A centrifugal outer bowl for blood separation, a centrifugal separation device and a method for correcting a deviation

Abstract

This invention discloses a centrifuge outer rotor, a centrifugation device, and a correction method for blood separation, belonging to the field of medical device technology. The centrifuge outer rotor includes an upper frame, a lower frame, a controller, and a drive mechanism for rotating the lower frame. The upper and lower frames are hinged. The lower frame has a receiving cavity containing a centrifuge housing. The lower frame's transverse axis is the X-axis, and its extension towards the housing is the Y-axis. A cover plate is provided on the lower frame, with a first counterweight mechanism for X-axis counterweight and a second counterweight mechanism for Y-axis counterweight. It exhibits good sensitivity, enabling timely and precise dynamic adjustment of the positions of the first and second counterweights, ensuring the centrifuge chamber always rotates in optimal dynamic balance.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a centrifuge outer drum, centrifuge separation device, and correction method for blood separation. Background Technology

[0002] Human blood is composed of red blood cells, white blood cells, lymphocytes, platelets, and plasma. In the application of apheresis technology, based on the different proportions of each blood component, a centrifuge assembly is used at high speed with disposable blood component separation consumables to extract only a portion of the blood as needed, and then the rest is returned to the blood donor.

[0003] Maintaining dynamic balance of the centrifuge chamber assembly during high-speed operation is crucial for centrifuges that use disposable blood component separation consumables. Imbalance in the centrifuge assembly can cause vibration and noise in the centrifuge chamber, damage the centrifuge spindle, shorten the centrifuge's lifespan, and even affect the quality of blood component collection.

[0004] The usual practice for calibrating the dynamic balance of a centrifuge chamber is to add a fixed-position, fixed-weight counterweight to the centrifuge chamber assembly to help balance it. However, the amount of blood entering and leaving the centrifuge chamber varies at different stages of the collection process, which can cause fluctuations in the dynamic balance deviation of the centrifuge chamber. This results in excessive vibration and noise during centrifugation, ultimately affecting the lifespan of the centrifuge. Summary of the Invention

[0005] The technical problem to be solved by this invention is that existing blood centrifuges have fluctuating dynamic balance deviation values, which leads to excessive vibration and noise during the centrifugation process, ultimately affecting the service life of the centrifuge.

[0006] The first objective of this invention is to provide a centrifuge outer rotor for blood separation, comprising an upper frame of the centrifuge chamber outer rotor, a lower frame of the centrifuge chamber outer rotor, a controller for the centrifuge chamber outer rotor, and a drive mechanism for rotating the lower frame of the centrifuge chamber outer rotor. The upper frame and the lower frame of the centrifuge chamber outer rotor are hinged together. The lower frame of the centrifuge chamber outer rotor is provided with a receiving cavity, and a centrifuge chamber outer cover is disposed within the receiving cavity. The horizontal direction of the lower frame of the centrifuge chamber outer rotor is the X-axis, and the direction in which the lower frame of the centrifuge chamber outer rotor extends toward the centrifuge chamber outer cover is the Y-axis.

[0007] The lower frame of the outer rotating cylinder of the centrifuge chamber is provided with a cover plate, and the cover plate is provided with a first counterweight mechanism for realizing X-axis counterweight and a second counterweight mechanism for realizing Y-axis counterweight.

[0008] The centrifuge outer drum controller is communicatively connected to the upper frame of the centrifuge outer drum, the first counterweight mechanism, and the second counterweight mechanism.

[0009] When the above technical solution is adopted,

[0010] By setting a first counterweight mechanism and a second counterweight mechanism on the lower frame of the outer rotating drum of the centrifuge chamber, the first counterweight mechanism is positioned along the X-axis and the second counterweight mechanism is positioned along the Y-axis, that is, the first counterweight mechanism and the second counterweight mechanism are perpendicular to each other, so that the centrifugal center of gravity is always on the Z-axis (i.e., the rotation axis) during the centrifugation process, thereby reducing vibration and noise during the centrifugation process, extending the service life of the centrifuge and improving the quality of blood separation components.

