竹节参多糖在制备抗流感病毒药物中的应用
The preparation of anti-influenza virus drugs by extracting polysaccharides from *Panax notoginseng* solves the problems of large side effects and easy drug resistance in existing drugs, and achieves effective inhibition of the H1N1 subtype of influenza A virus and lung protection effect, thus expanding the application field of *Panax notoginseng* polysaccharides.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ACAD OF MILITARY SCI PLA CHINA ACAD OF MILITARY MEDICAL SCI INST OF MILITARY VETERINARY MEDICINE
- Filing Date
- 2023-12-27
- Publication Date
- 2026-07-17
AI Technical Summary
Existing antiviral drugs for influenza have significant side effects and are prone to drug resistance. Furthermore, there is limited research on the application of Panax notoginseng polysaccharide in antiviral activity, which limits its efficacy.
Polysaccharide extracts from *Panax notoginseng* were purified by water extraction and alcohol precipitation, ion exchange chromatography, and gel size exclusion chromatography to obtain polysaccharides with molecular weights between 50.0 kDa and 100.0 kDa. These polysaccharides are used to prepare antiviral drugs and lung protectants targeting the H1N1 subtype of influenza A virus.
The polysaccharide of *Panax notoginseng* significantly inhibits the activity of influenza virus, prolongs the survival time of experimental animals, and improves the pathological damage to the lungs caused by influenza virus, thus expanding the scope of efficacy of *Panax notoginseng* polysaccharide and providing a new direction for the prevention and treatment of influenza virus.
Smart Images
Figure CN117618459B_ABST