for acne removal, exhibiting significantly better acne-removing efficacy than the aforementioned extracts. The anti-aging and exfoliating effects of the extracts enhance the acne-removing effect, resulting in a more effective spray. Therefore, the acne-removing spray prepared in this invention not only possesses anti-aging and exfoliating properties but also exhibits a more pronounced acne-removing effect.

[0028] In some embodiments, the molecular weight of sodium hyaluronate is 3000 to 4000.

[0029] In some embodiments, the spatial structural formula of the bamboo red fungus active oxygen essence is: , The bamboo red fungus active oxygen essence has a hollow capsule structure; and the bamboo red fungus active oxygen essence is composed of triangular blocks B and olefin-containing chains A, as shown in the following structural unit: , The structural unit consists of a triangular block B and an olefin-containing chain A; each structural unit has three Si-containing branches; the Si-containing branches between different structural units are connected to form a hollow capsule structure; wherein, the value of n is 4 to 80, preferably 22 to 68, and more preferably 45.

[0030] like Figure 1 The diagram shows the synthetic route of the aforementioned bamboo red fungus glycoside active oxygen essence (COP2T-HA). It is prepared by loading bamboo red fungus glycoside (HA) onto the covalent organic polyhedral cage-like compound COP2T and then cross-linking it with polyethylene glycol (PEG). The COP2T-HA structural unit is a combination of triangular block B and olefin-containing chain A in a hollow capsule structure; each structural unit has three Si-containing branches; the Si-containing branches between different structural units connect to form a hollow capsule structure. These are the three -COOH reaction sites corresponding to the COP2T structural unit; two are modified with polyethylene glycol, and one is modified with bamboo red fungus glycoside to obtain the product. The ends of the Si-containing branches indicate the connection points with corresponding segments of other identical structural units.

[0031] The specific preparation process of this bamboo red fungus active oxygen essence (COP2T-HA) includes the following steps: S1: Covalent organic polyhedral cage compound COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide were mixed, and ultra-dry tetrahydrofuran was added to the mixture and stirred at room temperature for 40-60 h; then polyethylene glycol was added and the reaction was continued for 60-80 h; after the reaction was completed, the filtrate was evaporated to dryness to obtain a solid. S2: The solid obtained in step S1 is placed into a cellulose dialysis bag for dialysis treatment to obtain a suspension; S3: Dissolve and filter the suspension obtained in step S2. The filtrate is the active oxygen essence of bamboo red fungus A.

[0032] Bamboo red fungus extract is insoluble in water, so it cannot be made into a water-soluble essence for direct use in acne spray products. Only COP2T-HA, obtained by condensing it with the covalent organic polyhedral cage compound COP2T and modifying it with polyethylene glycol, can dissolve in water and thus become an effective load to exert an acne-removing effect.

[0033] In some embodiments, in step S1, the spatial structural formula of the covalent organic polyhedral cage compound COP2T is: , The covalent organic polyhedral cage compound COP2T has an open hollow capsule structure; and this covalent organic polyhedral cage compound COP2T is composed of eight triangular blocks B and twelve olefin-containing chains A, wherein the molecular formula of the triangular blocks B is: Among them, the molecular structural unit of R4 is In this structure, R5, R6, and R7 are hydrogen atoms; the structural formula containing olefin chain A is... , Where R1 is: And R2 is: The structural unit of the covalent organic polyhedral cage compound COP2T is shown below: , The structural unit consists of a triangular block B and an olefinic chain A; each structural unit has three Si-containing branches; the Si-containing branches connecting different structural units form a hollow capsule structure. Each structure of COP2T has three reactive sites, namely three -COOH groups, and each cage-like molecule has 24 reactive sites. The ends of the Si-containing branches indicate the connection points with corresponding segments of other identical structural units.

