Electrophysiological sensor based on graphene and silver composite material and preparation method thereof

Abstract

The application discloses an electrophysiological sensor based on a graphene and silver composite material and a preparation method thereof, and the method comprises the following steps: S1, preparing a carrier with a laser-induced graphene electrode; S2, dropping a silver ion solution on the laser-induced graphene electrode of the carrier to form a graphene-nano silver composite electrode; S3, uniformly coating SEBS on the graphene-nano silver composite electrode of the carrier to form a graphene-nano silver composite electrode with ultra-thin SEBS as a substrate, and removing the carrier, and the obtained electrode is the electrophysiological sensor based on the graphene and silver composite material. The silver nano-particles are prepared in the silver ion solution coating mode, the requirement for the preparation process is relatively low, and the silver nano-particles can be stably generated on the electrode; the electrophysiological sensor has good adhesion, and the high conductivity and shape-retaining contact capacity of the electrophysiological sensor can enable the electrode to more stably collect high-quality signals.

Description

Technical Field

[0001] This invention relates to the field of electrophysiological sensor fabrication technology, and in particular to an electrophysiological sensor based on graphene and silver composite materials and its fabrication method. Background Technology

[0002] Laser-induced graphene (LIG) has poor conductivity, and commonly used methods to enhance conductivity, such as mask spraying and electroplating, are cumbersome processes that cannot be directly and selectively deposited on LIG patterns.

[0003] Laser-induced graphene (LIG) is typically generated on substrates lacking flexibility, such as polyimide (PI). When these materials are directly applied to the skin, they cannot maintain good conformal contact, leading to unstable electrophysiological signals and low signal-to-noise ratios. A common method to improve the flexibility of LIG is to transfer it onto flexible substrates such as PDMS and Ecoflex. However, when these materials are made into ultrathin layers, they have low strength, are prone to breakage, and exhibit significant conductivity loss during transfer.

[0004] Commonly used methods to enhance the conductivity of LIGs are mask spraying and electroplating, but these methods are complicated. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide an electrophysiological sensor based on graphene and silver composite materials and its preparation method, which addresses the shortcomings of the prior art.

[0006] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is: a method for preparing an electrophysiological sensor based on graphene and silver composite materials, comprising the following steps:

[0007] S1. Preparation of a carrier with laser-induced graphene electrodes;

[0008] S2. Add silver ion solution to the laser-induced graphene electrode on the carrier to form a graphene-silver nanocomposite electrode;

[0009] S3. SEBS is uniformly coated on the graphene-silver nanocomposite electrode of the carrier to form a graphene-silver nanocomposite electrode based on ultrathin SEBS. The carrier is removed, and the resulting electrode is the electrophysiological sensor based on graphene and silver composite material.

[0010] Preferably, step S1 specifically includes:

[0011] S1-1. Double-sided adhesive, single-sided hydrosol, and PI film are sequentially attached to the substrate to form a carrier. The non-adhesive side of the single-sided hydrosol is attached to the double-sided adhesive, and the adhesive side is attached to the PI film.

[0012] S1-2. According to the pre-designed electrode pattern, a laser is used to print on the surface of the PI film, thereby obtaining a laser-induced graphene electrode on the PI film of the carrier.

[0013] Preferably, step S1 specifically includes:

[0014] S1-1. Double-sided tape, single-sided hydrosol, and PI film are sequentially attached to a 10cm×10cm glass substrate to form a carrier. The non-adhesive side of the single-sided hydrosol is attached to the double-sided tape, and the adhesive side is attached to the PI film.

[0015] S1-2. According to the pre-designed electrode pattern, the grating pattern on the surface of the PI film is printed using a VLS 3.50 carbon dioxide laser, thereby obtaining a laser-induced graphene electrode on the PI film of the carrier.

[0016] Preferably, step S2 specifically includes:

[0017] S2-1. While stirring, add ammonia water dropwise to anhydrous silver acetate, then add formic acid dropwise, and let the reaction stand.

[0018] S2-2. Filter with a filter, discard the filter residue, and obtain silver ion solution;

[0019] S2-3. The silver ion solution prepared in step S2-2 is added dropwise to the laser-induced graphene electrode prepared in step S1, and reacted under heating to obtain a graphene-silver nanocomposite electrode formed on the support.

