An acne-removing facial mask liquid, a preparation method thereof and an acne-removing facial mask

Abstract

The application discloses an acne-removing facial mask liquid, a preparation method thereof and an acne-removing facial mask. The acne-removing facial mask liquid comprises the following components in mass percentage: 1.0-5.0% of glycerol, 1.0-5.0% of polyethylene glycol, 0.1-1.0% of sodium hyaluronate, 0.1-1.0% of hydroxyethyl cellulose, 0.1-0.5% of allantoin, 0.1-0.8% of nicotinamide, 0.01-0.3% of bambuterol essence, and the balance of water. The acne-removing facial mask liquid is prepared by compounding glycerol, polyethylene glycol, sodium hyaluronate, hydroxyethyl cellulose, allantoin, nicotinamide and bambuterol essence, and the acne-removing facial mask is prepared, and the obtained acne-removing facial mask has excellent acne-removing effect.

Description

Technical Field

[0001] This invention belongs to the field of facial mask preparation technology. Specifically, this invention relates to an acne-removing facial mask liquid, its preparation method, and an acne-removing facial mask. Background Technology

[0002] In today's fast-paced and stressful world, staying up late is almost a common occurrence. These factors contribute to moisture loss in the skin, leading to roughness, dullness, fine lines, and various other skin problems. Oily and combination skin types, in particular, experience increased oil production in spring and summer, especially on the nose, T-zone, and forehead, resulting in enlarged pores and acne breakouts. Therefore, hydrating, moisturizing, and controlling oil and acne are crucial. However, existing face masks often fail to meet these needs. Developing a hydrating, moisturizing, and acne-reducing face mask to address the shortcomings of current masks in these areas is therefore of significant importance. Summary of the Invention

[0003] The present invention aims to at least partially solve one of the technical problems in related technologies. To this end, embodiments of the present invention provide an acne-removing facial mask liquid, its preparation method, and an acne-removing facial mask.

[0004] In a first aspect, embodiments of the present invention provide an acne-removing facial mask liquid, including but not limited to the following components in weight percentage: 1.0–5.0% glycerin, 1.0–5.0% polyethylene glycol, 0.1–1.0% sodium hyaluronate, 0.1–1.0% hydroxyethyl cellulose, 0.1–0.5% allantoin, 0.1–0.8% niacinamide, 0.01–0.3% bamboo red fungus extract, with the balance being water.

[0005] This invention provides an acne-removing mask liquid prepared by compounding glycerin, polyethylene glycol, sodium hyaluronate, hydroxyethyl cellulose, allantoin, niacinamide, and bamboo red fungus extract. Glycerin, polyethylene glycol, and sodium hyaluronate are used as moisturizers; hydroxyethyl cellulose is used as a thickener; allantoin and niacinamide are used as skin conditioning agents; and bamboo red fungus extract is used as a bactericidal active agent. Water is used as a solvent. The resulting acne-removing mask liquid exhibits excellent acne-removing effects.

[0006] In some embodiments, the molecular weight of the polyethylene glycol is 200 to 4000.

[0007] In some embodiments, the bamboo red fungus extract is prepared by a method comprising the following steps:

[0008] S1: After mixing porous organic cage-like compound COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide, ultra-dry tetrahydrofuran was added to the mixture and the mixture was stirred at room temperature for 40-60 h; then, polyethylene glycol was added and the reaction was continued for 60-80 h; after the reaction was completed, the filtrate was evaporated to dryness to obtain a solid.

[0009] S2: The solid obtained in step S1 is placed into a cellulose dialysis bag for dialysis treatment to obtain a suspension;

[0010] S3: Dissolve and filter the suspension obtained in step S2. The filtrate is the bamboo red fungus extract.

[0011] In some embodiments, in step S1, the spatial structural formula of the porous organic cage-like compound COP2T is:

[0012]

[0013] The porous organic cage-like compound COP2T has a hollow capsule structure; the porous organic cage-like compound COP2T is composed of triangular blocks B and olefin-containing chains A, and the structural units are shown below:

[0014]

[0015] The structural unit consists of a triangular block B and an olefin-containing chain A; each structural unit has three Si-containing branches; the Si-containing branches between different structural units are connected to form a hollow capsule structure.

