An energy management system for an ultrasonic balloon catheter for a renal artery in vivo

Abstract

The application provides an energy management system of an ultrasonic balloon catheter for a renal artery in vivo, and belongs to the technical field of medical devices.The system comprises a man-machine interaction module for receiving a user-selected working mode;the working mode comprises a resonant frequency mode and an anti-resonant frequency mode; a frequency detection module for detecting the resonant frequency and the anti-resonant frequency of an ultrasonic transducer; a control module for generating a frequency control signal, a voltage control signal and an action time control signal according to the user-selected working mode, the resonant frequency and the anti-resonant frequency of the ultrasonic transducer; and a driving module for driving the ultrasonic transducer to emit ultrasonic waves according to the frequency control signal, the voltage control signal and the action time control signal.The application can control the frequency and emission time of ultrasonic energy, and for the first time uses an anti-resonant frequency treatment scheme in ultrasonic treatment, in combination with the resonant frequency, thereby improving the effectiveness of the ultrasonic balloon catheter acting on the tissue around the renal artery.

Description

Technical Field

[0001] This invention relates to the field of medical device technology and provides an energy management system for an ultrasonic balloon catheter used in the renal artery. Background Technology

[0002] Refractory hypertension is a type of hypertension that may be caused by factors such as drug resistance, inappropriate use of antihypertensive drugs, or changes in hormone levels. Refractory hypertension can significantly impact a patient's quality of life, and some patients may even experience serious complications such as acute myocardial infarction or heart failure.

[0003] Ultrasound renal denervation (URDN) is a novel treatment for refractory hypertension. It uses ultrasound energy to target the tissues surrounding the renal artery, reducing nerve activity and thus lowering blood pressure. Compared to traditional treatments and other surgical procedures, URDN offers significant advantages, providing patients with a more convenient and safer treatment option. However, current URDN treatment methods neglect energy efficiency, leading to less than ideal treatment outcomes. Summary of the Invention

[0004] The purpose of this invention is to provide an energy management system for an ultrasonic balloon catheter used in the renal artery, which can control the frequency and emission time of ultrasonic energy and improve the effectiveness of the ultrasonic balloon catheter in acting on the tissues surrounding the renal artery.

[0005] To achieve the above objectives, the present invention provides an energy management system for an ultrasound balloon catheter used in the renal artery, comprising:

[0006] The human-computer interaction module is used to receive the operating mode selected by the user; the operating mode includes resonant frequency mode and anti-resonant frequency mode.

[0007] A frequency detection module, connected to the ultrasonic transducer, is used to detect the resonant frequency and anti-resonant frequency of the ultrasonic transducer.

[0008] The control module is connected to the human-machine interaction module and the frequency detection module respectively, and is used to generate frequency control signals, voltage control signals and action time control signals according to the working mode selected by the user, the resonant frequency and anti-resonant frequency of the ultrasonic transducer.

[0009] The driving module is connected to the control module and the ultrasonic transducer respectively, and is used to drive the ultrasonic transducer to emit ultrasonic waves according to the frequency control signal, the voltage control signal and the action time control signal.

[0010] Optionally, the frequency detection module includes:

[0011] The signal detection submodule is connected to the ultrasonic transducer and is used to detect the dynamic resistance, dynamic inductance, dynamic capacitance and static capacitance of the piezoelectric vibrator in the ultrasonic transducer.

[0012] The resonant frequency determination submodule is connected to the signal detection submodule and is used to determine the resonant frequency of the ultrasonic transducer based on the dynamic resistance, dynamic inductance and dynamic capacitance of the piezoelectric vibrator in the ultrasonic transducer.

[0013] The anti-resonance frequency determination submodule, connected to the signal detection submodule, is used to determine the anti-resonance frequency of the ultrasonic transducer based on the dynamic resistance, dynamic inductance, dynamic capacitance, and static capacitance of the piezoelectric vibrator in the ultrasonic transducer.

