Pyridinium salt singlet oxygen type active oxygen photosensitizer, preparation method and application thereof

By synthesizing pyridine salt singlet oxygen photosensitizers, the problem of time-consuming and labor-intensive production of Bacillus subtilis spores has been solved, enabling rapid in vivo transformation and real-time fluorescence imaging monitoring, and exhibiting highly efficient bacterial inactivation capabilities.

CN117624035BActive Publication Date: 2026-07-21THE CHINESE UNIV OF HONG KONG (SHENZHEN)
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE CHINESE UNIV OF HONG KONG (SHENZHEN)
Filing Date
2023-11-29
Publication Date
2026-07-21

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Abstract

The pyridine salt singlet oxygen type ROS material system has the AIE performance, can realize the rapid transformation of the bacillus subtilis vegetative cell to the spore under normal temperature and normal pressure, and can monitor the transformation process of the vegetative cell to the spore in real time, so that the problems of the fluorescence aggregation quenching effect and the spore production unable to be monitored in real time in the prior art can be overcome. In addition, the pyridine salt singlet oxygen type ROS material can destroy the bacterial cell membrane and the cell wall of the bacillus subtilis, so that the bacillus subtilis can be inactivated.
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