[0016] In some embodiments, in step S1, the mass ratio of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide is (36-38):20:1:(18-20);

[0017] And / or, the mass ratio of the mixture of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide to the polyethylene glycol is 1:(5-8); the molecular weight of the polyethylene glycol is 1000-3000;

[0018] And / or, the drying temperature is 30–50°C.

[0019] In some embodiments, in step S2, the molecular weight cutoff of the cellulose dialysis bag is 3000-6000;

[0020] And / or, the dialysis treatment is performed 2 to 5 times, and each dialysis session lasts 5 to 10 hours.

[0021] Secondly, embodiments of the present invention provide a method for preparing an acne-removing facial mask liquid as described in the first aspect, comprising the following steps:

[0022] (1) Glycerin, polyethylene glycol, sodium hyaluronate, hydroxyethyl cellulose, allantoin, nicotinamide and water are mixed and then sterilized to obtain the base material;

[0023] (2) After cooling the base material to 20-30°C, add bamboo red fungus extract to the base material, mix and stir to obtain the acne-removing mask liquid.

[0024] In some embodiments, the aseptic treatment temperature is 85–95°C and the treatment time is 20–40 min.

[0025] Thirdly, the present invention also proposes an acne-removing mask, comprising an acne-removing mask liquid and a base material, wherein the acne-removing mask liquid is the acne-removing mask liquid described in the first aspect or the acne-removing mask liquid prepared by the preparation method described in the second aspect.

[0026] In some embodiments, the matrix material is nonwoven fabric or silk.

[0027] Fourthly, embodiments of the present invention provide a method for preparing an acne-removing facial mask as described in the third aspect, comprising the following steps: immersing a matrix material in an acne-removing facial mask liquid to obtain the acne-removing facial mask. Attached Figure Description

[0028] Figure 1 This is a synthetic route diagram for the bamboo red fungus extract of the present invention.

[0029] Figure 2 This is a synthetic route diagram for the porous organic cage-like compound COP2T.

[0030] Figure 3 The graph shows the inhibitory effect of different concentrations of bamboo red mycotoxin extract on Candida albicans. Detailed Implementation

[0031] The embodiments of the present invention are described in detail below. These embodiments are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention.

[0032] In this document, when values ​​are described as ranges, it should be understood that such disclosure includes disclosure of all possible subranges within that range, as well as the specific numerical values ​​falling within that range, regardless of whether the specific numerical value or specific subrange is explicitly specified.

[0033] In this article, the words “contain” and “include” and their various variations mean that other elements or wholes may be included but not specifically described.

[0034] In this article, the term "and / or" is merely a description of the relationship between related objects, indicating that there can be three kinds of relationships. For example, A and / or B can represent three cases: A exists alone, A and B exist simultaneously, and B exists alone.

[0035] In a first aspect, embodiments of the present invention provide an acne-removing facial mask liquid, including but not limited to the following components in weight percentage: 1.0–5.0% glycerin, 1.0–5.0% polyethylene glycol, 0.1–1.0% sodium hyaluronate, 0.1–1.0% hydroxyethyl cellulose, 0.1–0.5% allantoin, 0.1–0.8% niacinamide, 0.01–0.3% bamboo red fungus extract, with the balance being water.

[0036] In some embodiments, the molecular weight of polyethylene glycol is 200 to 4000.

[0037] like Figure 1 The diagram shows the synthetic route of the above-mentioned bamboo red fungus extract (COP2T-HA), which is prepared by loading bamboo red fungus extract (HA) onto a porous organic cage-like compound COP2T and then cross-linking it with polyethylene glycol (PEG). The specific preparation process includes the following steps:

[0038] S1: After mixing porous organic cage-like compound COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide, ultra-dry tetrahydrofuran was added to the mixture and the mixture was stirred at room temperature for 40-60 h; then, polyethylene glycol was added and the reaction was continued for 60-80 h; after the reaction was completed, the filtrate was evaporated to dryness to obtain a solid.

[0039] S2: The solid obtained in step S1 is placed into a cellulose dialysis bag for dialysis treatment to obtain a suspension;

[0040] S3: Dissolve and filter the suspension obtained in step S2. The filtrate is the bamboo red fungus extract.