[0014] Optionally, when the dynamic resistance of the piezoelectric vibrator in the ultrasonic transducer is 0, the resonant frequency determination submodule uses the formula... Determine the resonant frequency of the ultrasonic transducer; where, f r f is the resonant frequency of the ultrasonic transducer. m L1 is the maximum admittance frequency of the ultrasonic transducer, L1 is the dynamic inductance of the piezoelectric vibrator in the ultrasonic transducer, and C1 is the dynamic capacitance of the piezoelectric vibrator in the ultrasonic transducer.

[0015] Optionally, when the dynamic resistance of the piezoelectric vibrator in the ultrasonic transducer is 0, the anti-resonance frequency determination submodule uses the formula... Determine the anti-resonance frequency of the ultrasonic transducer; where, f a f is the anti-resonant frequency of the ultrasonic transducer. n L1 is the minimum admittance frequency of the ultrasonic transducer, C1 is the dynamic inductance of the piezoelectric vibrator in the ultrasonic transducer, C1 is the dynamic capacitance of the piezoelectric vibrator in the ultrasonic transducer, and C0 is the static capacitance of the piezoelectric vibrator in the ultrasonic transducer.

[0016] Optionally, the control module includes:

[0017] The microcontroller unit is connected to the human-machine interaction module and the frequency detection module respectively, and is used to generate frequency control signals, voltage control signals and action time control signals according to the working mode selected by the user, the resonant frequency and anti-resonant frequency of the ultrasonic transducer.

[0018] A digital signal processing chip is connected to both the microcontroller unit and the drive module, and is used to send the frequency control signal, voltage control signal and action time control signal to the drive module.

[0019] Optionally, the driving module includes:

[0020] A gate driver, connected to the control module, is used to generate a drive level signal based on the frequency control signal, the voltage control signal, and the action time control signal;

[0021] A power MOSFET is connected to both the gate driver and the ultrasonic transducer, and is used to cause the ultrasonic transducer to emit ultrasonic waves under the action of the drive level signal.

[0022] Optionally, the human-computer interaction module is also used to display the resonant frequency and anti-resonant frequency of the ultrasonic transducer.

[0023] Optionally, the energy management system of the ultrasound balloon catheter for in vivo renal artery further includes: an external power supply, which is connected to the ultrasound transducer, the human-machine interface module, the control module and the drive module respectively, for supplying power to the ultrasound transducer, the human-machine interface module, the control module and the drive module.

[0024] According to specific embodiments provided by the present invention, the present invention discloses the following technical effects: The present invention detects the resonant frequency and anti-resonant frequency of the ultrasonic transducer through a frequency detection module, and the control module generates a frequency control signal, a voltage control signal, and an action time control signal according to the user-selected working mode, the resonant frequency and anti-resonant frequency of the ultrasonic transducer. The drive module drives the ultrasonic transducer to emit ultrasonic waves of the corresponding frequency. The present invention can control the frequency and emission time of ultrasonic energy, and for the first time uses a treatment scheme with anti-resonant frequency in ultrasonic therapy. Combined with the resonant frequency, it improves the effectiveness of the ultrasonic balloon catheter in acting on the tissues surrounding the renal artery. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0026] Figure 1 A schematic diagram of the energy management system for the ultrasonic balloon catheter for in vivo renal artery provided by the present invention;

[0027] Figure 2 A schematic diagram of the equivalent circuit of a piezoelectric vibrator;

[0028] Figure 3 This is a schematic diagram of the resonant frequency versus admittance frequency curve;

[0029] Figure 4 This is a schematic diagram showing the relationship between the impedance, resistance, reactance, and series arm reactance of a piezoelectric vibrator and its frequency.

[0030] Symbol explanation: 1-External power supply, 2-DC-DC converter, 3-Human-machine interaction module, 4-Ultrasonic transducer, 5-Frequency detection module, 6-Control module, 7-Microcontroller unit, 8-Digital signal processing chip, 9-Drive module, 10-Gate driver, 11-Power MOSFET, 12-Debug module, 13-Flash memory card. Detailed Implementation

[0031] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0032] This invention addresses the energy emission of URDN ultrasound transducers by providing an energy management system for an ultrasound balloon catheter used in the renal artery. It offers two energy excitation methods: resonant frequency energy excitation and anti-resonant frequency energy excitation, optimizing the safety and energy efficiency of the ultrasound balloon catheter in clinical applications. This system has broad prospects for application in the treatment of hypertension in the renal artery peripheral nerves.

