Absorbable additive manufacturing bone repair material and preparation method and application thereof

Abstract

The application relates to the technical field of repair stents, and discloses an absorbable additive manufacturing bone repair material, a preparation method and application thereof. The preparation method comprises the following steps: soaking a stent body prepared through continuous melt micro-extrusion in a modified container provided with an alkali solution and capable of adjusting a rotating mode to perform surface modification, so as to form crack-shaped micro-nano structures with a groove width precision of 100nm-3um. The absorbable additive manufacturing bone repair material with higher precision and better uniformity of micro-nano structures can be prepared, the material has good biocompatibility, can promote cell adhesion, proliferation and differentiation, has higher biological activity relative to other stents, provides an ideal three-dimensional space for cell growth, is convenient for tissue ingrowth and regeneration, and the method can be widely applied to the field of oral craniomaxillofacial trauma repair.

Description

Technical Field

[0001] This invention relates to the field of repair scaffold technology, and more specifically, to an absorbable additive manufacturing bone repair material, its preparation method, and its application. Background Technology

[0002] The face is composed of many bones, which form the structural basis for the morphology and function of the oral and maxillofacial region. Defects in these bones will inevitably lead to facial deformities and functional impairments. Severe oral and maxillofacial trauma is often accompanied by bone tissue defects. To prevent secondary deformities caused by bone defect contraction, bone defect repair should be performed simultaneously whenever possible.

[0003] In recent years, more and more scaffold materials have been used for the repair of bone tissue defects, and the clinical repair effect of bone tissue defects is closely related to the material composition and microstructure.

[0004] However, existing repair scaffolds suffer from poor repair effects due to their own structure and precision limitations, and cell adhesion and growth are also unsatisfactory.

[0005] In view of this, the present invention is proposed. Summary of the Invention

[0006] The purpose of this invention is to provide an absorbable additive manufacturing bone repair material, its preparation method, and its application.

[0007] This invention is implemented as follows:

[0008] In a first aspect, the present invention provides a method for preparing an absorbable additive manufacturing bone repair material, comprising:

[0009] The scaffold body prepared by continuous melt micro-extrusion is immersed in a modified container with an adjustable rotation mode containing an alkaline solution to perform surface modification and form a crack-like micro / nano structure with a groove width accuracy of 100 nm-3 μm.

[0010] The rotation mode of the modified container is adjusted by a multi-degree-of-freedom rotation mechanism, which includes a base, a main rotation shaft, a connecting seat, sub-rotation shafts, and a storage tray. The bottom of the main rotation shaft is rotatably mounted on the base, and the top of the main rotation shaft is connected to the connecting seat. There are multiple sub-rotation shafts, all of which are tilted and rotatably connected to the connecting seat. The number of storage trays corresponds one-to-one with the number of sub-rotation shafts. Each storage tray is connected to the end of a sub-rotation shaft away from the connecting seat, and the modified container is mounted on the storage tray.

[0011] In an optional embodiment, the rotational speed of the main rotating shaft is 1-100 r / min, and the rotational speed of the secondary rotating shaft is 1-100 r / min.

[0012] In an optional implementation, the rotation mode includes forward and reverse rotation of the main rotation axis and the sub-rotation axis;

[0013] Preferably, the rotating shaft rotates forward at a speed of 50-100 r / min for 5-10 min, and then rotates backward at a speed of 1-50 r / min for 5-10 min as a cycle, and repeats the cycle until the modification is completed.

[0014] In an optional embodiment, the included angle between the rotating shaft and the connecting seat is 0-180°.

[0015] In an optional embodiment, the tray is provided with a fixing mechanism for fixing the modified container, the fixing mechanism including a clamp, a threaded connection or a slider connection.

[0016] In an optional embodiment, during the surface modification process, the concentration of the alkaline solution, the modification time, and the modification temperature are adjusted to control the precision of the surface modification.

[0017] Preferably, the alkaline solution comprises at least one of sodium hydroxide, potassium hydroxide, sodium bicarbonate, sodium carbonate, potassium bicarbonate, and potassium carbonate.

[0018] Preferably, the concentration of the alkaline solution is 0.1-10 mol / L; preferably, the modification time is 1-72 h;

[0019] Preferably, the modification temperature is 20-40℃.

[0020] In an optional embodiment, the method for preparing the stent body includes:

[0021] The polymer and ceramic are dissolved in a solvent and mixed by rotation and ultrasonic superposition. After mixing, the solvent is evaporated to form a composite material. The composite material is continuously placed in the printing chamber of additive manufacturing for melt micro-extrusion to print a porous scaffold. The printing accuracy of the porous scaffold is 50-1000μm.