[0020] Preferably, step S2 specifically includes:

[0021] S2-1. Weigh 0.5-2g of anhydrous silver acetate and pour it into a brown glass bottle. While stirring continuously, add 1.5-5ml of 28% concentrated ammonia solution dropwise using a pipette. Then add 0.05-0.2ml of 97% formic acid dropwise. Seal the bottle and let it stand for 12-48 hours to react.

[0022] S2-2, Filter with a 0.22-micron filter, discard the filter residue, and obtain silver ion solution;

[0023] S2-3. Within one hour after printing, add the silver ion solution prepared in step S2-2 to the laser-induced graphene electrode prepared in step S1, and heat at 80-100℃ for 5-20 minutes to obtain a graphene-silver nanocomposite electrode formed on the carrier.

[0024] Preferably, step S2 specifically includes:

[0025] S2-1. Weigh 1g of anhydrous silver acetate and pour it into a brown glass bottle. While stirring continuously, add 2.5ml of 28% concentrated ammonia solution dropwise with a pipette. Then add 0.1ml of 97% formic acid. Seal the bottle and let it stand for 24 hours to react.

[0026] S2-2, Filter with a 0.22-micron filter, discard the filter residue, and obtain silver ion solution;

[0027] S2-3. Within one hour after printing, the silver ion solution prepared in step S2-2 is added to the laser-induced graphene electrode prepared in step S1, and heated at 90°C for 10 minutes to obtain a graphene-silver nanocomposite electrode formed on the carrier.

[0028] Preferably, step S3 specifically includes:

[0029] S3-1. Take SEBS granules, add toluene, and stir under a sealed environment to obtain a SEBS solution;

[0030] S3-2. Let the SEBS solution stand to defoam, then pour it evenly onto the graphene-silver nanocomposite electrode with the support obtained in step S2, and spin coat the SEBS solution evenly using a spin coater.

[0031] S3-3. Immerse the product from step S3-2 in deionized water to dissolve the single-sided hydrosol in the carrier. Then peel off the PI film with the graphene-nano silver composite electrode, rinse it with deionized water and wipe it dry.

[0032] S3-4. Add ethanolamine to deionized water, stir well, then add potassium hydroxide and stir until completely dissolved to obtain a potassium hydroxide solution.

[0033] S3-5. The PI film with graphene-silver nanoparticle composite electrode obtained in step S3-3 is introduced into the potassium hydroxide solution prepared in step S3-4. The PI film is dissolved under heating to finally obtain the graphene-silver nanoparticle composite electrode based on ultrathin SEBS, that is, the electrophysiological sensor based on graphene and silver composite material.

[0034] Preferably, step S3 specifically includes:

[0035] S3-1. Take 0.75-3g of SEBS granules, add 5-20ml of toluene, and stir under sealed conditions for 0.5-2h to obtain a SEBS solution.

[0036] S3-2. Let the SEBS solution stand for 5-20 minutes to defoam, then pour it evenly onto the graphene-silver nanocomposite electrode with the support obtained in step S2, and spin coat the SEBS solution evenly with a spin coater at a speed of 400-1000 rpm for 15-60 seconds, and then lay it flat for 15-60 minutes.

[0037] S3-3. Immerse the product from step S3-2 in deionized water to dissolve the single-sided hydrosol in the carrier. Then peel off the PI film with the graphene-nano silver composite electrode, rinse it with deionized water and wipe it dry.

[0038] S3-4. Add 15-60g of ethanolamine to 25-100ml of deionized water, stir well, then add 10-40g of potassium hydroxide and stir until completely dissolved to obtain a potassium hydroxide solution.

[0039] S3-5. The PI film with graphene-silver nanoparticle composite electrode obtained in step S3-3 is placed into the potassium hydroxide solution prepared in step S3-4 and heated at 70-90℃ for 0.5-2h to dissolve the PI film, and finally obtain the graphene-silver nanoparticle composite electrode based on ultrathin SEBS, that is, the electrophysiological sensor based on graphene and silver composite material.

[0040] Preferably, step S3 specifically includes:

[0041] S3-1. Take 1.5g of SEBS granules, add 10ml of toluene, and stir under sealed conditions for 1 hour to obtain a SEBS solution.

