Preparation device of high-temperature-resistant sterilization wrapping oligopeptide material stable solution

Abstract

The present application relates to the field of material package, more particularly to a kind of preparation device of high-temperature-resistant sterilization package oligopeptide material stable solution, including inner water phase tank, oil phase tank, outer water phase tank and discharge tank, four are located on the same central axis and are nested with each other, the diameter of inner water phase tank, oil phase tank and outer water phase tank gradually increases in turn, the inner diameter of outer water phase tank is equal to the maximum inner diameter of discharge tank, inner water phase tank includes inner water phase tank body and annular table, annular table is installed around the outer wall of inner water phase tank body, the upper end of oil phase tank is sealingly connected with the lower end of annular table, the top of outer water phase tank is sealingly connected with the outer wall of inner water phase tank, the bottom end of outer water phase tank is sealingly connected with the top end of discharge tank, so that oligopeptide liposome made in the mutual package of inner water phase, oil phase and outer water phase can be fully encapsulated, to further improve its stability and bioavailability, reduce microparticle size and distribution, realize mass production.

Description

Technical Field

[0001] This invention relates to the field of material encapsulation, and more specifically, to an apparatus for preparing a stable solution of a high-temperature sterilization encapsulated oligopeptide material. Background Technology

[0002] Oligopeptides, as small molecule peptides generally composed of 2-9 amino acids, can be prepared into powder products. However, in practical applications, powder products can affect the application form of oligopeptides in different situations, thereby affecting their application value and reducing their market share.

[0003] Liposomes are fine particles composed of components such as phospholipids and cholesterol, exhibiting excellent biocompatibility. Formulating oligopeptides into liposome formulations can further improve their stability and bioavailability, making them suitable for a wider range of applications while enhancing their efficacy.

[0004] In existing technologies, when using liposomes as carriers to prepare oligopeptide liposomes, the oligopeptide solution is usually used as the aqueous phase, and lipids and fat-soluble substances are dissolved in an organic solvent to obtain the oil phase. Then, the aqueous phase and the oil phase are mixed to produce the oligopeptide liposome solution product. However, this method not only has a low encapsulation rate, but also makes it difficult to control the particle size and distribution. It also exhibits poor thermodynamic stability in high-temperature sterilization, which limits its market application value. Summary of the Invention

[0005] 1. The problem to be solved

[0006] To address the problems existing in the prior art, the present invention aims to provide a device for preparing a stable solution of high-temperature sterilization encapsulated oligopeptide material. This device stabilizes the oligopeptide liposome solution system, thereby improving the encapsulation efficiency of the oligopeptide liposome solution and controlling the particle size and distribution, thus enabling mass production.

[0007] 2. Technical Solution

[0008] To solve the above problems, the present invention adopts the following technical solution.

[0009] A device for preparing a high-temperature sterilization-resistant, encapsulated oligopeptide material stable solution includes an inner aqueous phase tank, an oil phase tank, an outer aqueous phase tank, a discharge tank, and a homogenizing device. The inner aqueous phase tank, oil phase tank, outer aqueous phase tank, and discharge tank are nested together on the same central axis. The discharge tank has a discharge port at its bottom, and the homogenizing device is connected to the discharge tank through the discharge port. The inner aqueous phase tank includes an inner aqueous phase tank body and an annular platform, which is installed around the outer wall of the inner aqueous phase tank body.

[0010] The inner and outer aqueous phase tanks are not sealed at the bottom, the oil phase tank and the discharge tank are not sealed at the top, and the top of the outer aqueous phase tank has a circular notch.

[0011] The diameters of the inner aqueous phase tank, oil phase tank, and outer aqueous phase tank increase sequentially. The inner diameter of the outer aqueous phase tank is equal to the maximum inner diameter of the discharge tank. The upper end of the oil phase tank is sealed to the lower end of the annular platform of the inner aqueous phase tank. The circular notch at the top of the outer aqueous phase tank is sealed to the outer wall of the inner aqueous phase tank. The bottom end of the outer aqueous phase tank is sealed to the top end of the discharge tank.