[0034] Furthermore, the synthetic reaction design of the covalent organic polyhedral cage compound COP2T is as follows: the first step is to link the silane of compound A to the basic skeleton M1 of hexabromophenylbenzene; the second step is to functionalize the remaining three bromination reaction sites on hexabromophenylbenzene M1 through Suzuki coupling; the third step is to hydrolyze the ester group to obtain the carboxyl group; the fourth step is to complex with copper to obtain the complex crystal; and the fifth step is to complete the olefin metathesis reaction and stitch it together to obtain the porous organic cage compound COP2T.

[0035] The key point is that the first and second steps involve attaching different functional groups in a specific order. In the first step, the silane chain of compound A, which has greater steric hindrance, is attached to the M1 backbone first. By controlling the reaction temperature and time, it can be basically guaranteed that three bromination sites are attached, and they are spaced apart. If boric acid is reacted with the M1 bromination sites first, all six reaction sites will be filled directly, making it impossible to attach the silane chain of compound A later.

[0036] like Figure 2 The diagram shown is a synthetic route for the covalent organic polyhedral cage compound COP2T, which includes the following steps: Step 1: Synthesis of compound M2.

[0037] 26.8 g of p-dimethylaminobenzene (1.0 eq) was added to 100 mL of anhydrous diethyl ether and stirred for 10 min. Then, 1.86 g of lithium granules (2.0 eq) were added. After adding, the mixture was refluxed for 1 h and then cooled to room temperature. The reaction was then stirred at 0 °C. 30 g of compound M1 (0.25 eq) was dissolved in 200 mL of tetrahydrofuran and added to the reaction mixture at 0 °C. The mixture was stirred for 20 min. Then, 100 mL of tetrahydrofuran solution containing 78 g of compound A (2.0 eq) was slowly added dropwise to the reaction system and the reaction was carried out for 2 hours.

[0038] After the reaction was completed, 100 mL of water was added to quench the reaction. The reaction solution was then extracted with dichloromethane. The resulting organic solution was dried over anhydrous MgSO4, filtered, and the organic phases were combined. The organic phases were purified by column chromatography (petroleum ether: dichloromethane = 10:1 to 4:1) to give a total of 29.4 g of white solid M2, with a separation yield of 64%.

[0039] Step 2: Synthesis of compound M3.

[0040] 25 g of compound A (1.0 eq), 15.9 g of 3-methoxycarbonylpyridineboronic acid (4.5 eq), and 0.438 g of Pd(dppf)₂Cl₂ (0.03 eq) were added to a single-necked flask containing a mixture of 100 mL toluene and 100 mL ethanol. 12.5 g of sodium carbonate (6.0 eq) was dissolved in 100 mL of water and added to the reaction system. After purging with nitrogen five times, the reaction was carried out at 85 °C for 2 hours. TLC analysis showed that the reactants had not completely reacted. The reaction was paused and the mixture was cooled slightly. Then, 0.438 g of Pd(dppf)₂Cl₂ (0.03 eq) was added, and the reaction was repeated five times with nitrogen. The reaction was continued at 85 °C for 2 hours. TLC analysis showed that the reactants had completely reacted. The reaction was then stopped and the mixture was cooled to room temperature.

[0041] After the reaction was completed, the reaction solution was washed with water and saturated brine, extracted with dichloromethane, dried with anhydrous sodium sulfate, and the organic phases were combined and purified by column chromatography (petroleum ether: ethyl acetate = 40:1 to 20:1) to give a total of 14.1 g of white solid M3, with a separation yield of 51%.

[0042] Step 3: Synthesis of compound M4.

[0043] 10 g of compound M3 (1.0 eq) and 11.7 g of KOH (30.0 eq) were dissolved in a mixed solvent of 50 mL methanol, 50 mL water and 50 mL tetrahydrofuran. The reaction was carried out at 45 °C for 9 hours. The reaction was stopped after TLC was performed to check that the starting materials had reacted completely.