[0042] S3-2. Let the SEBS solution stand for 10 minutes to defoam, then pour it evenly onto the graphene-silver nanocomposite electrode with the support obtained in step S2, and spin coat the SEBS solution evenly with a spin coater at a speed of 800 rpm for 30 seconds, and then lay it flat for 30 minutes.

[0043] S3-3. Immerse the product from step S3-2 in deionized water to dissolve the single-sided hydrosol in the carrier. Then peel off the PI film with the graphene-nano silver composite electrode, rinse it with deionized water and wipe it dry.

[0044] S3-4. Add 30g of ethanolamine to 50ml of deionized water, stir well, then add 20g of potassium hydroxide and stir until completely dissolved to obtain a potassium hydroxide solution.

[0045] S3-5. The PI film with graphene-silver nanoparticle composite electrode obtained in step S3-3 is placed into the potassium hydroxide solution prepared in step S3-4 and heated at 80°C for 1 hour to dissolve the PI film, and finally a graphene-silver nanoparticle composite electrode based on ultrathin SEBS is obtained, that is, the electrophysiological sensor based on graphene and silver composite material.

[0046] The present invention also provides an electrophysiological sensor based on graphene and silver composite material, which is prepared by the method described above.

[0047] The beneficial effects of this invention are:

[0048] This invention provides a method for fabricating an electrophysiological sensor based on graphene and silver composite materials. The method employs a silver ion solution coating method to rapidly obtain a LIG-silver nanocomposite on a hydrophilic laser-induced graphene electrode, and then transfers it onto an SEBS ultrathin substrate to fabricate the electrophysiological sensor. Specifically, the silver nanoparticles are prepared by silver ion solution coating, allowing for selective adsorption of silver ions onto the laser-induced graphene electrode. This eliminates the need for masking and electroplating, reducing the requirements for the fabrication process, and ensuring stable generation of silver nanoparticles on the electrode. Furthermore, the SEBS ultrathin substrate enhances the conformal contact capability of the electrode. The electrophysiological sensor of this invention exhibits excellent adhesion, and its high conductivity and conformal contact capability enable the electrode to more stably acquire high-quality signals. Attached Figure Description

[0049] Figure 1 This is a schematic diagram illustrating the process of fabricating the electrophysiological sensor based on graphene and silver composite materials according to the present invention.

[0050] Figure 2 SEM images of laser-induced graphene (i) and graphene after silver ion solution was dropped onto it (ii);

[0051] Figure 3 The image shows the XRD pattern of the graphene-silver nanoparticle composite electrode.

[0052] Figure 4 The graphene-silver nanocomposite electrode before electrode transfer (Berore Transfer) and the final electrophysiological sensor based on graphene and silver composite material (Transfer) prepared after electrode transfer are shown as curves of surface resistance as a function of drop coating amount.

[0053] Figure 5 The skin contact resistance of silver electrode (Ag / AgCl), laser-induced graphene (LIG), and graphene-silver nanocomposite electrode (LIG-Ag);

[0054] Figure 6 Strain resistance curves of laser-induced graphene (LIG) and two graphene-silver nanocomposite electrodes with different Ag concentrations (LIG@Ag).

[0055] Figure 7 The electrophysiological monitoring results are compared between silver electrode (Ag / AgCl), laser-induced graphene (LIG), and graphene-silver nanoparticle composite electrode (LIG-Ag). Detailed Implementation

[0056] The present invention will be further described in detail below with reference to embodiments, so that those skilled in the art can implement it based on the description.

[0057] It should be understood that terms such as “having,” “comprising,” and “including” as used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0058] Unless otherwise specified, the experimental methods used in the following examples are conventional methods. Unless otherwise specified, the materials and reagents used in the following examples are commercially available. For examples where specific conditions are not specified, conventional conditions or conditions recommended by the manufacturer are followed. For reagents or instruments whose manufacturers are not specified, they are all commercially available products.

[0059] Example 1

[0060] An electrophysiological sensor based on graphene and silver composite materials, referring to Figure 1 Its preparation method includes the following steps:

[0061] S1. Preparation of a carrier with laser-induced graphene electrodes:

[0062] S1-1. Double-sided tape, single-sided hydrosol, and PI film are sequentially attached to a 10cm×10cm glass substrate to form a carrier. The non-adhesive side of the single-sided hydrosol is attached to the double-sided tape, and the adhesive side is attached to the PI film.