[0033] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0034] like Figure 1 As shown, the energy management system for an in vivo renal artery ultrasound balloon catheter provided by the present invention includes: a human-computer interaction module 3, a frequency detection module 5, a control module 6, a drive module 9, and an external power supply 1.

[0035] An external power supply 1 is connected to the ultrasonic transducer 4, the human-machine interaction module 3, the control module 6, and the drive module 9, respectively. The external power supply 1 is used to supply power to the ultrasonic transducer 4, the human-machine interaction module 3, the control module 6, and the drive module 9.

[0036] In this embodiment, the external power supply 1 supplies power to each functional module through the DC-DC converter 2.

[0037] The human-computer interaction module 3 is used to receive the operating mode selected by the user. The operating modes include resonant frequency mode and anti-resonant frequency mode.

[0038] Furthermore, the human-computer interaction module 3 is also used to display the resonant frequency and anti-resonant frequency of the ultrasonic transducer 4. In one specific implementation, the human-computer interaction module 3 is a screen, through which the user can select the resonant frequency or anti-resonant frequency, and simultaneously observe the energy release process and its current stage on the human-computer interaction module 3.

[0039] In addition, an automatic optimization suggestion option can be added to the human-computer interaction module 3. Based on the automatic detection characteristics after the ultrasound balloon catheter is inserted, the optimal working mode can be detected and recommended to further improve treatment efficiency.

[0040] The frequency detection module 5 is connected to the ultrasonic transducer 4, and the frequency detection module 5 is used to detect the resonant frequency and anti-resonant frequency of the ultrasonic transducer 4.

[0041] After the ultrasonic balloon catheter is inserted into the renal artery, the frequency detection module 5 starts working to detect the ultrasonic transducer 4 and determine the resonant operating frequency and anti-resonant operating frequency of the ultrasonic transducer 4.

[0042] Specifically, the frequency detection module 5 includes: a signal detection submodule, a resonant frequency determination submodule, and an anti-resonant frequency determination submodule.

[0043] The signal detection submodule is connected to the ultrasonic transducer 4 and is used to detect the dynamic resistance, dynamic inductance, dynamic capacitance, and static capacitance of the piezoelectric vibrator in the ultrasonic transducer 4. Figure 2 The diagram shown is the equivalent circuit diagram of the piezoelectric vibrator in ultrasonic transducer 4.

[0044] The piezoelectric vibrator in ultrasonic transducer 4 is a polarized piezoelectric body, which is an elastic body and has a natural vibration frequency (resonant frequency) f. r When the frequency of the electrical signal applied to the piezoelectric oscillator is equal to its natural vibration frequency f. r At this point, the piezoelectric oscillator's elastic energy is at its maximum, thus achieving resonance. Furthermore, the piezoelectric oscillator also possesses an anti-resonance frequency f. a Series resonant frequency f s Parallel resonant frequency f p Maximum admittance frequency f m and minimum admittance frequency f n Important critical frequencies. This invention mainly focuses on the resonant frequency f. r and anti-resonant frequency f a Conduct research and testing. For example... Figure 3 and Figure 4 The graph shown is a relationship between frequency and other parameters of the piezoelectric oscillator. Figure 3 and Figure 4 In the diagram, |Z| represents the impedance of the piezoelectric oscillator, and R... e X is the resistance of the piezoelectric oscillator.e Z is the reactance of the piezoelectric vibrator, X1 is the series arm reactance of the piezoelectric vibrator, and Z is the reactance of the piezoelectric vibrator. m The maximum admittance frequency f m Minimum impedance, R r The resonant frequency f r Lower impedance, R a The anti-resonant frequency f a Lower impedance, Z n The minimum admittance frequency f n Maximum impedance.

