Crystal form of garlicin-cyclodextrin inclusion complex co-crystal and preparation method and application thereof

By preparing a cocrystal of allicin and cyclodextrin inclusion complexes, the problems of poor water solubility and easy degradation of allicin were solved, achieving better water solubility and stability, which is suitable for the preparation of antibacterial and anti-inflammatory chemical agents, drugs, food or feed.

CN117551222BActive Publication Date: 2026-07-21ZHONGSHAN INST FOR DRUG DISCOVERY SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHONGSHAN INST FOR DRUG DISCOVERY SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Filing Date
2022-08-04
Publication Date
2026-07-21

AI Technical Summary

Technical Problem

Allicin has problems in practical applications, such as poor water solubility, easy degradation, strong odor, and strong irritation, which are difficult to solve effectively with existing technologies.

Method used

By preparing inclusion cocrystals of allicin with α-cyclodextrin, β-cyclodextrin, or γ-cyclodextrin, and using solvent injection and antisolvent methods combined with appropriate heating temperatures, inclusion cocrystals with well-defined crystal structures are formed, thereby improving water solubility and stability.

Benefits of technology

Allicin-cyclodextrin inclusion complex eutectic exhibits good water solubility and stability, is not easily degraded, and can effectively solidify allicin, making it suitable for the preparation of various formulations and improving the application effect of allicin.

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Abstract

The present application relates to a crystalline form of allicin-cyclodextrin inclusion complex co-crystal and a preparation method and application thereof. The cyclodextrin in the crystalline form of allicin-cyclodextrin inclusion complex co-crystal is alpha-cyclodextrin, beta-cyclodextrin or gamma-cyclodextrin. The crystalline form of allicin-cyclodextrin inclusion complex co-crystal has good water solubility, stable properties and is not easy to degrade.
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