[0012] Furthermore, the homogenizing device includes a booster pump, a homogenizing channel, and a second discharge port. One side of the booster pump is connected to the first discharge port as an input end, and the other side is connected to the homogenizing channel through a pipe as an output end. A pressure gauge is installed on the pipe to detect the pressure. The homogenizing channel consists of several mutually perpendicular channels, and the space at the junction of the channels at the perpendicular angles is a polyhedron. The end of the homogenizing channel is connected to the discharge port.

[0013] Furthermore, the inner water phase tank also includes an inner water phase inlet, an upper inner water phase chamber, a lower inner water phase chamber, and a manifold plate. The inner water phase inlet is located above the inner water phase tank. The internal space of the inner water phase tank is divided into an upper inner water phase chamber located at the top and a lower inner water phase chamber located at the bottom. The upper inner water phase chamber is connected to the lower inner water phase chamber through an inner water phase hole. The manifold plate is circular and installed on the inner wall of the lower inner water phase chamber. Several slender holes are opened on the manifold plate.

[0014] Furthermore, the oil phase tank includes an oil phase tank body, an oil phase inlet, and a manifold II. The oil phase inlet is located below the oil phase tank body. The manifold II is annular and installed on the inner wall of the oil phase tank body. Several elongated holes are opened on the manifold II. A cylindrical mixing substrate is provided on the upper part of the oil phase tank body. The cylindrical mixing substrate is located in the area above the manifold II and has several liquid outlet holes.

[0015] Furthermore, the external water phase tank includes an external water phase tank body, an external water phase inlet, and a manifold plate. The external water phase inlet is located above the external water phase tank body. The manifold plate is annular and installed on the inner wall of the external water phase tank body. Several slender holes are opened on the manifold plate.

[0016] Furthermore, the upper inner water phase chamber is funnel-shaped, and the inner diameter of the inner water phase hole on the side closer to the upper inner water phase chamber is larger than the inner diameter on the other side, and the inner diameter of the elongated hole on the side closer to the lower inner water phase chamber is larger than the inner diameter on the other side.

[0017] Furthermore, the inner diameter of the elongated hole on the side near the oil phase inlet is larger than the inner diameter on the other side. The bottom of the oil phase tank is provided with a normally closed overflow port 2 that connects the internal space of the oil phase tank to the outside. The inner diameter of the outlet hole on the side near the inner wall of the oil phase tank is larger than the inner diameter on the other side.

[0018] Furthermore, the inner diameter of the elongated hole three on the side near the external aqueous phase inlet is larger than the inner diameter on the other side.

[0019] Furthermore, busbar 1, busbar 2, and busbar 3 are located on the same horizontal plane.

[0020] Furthermore, the annular platform is provided with a space for water storage, and the annular platform is provided with a normally closed overflow port that connects the water storage space to the outside. The external water phase inlet extends into the bottom area of ​​the water storage space of the annular platform.

[0021] Furthermore, the inner wall of the inner aqueous phase tank is slidably connected to a first manifold, which is circular; the inner wall of the oil phase tank is slidably connected to the outer wall of a second manifold, which is annular, and the inner wall of the second manifold is slidably connected to the outer wall of the inner aqueous phase tank; the inner wall of the outer aqueous phase tank is slidably connected to the outer wall of a third manifold, which is annular, and the inner wall of the third manifold is slidably connected to the outer wall of the oil phase tank.

[0022] Furthermore, the preparation device also includes an interleaved propulsion mechanism, which includes several transmission components, sealing components, and cylinders. The inner aqueous phase tank, oil phase tank, and outer aqueous phase tank are symmetrically provided with several through holes at three locations close to the manifold 1, manifold 2, and manifold 3. The through holes are located on the same horizontal plane. The transmission components are Z-shaped, and the middle part of the transmission components is installed in the through holes. Both ends of the Z-shaped transmission components extend out of the inner aqueous phase tank, oil phase tank, or outer aqueous phase tank. The Z-shaped orientation of adjacent transmission components is opposite.

[0023] Furthermore, each of the three busbars, including busbar 1, busbar 2, and busbar 3, has a locking block fixedly installed near the through hole. The two ends of the transmission component slide and engage with the locking block to achieve linkage between the transmission component and busbar 1, busbar 2, or busbar 3.