[0044] After the reaction was completed, dilute hydrochloric acid was slowly added to adjust the pH to acidic on the pH test paper. Water and petroleum ether were added for extraction, and the organic phases were dried with anhydrous sodium sulfate and combined. The organic phases were purified by column chromatography (dichloromethane:ethanol = 10:1) to obtain a total of 9.17 g of white solid M4, with a separation yield of 94%.

[0045] Step 4: Synthesis of Crystal M5 Dissolve 30g of compound M4 (1.0eq) in 3L of DMF and add it to a single-necked flask. Dissolve 31g of copper nitrate trihydrate (6.0eq) in 1L of ethanol and add it to the single-necked flask. Then add 3.76g of fluoroboric acid (2.0eq) dropwise to the single-necked flask. Seal the flask with a glass stopper and place it in a 75℃ constant temperature oven for 30h.

[0046] After 30 hours, blue crystals were observed to precipitate in the solution. The solution was removed, cooled to room temperature, and filtered under reduced pressure using a Buchner funnel. The solid solvent was kept moist, and the solution was washed three times with 100 mL of methanol each time. After drying, 32 g of blue crystals M5 were obtained.

[0047] Step 5: Synthesis of the porous organic cage-like compound COP2T Dissolve 30g of blue crystal M5 in 400mL of ultra-dry THF, filter to remove a small amount of insoluble solids, add the filtrate to a three-necked flask, then add 2.6L of ultra-dry tetrahydrofuran, and purge with nitrogen three times; add 3g of cuprous iodide, bubble with nitrogen for 20min, then add 6g of Grubbs2 catalyst, the color is dark brown, purge with nitrogen three times; heat to 45℃ and stir for 10min, the color turns dark green, keep the oil level in the 45℃ oil pan slightly higher than the system liquid level, and react for 4 days; After the reaction was completed, the system was cooled to room temperature, stirring was stopped, hydrochloric acid was added for acidification, and stirring was carried out overnight. The reaction solution was filtered and washed three times with tetrahydrofuran, 100 mL each time. The filtrates were combined and evaporated to dryness. After evaporation, 300 mL of methanol was added to the solid and stirred for 1 hour. After filtration, a filter cake was obtained. The filter cake was washed five times with methanol, 100 mL each time, until the mother liquor was colorless and transparent. The solid was dried to obtain 17 g of grayish-white solid COP2T, with a yield of 56.7% (by mass).

[0048] To enhance the acne-fighting efficacy of the serum and its corresponding spray product, the COP2T structure described in this invention is meticulously designed. Regarding the aforementioned COP2T structure, firstly, the addition of a benzyl group to R2 compared to the common alkyl chain structure makes the cage-like structure more stable. More importantly, by selecting the R2 structural unit, a cage-like COP2T molecule with a larger cavity structure can be prepared. Because the larger cavity reduces the resistance to the condensation reaction of hyaluronic acid (HA) with COP2T, the reaction proceeds more easily, resulting in a higher loading of hyaluronic acid. Simultaneously, R4 is changed from the common 3-benzoic acid structure to the structure of 3-pyridinecarboxylic acid (nicotinic acid), a natural vitamin found in the human body. This increases skin affinity and reduces discomfort when used in a mask serum. Furthermore, the carboxyl group of 3-pyridinecarboxylic acid is more reactive than that of 3-benzoic acid, making it easier to undergo a condensation reaction with the hydroxyl group on hyaluronic acid, thereby further increasing the loading of hyaluronic acid and thus enhancing the acne-fighting efficacy of the serum. Structural units, compared to the past The structural units are more hydrophilic, so the product COP2T-HA has better water solubility and is less prone to supersaturation and precipitation, which is equivalent to increasing the effective loading of bamboo red mycotoxin essence.

[0049] In some embodiments, in step S1, the mass ratio of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungin is (36-38):20:1:(18-20); And / or, the mass ratio of the mixture of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide to polyethylene glycol is 1:(5-8); and the molecular weight of polyethylene glycol is 1000-3000, preferably 2000; And / or, the rotary drying temperature is 30–50°C.