[0041] This invention provides an acne-removing mask liquid prepared by compounding glycerin, polyethylene glycol, sodium hyaluronate, hydroxyethyl cellulose, allantoin, niacinamide, and bamboo red fungus extract. Compared to traditional acne-removing masks, which are mostly chemically synthesized antibacterial inhibitors, bamboo red fungus extract, as a natural photosensitive pigment, has a high singlet reactive oxygen species yield and no toxic side effects on human skin tissue. However, bamboo red fungus extract is poorly soluble in water, making it difficult to directly add as a water-soluble antibacterial inhibitor essence to acne-removing masks. After being modified by the porous organic cage-like compound COP2T of this invention, its hydrophilicity is significantly improved, making it suitable as an active essence for acne-removing masks.

[0042] Currently, the effective ingredients in acne-removing masks on the market mainly fall into two categories: one is chemically synthesized antibacterial small-molecule drugs, and the other is extracts from natural plants with antibacterial effects. This invention, however, uses a porous organic cage-like compound COP2T as a framework, and branches the natural product photosensitive pigment, bamboo red fungus A, into the cavity of the porous organic cage-like compound COP2T via ester bonds. This results in a novel antibacterial natural product modified with a porous organic cage-like compound. This not only preserves the original efficacy and improves the drug's water solubility and skin affinity, but also makes the molecular structure of the effective ingredient, bamboo red fungus A, more stable, ensuring the stability of the essence in subsequent production and storage.

[0043] In some embodiments, in step S1, the spatial structural formula of the porous organic cage-like compound COP2T is:

[0044]

[0045] The porous organic cage-like compound COP2T has an open hollow capsule structure; and it consists of eight triangular blocks B and twelve olefin-containing chains A, wherein the molecular formula of the triangular blocks B is: Among them, the molecular structural unit of R4 is Wherein, R5, R6, and R7 are hydrogen atoms; the structural formula containing olefin chain A is... Where R1 is: And R2 is: The structural units of the porous organic cage-like compound COP2T are shown below:

[0046]

[0047] The structural unit consists of a triangular block B and an olefinic chain A; each structural unit has three Si-containing branches; the Si-containing branches connecting different structural units form a hollow capsule structure. Each structure of COP2T has three reactive sites, namely three -COOH groups, and each cage-like molecule has 24 reactive sites. The ends of the Si-containing branches indicate the connection points with corresponding segments of other identical structural units.

[0048] Furthermore, the synthetic reaction design of the porous organic cage compound COP2T is as follows: the first step is to link the silane of compound A to the basic skeleton M1 of hexabromophenylbenzene; the second step is to functionalize the remaining three bromination reaction sites on hexabromophenylbenzene M1 through Suzuki coupling; the third step is to hydrolyze the ester group to obtain the carboxyl group; the fourth step is to complex with copper to obtain the complex crystal; and the fifth step is to complete the olefin metathesis reaction and stitch it together to obtain the porous organic cage compound COP2T.

[0049] The key point is that the first and second steps involve attaching different functional groups in a specific order. In the first step, the silane chain of compound A, which has greater steric hindrance, is attached to the M1 backbone first. By controlling the reaction temperature and time, it can be basically guaranteed that three bromination sites are attached, and they are spaced apart. If boric acid is reacted with the M1 bromination sites first, all six reaction sites will be filled directly, making it impossible to attach the silane chain of compound A later.

[0050] like Figure 2 The diagram shows the synthetic route for the porous organic cage-like compound COP2T, which includes the following steps:

[0051] Step 1: Synthesis of compound M2.

[0052] 26.8 g of p-dimethylaminobenzene (1.0 eq) was added to 100 mL of anhydrous diethyl ether and stirred for 10 min. Then, 1.86 g of lithium granules (2.0 eq) were added. After adding, the mixture was refluxed for 1 h and then cooled to room temperature. The reaction was then stirred at 0 °C. 30 g of compound M1 (0.25 eq) was dissolved in 200 mL of tetrahydrofuran and added to the reaction mixture at 0 °C. The mixture was stirred for 20 min. Then, 100 mL of tetrahydrofuran solution containing 78 g of compound A (2.0 eq) was slowly added dropwise to the reaction system and the reaction was carried out for 2 hours.

[0053] After the reaction was completed, 100 mL of water was added to quench the reaction. The reaction solution was then extracted with dichloromethane. The resulting organic solution was dried over anhydrous MgSO4, filtered, and the organic phases were combined. The organic phases were purified by column chromatography (petroleum ether: dichloromethane = 10:1 to 4:1) to give a total of 29.4 g of white solid M2, with a separation yield of 64%.

[0054] Step 2: Synthesis of compound M3.