[0024] Furthermore, the seal is located inside the through hole and is in a sliding sealing connection with the transmission component without affecting the rotation of the transmission component.

[0025] Furthermore, the staggered propulsion mechanism also includes a movable plate, a movable rod, a push block, and a support plate. The transmission component rotatably connected to the outer water phase tank is an outer transmission component group three. One end of the transmission component of the outer transmission component group three is engaged with a locking block on the manifold three, and the other end extends out of the outer water phase tank. The portion extending out of the outer water phase tank is fixedly connected to one side of the movable plate. The movable plate has a sliding groove, and a slider is installed in the sliding groove. One end of the movable rod is rotatably connected to the slider, and the other end of the movable rod is rotatably connected to the push block. The push block is fixedly connected to a cylinder. The support plate supports the push block and the cylinder. The support plate has a moving groove and a limiting groove. The push block is slidably connected to the moving groove and moves back and forth in the moving groove under the push of the cylinder.

[0026] 3. Beneficial effects

[0027] Compared with the prior art, the advantages of this invention are:

[0028] (1) The present invention nests the inner aqueous phase tank, the oil phase tank, the outer aqueous phase tank and the discharge tank on the same central axis, so that the oligopeptide liposomes made by the inner aqueous phase, the oil phase and the outer aqueous phase are wrapped together can improve the encapsulation rate, thereby further improving their stability and bioavailability, reducing the particle size and distribution, and realizing mass production.

[0029] (2) In this invention, the inner water phase tank is divided into two parts: an upper inner water phase chamber and a lower inner water phase chamber. The upper inner water phase chamber is funnel-shaped. By gradually reducing the area of ​​the flow cross section through which the liquid passes, sudden changes in liquid pressure are avoided.

[0030] (3) The present invention also includes an interleaved propulsion mechanism, which drives the rotation of the transmission component by the cylinder to drive the interleaved lifting and lowering of the manifold, thereby changing the particle size of the liposome by adjusting the pushing speed of the cylinder, and further stabilizing the properties of the oligopeptide liposome according to product requirements. Attached Figure Description

[0031] Figure 1 This is a three-dimensional structural view of the present invention;

[0032] Figure 2 This is a cross-sectional view of the structure of the present invention;

[0033] Figure 3 This is a cross-sectional view of the internal water phase tank of the present invention;

[0034] Figure 4 This is a cross-sectional view of the oil phase tank of the present invention;

[0035] Figure 5 This is a cross-sectional view of the external aqueous phase tank of the present invention;

[0036] Figure 6 This is a cross-sectional view of the discharge tank of the present invention;

[0037] Figure 7 This is a schematic diagram of the flow direction of the present invention;

[0038] Figure 8 This is a three-dimensional structural view of Embodiment 2 of the present invention;

[0039] Figure 9 This is a cross-sectional view of the structure of Embodiment 2 of the present invention;

[0040] Figure 10 For the present invention Figure 9 A partial schematic diagram of point A in the middle;

[0041] Figure 11 This is a partial three-dimensional view of the structure of the present invention;

[0042] Figure 12 This is a partial three-dimensional view of the structure of the present invention;

[0043] Figure 13 This is a schematic diagram of the installation structure of the transmission component of the present invention.

[0044] Explanation of the labels in the diagram:

[0045] 1. Inner aqueous phase tank, 11. Inner aqueous phase inlet, 12. Upper inner aqueous phase chamber, 13. Lower inner aqueous phase chamber, 14. Inner aqueous phase hole, 15. Manifold I, 16. Annular platform, 17. Overflow port I, 2. Oil phase tank, 21. Oil phase inlet, 22. Manifold II, 23. Overflow port II, 24. Cylindrical mixing plate, 3. Outer aqueous phase tank, 31. Outer aqueous phase inlet, 32. Manifold III, 4. Discharge tank, 41. Discharge port I, 5. Homogenizing device, 51. Booster pump, 52. Pressure gauge, 53. Homogenizing channel, 54. Discharge port II, 6. Staggered propulsion mechanism, 61. Transmission component, 611. Locking block, 62. Sealing component, 63. Movable plate, 631. Slide groove, 632. Slider, 64. Movable rod, 65. Push block, 66. Support plate, 661. Moving groove, 662. Movable groove, 67. Cylinder. Detailed Implementation