[0050] In some embodiments, in step S2, the molecular weight cutoff of the cellulose dialysis bag is 3000 to 6000; And / or, the number of dialysis treatments is 2 to 5 times, and the duration of each dialysis treatment is 5 to 10 hours.

[0051] Another aspect of this invention provides a method for preparing the above-mentioned acne spray, comprising the following steps: (1) Dissolve the extracts of white willow bark, sophora flavescens, scutellaria baicalensis, honeysuckle flower, glycerin and linear asparagine in water, stir and mix, and then heat and stir to react. (2) Add sodium hyaluronate and bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir and mix, and let stand to obtain spray liquid; (3) Adjust the pH of the spray obtained in step (2) to 5-7, and draw the spray into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0052] In some embodiments, in step (1), the stirring speed is 100-300 r / min and the stirring time is 10-60 min; And / or, the heating and stirring reaction is carried out under a nitrogen protective atmosphere, the reaction temperature is 60-80℃, and the reaction time is 0.5-3h.

[0053] In some embodiments, in step (2), the mixing time is 10 to 80 minutes; the settling time is 20 to 50 minutes.

[0054] In some embodiments, in step (3), the pH value of the spray liquid is adjusted using a citrate buffer solution.

[0055] The following are non-limiting embodiments and comparative examples of the present invention. It should be noted that the comparative examples are not prior art, but are only set up for comparison with the embodiments and are not intended to limit the present invention.

[0056] In the following examples and comparative examples, the bamboo red fungus active oxygen essence was prepared by a method including the following steps: S1: 14 mg COP2T (1.0 eq), 7.4 mg 1,3-dicyclohexylcarbodiimide (DCC, 25.4 eq), 0.37 mg 4-dimethylaminopyridine (DMAP, 2.0 eq), and 7.09 mg bamboo red fungicide (HA, 9.2 eq) were added to a 20 mL glass reaction flask and mixed. Then, 5 mL of ultra-dry tetrahydrofuran was added, and the mixture was stirred at room temperature for 48 h. After that, 200 mg of polyethylene glycol (PEG-2000, 89.0 eq) was added, and the reaction was continued for 72 h. After the reaction was completed, the filtrate was evaporated to dryness at 40 °C to obtain a solid. S2: The solid obtained in step S1 is placed into a cellulose dialysis bag (molecular weight cutoff 5000) and dialyzed in deionized water for 8 hours each time. The process is repeated 3 times to obtain a suspension. S3: Dissolve the suspension obtained in step S2 in 50 mL of deionized water and filter. The filtrate is the active oxygen essence of bamboo red fungus A.