[0045] The resonant frequency determination submodule is connected to the signal detection submodule. The resonant frequency determination submodule is used to determine the resonant frequency of the ultrasonic transducer 4 based on the dynamic resistance, dynamic inductance and dynamic capacitance of the piezoelectric vibrator in the ultrasonic transducer 4.

[0046] When the dynamic resistance of the piezoelectric vibrator in the ultrasonic transducer 4 is 0, the resonant frequency determination submodule uses the formula... Determine the resonant frequency of the ultrasonic transducer 4; where f r f is the resonant frequency of ultrasonic transducer 4. m L1 is the maximum admittance frequency of the ultrasonic transducer 4, L1 is the dynamic inductance of the piezoelectric vibrator in the ultrasonic transducer 4, and C1 is the dynamic capacitance of the piezoelectric vibrator in the ultrasonic transducer 4.

[0047] The anti-resonance frequency determination submodule is connected to the signal detection submodule. The anti-resonance frequency determination submodule is used to determine the anti-resonance frequency of the ultrasonic transducer 4 based on the dynamic resistance, dynamic inductance, dynamic capacitance and static capacitance of the piezoelectric vibrator in the ultrasonic transducer 4.

[0048] When the dynamic resistance of the piezoelectric vibrator in the ultrasonic transducer 4 is 0, the anti-resonance frequency determination submodule uses the formula... Determine the anti-resonance frequency of the ultrasonic transducer 4; where f a f is the anti-resonant frequency of ultrasonic transducer 4. n L1 is the minimum admittance frequency of the ultrasonic transducer 4, C1 is the dynamic inductance of the piezoelectric vibrator in the ultrasonic transducer 4, C1 is the dynamic capacitance of the piezoelectric vibrator in the ultrasonic transducer 4, and C0 is the static capacitance of the piezoelectric vibrator in the ultrasonic transducer 4.

[0049] When the ultrasonic transducer 4 is at its maximum admittance frequency f mWhen the output strain amplitude and the current flowing through the piezoelectric oscillator reach their maximum values, the corresponding frequency is called the minimum impedance frequency (or maximum admittance frequency). As the frequency of the applied signal continues to increase, the output current of the piezoelectric oscillator decreases, and the frequency at which the impedance reaches its maximum is called the maximum impedance frequency (or minimum admittance frequency). Let f be the frequency when the dynamic resistance R1 of the piezoelectric oscillator is 0Ω. m =f s =f r f n =f p =f a .

[0050] This invention is the first to use two operating points: resonant frequency and anti-resonant frequency. During operation, the two different operating points are simulated to accurately detect the resonant and anti-resonant frequency points of the ultrasonic transducer 4. The resonant or anti-resonant operating mode with high efficiency is selected, and different ultrasonic transducers 4 are self-tested. Before treatment, the appropriate operating frequency point and operating mode can be selected through the human-computer interaction module 3, so that the ultrasonic transducer 4 can emit energy with maximum efficiency, thereby improving treatment efficiency and safety.

[0051] The control module 6 is connected to the human-machine interaction module 3 and the frequency detection module 5 respectively. The control module 6 is used to generate frequency control signals, voltage control signals and action time control signals according to the working mode selected by the user, the resonant frequency and anti-resonant frequency of the ultrasonic transducer 4.

[0052] Specifically, the control module 6 includes a microcontroller unit 7 and a digital signal processing chip 8.

[0053] The microcontroller unit 7 is connected to the human-machine interaction module 3 and the frequency detection module 5 respectively. The microcontroller unit 7 is used to generate frequency control signals, voltage control signals and action time control signals according to the working mode selected by the user, the resonant frequency and anti-resonant frequency of the ultrasonic transducer 4.

[0054] The digital signal processing chip 8 is connected to both the microcontroller unit 7 and the drive module 9. The digital signal processing chip 8 is used to send the frequency control signal, voltage control signal, and duration control signal to the drive module 9. In this embodiment, the microcontroller unit 7 and the digital signal processing chip 8 are connected via a Serial Peripheral Interface (SPI).