[0046] Example 1:

[0047] Please see Figure 1-13 A device for preparing a high-temperature sterilization-resistant, encapsulated oligopeptide material stable solution includes an inner aqueous phase tank 1, an oil phase tank 2, an outer aqueous phase tank 3, a discharge tank 4, and a homogenizing device 5. The inner aqueous phase tank 1, oil phase tank 2, outer aqueous phase tank 3, and discharge tank 4 are nested together on the same central axis. The homogenizing device 5 is connected to the discharge tank 4 through a discharge port 41 provided at the bottom of the discharge tank 4.

[0048] It should be understood that an aqueous solution of oligopeptides is used as the inner aqueous phase α1, lipids are dissolved in an organic solvent to prepare the oil phase β, and a second aqueous solution is prepared as the outer aqueous phase α2. The inner aqueous phase α1 and the oil phase β are mixed to obtain an α1β mixture. The α1β mixture is then mixed with the outer aqueous phase α2 to obtain an α1βα2 mixture. This α1βα2 mixture is the oligopeptide liposome suspension.

[0049] like Figure 3 As shown, the inner water phase tank 1 includes an inner water phase tank body, an inner water phase inlet 11, an upper inner water phase chamber 12, a lower inner water phase chamber 13, a manifold 15, and an annular platform 16. The inner water phase inlet 11 is located above the inner water phase tank body. The inner water phase α1 enters the inner water phase tank body through the inner water phase inlet 11. The internal space of the inner water phase tank body is divided into an upper inner water phase chamber 12 and a lower inner water phase chamber 13. The upper inner water phase chamber 12 is funnel-shaped, gradually reducing the area of ​​the flow cross section through which the liquid passes, thus avoiding sudden changes in liquid pressure.

[0050] The upper inner water phase chamber 12 is connected to the lower inner water phase chamber 13 through the inner water phase hole 14. The inner diameter of the inner water phase hole 14 on the side closer to the upper inner water phase chamber 12 is larger than the inner diameter on the side closer to the lower inner water phase chamber 13, thereby ensuring the liquid flow direction. The inner water phase holes 14 are distributed in a circle around the central axis of the inner water phase tank 1, and the central axis of each inner water phase hole 14 is a horizontal line.

[0051] The manifold 15 is circular and is installed on the inner wall of the lower inner water phase chamber 13. Several elongated holes are opened on the manifold 15. The inner diameter of the elongated hole on the side closer to the lower inner water phase chamber 13 is larger than the inner diameter on the other side.

[0052] The annular platform 16 is installed around the outer wall of the inner water phase tank. The annular platform 16 is provided with a space for water storage. The annular platform 16 is provided with a normally closed overflow port 17 that connects the water storage space and the outside.

[0053] like Figure 4 As shown, the oil phase tank 2 includes an oil phase tank body, an oil phase inlet 21, and a manifold 22. The oil phase inlet 21 is located below the oil phase tank body. The oil phase β enters the oil phase tank body from the oil phase inlet 21. The manifold 22 is annular and installed on the inner wall of the oil phase tank body. Several elongated holes are opened on the manifold 22. The inner diameter of the elongated holes on the side near the oil phase inlet 21 is larger than the inner diameter on the other side. The bottom of the oil phase tank body is provided with a normally closed overflow port 23 that connects the internal space of the oil phase tank body to the outside.

[0054] The upper part of the oil phase tank is provided with a cylindrical mixing base plate 24, which is located in the area above the manifold 22. The cylindrical mixing base plate 24 is provided with several liquid outlet holes, and the inner diameter of the liquid outlet hole on the side closer to the inner wall of the oil phase tank is larger than the inner diameter of the other side.

[0055] like Figure 5 As shown, the external water phase tank 3 includes an external water phase tank body, an external water phase inlet 31, and a manifold 32. The external water phase inlet 31 is located above the external water phase tank body. The external water phase α2 enters the external water phase tank body through the external water phase inlet 31. The manifold 32 is annular and installed on the inner wall of the external water phase tank body. Several slender holes are opened on the manifold 32. The inner diameter of the slender holes on the side closer to the external water phase inlet 31 is larger than the inner diameter on the other side. The top of the external water phase tank 3 is provided with a circular notch.