[0057] Example 1 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 0.3g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0058] Example 2 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0059] Example 3 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 3g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0060] Example 4 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 0.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0061] Example 5 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0062] Example 6 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 2.5g of sophora flavescens extract, 0.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0063] Example 7 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 2.5g of sophora flavescens extract, 5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0064] Example 8 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 0.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0065] Example 9 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0066] Example 10 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 0.3g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0067] Example 11 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 3g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0068] Example 12 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99.4g, stir at 200r / min for 30min on a magnetic stirrer, and after fully dissolving and mixing, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.1g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid; (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0069] Example 13 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 98.5g, stir at 200r / min for 30min on a magnetic stirrer, and after fully dissolving and mixing, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 1g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0070] Example 14 This embodiment provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 98.5g, stir at 200r / min for 30min on a magnetic stirrer, and after fully dissolving and mixing, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 1g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0071] Comparative Example 1 This comparative example provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 2.5g of Sophora flavescens extract, 2.5g of Scutellaria baicalensis extract, 2.5g of Lonicera japonica extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0072] Comparative Example 2 This comparative example provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 0.3g of white willow bark extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0073] Comparative Example 3 This comparative example provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 0.3g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0074] Comparative Example 4 This comparative example provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 0.3g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, and after fully dissolving and mixing, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0075] Comparative Example 5 This comparative example provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 0.3g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract and 10g of glycerin into an aqueous phase pot, add deionized water to 99g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.5g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid. (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0076] Comparative Example 6 This comparative example provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 0.3g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99.5g, stir at 200r / min for 30min on a magnetic stirrer, after fully dissolving and mixing evenly, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 to the reaction product obtained in step (1), stir at room temperature for 30min, and then let stand for 30min to obtain the spray liquid; (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0077] Comparative Example 7 This comparative example provides a method for preparing an acne-removing spray, including the following steps: (1) Weigh 1.5g of white willow bark extract, 2.5g of sophora flavescens extract, 2.5g of scutellaria baicalensis extract, 2.5g of honeysuckle flower extract, 10g of glycerin and 1.5g of linear asparagus extract into an aqueous phase pot, add deionized water to 99.4g, stir at 200r / min for 30min on a magnetic stirrer, and after fully dissolving and mixing, heat to 70℃ under nitrogen protection and continue stirring for 1h. After the reaction is completed, cool the reaction product to room temperature. (2) Add 0.5g of sodium hyaluronate with a molecular weight of 3000 and 0.1g of bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir at room temperature for 30 minutes, and then let stand for 30 minutes to obtain the spray liquid; (3) Adjust the pH of the spray obtained in step (2) to 5-7 using citrate buffer solution, and then draw it into a vacuum spray bottle, seal and store it to obtain the acne spray.

[0078] Experimental Example 1 Acne-removing sprays prepared in Examples 1-14 and Comparative Examples 1-7 of this invention were tested for acne removal. The specific process is as follows: Twenty young adults aged 20-30 who frequently experience acne were selected as test subjects. Each person used Example 1 of this invention daily. The acne spray products prepared in Examples 14 and 1-7 were evaluated one month later according to three results: cured, improved, and ineffective. The acne treatment effectiveness rate was calculated after counting the number of people. Effectiveness rate = (number of cured + number of improved) / total number of people. The statistical results are shown in Table 1.

[0079] Explanation of the three evaluation criteria: cured, improved, and ineffective: Cure: The original acne is reduced by ≥90%. For example, if the test subject had 20 pimples on their face before using the product and now has 2 or fewer after one month of use, it can be considered cured. Improvement: The original acne has been reduced by 40% to 90% (including 40% but not including 90%). Ineffective: The original acne has been reduced by less than 40% (excluding 40%).

[0080] Table 1

[0081] As shown in Table 1, compared with Comparative Examples 1-7, Examples 1-14 of the present invention prepared an acne spray by compounding extracts of white willow bark, sophora flavescens, scutellaria baicalensis, honeysuckle flower, linear asparagus extract, and bamboo red fungus active oxygen essence. This mixture has a synergistic effect in the acne removal process, and the resulting acne spray has a better acne removal effect, with an acne removal efficiency of up to 70% or more.

[0082] Furthermore, as shown in the table above, the addition amounts of white willow bark extract, sophora flavescens extract, scutellaria baicalensis extract, honeysuckle flower extract, and linear asparagus extract have little impact on the acne-removing effect. However, the addition amount of bamboo red fungus active oxygen essence has a significant impact on the acne-removing effect. Data analysis from Example 14 and Comparative Example 7 shows that when the addition amount of bamboo red fungus active oxygen essence decreased from 1% to 0.1%, its acne-removing effectiveness decreased from 85% to 55%, indicating a significant reduction in acne-removing effect. Therefore, this application strictly controls the addition amount of bamboo red fungus active oxygen essence to ensure that the acne spray has a good acne-removing effect.

