Preparation method and application of a multi-morphology nano-carrier based on beta-gamma-CD dimer

Abstract

The application discloses a preparation method and application of a multi-morphology nano carrier based on beta-gamma-CD dimers, and the method comprises the following steps: using beta-gamma-CD dimers, PEG-C 60 , and drug molecules as raw materials, through host-guest interaction between gamma-CD in the beta-gamma-CD dimers and PEG-C 60 , host-guest interaction between beta-CD in the beta-gamma-CD dimers and the drug molecules, hydrophilic and hydrophobic interaction in the whole system, and hydrogen bond-induced arrangement between the cyclodextrin molecules as driving force, different morphology nano carriers are prepared through a co-solvent self-assembly strategy. The spherical nano particles, rod-like nano particles and single-layer vesicle-like nano carriers are used as carriers of drugs for treating tumors or rheumatoid arthritis. In the application, the asymmetric cyclodextrin is used as a host molecule, the drug molecules are wrapped in the hydrophobic inner cavity of the cyclodextrin through host-guest complexation, and the different morphology nano carriers prepared through the co-solvent self-assembly method all have stability.

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