[0055] 25 g of compound A (1.0 eq), 15.9 g of 3-methoxycarbonylpyridineboronic acid (4.5 eq), and 0.438 g of Pd(dppf)₂Cl₂ (0.03 eq) were added to a single-necked flask containing a mixture of 100 mL toluene and 100 mL ethanol. 12.5 g of sodium carbonate (6.0 eq) was dissolved in 100 mL of water and added to the reaction system. After purging with nitrogen five times, the reaction was carried out at 85 °C for 2 hours. TLC analysis showed that the reactants had not completely reacted. The reaction was paused and the mixture was cooled slightly. Then, 0.438 g of Pd(dppf)₂Cl₂ (0.03 eq) was added, and the reaction was repeated five times with nitrogen. The reaction was continued at 85 °C for 2 hours. TLC analysis showed that the reactants had completely reacted. The reaction was then stopped and the mixture was cooled to room temperature.

[0056] After the reaction was completed, the reaction solution was washed with water and saturated brine, extracted with dichloromethane, dried with anhydrous sodium sulfate, and the organic phases were combined and purified by column chromatography (petroleum ether: ethyl acetate = 40:1 to 20:1) to give a total of 14.1 g of white solid M3, with a separation yield of 51%.

[0057] Step 3: Synthesis of compound M4.

[0058] 10 g of compound M3 (1.0 eq) and 11.7 g of KOH (30.0 eq) were dissolved in a mixed solvent of 50 mL methanol, 50 mL water and 50 mL tetrahydrofuran. The reaction was carried out at 45 °C for 9 hours. The reaction was stopped after TLC was performed to check that the starting materials had reacted completely.

[0059] After the reaction was complete, dilute hydrochloric acid was slowly added to adjust the pH to acidic on the pH paper. Water and petroleum ether were added for extraction, and the mixture was dried over anhydrous sodium sulfate. The organic phases were combined and purified by column chromatography (dichloromethane:ethanol = 10:1) to obtain a total of 9.17 g of white solid M4, with a separation yield of 94%.

[0060] Step 4: Synthesis of Crystal M5

[0061] Dissolve 30g of compound M4 (1.0eq) in 3L of DMF and add it to a single-necked flask. Dissolve 31g of copper nitrate trihydrate (6.0eq) in 1L of ethanol and add it to the single-necked flask. Then add 3.76g of fluoroboric acid (2.0eq) dropwise to the single-necked flask. Seal the flask with a glass stopper and place it in a 75℃ constant temperature oven for 30h.

[0062] After 30 hours, blue crystals were observed to precipitate in the solution. The solution was removed, cooled to room temperature, and filtered under reduced pressure using a Buchner funnel. The solid solvent was kept moist, and the solution was washed three times with 100 mL of methanol each time. After drying, 32 g of blue crystals M5 were obtained.

[0063] Step 5: Synthesis of the porous organic cage-like compound COP2T

[0064] Dissolve 30g of blue crystal M5 in 400mL of ultra-dry THF, filter to remove a small amount of insoluble solids, add the filtrate to a three-necked flask, then add 2.6L of ultra-dry tetrahydrofuran, and purge with nitrogen three times; add 3g of cuprous iodide, bubble with nitrogen for 20min, then add 6g of Grubbs2 catalyst, the color is dark brown, purge with nitrogen three times; heat to 45℃ and stir for 10min, the color turns dark green, keep the oil level in the 45℃ oil pan slightly higher than the system liquid level, and react for 4 days;

[0065] After the reaction was completed, the system was cooled to room temperature, stirring was stopped, hydrochloric acid was added for acidification, and stirring was carried out overnight. The reaction solution was filtered and washed three times with tetrahydrofuran, 100 mL each time. The filtrates were combined and evaporated to dryness. After evaporation, 300 mL of methanol was added to the solid and stirred for 1 hour. After filtration, a filter cake was obtained. The filter cake was washed five times with methanol, 100 mL each time, until the mother liquor was colorless and transparent. The solid was dried to obtain 17 g of grayish-white solid COP2T, with a yield of 56.7% (by mass).