[0063] S1-2. Design the serpentine interconnected electrode pattern in CAD, input it into the VLS 3.50 CO2 laser software, and set the parameters as follows: power 4.2%, speed 5.5%, PPI (pulses per inch) 1000%, focal length 1.00mm, image density 6. Print in raster mode to obtain laser-induced graphene electrodes on the PI film of the carrier. Figure 1 The 'i' in the text.

[0064] Under the high temperature of the laser, the carbon bonds in the PI film break, and the instantaneous high pressure causes them to recombine, forming graphene with a porous structure. This porous structure is hydrophilic and also facilitates the adhesion of nanoparticles.

[0065] S2. A silver ion solution is dropped onto the laser-induced graphene electrode on the carrier to form a graphene-silver nanocomposite electrode:

[0066] S2-1. Weigh 1g of anhydrous silver acetate and pour it into a brown glass bottle. While stirring continuously, add 2.5ml of 28% concentrated ammonia solution dropwise using a pipette. Then add 0.1ml of 97% formic acid. Seal the bottle and let it stand for 24 hours. All steps are carried out in a fume hood.

[0067] S2-2, Filter with a 0.22-micron filter, discard the filter residue, and obtain a colorless and transparent silver ion solution;

[0068] S2-3. Within one hour after printing, drop the silver ion solution prepared in step S2-2 onto the laser-induced graphene electrode prepared in step S1 (if there is excess silver ion solution, absorb it with lint-free paper). Figure 1 In step ii, the silver ion solution is heated at 90°C for 10 minutes on a heating stage to react and generate silver nanoparticles, thus obtaining a graphene-silver nanoparticle composite electrode formed on a support. For example... Figure 1 iii in the text.

[0069] Because laser-induced graphene electrodes have good hydrophilicity, while PI films are hydrophobic, silver ion solutions will only selectively adsorb onto the laser-induced graphene electrodes.

[0070] S3. Ultrathin SEBS Transfer: SEBS is uniformly coated on the graphene-silver nanoparticle composite electrode of the carrier to form a graphene-silver nanoparticle composite electrode based on ultrathin SEBS. After removing the carrier, the resulting electrode is the electrophysiological sensor based on the graphene and silver composite material.

[0071] S3-1. Take 1.5g of SEBS granules and add them to a beaker. Add 10ml of toluene dropwise using a pipette. Seal the beaker by covering the mouth with plastic wrap and stir with a magnetic stirrer for 1 hour to obtain a SEBS solution.

[0072] S3-2. After stirring, let the SEBS solution stand for 10 minutes to defoam, then pour it evenly onto the graphene-silver nanocomposite electrode with the support obtained in step S2. Spin-coat the SEBS solution evenly using a spin coater at 800 rpm for 30 seconds, then lay it flat for 30 minutes. Figure 1 iv in the middle;

[0073] S3-3. Immerse the product from step S3-2 in deionized water to dissolve the single-sided hydrosol in the carrier. Then peel off the PI film with the graphene-silver nano-composite electrode, rinse it with deionized water, and dry it. Figure 1 The "v" in the text refers to the fact that all steps are performed in a fume hood.

[0074] S3-4. Add 30g of ethanolamine to 50ml of deionized water, stir well, then slowly add 20g of potassium hydroxide and stir until completely dissolved to obtain a potassium hydroxide solution.

[0075] S3-5. The PI film with graphene-silver nanoparticle composite electrode obtained in step S3-3 is placed into the potassium hydroxide solution prepared in step S3-4 and heated at 80°C for 1 hour to dissolve the PI film, finally obtaining a graphene-silver nanoparticle composite electrode based on ultrathin SEBS, i.e., the electrophysiological sensor based on graphene and silver composite materials. Figure 1 vi in ​​the text.

[0076] Performance testing and characterization

[0077] Reference Figure 2 The images show SEM images of laser-induced graphene (i) and graphene after silver ion solution was added (ii). It can be seen that the originally black laser-induced graphene turned silvery-white; and particles can be seen attached to the surface of the graphene, which are at the nanoscale.

[0078] Reference Figure 3 The XRD pattern of the graphene-silver nanocomposite electrode shows five distinct peaks after silver ion coating, clearly revealing the formation of silver and the crystallization properties of the nanocomposite. The two θ peaks obtained at 38.1°, 44.1°, 64.4°, 77.4°, and 81.5° correspond to the (111), (200), (220), (311), and (222) reflections of the face-centered crystal planes of silver.