[0056] Busbar 1 (15), Busbar 2 (22), and Busbar 3 (32) are located on the same plane.

[0057] like Figures 2-6As shown, the diameters of the inner aqueous phase tank 1, oil phase tank 2, and outer aqueous phase tank 3 increase sequentially. The inner diameter of the outer aqueous phase tank 3 is equal to the maximum inner diameter of the discharge tank 4. The upper end of the cylindrical mixing plate 24 of the oil phase tank 2 is sealed to the lower end of the annular platform 16 of the inner aqueous phase tank 1. The circular notch at the top of the outer aqueous phase tank 3 is sealed to the outer wall of the inner aqueous phase tank 1. The bottom end of the outer aqueous phase tank 3 is sealed to the top end of the discharge tank 4. The outer aqueous phase inlet 31 extends into the bottom area of ​​the water storage space of the annular platform 16.

[0058] The homogenizing device 5 includes a booster pump 51, a homogenizing channel 53, and a second outlet 54. One side of the booster pump 51 is connected to the first outlet 41 as the input end, and the other side is connected to the homogenizing channel 53 through a pipe as the output end. A pressure gauge 52 is installed on the pipe to detect the pressure. The homogenizing channel 53 is composed of several mutually perpendicular channels, and the space where the perpendicular angle is located is polyhedral, which increases the number of collisions between particles. The end of the homogenizing channel 53 is connected to the outlet 54.

[0059] The following will describe the usage and working principle of the preparation device. It should be noted that the parts not described in detail in this invention are all prior art. Any embodiments obtained by those skilled in the art by modifying the size, liquid flow rate, etc. of this invention without creative effort are still within the protection scope of this invention.

[0060] like Figure 7 As shown, the inner aqueous phase α1 is continuously injected into the inner aqueous phase inlet 11, the oil phase β is continuously injected into the oil phase inlet 21, and the outer aqueous phase α2 is continuously injected into the outer aqueous phase inlet 31. When the inner aqueous phase α1 passes through the inner aqueous phase hole 14, the shear force generated when it passes through the flow-limiting gap due to the surface tension of the fluid and the wall friction force will initially refine the inner aqueous phase α1. The initially refined inner aqueous phase α1 passes through the manifold 15 and merges with the oncoming oil phase β. The extremely fine inner aqueous phase α1 bundle is squeezed and wrapped by the oil phase β, forming intermittent and dispersed water bubbles in the wrapping of the oil phase β, thus obtaining the α1β mixture.

[0061] Under the impact pressure of the continuously injected inner aqueous phase α1 and oil phase β, the α1β mixture flows towards the cylindrical mixing substrate 24 along the gap between the inner wall of the oil phase tank 2 and the outer wall of the inner aqueous phase tank 1. It passes through the liquid outlet on the cylindrical mixing substrate 24 and merges with the oncoming outer aqueous phase α2. Because the outer aqueous phase inlet 31 extends into the bottom area of ​​the water storage space of the annular platform 16, the outer aqueous phase α2 will only overflow from the edge of the annular platform 16 after filling the water storage space. This makes the flow rate and fluid pressure distribution of the outer aqueous phase α2 more uniform. The extremely fine α1β mixture is squeezed and wrapped by the outer aqueous phase α2, forming intermittent and dispersed oil bubbles in the wrapping of the outer aqueous phase α2, thus obtaining the α1βα2 mixture.

[0062] The α1βα2 mixture flows out from the discharge port 41 and flows to the input end of the booster pump 51. The booster pump 51 pressurizes the α1βα2 mixture so that it passes through the homogenization channel 53 at high speed, thereby obtaining oligopeptide liposomes with uniform particle size and stable properties.

[0063] Example 2:

[0064] Please see Figure 1-13 A device for preparing a high-temperature sterilization-resistant encapsulated oligopeptide material stable solution, which differs from Example 1 in that it also includes an interleaved propulsion mechanism 6, and the first manifold 15, the second manifold 22 and the third manifold 32 are slidably connected to the inner aqueous phase tank 1, the oil phase tank 2 and the outer aqueous phase tank 3.