[0022] Preferably, the polymer comprises at least one of the monomers or copolymers of caprolactone, lactide, glycolide, urethane, ethylene glycol, and vinyl alcohol;

[0023] Preferably, the ceramic comprises at least one of hydroxyapatite, tricalcium phosphate, bioglass, nanoclay, silica, magnesium oxide, zinc oxide, silver oxide, strontium oxide, iron oxide, and lithium oxide;

[0024] Preferably, the rotational speed is 10-1500 r / min;

[0025] Preferably, the power of the ultrasound is 200-1000W.

[0026] In an optional embodiment, the additive manufacturing includes one or more of microextrusion, electrospinning, electrostatic direct writing, micro-inkjet printing, digital photoforming, and laser fused deposition.

[0027] Secondly, the present invention provides an absorbable additive manufacturing bone repair material, which is prepared by the method for preparing absorbable additive manufacturing bone repair material as described in any of the foregoing embodiments.

[0028] Thirdly, the present invention provides the application of absorbable additive manufacturing bone repair material as described in the foregoing embodiments in the repair of oral and maxillofacial trauma.

[0029] Preferably, the oral craniofacial trauma includes at least one of oral site preservation, jawbone cyst, alveolar ridge cleft, orbital repair, facial contour repair, hemifacial microsomia, cranial bone repair, cranial suture closure, nasal septum deviation, columella lengthening, and nasal base repair.

[0030] The present invention has the following beneficial effects:

[0031] The method for preparing absorbable additive manufacturing bone repair materials provided in this invention can prepare micro-nano structures with higher precision and more uniformity. The prepared absorbable additive manufacturing bone repair materials have good biocompatibility and can also promote cell adhesion, proliferation and differentiation. Compared with other scaffold materials, they have higher bioactivity, provide an ideal three-dimensional space for cell growth, and facilitate tissue ingrowth and regeneration. They can be widely used in the preparation of repair scaffolds for oral and maxillofacial trauma. Attached Figure Description

[0032] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0033] Figure 1 A schematic diagram of the multi-degree-of-freedom rotation mechanism for fabricating crack-like micro / nano structures provided in this application;

[0034] Figure 2 This is a SEM image of the crack-like micro / nano structure provided in Embodiment 1 of this application, with a scale bar of 5 μm.

[0035] Figure 3 This is a SEM image of the crack-like micro / nano structure provided in Embodiment 2 of this application, with a scale bar of 5 μm.

[0036] Figure 4This is a SEM image of the crack-like micro / nano structure provided in Embodiment 3 of this application at a scale bar of 5 μm;

[0037] Figure 5 SEM image of the support body provided in Comparative Example 1 of this application at a scale bar of 5 μm;

[0038] Figure 6 SEM image of the crack-like micro / nano structure provided in Comparative Example 2 of this application at a scale bar of 5 μm;

[0039] Figure 7 The images show the mixing and dispersion effects of the printed composite materials under different mixing methods provided in Example 1 and Comparative Example 3 of this application. In the image, A is the mixing and dispersion effect of Comparative Example 3, and B is the mixing and dispersion effect of Example 1.

[0040] Figure 8 This is a schematic diagram illustrating how the crack-like micro / nano structure provided in Embodiment 1 of this application promotes cell adhesion and growth.

[0041] Figure 9 This is a schematic diagram illustrating how the crack-like micro / nanostructure provided in Embodiment 1 of this application promotes tissue ingrowth and regeneration.

[0042] Figure 10 The images shown are SEM images of the repair stent prepared by immersion in alkaline solution according to Example 1 of this application, where A is an effect image of the center of the repair stent and B is an effect image of the surface of the repair stent.

[0043] Icons: 200 - Multi-degree-of-freedom rotation mechanism; 201 - Base; 202 - Main rotation axis; 203 - Connecting seat; 204 - Sub-rotation axis; 205 - Storage tray. Detailed Implementation

[0044] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. Where specific conditions are not specified in the embodiments, conventional conditions or conditions recommended by the manufacturer shall apply. Reagents or instruments whose manufacturers are not specified are all conventional products that can be purchased commercially.

[0045] This invention provides a method for preparing an absorbable additive manufacturing bone repair material, comprising the following steps:

[0046] S1. Preparation of the scaffold body.