[0083] In this invention, the terms "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to a specific feature, structure, material, or characteristic described in connection with that embodiment or example, which is included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0084] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. An acne-removing spray, characterized in that, The product includes, but is not limited to, the following components in weight percentage: white willow bark extract 0.3%–3.0%, sophora flavescens extract 0.5%–5.0%, scutellaria baicalensis extract 0.5%–5.0%, honeysuckle flower extract 0.5%–5.0%, glycerin 5%–10%, linear asparagus extract 0.3%–3.0%, sodium hyaluronate 0.1%–1.0%, bamboo red fungus active oxygen essence 0.5%–1.0%, and the balance being water; The bamboo red fungus active oxygen essence is prepared by a method including the following steps: S1: Covalent organic polyhedral cage compound COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide were mixed, and ultra-dry tetrahydrofuran was added to the mixture and stirred at room temperature for 40-60 h; then polyethylene glycol was added and the reaction was continued for 60-80 h; after the reaction was completed, the filtrate was evaporated to dryness to obtain a solid. S2: The solid obtained in step S1 is placed into a cellulose dialysis bag for dialysis treatment to obtain a suspension; S3: Dissolve and filter the suspension obtained in step S2. The filtrate is the active oxygen essence of bamboo red fungus A. In step S1, the spatial structural formula of the covalent organic polyhedral cage compound COP2T is: ， The covalent organic polyhedral cage compound COP2T has an open hollow capsule structure; and the covalent organic polyhedral cage compound COP2T is composed of eight triangular blocks B and twelve olefin-containing chains A, wherein the molecular formula of the triangular blocks B is: Among them, the molecular structural unit of R4 is R5, R6, and R7 are hydrogen atoms; the structural formula containing olefin chain A is... R1 is: R2 is: ; The structural unit of the covalent organic polyhedral cage-like compound COP2T is shown below: 。 2. The acne-removing spray according to claim 1, characterized in that, The spatial structural formula of the bamboo red fungus active oxygen essence is: ， The bamboo red fungus active oxygen essence has a hollow capsule structure; the bamboo red fungus active oxygen essence is composed of triangular blocks B and olefin-containing chains A, and the structural unit is shown below: ， The structural unit consists of a triangular block B and an olefin-containing chain A; each structural unit has three Si-containing branches; the Si-containing branches between different structural units are connected to form a hollow capsule structure; wherein, the value of n is 4 to 80.

3. The acne-removing spray according to claim 1, characterized in that, In step S1, the mass ratio of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide is (36-38):20:1:(18-20); And / or, the mass ratio of the mixture of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide to the polyethylene glycol is 1:(5-8); the molecular weight of the polyethylene glycol is 1000-3000; And / or, the drying temperature is 30–50°C.

4. The acne-removing spray according to claim 1, characterized in that, In step S2, the molecular weight cutoff of the cellulose dialysis bag is 3000-6000; And / or, the dialysis treatment is performed 2 to 5 times, with each dialysis session lasting 5 to 10 hours.

5. A method for preparing an acne-removing spray as described in any one of claims 1-4, characterized in that, Includes the following steps: (1) Dissolve the extracts of white willow bark, sophora flavescens, scutellaria baicalensis, honeysuckle flower, glycerin and linear asparagine in water, stir and mix, and then heat and stir to react. (2) Add sodium hyaluronate and bamboo red fungus active oxygen essence to the reaction product obtained in step (1), stir and mix, and let stand to obtain a spray liquid; (3) Adjust the pH value of the spray obtained in step (2) to 5-7, and draw the spray into a vacuum spray bottle, seal and store it to obtain the acne-removing spray.

6. The method for preparing the acne spray according to claim 5, characterized in that, In step (1), the stirring speed is 100-300 r / min and the stirring time is 10-60 min; And / or, the heating and stirring reaction is carried out under a nitrogen protective atmosphere, the reaction temperature is 60-80°C, and the reaction time is 0.5-3h.

7. The method for preparing the acne spray according to claim 5, characterized in that, In step (2), the mixing time is 10 to 80 minutes; the settling time is 20 to 50 minutes.

8. The method for preparing the acne spray according to claim 5, characterized in that, In step (3), the pH value of the spray liquid is adjusted by citrate buffer solution.

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