[0011] As one possible design, the first counterweight mechanism includes a first drive module, and the moving end of the first drive module is provided with a first counterweight block.

[0012] As one possible design, the second counterweight mechanism includes a second drive module, and the moving end of the second drive module is provided with a second counterweight block.

[0013] When the above technical solution is adopted,

[0014] The first drive module drives the first counterweight to move on the X-axis, thereby changing the position of the first counterweight on the X-axis; the second drive module drives the second counterweight to move on the Y-axis, thereby changing the position of the second counterweight on the Y-axis; thus adjusting the position of the centrifugal center of gravity during centrifugation so that it is located on the rotation axis.

[0015] The second objective of this invention is to provide a centrifugal separation device for blood separation, comprising a centrifugal chamber and the aforementioned outer centrifugal drum, wherein the centrifugal chamber is fixed inside the outer casing of the centrifugal chamber.

[0016] The third objective of this invention is to provide a blood separation correction method based on the aforementioned centrifugal separation device, comprising:

[0017] Start the drive mechanism and obtain the rotational speed and running time of the centrifugal outer drum;

[0018] The dynamic balance deviation is obtained based on the rotational speed and running time;

[0019] Adjust the position of the first counterweight on the X-axis and / or adjust the position of the second counterweight on the Y-axis according to the dynamic balance deviation.

[0020] When the above technical solution is adopted,

[0021] The blood separation correction method has good sensitivity and can dynamically adjust the positions of the first and second counterweights in a timely and accurate manner, so that the centrifuge chamber can always rotate in the best dynamic balance state.

[0022] As one possible design, the algorithm for adjusting the dynamic balance deviation of the centrifuge chamber at each stage is as follows:

[0023] D-balance=k1×A-distance+k2×B-distance

[0024] In the formula: D-balance is the current dynamic balance deviation of the centrifuge chamber, in mm;

[0025] A-distance is the distance the first counterweight moves, in mm;

[0026] K1 is the empirical correction coefficient for the first counterweight;

[0027] B-distance is the distance the second counterweight moves, in mm;

[0028] K2 is the empirical correction coefficient for the second counterweight;

[0029] The current dynamic balance deviation value of the centrifuge chamber is obtained by the dynamic balance deviation measurement sensor.

[0030] As one possible design, the positions of the first counterweight and the second counterweight are adjusted as follows:

[0031] Adjust the position of the first counterweight on the X-axis and / or the position of the second counterweight on the Y-axis.

[0032] As one possible design, the positions of the first counterweight and the second counterweight are adjusted as follows:

[0033] First, adjust the position of the second counterweight on the Y-axis. When the dynamic balance deviation obtained when the second counterweight is moved to the farthest or closest end does not meet the requirements, then adjust the position of the first counterweight on the X-axis.

[0034] As one possible design, when the dynamic balance deviations detected by the dynamic balance deviation measurement sensor are equal, the adjustment of the position of the second counterweight and the second counterweight shall be stopped. Attached Figure Description

[0035] To more clearly illustrate the technical solutions of the exemplary embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly described below. It should be understood that the following drawings only show some embodiments of the present invention and should not be considered as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort. In the drawings:

[0036] Figure 1 This is a schematic diagram of the structure of the centrifugal outer rotating cylinder in an embodiment of the present invention;

[0037] Figure 2This is a schematic diagram of the projection of the first drive mechanism and the second drive mechanism on the lower frame of the outer rotating cylinder of the centrifuge chamber in an embodiment of the present invention;

[0038] Figure 3 This is a schematic diagram of the structure consisting of the first driving mechanism, the second driving mechanism, and the cover plate in an embodiment of the present invention.

[0039] The attached diagram shows the markings and corresponding component names:

[0040] 1- Upper frame of centrifuge chamber outer rotating cylinder, 2- Lower frame of centrifuge chamber outer rotating cylinder, 3- Second drive module, 4- First drive module, 5- Cover plate, 6- First counterweight, 7- Second counterweight, 8- Centrifuge chamber outer cover, 9- Rotating shaft. Detailed Implementation

[0041] To make the objectives, technical solutions, and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the embodiments and accompanying drawings. The illustrative embodiments and descriptions of the present invention are only used to explain the present invention and are not intended to limit the present invention.