[0066] To enhance the acne-fighting efficacy of the serum and its corresponding mask products, the COP2T structure described in this invention is meticulously designed. Firstly, the addition of a benzyl group to R2 compared to the common alkyl chain structure makes the cage-like structure more stable. More importantly, by selecting the R2 structural unit, a cage-like COP2T molecule with a larger cavity structure can be prepared. The larger cavity reduces the resistance to the condensation reaction of hyaluronic acid (HA) with COP2T, making the reaction easier and allowing for a higher loading of HA. Simultaneously, R4 is changed from the common 3-benzoic acid structure to the structure of 3-pyridinecarboxylic acid (nicotinic acid), a natural vitamin found in the human body. This increases skin affinity and reduces discomfort in the mask serum. Furthermore, the carboxyl group of 3-pyridinecarboxylic acid is more reactive than that of 3-benzoic acid, making it easier to undergo a condensation reaction with the hydroxyl group on HA, thereby further increasing the loading of HA and enhancing the acne-fighting efficacy of the serum. Structural units, compared to the past The structural units are more hydrophilic, so the product COP2T-HA has better water solubility and is less prone to supersaturation and precipitation, which is equivalent to increasing the effective loading of bamboo red mycotoxin essence.

[0067] In some embodiments, in step S1, the mass ratio of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungin is (36-38):20:1:(18-20);

[0068] And / or, the mass ratio of the mixture of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide to polyethylene glycol is 1:(5-8); and the molecular weight of polyethylene glycol is 1000-3000, preferably 2000;

[0069] And / or, the rotary drying temperature is 30–50°C.

[0070] In some embodiments, in step S2, the molecular weight cutoff of the cellulose dialysis bag is 3000 to 6000;

[0071] And / or, the number of dialysis treatments is 2 to 5 times, and the duration of each dialysis treatment is 5 to 10 hours.

[0072] Secondly, embodiments of the present invention provide a method for preparing an acne-removing facial mask liquid as described in the first aspect, comprising the following steps:

[0073] (1) Glycerin, polyethylene glycol, sodium hyaluronate, hydroxyethyl cellulose, allantoin, nicotinamide and water are mixed and then sterilized to obtain the base material;

[0074] (2) After cooling the base material to 20-30°C, add bamboo red fungus extract to the base material, mix and stir to obtain the acne-removing mask liquid.

[0075] In some embodiments, the aseptic treatment temperature is 85–95°C and the treatment time is 20–40 min.

[0076] Thirdly, the present invention also proposes an acne-removing mask, comprising an acne-removing mask liquid and a base material, wherein the acne-removing mask liquid is the acne-removing mask liquid described in the first aspect or the acne-removing mask liquid prepared by the preparation method described in the second aspect.

[0077] In some embodiments, the matrix material is nonwoven fabric or silk.

[0078] Fourthly, embodiments of the present invention provide a method for preparing an acne-removing facial mask as described in the third aspect, comprising the following steps: immersing a matrix material in an acne-removing facial mask liquid to obtain the acne-removing facial mask.

[0079] The following are non-limiting embodiments and comparative examples of the present invention. It should be noted that the comparative examples are not prior art, but are only set up for comparison with the embodiments and are not intended to limit the present invention.

[0080] In the following examples and comparative examples, the bamboo red fungus extract was prepared by a method including the following steps:

[0081] S1: 14 mg COP2T (1.0 eq), 7.4 mg 1,3-dicyclohexylcarbodiimide (DCC, 25.4 eq), 0.37 mg 4-dimethylaminopyridine (DMAP, 2.0 eq), and 7.09 mg bamboo red fungicide (HA, 9.2 eq) were added to a 20 mL glass reaction flask and mixed. Then, 5 mL of ultra-dry tetrahydrofuran was added, and the mixture was stirred at room temperature for 48 h. After that, 200 mg of polyethylene glycol (PEG-2000, 89.0 eq) was added, and the reaction was continued for 72 h. After the reaction was completed, the filtrate was evaporated to dryness at 40 °C to obtain a solid.

[0082] S2: The solid obtained in step S1 is placed into a cellulose dialysis bag (molecular weight cutoff 5000) and dialyzed in deionized water for 8 hours each time. The process is repeated 3 times to obtain a suspension.

[0083] S3: Dissolve the suspension obtained in step S2 in 50 mL of deionized water and filter. The filtrate is the bamboo red fungus extract.

[0084] Example 1

[0085] This embodiment provides an acne-removing facial mask liquid, comprising the following components:

[0086] 1g glycerin, 2.5g polyethylene glycol 400, 0.5g sodium hyaluronate, 0.4g hydroxyethyl cellulose, 0.25g allantoin, 0.4g niacinamide and 0.15g bamboo red fungus extract, and then add deionized water to make up to 100g.