[0079] Reference Figure 4 The graph shows the surface resistance of the graphene-silver nanocomposite electrode before transfer and the final electrophysiological sensor based on graphene and silver composite material after transfer as a function of the amount of drop coating.

[0080] Figure 5 The skin contact resistance of silver electrode (Ag / AgCl), laser-induced graphene (LIG), and graphene-silver nanoparticle composite electrode (LIG-Ag) is shown. It can be seen that the LIG electrode coated with silver nanoparticles has a lower skin contact resistance.

[0081] Figure 6 The figures show strain resistance curves for laser-induced graphene (LIG) and two graphene-silver nanocomposite electrodes with different Ag concentrations (LIG@Ag); the figure shows the strain resistance curve for 5 μL / cm² graphene. 2 and 10 μL / cm 2 This indicates the volume of silver ion solution added per square centimeter.

[0082] Figure 7 The electrophysiological monitoring results of silver electrode (Ag / AgCl), laser-induced graphene (LIG), and graphene-silver nanoparticle composite electrode (LIG-Ag) show that the electrophysiological signals obtained by the electrophysiological electrode prepared by this method have better stability and higher signal-to-noise ratio.

[0083] Although the embodiments of the present invention have been disclosed above, they are not limited to the applications listed in the specification and embodiments. They can be applied to various fields suitable for the present invention. For those skilled in the art, other modifications can be easily made. Therefore, without departing from the general concept defined by the claims and their equivalents, the present invention is not limited to the specific details.

Claims

1. A method for fabricating an electrophysiological sensor based on graphene and silver composite materials, characterized in that, Includes the following steps: S1. Preparation of a carrier with laser-induced graphene electrodes; S2. Add silver ion solution to the laser-induced graphene electrode on the carrier to form a graphene-silver nanocomposite electrode; S3. SEBS is uniformly coated on the graphene-silver nanocomposite electrode of the carrier to form a graphene-silver nanocomposite electrode based on ultrathin SEBS. The carrier is removed, and the resulting electrode is the electrophysiological sensor based on graphene and silver composite material. Step S1 is as follows: S1-1. Double-sided adhesive, single-sided hydrosol, and PI film are sequentially attached to the substrate to form a carrier. The non-adhesive side of the single-sided hydrosol is attached to the double-sided adhesive, and the adhesive side is attached to the PI film. S1-2. According to the pre-designed electrode pattern, a laser is used to print on the surface of the PI film to obtain a laser-induced graphene electrode on the PI film of the carrier. Step S2 is as follows: S2-1. Weigh 0.5-2g of anhydrous silver acetate and pour it into a brown glass bottle. While stirring continuously, add 1.5-5ml of 28% concentrated ammonia solution dropwise using a pipette. Then add 0.05-0.2ml of 97% formic acid dropwise. Seal the bottle and let it stand for 12-48 hours to react. S2-2. Filter with a 0.22-micron filter, discard the filter residue, and obtain a silver ion solution; S2-3. Within one hour after printing, the silver ion solution prepared in step S2-2 is dropped onto the laser-induced graphene electrode prepared in step S1, and heated at 80-100℃ for 5-20 minutes to obtain a graphene-silver nanocomposite electrode formed on the carrier. Step S3 is as follows: S3-1. Take SEBS granules, add toluene, and stir under a sealed environment to obtain a SEBS solution; S3-2. Let the SEBS solution stand to defoam, then pour it evenly onto the graphene-silver nanocomposite electrode with the support obtained in step S2, and spin coat the SEBS solution evenly using a spin coater. S3-3. Immerse the product from step S3-2 in deionized water to dissolve the single-sided hydrosol in the carrier. Then peel off the PI film with the graphene-nano silver composite electrode, rinse it with deionized water and wipe it dry. S3-4. Add ethanolamine to deionized water, stir well, then add potassium hydroxide and stir until completely dissolved to obtain a potassium hydroxide solution. S3-5. The PI film with graphene-silver nanoparticle composite electrode obtained in step S3-3 is introduced into the potassium hydroxide solution prepared in step S3-4. The PI film is dissolved under heating to finally obtain the graphene-silver nanoparticle composite electrode based on ultrathin SEBS, that is, the electrophysiological sensor based on graphene and silver composite material.