[0042] It should be noted that when a component is referred to as being "fixed to" or "set on" another component, it can be directly on or indirectly on that other component. When a component is referred to as being "connected to" another component, it can be directly connected to or indirectly connected to that other component.

[0043] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, "a plurality of" means two or more, unless otherwise explicitly specified. "Several" means one or more, unless otherwise explicitly specified.

[0044] In the description of this invention, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0045] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0046] Example 1

[0047] Existing blood centrifuges add a fixed-position, fixed-weight counterweight to the centrifuge chamber assembly to help balance the centrifuge chamber. However, the amount of blood entering and leaving the centrifuge chamber varies at different stages of the collection process, which causes fluctuations in the dynamic balance of the centrifuge chamber, resulting in vibration and noise, and further affecting the lifespan of the blood centrifuge.

[0048] To address the aforementioned problems, this invention provides a centrifuge outer rotor for blood separation, comprising an upper frame of the centrifuge chamber outer rotor, a lower frame of the centrifuge chamber outer rotor, a controller for the centrifuge chamber outer rotor, and a drive mechanism for rotating the lower frame of the centrifuge chamber outer rotor. The upper frame and the lower frame of the centrifuge chamber outer rotor are hinged together. The lower frame of the centrifuge chamber outer rotor has a receiving cavity, within which a centrifuge chamber outer cover is disposed. The horizontal axis of the lower frame of the centrifuge chamber outer rotor is the X-axis, and the direction in which the lower frame of the centrifuge chamber outer rotor extends toward the centrifuge chamber outer cover is the Y-axis. A cover plate is provided on the lower frame of the centrifuge chamber outer rotor, and a first counterweight mechanism for achieving X-axis counterweight and a second counterweight mechanism for achieving Y-axis counterweight are provided on the cover plate. The controller for the centrifuge chamber outer rotor is communicatively connected to the upper frame of the centrifuge chamber outer rotor, the first counterweight mechanism, and the second counterweight mechanism.

[0049] By setting up a first counterweight mechanism and a second counterweight mechanism, the first counterweight mechanism achieves counterweight on the X-axis and the second counterweight mechanism achieves counterweight on the Y-axis. By adjusting the position of the first counterweight mechanism on the X-axis and the position of the second counterweight mechanism on the Y-axis, the centrifugal center of gravity is always on the rotation axis, reducing vibration and noise and extending the service life of the blood centrifuge.

[0050] The first and second counterweight mechanisms can be the same or different, depending on the application. The first counterweight mechanism includes a first drive module, the moving end of which is equipped with a first counterweight block. The first drive module drives the first counterweight block to move along the X-axis. When the first and second counterweight mechanisms have the same structure, the second drive module drives the second counterweight block to move along the Y-axis. By adjusting the position of the first counterweight block on the X-axis and / or controlling the position of the second counterweight block on the Y-axis, the centrifugal center of gravity is positioned on the rotation axis.

[0051] The first drive module and the second drive module can be common drive devices in the art, such as hydraulic cylinders, with the piston of the hydraulic cylinder and the first counterweight fixedly connected.

[0052] As one possible implementation, the position range of the first counterweight on the X-axis can be set according to the blood inflow and outflow ranges. Figure 1 The positions between the solid and dashed lines representing the first counterweight block are all possible positions for the first counterweight block. Similarly, the position range of the second counterweight block on the Y-axis can also be set. Figure 1 The positions between the solid and dashed lines for the second counterweight are all possible positions for the second counterweight. The driving of the first and second drive modules can be automatically controlled by the centrifugal outer drum controller, thereby adjusting the positions of the first and second counterweights in real time and in a timely manner, so that the centrifugal center of gravity is always on the rotation axis.