[0047] The polymer and ceramic are dissolved in a solvent and mixed by rotation and ultrasonic superposition. After mixing, the solvent is evaporated to form a composite material. The composite material is continuously placed in the printing chamber of additive manufacturing for continuous melt micro-extrusion to print a porous scaffold with a printing accuracy of 50-1000μm.

[0048] The polymer and ceramic mass percentage is 55%-100%:45%-0%, wherein the polymer includes, but is not limited to, at least one of the following: polymers or copolymers of caprolactone, lactide, glycolide, urethane, ethylene glycol, and vinyl alcohol; the ceramic includes, but is not limited to, at least one of the following: hydroxyapatite, tricalcium phosphate, bioglass, nanoclay, silica, magnesium oxide, zinc oxide, silver oxide, strontium oxide, iron oxide, and lithium oxide. It should be understood that when the ceramic content is 0%, it means that the scaffold body is prepared solely using polymers. When the polymer is a monomer, it can be, for example, at least one of polycaprolactone, polylactide, polyglycolic acid, polyurethane, polyethylene glycol, and polyvinyl alcohol, etc. When the polymer is a copolymer, it can be a commercially available conventional copolymer, such as at least one of PLGA or PLCL.

[0049] In this application, a better mixing effect of polymer and ceramic can be achieved by superimposing rotation and ultrasound. Specifically, the rotation speed is 10-1500 r / min and the ultrasound power is 200-1000 W.

[0050] The raw materials selected in this invention have good biocompatibility and can also promote the release of active factors from cells, promote cell adhesion, proliferation and differentiation, making them ideal scaffold materials for the repair of soft tissue defects in the oral and maxillofacial region.

[0051] The additive manufacturing in this invention includes one or more of micro-extrusion, electrospinning, electrostatic direct writing, micro-inkjet printing, digital photoforming, and laser fused deposition.

[0052] S2. The scaffold body prepared by continuous melt micro-extrusion is immersed in a modified container with an adjustable rotation mode containing an alkaline solution to perform surface modification and form a crack-like micro / nano structure with a groove width accuracy of 100nm-3μm.

[0053] The scaffold body was immersed in a modification container containing an alkaline solution for surface modification. During the surface modification process, the concentration of the alkaline solution, the modification time, the modification temperature, and the rotation mode of the modification container were adjusted to control the precision of the surface modification; the precision of the crack-like groove width was 100nm-3μm.

[0054] In this invention, the alkaline solution can etch the scaffold body to form cracks. The alkaline solution includes, but is not limited to, at least one of sodium hydroxide, potassium hydroxide, sodium bicarbonate, sodium carbonate, potassium bicarbonate, and potassium carbonate; the concentration of the alkaline solution is 0.1-10 mol / L; the modification time is 1-72 h; and the modification temperature is 20-40℃. Performing the modification for a preset time under the above concentration and temperature conditions can result in cracks with superior precision.

[0055] Further, please refer to Figure 1The rotation mode is a multi-degree-of-freedom rotation. The rotation mode is adjusted by a multi-degree-of-freedom rotation mechanism 200, which includes a base 201, a main rotation shaft 202, a connecting seat 203, sub-rotation shafts 204, and a storage tray 205. The bottom of the main rotation shaft 202 is rotatably mounted on the base 201, and the top of the main rotation shaft 202 is connected to the connecting seat 203. Multiple sub-rotation shafts 204 are rotatably connected to the connecting seat 203 at an angle. Preferably, the angle between the sub-rotation shafts 204 and the connecting seat 203 is 0-180°. The number of storage trays 205 corresponds one-to-one with the number of sub-rotation shafts 204. Each storage tray 205 is connected to the end of the sub-rotation shaft 204 furthest from the connecting seat 203. The modified container is mounted on the storage tray 205. Simultaneously, the sub-rotation shafts 204 can be switched between forward and reverse rotation. This invention utilizes a multi-degree-of-freedom rotation mechanism 200 to rotate the modification container, resulting in superior modification effects and significantly improved uniformity. Since the sub-rotation shaft 204 in this embodiment is inclinedly connected to the connecting seat 203, the connecting seat 203 can achieve multi-degree-of-freedom rotation of the modification container, which is beneficial for improving the modification of the NaOH solution and the support body within the container, while also enhancing the uniformity of the modification, thereby achieving a modified crack morphology. The main rotation shaft 202 rotates at a speed of 1-100 r / min, and both the sub-rotation shaft 204 and the main rotation shaft 204 rotate at a speed of 1-100 r / min.