[0087] The preparation method of this acne-removing facial mask liquid includes the following steps:

[0088] (1) Mix 1g glycerin, 2.5g polyethylene glycol 400, 0.5g sodium hyaluronate, 0.4g hydroxyethyl cellulose, 0.25g allantoin, 0.4g nicotinamide and 94.8g deionized water evenly, and then sterilize at 90℃ for 30min to obtain the base material;

[0089] (2) After cooling the base material to 25°C, add 0.15g of bamboo red fungus extract to the base material, mix and stir evenly to obtain the acne-removing mask liquid.

[0090] Example 2

[0091] This embodiment is basically the same as Embodiment 1, except that the content of glycerol in this embodiment is 2g.

[0092] Example 3

[0093] This embodiment is basically the same as Embodiment 1, except that the content of glycerol in this embodiment is 3g.

[0094] Example 4

[0095] This embodiment is basically the same as Embodiment 1, except that the content of glycerol in this embodiment is 4g.

[0096] Example 5

[0097] This embodiment is basically the same as Embodiment 1, except that the content of glycerol in this embodiment is 5g.

[0098] Example 6

[0099] This embodiment is basically the same as Embodiment 1, except that the content of glycerol in this embodiment is 2.5g and the content of polyethylene glycol 400 is 1g.

[0100] Example 7

[0101] This embodiment is basically the same as embodiment 6, except that the content of polyethylene glycol 400 in this embodiment is 2g.

[0102] Example 8

[0103] This embodiment is basically the same as embodiment 6, except that the content of polyethylene glycol 400 in this embodiment is 3g.

[0104] Example 9

[0105] This embodiment is basically the same as embodiment 6, except that the content of polyethylene glycol 400 in this embodiment is 4g.

[0106] Example 10

[0107] This embodiment is basically the same as embodiment 6, except that the content of polyethylene glycol 400 in this embodiment is 5g.

[0108] Example 11

[0109] This embodiment is basically the same as Embodiment 1, except that the content of glycerol in this embodiment is 2.5g and the content of sodium hyaluronate is 0.2g.

[0110] Example 12

[0111] This embodiment is basically the same as embodiment 11, except that the content of sodium hyaluronate in this embodiment is 0.4g.

[0112] Example 13

[0113] This embodiment is basically the same as embodiment 11, except that the content of sodium hyaluronate in this embodiment is 0.6g.

[0114] Example 14

[0115] This embodiment is basically the same as embodiment 11, except that the content of sodium hyaluronate in this embodiment is 0.8g.

[0116] Example 15

[0117] This embodiment is basically the same as that of embodiment 11, except that the content of sodium hyaluronate in this embodiment is 1.0g.

[0118] Example 16

[0119] This embodiment is basically the same as Embodiment 1, except that the content of glycerol in this embodiment is 2.5g and the content of hydroxyethyl cellulose is 0.2g.

[0120] Example 17

[0121] This embodiment is basically the same as that of embodiment 16, except that the content of hydroxyethyl cellulose in this embodiment is 0.4g.

[0122] Example 18

[0123] This embodiment is basically the same as that of Embodiment 16, except that the content of hydroxyethyl cellulose in this embodiment is 0.6g.

[0124] Example 19

[0125] This embodiment is basically the same as that of Embodiment 16, except that the content of hydroxyethyl cellulose in this embodiment is 0.8g.

[0126] Example 20

[0127] This embodiment is basically the same as Embodiment 1, except that the content of glycerol in this embodiment is 2.5g and the content of allantoin is 0.1g.

[0128] Example 21

[0129] This embodiment is basically the same as that of embodiment 20, except that the content of allantoin in this embodiment is 0.2g.

[0130] Example 22

[0131] This embodiment is basically the same as embodiment 20, except that the allantoin content in this embodiment is 0.3g.

[0132] Example 23

[0133] This embodiment is basically the same as embodiment 20, except that the content of allantoin in this embodiment is 0.4g.

[0134] Example 24

[0135] This embodiment is basically the same as embodiment 20, except that the allantoin content in this embodiment is 0.5g.

[0136] Example 25

[0137] This embodiment is basically the same as Embodiment 1, except that the content of glycerol in this embodiment is 2.5g and the content of nicotinamide is 0.1g.