[0053] As one possible implementation, the centrifuge outer drum controller can obtain the dynamic balance deviation based on the rotational speed and running time of the centrifuge outer drum, and adjust the positions of the first and second counterweights according to the magnitude of the balance deviation. When the balance deviation is at its minimum, the first and second counterweights are closest to the lower frame of the centrifuge outer drum. Figure 1 (Solid line position); When the balance deviation is at its maximum, the distance between the first and second counterweights and the lower frame of the outer rotating cylinder of the centrifuge chamber is the greatest. Figure 1 (Position of the middle dashed line).

[0054] Specifically, a dynamic balance deviation measurement sensor is installed on the upper or lower frame of the outer rotating drum of the centrifuge chamber, and the dynamic balance deviation measurement sensor is communicatively connected to the controller of the outer rotating drum of the centrifuge chamber.

[0055] In one possible implementation, the first counterweight mechanism and the lower frame of the centrifuge chamber's outer rotating cylinder are detachably connected, specifically by bolts. When the projection of the moving end of the second counterweight mechanism onto the cover plate does not coincide with that of the first counterweight mechanism during movement, the second counterweight mechanism and the lower frame of the centrifuge chamber's outer rotating cylinder can also be bolted together. When the projection of the moving end of the second counterweight mechanism onto the cover plate coincides with that of the first counterweight mechanism during movement, the second counterweight mechanism is mounted on the cover plate via a bracket, and its moving end does not contact the first counterweight mechanism during movement. This avoids mutual interference between the two during adjustment.

[0056] Example 2

[0057] This embodiment discloses a centrifugal separation device for blood separation, including a centrifuge chamber and an outer centrifuge drum as described in Embodiment 1, wherein the centrifuge chamber is fixed inside the outer casing of the centrifuge chamber. This achieves stable blood separation.

[0058] Example 3

[0059] Based on Example 1, this example discloses a blood separation correction method, including:

[0060] S1. Start the drive mechanism and obtain the rotational speed and running time of the centrifugal outer drum;

[0061] S2. Obtain the dynamic balance deviation based on the rotational speed and running time;

[0062] S3. Adjust the position of the first counterweight on the X-axis and / or adjust the position of the second counterweight on the Y-axis according to the dynamic balance deviation.

[0063] In step S2, the method for obtaining the dynamic balance deviation is as follows:

[0064] The data can be obtained directly from a dynamic balance deviation measurement sensor or from laboratory test data; both are conventional techniques in this field and will not be described in detail here.

[0065] Step S3 is as follows:

[0066] The adjustment algorithm for the dynamic balance deviation of the centrifuge chamber at each stage is as follows:

[0067] D-balance=k1×A-distance+k2×B-distance

[0068] In the formula: D-balance is the current dynamic balance deviation of the centrifuge chamber, in mm;

[0069] A-distance is the distance the first counterweight moves, in mm;

[0070] K1 is the empirical correction coefficient for the first counterweight, typically ;

[0071] B-distance is the distance the second counterweight moves, in mm;

[0072] K2 is the empirical correction coefficient for the second counterweight, which is generally [value missing].

[0073] The positions of the first counterweight and the second counterweight are adjusted as follows:

[0074] Adjust the position of the first counterweight on the X-axis and / or the position of the second counterweight on the Y-axis.

[0075] Preferably, the positions of the first counterweight and the second counterweight are adjusted as follows:

[0076] First, adjust the position of the second counterweight on the Y-axis. When the dynamic balance deviation obtained when the second counterweight is moved to the farthest or closest end does not meet the requirements, then adjust the position of the first counterweight on the X-axis.

[0077] When the data on both sides of the equation are equal, stop adjusting the first and second counterweights. At this point, the function of adjusting the dynamic balance deviation of the centrifuge chamber is completed.