[0055] In addition, the microcontroller unit 7 is also used to control the power supply output of the DC-DC converter 2 to generate an adjustable ultrasonic waveform of a specific frequency for the digital signal processing chip 8.

[0056] Furthermore, the energy management system for the in vivo renal artery ultrasound balloon catheter provided by the present invention also includes a debugging module 12 and a flash memory card. Both the debugging module 12 and the flash memory card 13 are connected to the microcontroller unit 7.

[0057] The drive module 9 is connected to the control module 6 and the ultrasonic transducer 4 respectively. The drive module 9 is used to drive the ultrasonic transducer 4 to emit ultrasonic waves according to the frequency control signal, the voltage control signal and the action time control signal.

[0058] Specifically, the driving module 9 includes a gate driver 10 and a power field-effect transistor 11.

[0059] The gate driver 10 is connected to the control module 6 and is used to generate a drive level signal according to the frequency control signal, the voltage control signal and the action time control signal.

[0060] The power field-effect transistor 11 is connected to the gate driver 10 and the ultrasonic transducer 4 respectively. The power field-effect transistor 11 is used to make the ultrasonic transducer 4 emit ultrasonic waves under the action of the driving level signal.

[0061] The gate driver 10 converts the signal output by the digital signal processing chip 8 into a driving level signal for the power field-effect transistor 11. The switching state generated by the power field-effect transistor 11 controls the transformer to step up, generating a stepped-up resonant frequency or anti-resonant frequency signal, which in turn drives the ultrasonic transducer 4 to remove the renal nerve.

[0062] This invention monitors the frequency response of an ultrasonic transducer, analyzes the characteristics of its ultrasonic waveform, and automatically optimizes the frequency and emission time of ultrasonic energy based on these characteristics. This ensures that the vast majority of the energy is used to remove nerves, avoiding excessive current passing between electrodes and generating heat that could compromise the stability and reliability of the catheter. It also prevents excessively high ultrasonic energy from generating heat that could damage blood vessels and surrounding tissues, thus reducing harm to blood vessels and tissues.

[0063] By controlling the magnitude of the output voltage, the frequency of the generated ultrasonic energy can be controlled, and the energy efficiency of the heat generated by the ultrasonic transducer 4 can be improved, thereby maximizing the effect of a single treatment cycle.

[0064] Ultrasonic balloon catheters operate at an anti-resonant frequency, which effectively reduces the amount of catheter current and the heat generated by the ultrasonic balloon catheter itself. Clinically, this ensures that sufficient energy is applied to the tissues surrounding the renal artery, reducing nerve activity and thus lowering blood pressure. It also minimizes the risk of postoperative complications.

[0065] This document uses specific examples to illustrate the principles and implementation methods of the present invention. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of the present invention. Furthermore, those skilled in the art will recognize that, based on the ideas of the present invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. An energy management system for an ultrasonic balloon catheter used in the renal artery, wherein the ultrasonic balloon catheter is equipped with an ultrasonic transducer, characterized in that, The energy management system of the ultrasound balloon catheter for in vivo renal artery includes: The human-computer interaction module is used to receive the operating mode selected by the user; the operating mode includes resonant frequency mode and anti-resonant frequency mode. A frequency detection module, connected to the ultrasonic transducer, is used to detect the resonant frequency and anti-resonant frequency of the ultrasonic transducer. The control module is connected to the human-machine interaction module and the frequency detection module respectively, and is used to generate frequency control signals, voltage control signals and action time control signals according to the working mode selected by the user, the resonant frequency and anti-resonant frequency of the ultrasonic transducer. The driving module, connected to both the control module and the ultrasonic transducer, drives the ultrasonic transducer to emit ultrasonic waves according to the frequency control signal, the voltage control signal, and the action time control signal. Specifically, by monitoring the frequency response of the ultrasonic transducer and analyzing its ultrasonic wave characteristics, the module automatically optimizes the frequency and emission time of the ultrasonic energy. This ensures that the majority of the energy is used to remove nerves, avoiding excessive current passing between electrodes and generating heat that could compromise the stability and reliability of the catheter. It also prevents excessively high ultrasonic energy from generating heat that could damage blood vessels and surrounding tissues, reducing harm to these structures. By controlling the output voltage, the module controls the frequency of the generated ultrasonic energy and improves the energy efficiency of the heat generated by the ultrasonic transducer, maximizing the effectiveness of each treatment cycle. The frequency detection module includes: The signal detection submodule is connected to the ultrasonic transducer and is used to detect the dynamic resistance, dynamic inductance, dynamic capacitance and static capacitance of the piezoelectric vibrator in the ultrasonic transducer. The resonant frequency determination submodule is connected to the signal detection submodule and is used to determine the resonant frequency of the ultrasonic transducer based on the dynamic resistance, dynamic inductance and dynamic capacitance of the piezoelectric vibrator in the ultrasonic transducer. The anti-resonance frequency determination submodule, connected to the signal detection submodule, is used to determine the anti-resonance frequency of the ultrasonic transducer based on the dynamic resistance, dynamic inductance, dynamic capacitance, and static capacitance of the piezoelectric vibrator in the ultrasonic transducer.