[0138] Example 26

[0139] This embodiment is basically the same as embodiment 25, except that the content of nicotinamide in this embodiment is 0.2g.

[0140] Example 27

[0141] This embodiment is basically the same as embodiment 25, except that the content of nicotinamide in this embodiment is 0.3g.

[0142] Example 28

[0143] This embodiment is basically the same as embodiment 25, except that the content of nicotinamide in this embodiment is 0.4g.

[0144] Example 29

[0145] This embodiment is basically the same as Embodiment 1, except that: the content of glycerin in this embodiment is 2.5g, and the content of bamboo red fungus extract is 0.01g.

[0146] Example 30

[0147] This embodiment is basically the same as embodiment 29, except that the content of bamboo red fungus A extract in this embodiment is 0.02g.

[0148] Example 31

[0149] This embodiment is basically the same as embodiment 29, except that the content of bamboo red fungus A extract in this embodiment is 0.04g.

[0150] Example 32

[0151] This embodiment is basically the same as embodiment 29, except that the content of bamboo red fungus A extract in this embodiment is 0.08g.

[0152] Example 33

[0153] This embodiment is basically the same as embodiment 29, except that the content of bamboo red fungus A extract in this embodiment is 0.16g.

[0154] Example 34

[0155] This embodiment is basically the same as embodiment 29, except that the content of bamboo red fungus A extract in this embodiment is 0.3g.

[0156] Comparative Example 1

[0157] This comparative example is basically the same as Example 1, except that this comparative example does not contain glycerol.

[0158] Comparative Example 2

[0159] This comparative example is basically the same as Example 6, except that this comparative example does not contain polyethylene glycol 400.

[0160] Comparative Example 3

[0161] This comparative example is basically the same as Example 11, except that this comparative example does not contain sodium hyaluronate.

[0162] Comparative Example 4

[0163] This comparative example is basically the same as Example 16, except that this comparative example does not contain hydroxyethyl cellulose.

[0164] Comparative Example 5

[0165] This comparative example is basically the same as Example 20, except that this comparative example does not contain allantoin.

[0166] Comparative Example 6

[0167] This comparative example is basically the same as Example 25, except that this comparative example does not contain nicotinamide.

[0168] Comparative Example 7

[0169] This comparative example is basically the same as Example 29, except that this comparative example does not contain bamboo red fungus A extract.

[0170] Performance testing:

[0171] (1) Antibacterial activity test of key additive bamboo red fungus extract

[0172] Bamboo red fungus A is insoluble in water, so it cannot be made into a water-soluble essence for direct use in face masks. However, COP2T-HA, obtained by PEG modification and condensation with COP2T, is both soluble in water and has a good inhibitory effect on bacteria such as Candida albicans.

[0173] The bactericidal activity of bamboo red fungus extract was determined by the MIC method. It showed significant growth inhibition against acne-associated pathogens Propionibacterium acnes (MIC 50 μg / mL), Candida albicans (MIC 12.5 μg / mL), and Dysenteriae (MIC 75 μg / mL).

[0174] For example, Figure 3 The image shows the inhibitory effect of different concentrations of bamboo red mycotoxin extract on Candida albicans. The inhibitory effect of bamboo red mycotoxin extract on Candida albicans was tested at different concentrations, from left to right: 0 μg / mL, 6.25 μg / mL, 12.5 μg / mL, 25 μg / mL, and 50 μg / mL. Figure 3 It is very clear that the growth of Candida albicans can be inhibited at a concentration of approximately 12.5 μg / mL.

[0175] (2) Mask safety test:

[0176] Twenty participants were selected, all of whom signed informed consent forms. During the test, the participants' left forearm was used as the test site. The sample mask was applied once daily for 15-20 minutes, gently massaging until fully absorbed. The participants' right forearm served as a blank control, and skin reactions were observed after 24 hours. Testing revealed that the product had good odor and stability, and none of the participants experienced abnormal reactions such as erythema or itching. Continued observation for 3-4 days showed no further reaction, indicating that the acne-removing mask prepared using this technology is a safe product.

[0177] (3) Mask effect test

[0178] Twenty volunteers, 10 men and 10 women, who frequently suffer from acne, were selected as test subjects. Each person used an acne-removing mask made from the acne-removing mask liquid in Examples 1-34 and Comparative Examples 1-7 of this invention, as well as two commercially available acne-removing masks, every day. The effects of the masks on acne removal before and after treatment were tested. The results after two months are shown in Table 1.