[0056] This application employs various rotation modes, including, for example, the forward and reverse rotation of the main rotation shaft 202 and the sub-rotation shaft 204. Preferably, the sub-rotation shaft 204 rotates forward at a speed of 50-100 r / min for 5-10 minutes, followed by reverse rotation at a speed of 1-50 r / min for 5-10 minutes as one cycle, repeating this cycle until the modification is complete. In this application, by using a high-speed forward rotation + low-speed reverse rotation mode, the movement speed and direction of the alkaline solution within the container can be altered, thereby ensuring more thorough contact between the solution and the support body, which is beneficial for improving the uniformity of modification. Simultaneously, during the rotation process, the support body rotates accordingly, adjusting the crack morphology and achieving excellent modification results.

[0057] Furthermore, in this application, the storage tray 205 is provided with a fixing mechanism (not shown) for fixing the modified container. The fixing mechanism includes a clamp, a threaded connection, or a slider connection. Any mechanism that can fix the modified container to the storage tray 205 is acceptable.

[0058] The absorbable additive bone repair material prepared by the above method has a more precise and uniform micro-nano structure. Compared with other scaffold materials, it has higher bioactivity, can better promote cell adhesion and proliferation, provides an ideal three-dimensional space for cell growth, and facilitates tissue ingrowth and regeneration. It can be widely used to prepare repair scaffolds for oral and craniofacial trauma. Specifically, oral and craniofacial trauma includes at least one of the following: oral site preservation, jaw cysts, alveolar ridge clefts, orbital repair, facial contour repair, hemifacial microsomia, cranial bone repair, craniosynostosis, nasal septum deviation, columellar lengthening, and nasal base repair.

[0059] The features and performance of the present invention will be further described in detail below with reference to embodiments.

[0060] Example 1

[0061] This embodiment provides a method for preparing an absorbable additive manufacturing bone repair material, which includes the following steps:

[0062] S1. Prepare the scaffold body.

[0063] 4g of polycaprolactone and 1g of tricalcium phosphate were dissolved in a solvent (dichloromethane) and mixed by a combination of rotation and ultrasound. The rotation speed was 1500 r / min, and the ultrasound power was 400 W. After mixing, the solvent was evaporated overnight through a fume hood to form a composite material. The composite material was then printed into a porous scaffold using the micro-extrusion mode of an OPUS printer at 120℃, 800 kPa, and 250 mm / min. The macroscopic dimensions of the printed scaffold body were 50×50×1.3 mm, the filament diameter was 200 μm, the filament spacing was 1 mm, and the structure was triangular.

[0064] S2. Prepare crack-like micro / nano structures.

[0065] The scaffold body was immersed in a modification container containing a 1 mol / L NaOH solution. The modification container was then placed on the placement disk 205 of the multi-degree-of-freedom rotation mechanism 200. The main rotation shaft 202 was then used to rotate the connecting seat 203, its subsidiary rotation shaft 204, and the placement disk 205 at a speed of 100 r / min. Simultaneously, the subsidiary rotation shaft 204 rotated the placement disk 205 at 100 r / min. Modification was carried out at 40℃ for 12 hours. This unique rotation method significantly improves the uniformity and permeability of the modification. The modified scaffold body surface forms a uniform crack-like micro / nano structure. (See [link to relevant documentation]). Figure 2 and Figure 5 It can be seen that the crack width after modification is 100-1000nm.

[0066] Example 2-3

[0067] Examples 2 and 3 are basically the same as Example 1, except that the parameters in step S2 are different:

[0068] In Example 2, the support body was immersed in a modification container containing a 3 mol / L NaOH solution. The modification container was placed on the placement plate 205 of the multi-degree-of-freedom rotation mechanism 200. Then, the main rotation shaft 202 rotated at 20 r / min, driving the connecting seat 203, the sub-rotation shaft 204 mounted on the connecting seat 203, and the placement plate 205 to rotate. Simultaneously, the sub-rotation shaft 204 rotated at 20 r / min, driving the placement plate 205 to rotate. Modification was carried out at a modification temperature of 30°C for 24 hours. Please refer to [link / reference]. Figure 3 and Figure 5 The modified crack width is 700-2000nm.