[0065] The staggered propulsion mechanism 6 includes a transmission component 61, a seal 62, a movable plate 63, a movable rod 64, a push block 65, a support plate 66, and a cylinder 67, as follows: Figure 9 , Figure 10 As shown, several through holes are symmetrically opened near the manifold 15, manifold 22, and manifold 33 of the inner water phase tank 1, oil phase tank 2, and outer water phase tank 3, respectively. Several transmission components 61 are installed in the through holes and are rotatably connected to the inner water phase tank 1, oil phase tank 2, and outer water phase tank 3. The transmission components 61 are Z-shaped, and the Z-shaped orientations of adjacent transmission components 61 are opposite. Figure 13 As shown, the transmission component 61 rotatably connected to the inner water phase tank 1 is the inner layer transmission component group one, the transmission component 61 rotatably connected to the oil phase tank 2 is the middle layer transmission component group two, and the transmission component 61 rotatably connected to the outer water phase tank 3 is the outer layer transmission component group three. The manifold 15 and the manifold 22 are linked through the inner layer transmission component group one, the manifold 22 and the manifold 32 are linked through the middle layer transmission component group two, and the manifold 32 is linked to the outside of the outer water phase tank 3 through the outer layer transmission component group three.

[0066] Busbar 15, busbar 22, and busbar 32 are all fixedly installed with locking blocks 611 near the through hole. The locking blocks 611 are provided with strip-shaped locking grooves. The two ends of the transmission component 61 are respectively slidably engaged with the strip-shaped locking grooves on the locking blocks 611 to realize linkage with busbar 15, busbar 22, or busbar 32. When the outer transmission component group 3 rotates, busbar 32 descends, driving the middle transmission component group 2 to rotate, busbar 22 rises, driving the inner transmission component group 1 to rotate, and busbar 15 descends, and vice versa. The sealing component 62 is slidably and sealingly connected to the outer wall of the transmission component 61 in the internal space of the through hole, sealing the through hole without affecting the rotation of the transmission component 61.

[0067] like Figure 11 , Figure 12As shown, one end of the transmission component 61 of the outer layer transmission component group 3 is engaged with the manifold 32, and the other end extends out of the outer water phase tank 3. The part of the outer layer transmission component 61 extending out of the outer water phase tank 3 is fixedly connected to one side of the movable plate 63. The movable plate 63 has a sliding groove 631 and a slider 632 is installed. One end of the movable rod 64 is rotatably connected to the slider 632, and the other end of the movable rod 64 is rotatably connected to the push block 65. The push block 65 is fixedly connected to the cylinder 67. The support plate 66 supports the push block 65 and the cylinder 67. The support plate 66 has a moving groove 661 and a limiting groove 662. The push block 65 moves back and forth on the moving groove 662 by slidingly connecting with the moving groove 661.

[0068] In use, cylinder 67 drives push block 65 to reciprocate in movable groove 662. As push block 65 gradually approaches outer water phase tank 3, the end of movable rod 64 rotatably connected to slider 632 is raised. Slider 632 pushes movable plate 63 upward, causing outer transmission component assembly three to rotate. Since the path formed by the outer end of transmission component 61 when it rotates is arc-shaped, this end is compensated for the path through sliding groove 631. At the same time as this end of outer transmission component assembly three is pushed upward, the part of outer transmission component assembly three located inside outer water phase tank 3 descends, pushing manifold 32 downward. Since the path formed by the outer end of transmission component 61 when it rotates is arc-shaped, this end is compensated for the path through strip groove provided on locking block 611. The same applies below.

[0069] As the manifold 32 descends, the portion of the middle transmission assembly 2 located inside the outer water phase tank 3 descends, while the portion located inside the oil phase tank 2 rises, causing the manifold 22 to rise. The portion of the inner transmission assembly 1 located inside the oil phase tank 2 rises, while the portion located inside the inner water phase tank 1 descends, causing the manifold 15 to descend. The same applies when the propulsion direction is reversed.

[0070] During the alternating movement of manifold 15, manifold 22 and manifold 32, the particle size of the liposomes is adjusted by adjusting the pushing speed of the cylinder, thereby improving the encapsulation rate and further stabilizing the properties of the oligopeptide liposomes.