[0179] Table 1

[0180]

[0181]

[0182] As shown in the table above, in Examples 1-28, the effects of moisturizers, thickeners, and skin conditioning agents such as glycerin, polyethylene glycol, sodium hyaluronate, hydroxyethyl cellulose, allantoin, and niacinamide on the acne-removing effect were minimal at different mass fractions. However, Examples 29-34 show that the acne-removing mask prepared with 0.01% bamboo red fungus extract showed a significant improvement in acne-removing effect. When the amount of bamboo red fungus extract added was 0.04% to 0.08%, the effect was superior compared to two acne-removing masks with the same efficacy on the market.

[0183] In this invention, the terms "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., refer to a specific feature, structure, material, or characteristic described in connection with that embodiment or example, which is included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0184] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. An acne-removing facial mask liquid, characterized in that, It includes, but is not limited to, the following components in weight percentage: 1.0–5.0% glycerin, 1.0–5.0% polyethylene glycol, 0.1–1.0% sodium hyaluronate, 0.1–1.0% hydroxyethyl cellulose, 0.1–0.5% allantoin, 0.1–0.8% nicotinamide, 0.01–0.3% bamboo red fungus extract, with the balance being water; The bamboo red fungus extract is prepared by a method comprising the following steps: S1: After mixing porous organic cage-like compound COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide, ultra-dry tetrahydrofuran was added to the mixture and the mixture was stirred at room temperature for 40-60 h; then, polyethylene glycol was added and the reaction was continued for 60-80 h; after the reaction was completed, the filtrate was evaporated to dryness to obtain a solid. S2: The solid obtained in step S1 is placed into a cellulose dialysis bag for dialysis treatment to obtain a suspension; S3: Dissolve and filter the suspension obtained in step S2. The filtrate is the bamboo red fungus A extract. In step S1, the spatial structural formula of the porous organic cage-like compound COP2T is: ， The porous organic cage-like compound COP2T has a hollow capsule structure; and the porous organic cage-like compound COP2T is composed of eight triangular blocks B and twelve olefin-containing chains A, wherein the molecular formula of the triangular blocks B is: Among them, the molecular structural unit of R4 is R5, R6, and R7 are hydrogen atoms; the structural formula containing olefin chain A is... R1 is: R2 is: ; The structural unit of the porous organic cage-like compound COP2T is shown below: 。 2. The acne-removing facial mask liquid according to claim 1, characterized in that, In step S1, the mass ratio of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide is (36-38):20:1:(18-20); And / or, the mass ratio of the mixture of COP2T, 1,3-dicyclohexylcarbodiimide, 4-dimethylaminopyridine and bamboo red fungicide to the polyethylene glycol is 1:(5-8); the molecular weight of the polyethylene glycol is 1000-3000; And / or, the drying temperature is 30–50°C.

3. The acne-removing facial mask liquid according to claim 1, characterized in that, In step S2, the molecular weight cutoff of the cellulose dialysis bag is 3000-6000; And / or, the dialysis treatment is performed 2 to 5 times, with each dialysis session lasting 5 to 10 hours.

4. A method for preparing an acne-removing facial mask liquid as described in any one of claims 1-3, characterized in that, Includes the following steps: (1) Glycerin, polyethylene glycol, sodium hyaluronate, hydroxyethyl cellulose, allantoin, nicotinamide and water are mixed and then sterilized to obtain the base material; (2) After cooling the base material to 20-30°C, add bamboo red fungus A extract to the base material, mix and stir to obtain the acne-removing mask liquid.

5. The method for preparing the acne-removing facial mask liquid according to claim 4, characterized in that, The aseptic treatment temperature is 85–95°C, and the treatment time is 20–40 min.

6. An acne-removing facial mask, comprising an acne-removing mask liquid and a base material, characterized in that, The acne-removing facial mask liquid is the acne-removing facial mask liquid according to any one of claims 1-3 or the acne-removing facial mask liquid prepared by the preparation method according to claim 4 or 5.

7. The acne-removing facial mask according to claim 6, characterized in that, The matrix material is non-woven fabric or silk.

8. A method for preparing an acne-removing facial mask as described in claim 6 or 7, characterized in that, The process includes the following steps: soaking the base material in an acne-removing mask liquid to obtain the acne-removing mask.

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