2. The energy management system for an in vivo renal artery ultrasound balloon catheter according to claim 1, characterized in that, When the dynamic resistance of the piezoelectric vibrator in the ultrasonic transducer is 0, the resonant frequency determination submodule uses the formula... Determine the resonant frequency of the ultrasonic transducer; wherein, f r This is the resonant frequency of the ultrasonic transducer. f m The maximum admittance frequency of the ultrasonic transducer. L 1 represents the dynamic inductance of the piezoelectric vibrator in the ultrasonic transducer. C 1 represents the dynamic capacitance of the piezoelectric vibrator in the ultrasonic transducer.

3. The energy management system for an in vivo renal artery ultrasound balloon catheter according to claim 1, characterized in that, When the dynamic resistance of the piezoelectric vibrator in the ultrasonic transducer is 0, the anti-resonance frequency determination submodule uses the formula... Determine the anti-resonance frequency of the ultrasonic transducer; wherein, f a This is the anti-resonant frequency of the ultrasonic transducer. f n The minimum admittance frequency of the ultrasonic transducer. L 1 represents the dynamic inductance of the piezoelectric vibrator in the ultrasonic transducer. C 1 represents the dynamic capacitance of the piezoelectric vibrator in the ultrasonic transducer. C 0 represents the static capacitance of the piezoelectric vibrator in the ultrasonic transducer.

4. The energy management system for an in vivo renal artery ultrasound balloon catheter according to claim 1, characterized in that, The control module includes: The microcontroller unit is connected to the human-machine interaction module and the frequency detection module respectively, and is used to generate frequency control signals, voltage control signals and action time control signals according to the working mode selected by the user, the resonant frequency and anti-resonant frequency of the ultrasonic transducer. A digital signal processing chip is connected to both the microcontroller unit and the drive module, and is used to send the frequency control signal, voltage control signal and action time control signal to the drive module.

5. The energy management system for an in vivo renal artery ultrasound balloon catheter according to claim 1, characterized in that, The driving module includes: A gate driver, connected to the control module, is used to generate a drive level signal based on the frequency control signal, the voltage control signal, and the action time control signal; A power MOSFET is connected to both the gate driver and the ultrasonic transducer, and is used to cause the ultrasonic transducer to emit ultrasonic waves under the action of the drive level signal.

6. The energy management system for an in vivo renal artery ultrasound balloon catheter according to claim 1, characterized in that, The human-computer interaction module is also used to display the resonant frequency and anti-resonant frequency of the ultrasonic transducer.

7. The energy management system for an in vivo renal artery ultrasound balloon catheter according to claim 1, characterized in that, The energy management system for the ultrasound balloon catheter used in the renal artery also includes: An external power supply is connected to the ultrasonic transducer, the human-machine interface module, the control module, and the drive module, respectively, to provide power to the ultrasonic transducer, the human-machine interface module, the control module, and the drive module.

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