[0078] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A centrifuge outer rotor for blood separation, comprising an upper frame of the centrifuge chamber outer rotor, a lower frame of the centrifuge chamber outer rotor, a controller for the centrifuge outer rotor, and a drive mechanism for rotating the lower frame of the centrifuge chamber outer rotor, wherein the upper frame and the lower frame of the centrifuge chamber outer rotor are hinged; the lower frame of the centrifuge chamber outer rotor is provided with a receiving cavity, and a centrifuge chamber outer cover is disposed within the receiving cavity, characterized in that, The horizontal direction of the lower frame of the outer rotating cylinder of the centrifuge chamber is the X-axis, and the direction in which the lower frame of the outer rotating cylinder of the centrifuge chamber extends toward the outer cover of the centrifuge chamber is the Y-axis. The lower frame of the outer rotating cylinder of the centrifuge chamber is provided with a cover plate, and the cover plate is provided with a first counterweight mechanism for achieving X-axis counterweight and a second counterweight mechanism for achieving Y-axis counterweight. The centrifuge outer drum controller is communicatively connected to the upper frame of the centrifuge outer drum, the first counterweight mechanism, and the second counterweight mechanism; The first counterweight mechanism includes a first drive module, and the moving end of the first drive module is provided with a first counterweight block; The second counterweight mechanism includes a second drive module, and the moving end of the second drive module is provided with a second counterweight block; The first counterweight mechanism and the lower frame of the outer rotating cylinder of the centrifuge chamber are detachably connected; When the projection of the moving end of the second counterweight mechanism onto the cover plate does not coincide with that of the first counterweight mechanism during the movement, the second counterweight mechanism and the lower frame of the outer rotating cylinder of the centrifuge chamber are bolted together. When the projection of the moving end of the second counterweight mechanism onto the cover plate coincides with that of the first counterweight mechanism during movement, the second counterweight mechanism is mounted on the cover plate by a bracket, and its moving end does not contact the first counterweight mechanism during movement.

2. The centrifuge outer drum for blood separation according to claim 1, characterized in that, A dynamic balance deviation measurement sensor is installed on the upper or lower frame of the centrifuge outer drum, and the dynamic balance deviation measurement sensor is communicatively connected to the centrifuge outer drum controller.

3. A centrifugal separation device for blood separation, comprising a centrifuge chamber, characterized in that, It also includes the centrifugal outer rotating drum as described in any one of claims 1-2, wherein the centrifugal chamber is fixed inside the outer cover of the centrifugal chamber.

4. A blood separation correction method based on the centrifugal separation device according to claim 3, characterized in that, The blood separation and correction method includes: Start the drive mechanism and obtain the rotational speed and running time of the centrifugal outer drum; The dynamic balance deviation is obtained based on the rotational speed and running time; Adjust the position of the first counterweight on the X-axis and / or adjust the position of the second counterweight on the Y-axis according to the dynamic balance deviation.

5. The blood separation and correction method according to claim 4, characterized in that, The adjustment algorithm for the dynamic balance deviation of the centrifuge chamber at each stage is as follows: D-balance=k1×A-distance+k2×B-distance In the formula: D-balance is the current dynamic balance deviation of the centrifuge chamber, in mm; A-distance is the distance the first counterweight moves, in mm; K1 is the empirical correction coefficient for the first counterweight; B-distance is the distance the second counterweight moves, in mm; K2 is the empirical correction coefficient for the second counterweight; The current dynamic balance deviation value of the centrifuge chamber is obtained by the dynamic balance deviation measurement sensor.

6. The blood separation and correction method according to claim 5, characterized in that, The positions of the first and second counterweights are adjusted as follows: Adjust the position of the first counterweight on the X-axis and / or the position of the second counterweight on the Y-axis.

7. The blood separation and correction method according to claim 6, characterized in that, The positions of the first and second counterweights are adjusted as follows: First, adjust the position of the second counterweight on the Y-axis. When the dynamic balance deviation obtained when the second counterweight is moved to the farthest or closest end does not meet the requirements, then adjust the position of the first counterweight on the X-axis.

8. The blood separation and correction method according to claim 5, characterized in that, When the dynamic balance deviations detected by the dynamic balance deviation measurement sensor are equal, the adjustment of the positions of the second counterweight and the second counterweight shall be stopped.

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