2. The method for preparing the electrophysiological sensor based on graphene and silver composite materials according to claim 1, characterized in that, Step S1 is as follows: S1-1. Double-sided tape, single-sided hydrosol, and PI film are sequentially attached to a 10cm×10cm glass substrate to form a carrier. The non-adhesive side of the single-sided hydrosol is attached to the double-sided tape, and the adhesive side is attached to the PI film. S1-2. According to the pre-designed electrode pattern, the grating pattern on the surface of the PI film is printed using a VLS 3.50 carbon dioxide laser, thereby obtaining a laser-induced graphene electrode on the PI film of the carrier.

3. The method for preparing the electrophysiological sensor based on graphene and silver composite materials according to claim 1, characterized in that, Step S2 is as follows: S2-1. Weigh 1g of anhydrous silver acetate and pour it into a brown glass bottle. While stirring continuously, add 2.5ml of 28% concentrated ammonia solution dropwise with a pipette. Then add 0.1ml of 97% formic acid. Seal the bottle and let it stand for 24 hours to react. S2-2. Filter with a 0.22-micron filter, discard the filter residue, and obtain a silver ion solution; S2-3. Within one hour after printing, the silver ion solution prepared in step S2-2 is dropped onto the laser-induced graphene electrode prepared in step S1, and heated at 90°C for 10 minutes to obtain a graphene-silver nanocomposite electrode formed on the carrier.

4. The method for preparing the electrophysiological sensor based on graphene and silver composite materials according to claim 1, characterized in that, Step S3 is as follows: S3-1. Take 0.75-3g of SEBS granules, add 5-20ml of toluene, and stir under sealed conditions for 0.5-2h to obtain a SEBS solution. S3-2. Let the SEBS solution stand for 5-20 minutes to defoam, then pour it evenly onto the graphene-silver nanocomposite electrode with the support obtained in step S2, and spin coat the SEBS solution evenly with a spin coater at a speed of 400-1000 rpm for 15-60 seconds, and then lay it flat for 15-60 minutes. S3-3. Immerse the product from step S3-2 in deionized water to dissolve the single-sided hydrosol in the carrier. Then peel off the PI film with the graphene-nano silver composite electrode, rinse it with deionized water and wipe it dry. S3-4. Add 15-60g of ethanolamine to 25-100ml of deionized water, stir well, then add 10-40g of potassium hydroxide and stir until completely dissolved to obtain a potassium hydroxide solution. S3-5. The PI film with graphene-silver nanoparticle composite electrode obtained in step S3-3 is placed into the potassium hydroxide solution prepared in step S3-4 and heated at 70-90℃ for 0.5-2h to dissolve the PI film, and finally obtain the graphene-silver nanoparticle composite electrode based on ultrathin SEBS, that is, the electrophysiological sensor based on graphene and silver composite material.

5. The method for preparing the electrophysiological sensor based on graphene and silver composite materials according to claim 4, characterized in that, Step S3 is as follows: S3-1. Take 1.5g of SEBS granules, add 10ml of toluene, and stir under sealed conditions for 1 hour to obtain a SEBS solution. S3-2. Let the SEBS solution stand for 10 minutes to defoam, then pour it evenly onto the graphene-silver nanocomposite electrode with the support obtained in step S2, and spin coat the SEBS solution evenly with a spin coater at a speed of 800 rpm for 30 seconds, and then lay it flat for 30 minutes. S3-3. Immerse the product from step S3-2 in deionized water to dissolve the single-sided hydrosol in the carrier. Then peel off the PI film with the graphene-nano silver composite electrode, rinse it with deionized water and wipe it dry. S3-4. Add 30g of ethanolamine to 50ml of deionized water, stir well, then add 20g of potassium hydroxide and stir until completely dissolved to obtain a potassium hydroxide solution. S3-5. The PI film with graphene-silver nanoparticle composite electrode obtained in step S3-3 is placed into the potassium hydroxide solution prepared in step S3-4 and heated at 80°C for 1 hour to dissolve the PI film, and finally a graphene-silver nanoparticle composite electrode based on ultrathin SEBS is obtained, that is, the electrophysiological sensor based on graphene and silver composite material.

6. An electrophysiological sensor based on graphene and silver composite materials, characterized in that, It is prepared by the method described in any one of claims 1-5.

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