[0069] In Example 3, the support body was immersed in a modification container containing a 5 mol / L NaOH solution. The modification container was placed on the placement plate 205 of the multi-degree-of-freedom rotation mechanism 200. Then, the main rotation shaft 202 rotated at 40 r / min, driving the connecting seat 203, the sub-rotation shaft 204 mounted on the connecting seat 203, and the placement plate 205 to rotate. Simultaneously, the sub-rotation shaft 204 rotated at 40 r / min, driving the placement plate 205 to rotate. Modification was carried out at a modification temperature of 40°C for 8 hours. Please refer to [link / reference]. Figure 4 and Figure 5 The modified crack width is 2000-3000nm.

[0070] Example 4

[0071] This embodiment is basically the same as Embodiment 1, except that the rotation mode of the rotating shaft 204 is different. In this embodiment, the rotating shaft 204 rotates forward at a speed of 100 r / min to drive the placement plate 205 to rotate for 10 minutes, and then rotates in the opposite direction at a speed of 50 r / min to drive the placement plate 205 to rotate for 10 minutes. The above forward + reverse rotation is one cycle, and the above cycle is repeated until the modification is completed. After modification, the crack width is 1000-1500 nm, and the uniformity of the crack groove width is better.

[0072] Comparative Example 1

[0073] This comparative example only provides a stent body according to the method of Example 1. The surface of the stent body in this comparative example has not been modified. Please refer to [link / reference]. Figure 5 .

[0074] Comparative Example 2

[0075] This comparative example is basically the same as Example 1, except that in this comparative example, step S2 includes: immersing the scaffold body in a modification container containing a 5 mol / L NaOH solution, and modifying it at a modification temperature of 40°C for 12 hours. The precision of the obtained crack-like micro / nano structure is 3-10 μm. Please refer to [link to relevant documentation]. Figure 6 .

[0076] Comparative Example 3

[0077] This comparative example is basically the same as Example 1, except that ultrasonic mixing was omitted in this comparative example. In this case, the dispersion effect of TCP in the material is worse than that in Example 1. (Refer to...) Figure 7 .from Figure 7 It can be seen that the composite material (B) formed by rotation and ultrasonic superposition mixing has a more uniform dispersion of phosphate particles than the composite material (A) formed by rotation mixing alone.

[0078] Experimental Example

[0079] The repair scaffolds prepared in Examples 1-4 and Comparative Examples 1-3 were subjected to in vitro cell culture experiments.

[0080] The experimental method for cell growth effect was the MTT assay, and the evaluation criterion was cell viability.

[0081]

[0082] As shown in the table above, surface crack-like micro / nano structure modification was performed in Examples 1-3. The modification precision of the surface crack-like micro / nano structure was controlled by adjusting parameters such as alkaline solution concentration, modification time, and modification temperature. Different crack widths resulted in different cell viability. Good cell viability was observed in crack widths ranging from 100 nm to 3 μm, with the best cell viability observed when the crack width was 100-1000 nm. Example 4, which incorporated a rotation mode, showed that the crack width range formed in Example 4 was more uniform, and the cell viability was higher. Compared to Comparative Example 1, the scaffold without surface micro / nano modification had the lowest cell viability. Compared to Comparative Example 2, increasing both the alkaline solution concentration and modification time resulted in a surface crack width of 3-10 μm on the scaffold, leading to a deterioration in cell viability. In Comparative Example 3, the omission of ultrasonic mixing resulted in poor material dispersion in the scaffold body. Even with crack modification, the effect was still significantly worse than in Example 1.

[0083] from Figure 8 and Figure 9 As can be seen, the scaffold with surface micro / nano modification provided in Example 1 can effectively achieve cell and tissue ingrowth.

[0084] from Figure 10 It can be seen that the scaffold treated with alkaline solution only formed a uniform crack-like micro / nano structure on its surface, while the center of the scaffold still had a uniform and dense structure.

[0085] In summary, the method for preparing absorbable additive manufacturing bone repair materials provided in this invention can prepare micro-nano structures with higher precision and uniformity. The prepared absorbable additive manufacturing bone repair materials have good biocompatibility and can also promote cell adhesion, proliferation and differentiation. Compared with other scaffold materials, they have higher bioactivity, provide an ideal three-dimensional space for cell growth, and facilitate tissue ingrowth and regeneration. They can be widely used in the preparation of repair scaffolds for oral and maxillofacial trauma.