Claims

1. A device for preparing a stable solution of high-temperature sterilization-resistant encapsulated oligopeptide material, characterized in that: It includes an inner aqueous phase tank (1), an oil phase tank (2), an outer aqueous phase tank (3), a discharge tank (4), and a homogenizing device (5). The inner aqueous phase tank (1), the oil phase tank (2), the outer aqueous phase tank (3), and the discharge tank (4) are nested on the same central axis. The discharge tank (4) has a discharge port (41) at the bottom. The homogenizing device (5) is connected to the discharge tank (4) through the discharge port (41). The inner aqueous phase tank (1) includes an inner aqueous phase tank body and an annular platform (16). The annular platform (16) is installed around the outer wall of the inner aqueous phase tank body. The inner aqueous phase tank (1) and the outer aqueous phase tank (3) are not sealed at the bottom, the oil phase tank (2) and the discharge tank (4) are not sealed at the top, and the outer aqueous phase tank (3) has a circular notch at the top; The diameters of the inner water phase tank (1), oil phase tank (2) and outer water phase tank (3) increase sequentially. The inner diameter of the outer water phase tank (3) is equal to the maximum inner diameter of the discharge tank (4). The upper end of the oil phase tank (2) is sealed to the lower end of the annular platform (16) of the inner water phase tank (1). The circular notch at the top of the outer water phase tank (3) is sealed to the outer wall of the inner water phase tank (1). The bottom end of the outer water phase tank (3) is sealed to the top end of the discharge tank (4). The inner water phase tank (1) also includes an inner water phase inlet (11), an upper inner water phase chamber (12), a lower inner water phase chamber (13), and a manifold plate (15). The inner water phase inlet (11) is located above the inner water phase tank. The internal space of the inner water phase tank is divided into an upper inner water phase chamber (12) located at the top and a lower inner water phase chamber (13) located at the bottom. The upper inner water phase chamber (12) is connected to the lower inner water phase chamber (13) through an inner water phase hole (14). The manifold plate (15) is circular and is installed on the inner wall of the lower inner water phase chamber (13). Several slender holes are opened on the manifold plate (15). The oil phase tank (2) includes an oil phase tank body, an oil phase inlet (21), and a manifold (22). The oil phase inlet (21) is located below the oil phase tank body. The manifold (22) is annular and installed on the inner wall of the oil phase tank body. Several elongated holes are opened on the manifold (22). A cylindrical mixing substrate (24) is provided on the upper part of the oil phase tank body. The cylindrical mixing substrate (24) is located in the area above the manifold (22). Several liquid outlet holes are provided on the cylindrical mixing substrate (24). The external water phase tank (3) includes an external water phase tank body, an external water phase inlet (31), and a manifold plate (32). The external water phase inlet (31) is located above the external water phase tank body. The manifold plate (32) is ring-shaped and installed on the inner wall of the external water phase tank body. Several slender holes are opened on the manifold plate (32).

2. The apparatus for preparing a high-temperature sterilization-resistant encapsulated oligopeptide material stable solution according to claim 1, characterized in that: The homogenizing device (5) includes a booster pump (51), a homogenizing channel (53), and a second outlet (54). The booster pump (51) is connected to the first outlet (41) on one side as an input end, and to the homogenizing channel (53) on the other side as an output end through a pipe. A pressure gauge (52) is installed on the pipe to detect the pressure. The homogenizing channel (53) is composed of several mutually perpendicular channels, and the space at the junction of the channels at the perpendicular angle is a polyhedron. The end of the homogenizing channel (53) is connected to the second outlet (54).

3. The apparatus for preparing a high-temperature sterilization-resistant encapsulated oligopeptide material stable solution according to claim 1, characterized in that: The upper inner water phase chamber (12) is funnel-shaped, and the inner diameter of the inner water phase hole (14) on the side near the upper inner water phase chamber (12) is larger than the inner diameter on the other side. The inner diameter of the elongated hole on the side near the lower inner water phase chamber (13) is larger than the inner diameter on the other side.

4. The apparatus for preparing a high-temperature sterilization-resistant encapsulated oligopeptide material stable solution according to claim 1, characterized in that: The inner diameter of the elongated hole 2 on the side near the oil phase inlet (21) is larger than the inner diameter on the other side. The bottom of the oil phase tank is provided with a normally closed overflow port 2 (23) that connects the internal space of the oil phase tank to the outside. The inner diameter of the outlet hole on the side near the inner wall of the oil phase tank is larger than the inner diameter on the other side.

5. The apparatus for preparing a high-temperature sterilization-resistant encapsulated oligopeptide material stable solution according to claim 1, characterized in that: The inner diameter of the elongated hole on the side near the external water phase inlet (31) is larger than the inner diameter on the other side.

6. The apparatus for preparing a high-temperature sterilization-resistant encapsulated oligopeptide material stable solution according to claim 1, characterized in that: Busbar 1 (15), busbar 2 (22) and busbar 3 (32) are located on the same horizontal plane.

7. The apparatus for preparing a high-temperature sterilization-resistant encapsulated oligopeptide material stable solution according to claim 1, characterized in that: The annular platform (16) is provided with a space for water storage. The annular platform (16) is provided with a normally closed overflow port (17) that connects the water storage space to the outside. The external water phase inlet (31) extends into the bottom area of ​​the water storage space of the annular platform (16).

8. The apparatus for preparing a high-temperature sterilization-resistant encapsulated oligopeptide material stable solution according to claim 1, characterized in that: The inner wall of the inner water phase tank (1) is slidably connected to the first manifold (15), which is circular; the inner wall of the oil phase tank (2) is slidably connected to the outer wall of the second manifold (22), which is annular, and the inner wall of the second manifold (22) is slidably connected to the outer wall of the inner water phase tank (1); the inner wall of the outer water phase tank (3) is slidably connected to the outer wall of the third manifold (32), which is annular, and the inner wall of the third manifold (32) is slidably connected to the outer wall of the oil phase tank (2); The preparation device also includes an interleaved propulsion mechanism (6), which includes several transmission components (61), sealing components (62) and cylinders (67). The inner water phase tank (1), oil phase tank (2) and outer water phase tank (3) are symmetrically provided with several through holes close to the first manifold (15), the second manifold (22) and the third manifold (32). The several through holes are located on the same horizontal plane. The transmission components (61) are Z-shaped. The middle part of several transmission components (61) is installed in the through holes. The two ends of the Z-shaped transmission components (61) extend out of the inner water phase tank (1), the oil phase tank (2) or the outer water phase tank (3). The Z-shaped installation of adjacent transmission components (61) is opposite in orientation. Busbar 1 (15), busbar 2 (22) and busbar 3 (32) are all fixedly installed with a locking block (611) near the through hole. The two ends of the transmission component (61) are slidably engaged with the locking block (611) to realize the linkage between the transmission component (61) and busbar 1 (15), busbar 2 (22) or busbar 3 (32); The seal (62) is located inside the through hole and is in sliding sealing connection with the transmission component (61) without affecting the rotation of the transmission component (61).

9. The apparatus for preparing a high-temperature sterilization-resistant encapsulated oligopeptide material stable solution according to claim 8, characterized in that: The staggered propulsion mechanism (6) also includes a movable plate (63), a movable rod (64), a push block (65), and a support plate (66). The transmission component (61) rotatably connected to the outer water phase tank (3) is an outer transmission component group three. One end of the transmission component (61) of the outer transmission component group three is engaged with a locking block (611) on the manifold three (32), and the other end extends out of the outer water phase tank (3). The portion extending out of the outer water phase tank (3) is fixedly connected to one side of the movable plate (63). The movable plate (63) has a sliding groove (631). A slider (632) is installed inside 631. One end of the movable rod (64) is rotatably connected to the slider (632), and the other end of the movable rod (64) is rotatably connected to the push block (65). The push block (65) is fixedly connected to the cylinder (67). The support plate (66) supports the push block (65) and the cylinder (67). The support plate (66) is provided with a moving groove (661) and a limiting groove (662). The push block (65) is slidably connected to the moving groove (661) and moves back and forth in the moving groove (662) under the push of the cylinder (67).

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