[0086] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A method for preparing an absorbable additive bone repair material, characterized in that, It includes: A scaffold body prepared by continuous melt micro-extrusion of a polymer and ceramic composite material is immersed in a modified container with an adjustable rotation mode containing an alkaline solution for surface modification to form a crack-like micro / nano structure with a groove width accuracy of 100 nm-3 μm. The rotation mode of the modified container is adjusted by a multi-degree-of-freedom rotation mechanism, which includes a base, a main rotation shaft, a connecting seat, sub-rotation shafts, and a storage tray. The bottom of the main rotation shaft is rotatably mounted on the base, and the top of the main rotation shaft is connected to the connecting seat. There are multiple sub-rotation shafts, all of which are tilted and rotatably connected to the connecting seat. The number of storage trays corresponds one-to-one with the number of sub-rotation shafts. Each storage tray is connected to the end of a sub-rotation shaft away from the connecting seat, and the modified container is mounted on the storage tray.

2. The method for preparing absorbable additive bone repair material according to claim 1, characterized in that, The main rotating shaft rotates at a speed of 1-100 r / min, and the secondary rotating shaft rotates at a speed of 1-100 r / min.

3. The method for preparing absorbable additive bone repair material according to claim 1, characterized in that, The rotation mode includes the forward and reverse rotation of the main rotation axis and the sub-rotation axis.

4. The method for preparing absorbable additive bone repair material according to claim 3, characterized in that, The rotating shaft rotates forward at a speed of 50-100 r / min for 5-10 minutes, and then rotates backward at a speed of 1-50 r / min for 5-10 minutes as one cycle. This cycle is repeated until the modification is complete.

5. The method for preparing absorbable additive bone repair material according to claim 1, characterized in that, The angle between the rotating shaft and the connecting seat is 0-180°.

6. The method for preparing absorbable additive bone repair material according to claim 1, characterized in that, The storage tray is provided with a fixing mechanism for fixing the modified container, the fixing mechanism including a clamp, a threaded connection or a slider connection.

7. The method for preparing absorbable additive bone repair material according to claim 1, characterized in that, During the surface modification process, the concentration of the alkaline solution, the modification time, and the modification temperature are adjusted to control the precision of the surface modification.

8. The method for preparing absorbable additive bone repair material according to claim 7, characterized in that, The alkaline solution includes at least one of sodium hydroxide, potassium hydroxide, sodium bicarbonate, sodium carbonate, potassium bicarbonate, and potassium carbonate.

9. The method for preparing absorbable additive bone repair material according to claim 7, characterized in that, The concentration of the alkaline solution is 0.1-10 mol / L.

10. The method for preparing absorbable additive bone repair material according to claim 7, characterized in that, The modification time is 1-72 hours.

11. The method for preparing absorbable additive bone repair material according to claim 7, characterized in that, The modification temperature is 20-40℃.

12. The method for preparing absorbable additive bone repair material according to claim 1, characterized in that, The method for preparing the stent body includes: The polymer and ceramic are dissolved in a solvent and mixed by rotation and ultrasonic superposition. After mixing, the solvent is evaporated to form a composite material. The composite material is continuously placed in the printing chamber of additive manufacturing for melt micro-extrusion to print a porous scaffold with a printing accuracy of 50-1000μm.

13. The method for preparing absorbable additive bone repair material according to claim 12, characterized in that, The polymer includes at least one of the monomers or copolymers of caprolactone, lactide, glycolide, urethane, ethylene glycol, and vinyl alcohol.

14. The method for preparing absorbable additive bone repair material according to claim 12, characterized in that, The ceramic comprises at least one of hydroxyapatite, tricalcium phosphate, bioglass, nanoclay, silica, magnesium oxide, zinc oxide, silver oxide, strontium oxide, iron oxide, and lithium oxide.

15. The method for preparing absorbable additive bone repair material according to claim 12, characterized in that, The rotation speed is 10-1500 r / min when the polymer and the ceramic are dissolved in the solvent and mixed.

16. The method for preparing absorbable additive bone repair material according to claim 12, characterized in that, The power of the ultrasound is 200-1000W.

17. An absorbable additive bone repair material, characterized in that, It is prepared using the method for preparing absorbable additive manufacturing bone repair material as described in any one of claims 1-16.

18. The application of the absorbable additive manufacturing bone repair material as described in claim 17 in the repair of oral and maxillofacial trauma.

19. The application according to claim 18, characterized in that, The oral and craniofacial trauma includes at least one of the following: oral site preservation, jawbone cyst, alveolar ridge cleft, orbital repair, facial contour repair, hemifacial microsomia, cranial bone repair, cranial suture closure, nasal septum deviation, columella lengthening, and nasal base repair.

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